FR2107902A1 - Technetium 99m co-pptd sulphur-albumin prepn - - for lung scanning - Google Patents

Technetium 99m co-pptd sulphur-albumin prepn - - for lung scanning

Info

Publication number
FR2107902A1
FR2107902A1 FR7134097A FR7134097A FR2107902A1 FR 2107902 A1 FR2107902 A1 FR 2107902A1 FR 7134097 A FR7134097 A FR 7134097A FR 7134097 A FR7134097 A FR 7134097A FR 2107902 A1 FR2107902 A1 FR 2107902A1
Authority
FR
France
Prior art keywords
albumin
prepn
sulphur
pptd
technetium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7134097A
Other languages
French (fr)
Other versions
FR2107902B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2107902A1 publication Critical patent/FR2107902A1/en
Application granted granted Critical
Publication of FR2107902B1 publication Critical patent/FR2107902B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1255—Granulates, agglomerates, microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Macro-agglomerate title composn. is prepd. by treating a sulphur cpd. such as hyposulphite with an acid in the presence of Tc-99m to give a colloid, adding denatured albumin (pref. normal serum albumin in the first stage of denaturation), adjusting the pH to the isoelectric pt. of the protein to form agglomerates, which are heated to produce uniform particles of the required size, pref. 10-100 mu. 75 - 100% localises in the lungs, very little in the liver and the prepn. clears the lungs after 4-24 hrs. It is intended that the material is prepd. immediately before use.
FR7134097A 1970-09-23 1971-09-22 Technetium 99m co-pptd sulphur-albumin prepn - - for lung scanning Granted FR2107902A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7488270A 1970-09-23 1970-09-23

Publications (2)

Publication Number Publication Date
FR2107902A1 true FR2107902A1 (en) 1972-05-12
FR2107902B1 FR2107902B1 (en) 1975-02-07

Family

ID=22122231

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7134097A Granted FR2107902A1 (en) 1970-09-23 1971-09-22 Technetium 99m co-pptd sulphur-albumin prepn - - for lung scanning

Country Status (4)

Country Link
BE (1) BE772946A (en)
DE (1) DE2147621A1 (en)
FR (1) FR2107902A1 (en)
NL (1) NL7113117A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057924A2 (en) * 1999-03-26 2000-10-05 London Health Sciences Centre Colloid for scintigraphy
US6706251B1 (en) 1999-03-26 2004-03-16 London Health Sciences Centre Colloid for scintigraphy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
REVUE: JOURNAL OF NUCLEAR MEDICINE, VOLUME 10, PAGES 621 623 1969 ) *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057924A2 (en) * 1999-03-26 2000-10-05 London Health Sciences Centre Colloid for scintigraphy
WO2000057924A3 (en) * 1999-03-26 2001-03-22 London Health Sciences Ct Colloid for scintigraphy
US6706251B1 (en) 1999-03-26 2004-03-16 London Health Sciences Centre Colloid for scintigraphy

Also Published As

Publication number Publication date
DE2147621A1 (en) 1973-08-09
FR2107902B1 (en) 1975-02-07
BE772946A (en) 1972-03-22
NL7113117A (en) 1972-03-27

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Legal Events

Date Code Title Description
ST Notification of lapse