WO2000054776A1 - Utilisation d'inhibiteurs de la prolactine dans le traitement des problemes de fecondite dans diverses especes animales - Google Patents

Utilisation d'inhibiteurs de la prolactine dans le traitement des problemes de fecondite dans diverses especes animales Download PDF

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Publication number
WO2000054776A1
WO2000054776A1 PCT/IB1999/000448 IB9900448W WO0054776A1 WO 2000054776 A1 WO2000054776 A1 WO 2000054776A1 IB 9900448 W IB9900448 W IB 9900448W WO 0054776 A1 WO0054776 A1 WO 0054776A1
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WO
WIPO (PCT)
Prior art keywords
treatment
prolactin inhibitor
animal species
cabergoline
fertility problems
Prior art date
Application number
PCT/IB1999/000448
Other languages
English (en)
Inventor
Eugen Eigenmann
Original Assignee
Eugen Eigenmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eugen Eigenmann filed Critical Eugen Eigenmann
Priority to AU26355/99A priority Critical patent/AU2635599A/en
Priority to PCT/IB1999/000448 priority patent/WO2000054776A1/fr
Publication of WO2000054776A1 publication Critical patent/WO2000054776A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Definitions

  • the present invention is concerned with the use of a medicament in the treatment of fertility problems in various animal species. Furthermore the invention is concerned with a method for a treatment of fertility problems with said medicament.
  • the postpartum period is associated with fertility problems in many species (1) .
  • the problem has been highlighted some time ago (2) . Allusion has been made at that time to under- nutrition. However undernutrition is not specific for the postpartum period.
  • lacta- tional anoestrus Eigenmann, J.E.
  • Such cows on rectal palpation exhibit a corpus luteum persistens, an ovarian cyst or nothing (Acyclia) .
  • Gestagens include intravaginal devices or oral forms. Intravaginal devices often induce vaginitis and oral forms are time consuming.
  • this Gestagen treatment which is also called synchronization method is derived from the synchronization of normal young. animals. In cows undergoing Gestagen treatment a new oestrus should appear approximately 3-10 days after withdrawal. Not uncommonly prostaglandin F2 ⁇ is administered in order to remove any residual corpus luteum tissue. Hence the treatment is expensive, nonspecific and most likely unsuccessful in many cases. 30 - 40% of premature slaughtering is due to unresolved fertility problems (3) .
  • prolactin which is important in the development of the mammary gland, is said by some veterinarians to be of no importance in milk production there are no good data to reject the hypothesis that specifically in the postpartum period prolactin induces and/or maintains a high milk yield. It is strongly believed that it must be Prolactin which inhibits LH-secretion leading to ovarian dysfunction (6, 7, 8) .
  • a further object of the present invention has been a method for the treatment of said fertility problems which is, due to the characterics of the medicament according to the present invention, less time consuming and which allows an easier application of said mediament.
  • This object has been achieved by administering a prolactin inhibitor to anovulatory animal species in the PP period.
  • alkaloids Due to their specific effect, especially on the nervous system, alkaloids are a well known class of substances widely used in pharmacology. Examples for such alkaloids are, beside others, caffeine, morphine, strychnine, colchicine, and the socalled ergot alkaloids.
  • Ergot (Claviceps purpurea) is a filamentous fungus growing on various types of grain, especially secale. Ergot alkaloids have been used in the past as labour stimulating and uterus contracting agents.
  • these substances are applied inter alia in cancer treatment.
  • Biller et al. (6) used Cabergoline (Pharmacia, Columbus, OH), an ergotamine derivative specific for the D2 receptor, for the treatment of prolactinomas, the most commonly occuring pituarity tumour in men.
  • Dostinex (Pharmacia & UpJohn/Cabergoline) (7) was chosen. The compound was pulverized and 2x10, 9, 8 and 3,5 mg were dissolved in 20 ml 0,9%-ige NaCl. The compound was administered into the uterus. Each catheter was rinsed with another 20 ml NaCl.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur le traitement des problèmes de fécondité chez l'animal, et en particulier le porc, à l'aide d'un inhibiteur de la prolactine. L'invention porte également sur une méthode de traitement des problèmes de fécondité et sur un procédé de préparation d'un médicament incluant ledit inhibiteur.
PCT/IB1999/000448 1999-03-17 1999-03-17 Utilisation d'inhibiteurs de la prolactine dans le traitement des problemes de fecondite dans diverses especes animales WO2000054776A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU26355/99A AU2635599A (en) 1999-03-17 1999-03-17 Use of prolactin inhibitors for the treatment of fertility problems in animal species
PCT/IB1999/000448 WO2000054776A1 (fr) 1999-03-17 1999-03-17 Utilisation d'inhibiteurs de la prolactine dans le traitement des problemes de fecondite dans diverses especes animales

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB1999/000448 WO2000054776A1 (fr) 1999-03-17 1999-03-17 Utilisation d'inhibiteurs de la prolactine dans le traitement des problemes de fecondite dans diverses especes animales

Publications (1)

Publication Number Publication Date
WO2000054776A1 true WO2000054776A1 (fr) 2000-09-21

Family

ID=11004835

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/000448 WO2000054776A1 (fr) 1999-03-17 1999-03-17 Utilisation d'inhibiteurs de la prolactine dans le traitement des problemes de fecondite dans diverses especes animales

Country Status (2)

Country Link
AU (1) AU2635599A (fr)
WO (1) WO2000054776A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2936710A1 (fr) * 2008-10-07 2010-04-09 Ceva Sante Animale Composition veterinaire antiprolactinique destinee aux ruminants
US20200375980A1 (en) * 2018-01-30 2020-12-03 Ceva Sante Animale Veterinary antiprolactinic composition

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959288A (en) * 1974-12-13 1976-05-25 Eli Lilly And Company 8-Oxymethylergolines and process therefor
US3985752A (en) * 1974-12-06 1976-10-12 Eli Lilly And Company 6-Methyl-8-(substituted) methylergolines
FR2336135A1 (fr) * 1975-12-23 1977-07-22 Sandoz Sa Nouveaux derives de l'ergoline, leur preparation et leur application comme medicaments
US4054660A (en) * 1975-04-14 1977-10-18 Eli Lilly And Company Method of inhibiting prolactin
EP0003286A2 (fr) * 1978-01-20 1979-08-08 Sandoz Ag Dérivés d'alcaloides ergopeptidiques, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0003667A1 (fr) * 1978-02-08 1979-08-22 Eli Lilly And Company Dérivés de l'ergoline, leur préparation et compositions pharmaceutiques les contenant
GB2173699A (en) * 1985-04-05 1986-10-22 Poli Ind Chimica Spa Pharmaceutical compositions with antilactational activity
EP0781774A2 (fr) * 1995-12-08 1997-07-02 Takeda Chemical Industries, Ltd. Inhibiteurs de la synthèse de prolactin

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985752A (en) * 1974-12-06 1976-10-12 Eli Lilly And Company 6-Methyl-8-(substituted) methylergolines
US3959288A (en) * 1974-12-13 1976-05-25 Eli Lilly And Company 8-Oxymethylergolines and process therefor
US4054660A (en) * 1975-04-14 1977-10-18 Eli Lilly And Company Method of inhibiting prolactin
FR2336135A1 (fr) * 1975-12-23 1977-07-22 Sandoz Sa Nouveaux derives de l'ergoline, leur preparation et leur application comme medicaments
EP0003286A2 (fr) * 1978-01-20 1979-08-08 Sandoz Ag Dérivés d'alcaloides ergopeptidiques, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0003667A1 (fr) * 1978-02-08 1979-08-22 Eli Lilly And Company Dérivés de l'ergoline, leur préparation et compositions pharmaceutiques les contenant
GB2173699A (en) * 1985-04-05 1986-10-22 Poli Ind Chimica Spa Pharmaceutical compositions with antilactational activity
EP0781774A2 (fr) * 1995-12-08 1997-07-02 Takeda Chemical Industries, Ltd. Inhibiteurs de la synthèse de prolactin

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2936710A1 (fr) * 2008-10-07 2010-04-09 Ceva Sante Animale Composition veterinaire antiprolactinique destinee aux ruminants
WO2010040765A1 (fr) * 2008-10-07 2010-04-15 Ceva Sante Animale Sa Composition veterinaire antiprolactinique destinee aux ruminants
CN102215843A (zh) * 2008-10-07 2011-10-12 诗华动物保健股份有限公司 用于反刍动物的抗催乳素兽医学组合物
JP2012505178A (ja) * 2008-10-07 2012-03-01 セヴァ・サンテ・アニマル 反芻動物のための獣医用抗プロラクチン組成物
AU2009301134B2 (en) * 2008-10-07 2013-12-05 Ceva Sante Animale Sa Antiprolactinic veterinary composition for ruminants
RU2528892C2 (ru) * 2008-10-07 2014-09-20 Сева Санте Анималь Са Ветеринарная антипролактиновая композиция для жвачных
US9730923B2 (en) 2008-10-07 2017-08-15 Ceva Sante Animale Antiprolactinic veterinary composition for ruminants
US9744158B2 (en) 2008-10-07 2017-08-29 Ceva Sante Animale Veterinary antiprolactinic composition for ruminants
KR101892559B1 (ko) * 2008-10-07 2018-08-28 세바상뜨 아니말르 사 반추 동물용 항프롤락틴성 수의학적 조성물
US20200375980A1 (en) * 2018-01-30 2020-12-03 Ceva Sante Animale Veterinary antiprolactinic composition

Also Published As

Publication number Publication date
AU2635599A (en) 2000-10-04

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