WO2000054724A2 - Precision dispenser for liquids - Google Patents

Precision dispenser for liquids Download PDF

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Publication number
WO2000054724A2
WO2000054724A2 PCT/EP2000/002222 EP0002222W WO0054724A2 WO 2000054724 A2 WO2000054724 A2 WO 2000054724A2 EP 0002222 W EP0002222 W EP 0002222W WO 0054724 A2 WO0054724 A2 WO 0054724A2
Authority
WO
WIPO (PCT)
Prior art keywords
pump
flask
liquid
dispenser
reservoir
Prior art date
Application number
PCT/EP2000/002222
Other languages
French (fr)
Other versions
WO2000054724A3 (en
Inventor
Roberto Angeli
Original Assignee
Molteni L. E C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE60017373T priority Critical patent/DE60017373T2/en
Priority to AT00916935T priority patent/ATE286705T1/en
Priority to EP00916935A priority patent/EP1165010B1/en
Priority to EEP200100462A priority patent/EE04538B1/en
Priority to AU38109/00A priority patent/AU3810900A/en
Priority to IL14543800A priority patent/IL145438A0/en
Priority to UA2001107006A priority patent/UA69447C2/en
Priority to SI200030649T priority patent/SI1165010T1/xx
Application filed by Molteni L. E C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. filed Critical Molteni L. E C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A.
Priority to BR0008981-8A priority patent/BR0008981A/en
Priority to DK00916935T priority patent/DK1165010T3/en
Priority to HU0200364A priority patent/HU228553B1/en
Priority to SK1300-2001A priority patent/SK286699B6/en
Priority to CA002366878A priority patent/CA2366878C/en
Priority to PL350280A priority patent/PL196346B1/en
Publication of WO2000054724A2 publication Critical patent/WO2000054724A2/en
Publication of WO2000054724A3 publication Critical patent/WO2000054724A3/en
Priority to HR20010680A priority patent/HRP20010680B1/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
    • B65D1/0261—Bottom construction
    • B65D1/0276—Bottom construction having a continuous contact surface, e.g. Champagne-type bottom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/08—Flasks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
    • B65D1/023—Neck construction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
    • B65D1/0261—Bottom construction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F13/00—Apparatus for measuring by volume and delivering fluids or fluent solid materials, not provided for in the preceding groups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00613—Quality control
    • G01N35/00663—Quality control of consumables
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G—PHYSICS
    • G07—CHECKING-DEVICES
    • G07F—COIN-FREED OR LIKE APPARATUS
    • G07F11/00—Coin-freed apparatus for dispensing, or the like, discrete articles
    • G07F11/02—Coin-freed apparatus for dispensing, or the like, discrete articles from non-movable magazines
    • G07F11/04—Coin-freed apparatus for dispensing, or the like, discrete articles from non-movable magazines in which magazines the articles are stored one vertically above the other
    • G07F11/16—Delivery means
    • G07F11/165—Delivery means using xyz-picker or multi-dimensional article picking arrangements
    • G07F11/1657—Delivery means using xyz-picker or multi-dimensional article picking arrangements the picking arrangements using suction
    • G—PHYSICS
    • G07—CHECKING-DEVICES
    • G07F—COIN-FREED OR LIKE APPARATUS
    • G07F13/00—Coin-freed apparatus for controlling dispensing or fluids, semiliquids or granular material from reservoirs
    • G07F13/02—Coin-freed apparatus for controlling dispensing or fluids, semiliquids or granular material from reservoirs by volume
    • G07F13/025—Coin-freed apparatus for controlling dispensing or fluids, semiliquids or granular material from reservoirs by volume wherein the volume is determined during delivery
    • G—PHYSICS
    • G07—CHECKING-DEVICES
    • G07F—COIN-FREED OR LIKE APPARATUS
    • G07F17/00—Coin-freed apparatus for hiring articles; Coin-freed facilities or services
    • G07F17/0092—Coin-freed apparatus for hiring articles; Coin-freed facilities or services for assembling and dispensing of pharmaceutical articles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B01L2300/022—Transponder chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2231/00—Means for facilitating the complete expelling of the contents
    • B65D2231/005—Means for facilitating the complete expelling of the contents the container being rigid
    • B65D2231/007—Funnels or the like
    • B65D2231/008—Funnels or the like integral with the container wall
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00613—Quality control
    • G01N35/00663—Quality control of consumables
    • G01N2035/00673—Quality control of consumables of reagents

Definitions

  • the present invention regards a precision dispenser for controlled delivery of liquid products, in particular methadone or other medicinal preparations.
  • dispensers of liquid methadone are known in which a pre-set amount of liquid is taken from a feed reservoir by means of a peristaltic pump. The dose of liquid is then poured into a glass to be taken by the patient.
  • dispensers are moreover generally managed by a computer for identification and management of the administrations envisaged for the various patients.
  • the known dispensers present a number of drawbacks linked in particular to the precision that they are able to provide in dosing, this aspect being of particular consequence in the administration of methadone, both on account of the importance and delicacy of the cases treated, and on account of the need for being able to certify exactly the amounts of methadone actually supplied. Scope of the invention
  • a prime purpose of the present invention is therefore to provide a dispenser for liquid products, and in particular methadone, that affords high precision both in dosing and in calculating the quantities handled during operation.
  • the hydraulic circuit comprises a sector for circulation of the liquid handled.
  • the circulation makes it possible to set initial conditions that can be repeated in an identical manner at each new delivery.
  • the circuit is moreover provided with an intermediate reservoir which is distinct from the supply flask and serves as a bleeder for possible air bubbles and has a check point for checking the amount of liquid present in the circuit, as well as for checking the temperature conditions.
  • the hydraulic circuit according to the invention comprises a first pump, preferably a peristaltic pump, which is fed by an interchangeable flask containing liquid and sends the liquid on to an intermediate reservoir.
  • the output of the latter is connected, via a manual valve, to a second, high-precision, pump, preferably of the piston type, and subsequently to a three-way solenoid valve, which has one output connected to the intermediate reservoir and the other output connected to the final receptacle of the amount of liquid to be delivered.
  • the intermediate reservoir is equipped with level probes, and possibly with a temperature probe.
  • a second advantage is represented by the possibility of maintaining the liquid in movement when the device is not in use, so preventing any possible precipitation or separation of various phases.
  • Figure 1 shows a diagram of the dispenser according to the invention
  • FIG. 2.1 , 2.2, 2.3, and 2.4 present a flowchart showing the various phases of the method according to the invention, in which P1 stands for Peristaltic pump, P2 stands for Piston pump, EV stands for Solenoid valve, S2 stands for Intermediate tank, M2 stands for Maximum level of S2.
  • P1 stands for Peristaltic pump
  • P2 stands for Piston pump
  • EV stands for Solenoid valve
  • S2 stands for Intermediate tank
  • M2 stands for Maximum level of S2.
  • figures 2.1 and 2.2 relate to the filling and maintenance of level in intermediate reservoir (Routine 01 ) and figures 2.3 and 2.4 relate to the charging of circuit of main pump (Routine 02); and
  • FIG. 3a and 3b present, respectively, a side view and a top view of a flask for the apparatus of Figure 1.
  • a dispenser according to the invention is made up of:
  • a first pump 2 for example a peristaltic pump, fed, via pipes 12, by an interchangeable flask 1 containing liquid;
  • a second, high-precision, pump 4 preferably of the type with one or more pistons, fed, via pipes 35 and valve 7, by the said reservoir 3;
  • a microprocessor unit for control and management of the pumps 2, 4, of the maintenance functions and of the probes 31-34.
  • the part of the hydraulic circuit between the reservoir 3 and the solenoid valve 5 makes up a circulation circuit H, in which the liquid can be made to circulate by means of the pump 4 and the three-way valve 5.
  • the pump 2 sucks up liquid from the flask 1 and sends it into the reservoir 3 until an appropriate level is reached (which is subsequently maintained), this being detected by the probes 31-33. If the level is sufficient, the pump 4 starts to circulate the liquid until it ensures complete filling of the pipes.
  • the control unit opens the valve 5 for delivery (hence, of course, closing the circulation way) for the period of delivery of the amount of liquid required.
  • the pump is a piston-type pump (TRAVCYL ® , MODEL 16, manufactured by Encynova International Inc.), which is operated by a stepper motor and in which, at every cycle of known duration, the amount of liquid displaced is known exactly.
  • TRAVCYL ® piston-type pump
  • MODEL 16 manufactured by Encynova International Inc.
  • the pump 4 In the event of pauses in use between successive deliveries that might cause changes in the state of the liquid or deviations with respect to the pre-set start-of- delivery conditions, the pump 4 carries out a predetermined number of cycles. In order to guarantee the exact repetition of each delivery, the pump 4 is moreover provided with means for the determination of an initial zero, from which to start measurement of the amount being delivered. According to the invention, the pump 4 is then reset at each delivery and is brought back to a start-of-delivery position.
  • the above-mentioned means consist of an electromagnetic proximity sensor which acts as reference for the stroke of the pump piston and which controls advance of the stepper motor.
  • the dispenser In the case where the dispenser is to be used for delivery of liquid methadone, it is particularly important to guarantee complete delivery of the liquid contained in the flasks and, in addition, to ensure that it is possible to check also management of the flasks with certainty.
  • the flasks according to the invention consist of a main body 1 provided with a threaded neck 8 for connection to a seal-type packing plug.
  • the neck is moreover provided with teeth 81 for the bayonet joint of a coupling 13 for connection with the hydraulic circuit of the apparatus.
  • the bottom of the flask consists of a pair of surfaces 9, 91 , which are slightly inclined and which converge into a hemispherical cup 93 which forms the lowest point of storage of the liquid in the flask.
  • a fin 92 is provided underneath the surface 9 to guarantee horizontal support for the flask in its housing on the apparatus.
  • the tube is advantageously made so that it is integral with the attachment 13, which in turn finds a secure top reference point in the bayonet connection.
  • the flask 1 is further equipped with means of identification 12, which may be read by appropriate sensors 14 of the dispenser.
  • the said means 12 are of the RFID radio-frequency type, according to a recognition technique which is in itself already known, whilst the corresponding sensors 13 are fixed to the apparatus and connected to the control unit of the apparatus, which checks the volumes and the destination of the amounts delivered.
  • the invention further comprises a method for precision dosing of liquids, in particular by means of a dispenser of the type described above.
  • the method comprises the following steps:
  • the circulation routine 02 is carried out to prevent any possible modifications in the state of the liquid (separation of phases, formation of air bubbles, etc.) present in the circuit of the pump 4.
  • the present invention has been described with reference to a preferred embodiment thereof, but it is understood that equivalent modifications may be made by a person skilled in the branch without thereby departing from the sphere of protection granted to the present patent for industrial invention.

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  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Ceramic Engineering (AREA)
  • Quality & Reliability (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reciprocating Pumps (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Devices For Dispensing Beverages (AREA)
  • Loading And Unloading Of Fuel Tanks Or Ships (AREA)
  • Detergent Compositions (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Control Of Positive-Displacement Pumps (AREA)
  • Closures For Containers (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Basic Packing Technique (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Coating Apparatus (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Details Of Reciprocating Pumps (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

A precision dispenser for liquids consisting of: a first pump (2) fed by a flask (1) containing liquid, connected thereto via an attachment (13) provided with a suction tube (16); an intermediate reservoir (3) fed by the first pump (2) and provided with one or more level probes (31-33); a second, high-precision, pump (4) downstream of said reservoir (3); a three-way solenoid valve (5) set downstream of the pump (4), from which it receives the liquid at input, and having two output ways, one output leading to the reservoir (3) and the other leading to a final receptacle (6) for collecting the liquid delivered; and a microprocessor unit for control and management of the pumps (2, 4), probes (31-33) and maintenance functions.

Description

PRECISION DISPENSER FOR LIQUIDS Field of the invention and prior art
The present invention regards a precision dispenser for controlled delivery of liquid products, in particular methadone or other medicinal preparations. In the current state of the art, dispensers of liquid methadone are known in which a pre-set amount of liquid is taken from a feed reservoir by means of a peristaltic pump. The dose of liquid is then poured into a glass to be taken by the patient. These known dispensers are moreover generally managed by a computer for identification and management of the administrations envisaged for the various patients.
However, the known dispensers present a number of drawbacks linked in particular to the precision that they are able to provide in dosing, this aspect being of particular consequence in the administration of methadone, both on account of the importance and delicacy of the cases treated, and on account of the need for being able to certify exactly the amounts of methadone actually supplied. Scope of the invention
A prime purpose of the present invention is therefore to provide a dispenser for liquid products, and in particular methadone, that affords high precision both in dosing and in calculating the quantities handled during operation. Summary of the invention
The above purpose has been achieved according to the invention with a dispenser of liquid methadone, in which the hydraulic circuit comprises a sector for circulation of the liquid handled. The circulation makes it possible to set initial conditions that can be repeated in an identical manner at each new delivery. The circuit is moreover provided with an intermediate reservoir which is distinct from the supply flask and serves as a bleeder for possible air bubbles and has a check point for checking the amount of liquid present in the circuit, as well as for checking the temperature conditions. The hydraulic circuit according to the invention comprises a first pump, preferably a peristaltic pump, which is fed by an interchangeable flask containing liquid and sends the liquid on to an intermediate reservoir. The output of the latter is connected, via a manual valve, to a second, high-precision, pump, preferably of the piston type, and subsequently to a three-way solenoid valve, which has one output connected to the intermediate reservoir and the other output connected to the final receptacle of the amount of liquid to be delivered. The intermediate reservoir is equipped with level probes, and possibly with a temperature probe. A first advantage is represented by the high precision achievable and the assurance of being able to repeat delivery of liquid with identical circuit starting conditions.
A second advantage is represented by the possibility of maintaining the liquid in movement when the device is not in use, so preventing any possible precipitation or separation of various phases.
These and other advantages will emerge more clearly from the ensuing description and from the annexed drawings, which are provided as a non-limiting example.
Brief description of the drawings - Figure 1 shows a diagram of the dispenser according to the invention;
- Figures 2.1 , 2.2, 2.3, and 2.4 present a flowchart showing the various phases of the method according to the invention, in which P1 stands for Peristaltic pump, P2 stands for Piston pump, EV stands for Solenoid valve, S2 stands for Intermediate tank, M2 stands for Maximum level of S2. In particular, figures 2.1 and 2.2 relate to the filling and maintenance of level in intermediate reservoir (Routine 01 ) and figures 2.3 and 2.4 relate to the charging of circuit of main pump (Routine 02); and
- Figures 3a and 3b present, respectively, a side view and a top view of a flask for the apparatus of Figure 1.
Detailed description of the invention With reference to the attached figures, a dispenser according to the invention is made up of:
- a first pump 2, for example a peristaltic pump, fed, via pipes 12, by an interchangeable flask 1 containing liquid;
- an intermediate reservoir 3 fed, via pipes 21 , by the first pump 2 and provided with one or more level probes 31-33, and possibly a temperature probe 34;
- a second, high-precision, pump 4, preferably of the type with one or more pistons, fed, via pipes 35 and valve 7, by the said reservoir 3; - a three-way valve 5, set downstream of the pump 4, from which it receives the liquid at input, and having two output ways, one output leading, via pipes 51 , to the reservoir 3, and the other leading, via further pipes 52, to a final receptacle 6 for collecting the liquid to be delivered; and - a microprocessor unit for control and management of the pumps 2, 4, of the maintenance functions and of the probes 31-34.
According to the invention, and as may be seen from the attached drawings, the part of the hydraulic circuit between the reservoir 3 and the solenoid valve 5 makes up a circulation circuit H, in which the liquid can be made to circulate by means of the pump 4 and the three-way valve 5.
During operation, the pump 2 sucks up liquid from the flask 1 and sends it into the reservoir 3 until an appropriate level is reached (which is subsequently maintained), this being detected by the probes 31-33. If the level is sufficient, the pump 4 starts to circulate the liquid until it ensures complete filling of the pipes. At the first request for delivery, the control unit opens the valve 5 for delivery (hence, of course, closing the circulation way) for the period of delivery of the amount of liquid required.
Advantageously, in the example described the pump is a piston-type pump (TRAVCYL®, MODEL 16, manufactured by Encynova International Inc.), which is operated by a stepper motor and in which, at every cycle of known duration, the amount of liquid displaced is known exactly.
In the event of pauses in use between successive deliveries that might cause changes in the state of the liquid or deviations with respect to the pre-set start-of- delivery conditions, the pump 4 carries out a predetermined number of cycles. In order to guarantee the exact repetition of each delivery, the pump 4 is moreover provided with means for the determination of an initial zero, from which to start measurement of the amount being delivered. According to the invention, the pump 4 is then reset at each delivery and is brought back to a start-of-delivery position. The above-mentioned means consist of an electromagnetic proximity sensor which acts as reference for the stroke of the pump piston and which controls advance of the stepper motor. In the case where the dispenser is to be used for delivery of liquid methadone, it is particularly important to guarantee complete delivery of the liquid contained in the flasks and, in addition, to ensure that it is possible to check also management of the flasks with certainty.
With reference to Figures 3a and 3b, the flasks according to the invention consist of a main body 1 provided with a threaded neck 8 for connection to a seal-type packing plug. The neck is moreover provided with teeth 81 for the bayonet joint of a coupling 13 for connection with the hydraulic circuit of the apparatus.
The bottom of the flask consists of a pair of surfaces 9, 91 , which are slightly inclined and which converge into a hemispherical cup 93 which forms the lowest point of storage of the liquid in the flask.
A fin 92 is provided underneath the surface 9 to guarantee horizontal support for the flask in its housing on the apparatus.
In order to ensure that the suction tube 16 always draws from the minimum-level point of the cup 93, the tube is advantageously made so that it is integral with the attachment 13, which in turn finds a secure top reference point in the bayonet connection.
The flask 1 is further equipped with means of identification 12, which may be read by appropriate sensors 14 of the dispenser.
In a preferred embodiment, the said means 12 are of the RFID radio-frequency type, according to a recognition technique which is in itself already known, whilst the corresponding sensors 13 are fixed to the apparatus and connected to the control unit of the apparatus, which checks the volumes and the destination of the amounts delivered.
With reference to Figures 2.1 - 2.4, the invention further comprises a method for precision dosing of liquids, in particular by means of a dispenser of the type described above.
The method comprises the following steps:
- check of the control probes and sensors of the dispenser;
- charging, for example by means of a peristaltic pump fed by a flask containing the liquid to be delivered, of an intermediate reservoir S2 up to a maximum level
M2 (routine 01 ) detected by a level probe;
- charging of a circulation circuit operated by a main pump P2 (routine 02), for example of the piston type, the circuit extending from the reservoir S2 up to a delivery valve EV;
- in the case of a command for first delivery, charging of the spout of the flask for feeding the liquid, and search for a zero point of the pump; for subsequent deliveries with the same flask, search for the zero point of the pump;
- opening of the delivery valve EV and operation of the pump P2;
- execution of routine 01 for check on level of the reservoir S2;
- check on the amount delivered: if it corresponds to the amount envisaged, interruption of delivery and closing of the delivery valve EV; and - waiting for new command for delivery.
In addition, in the event of prolonged inactivity between successive deliveries, according to the method the circulation routine 02 is carried out to prevent any possible modifications in the state of the liquid (separation of phases, formation of air bubbles, etc.) present in the circuit of the pump 4. The present invention has been described with reference to a preferred embodiment thereof, but it is understood that equivalent modifications may be made by a person skilled in the branch without thereby departing from the sphere of protection granted to the present patent for industrial invention.

Claims

1 1. A precision dispenser for liquids consisting of:
2 - a first pump (2), fed by a flask (1 ) containing liquid, connected by means of an
3 attachment (13) provided with a suction tube (16);
4 - an intermediate reservoir (3) fed by the first pump (2) and provided with one or
5 more level probes (31 -33);
6 - a second, high-precision, pump (4) downstream of said reservoir 3;
7 - a three-way solenoid valve (5), set downstream of the pump (4), from which it
8 receives the liquid at input, and having two output ways, one output leading to the
9 reservoir (3), and the other leading to a final receptacle (6) for collecting the liquid 10 to be delivered; and l i - a microprocessor unit for control and management of the pumps (2, 4), of the
12 probes (31-34) and of the maintenance functions.
1 2. A dispenser according to Claim 1 , characterized in that the part of the hydraulic
2 circuit between the reservoir (3) and the solenoid valve (5) forms a circulation
3 circuit H in which the liquid can be circulated by means of the pump (4) and the
4 three-way valve (5).
1 3. A dispenser according to Claim 2, characterized in that the pump (4) is of the
2 type with one or more pistons, operated by a stepper motor.
1 4. A dispenser according to Claim 1 , characterized in that it comprises means for
2 seeking a zero point of start of each delivery of the pump (4).
1 5. A dispenser according to Claim 4, characterized in that the said means are
2 constituted by a proximity sensor capable of detecting the position of the pistons of
3 the pump and controlling advance of the stepper motor.
1 6. A dispenser according to Claim 1 , characterized in that it comprises means (14)
2 for identifying the flask of liquid used.
1 7. A dispenser according to Claim 6, characterized in that the said means are
2 RFID sensors.
1 8. A dispenser according to Claim 1 , characterized in that it comprises a
2 temperature probe (34). l 9. A dispenser according to Claim 1 , characterized in that the said suction tube (16) is integral with the said attachment (13). 10. A flask for liquids, for use in dispensers according to at least one of Claims 1- 9, characterized in that it consists of a main body (1 ) provided with a threaded neck (8) equipped with means (81 ) for the press-block coupling of an attachment (13) of a dispenser, in which the bottom of the flask consists of a pair of surfaces (9, 91 ), which are inclined and which converge centrally into a cup (93) forming the lowest point of storage of the liquid in the flask (1 ). 11. A flask according to Claim 10, characterized in that the said means (81 ) consists of a bayonet coupling. 12. A flask according to Claim 10, characterized in that a fin (92) is provided underneath the surface (9) to guarantee horizontal support for the flask in its housing on the dispenser. 13. A flask according to Claim 10, characterized in that it is equipped with means of identification (12), which may be read by appropriate means (14) of the dispenser. 14. A flask according to Claim 13, characterized in that the said means (12) are of the RFID type. 15. A flask according to Claim 10, characterized in that it is made of plastic material. 16. A method for dosing liquids, comprising the following steps: - check of the control probes and sensors of the dispenser; - charging, for example by means of peristaltic pump fed by a flask containing the liquid to be delivered, of an intermediate reservoir S2 up to a maximum level M2 (routine 01 ) detected by a level probe; - charging of a circulation circuit operated by a main pump P2 (routine 02), for example of the piston type, the circuit extending from the reservoir S2 up to a multi-way delivery valve EV; - in the case of a command for first delivery, charging of the spout of the flask for feeding the liquid, and search for a zero point of the pump; for subsequent deliveries with the same flask, search for the zero point of the pump; - opening of the delivery valve EV and operation of the pump P2; - execution of routine 01 for check on level of the reservoir S2; - check on the amount delivered: if it corresponds to the amount envisaged, interruption of delivery and closing of the delivery valve EV; and - waiting for new command for delivery. 17. Method according to Claim 16, in which in the event of prolonged inactivity between successive deliveries, the circulation routine 02 is carried out to prevent any possible modifications in the state of the liquid present in the circuit of the pump 4.
PCT/EP2000/002222 1999-03-16 2000-03-14 Precision dispenser for liquids WO2000054724A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
BR0008981-8A BR0008981A (en) 1999-03-16 2000-03-14 Precision liquid distributor
AT00916935T ATE286705T1 (en) 1999-03-16 2000-03-14 PRECISION LIQUID DISPENSING DEVICE
DK00916935T DK1165010T3 (en) 1999-03-16 2000-03-14 Precision dispenser for liquids
AU38109/00A AU3810900A (en) 1999-03-16 2000-03-14 Precision dispenser for liquids
IL14543800A IL145438A0 (en) 1999-03-16 2000-03-14 Precision dispenser for liquids
UA2001107006A UA69447C2 (en) 1999-03-16 2000-03-14 Precision dispenser for liquids, flask, and dispensing technique
SI200030649T SI1165010T1 (en) 1999-03-16 2000-03-14
DE60017373T DE60017373T2 (en) 1999-03-16 2000-03-14 PRECISION DELIVERY DEVICE FOR LIQUIDS
EP00916935A EP1165010B1 (en) 1999-03-16 2000-03-14 Precision dispenser for liquids
EEP200100462A EE04538B1 (en) 1999-03-16 2000-03-14 Advanced Liquid Distributor and Method for Liquid Distribution
HU0200364A HU228553B1 (en) 1999-03-16 2000-03-14 Precision dispenser for liquids, and method for dispensing liquids
SK1300-2001A SK286699B6 (en) 1999-03-16 2000-03-14 Precision dispenser and method for dosing liquids
CA002366878A CA2366878C (en) 1999-03-16 2000-03-14 Precision dispenser for liquids
PL350280A PL196346B1 (en) 1999-03-16 2000-03-14 Precision dispenser for liquids
HR20010680A HRP20010680B1 (en) 1999-03-16 2001-09-14 Precision dispenser for liquids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITFI99A000052 1999-03-16
IT1999FI000052A IT1308253B1 (en) 1999-03-16 1999-03-16 PRECISION DISPENSER FOR LIQUIDS.

Publications (2)

Publication Number Publication Date
WO2000054724A2 true WO2000054724A2 (en) 2000-09-21
WO2000054724A3 WO2000054724A3 (en) 2000-12-21

Family

ID=11352847

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/002222 WO2000054724A2 (en) 1999-03-16 2000-03-14 Precision dispenser for liquids

Country Status (24)

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EP (2) EP1502567B1 (en)
CN (2) CN1326510C (en)
AT (2) ATE286705T1 (en)
AU (1) AU3810900A (en)
BG (2) BG65557B1 (en)
BR (1) BR0008981A (en)
CA (2) CA2366878C (en)
CZ (1) CZ299981B6 (en)
DE (2) DE60017373T2 (en)
DK (1) DK1165010T3 (en)
EE (1) EE04538B1 (en)
ES (2) ES2264086T3 (en)
HR (1) HRP20010680B1 (en)
HU (1) HU228553B1 (en)
IL (1) IL145438A0 (en)
IT (1) IT1308253B1 (en)
PL (1) PL196346B1 (en)
PT (1) PT1165010E (en)
RU (1) RU2241433C2 (en)
SI (1) SI1165010T1 (en)
SK (1) SK286699B6 (en)
TR (2) TR200102725T2 (en)
UA (1) UA69447C2 (en)
WO (1) WO2000054724A2 (en)

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US6879876B2 (en) * 2001-06-13 2005-04-12 Advanced Technology Materials, Inc. Liquid handling system with electronic information storage
WO2005043469A1 (en) * 2003-11-04 2005-05-12 L. Molteni & C. Dei Fratelli Alitti - Societa' Di Esercizio S.P.A. Dispenser for liquids equipped with electronic device for user identification
WO2005099336A2 (en) * 2004-04-16 2005-10-27 Perez Gonzalez Miguel Angel Pharmaceutical dispenser
EP1624303A2 (en) * 2004-08-04 2006-02-08 Imi Vision Limited In-Vitro diagnostics
US7017807B2 (en) 2003-09-08 2006-03-28 Francis M. Claessens Apparatus and method for detecting tampering with containers and preventing counterfeiting thereof
US7048179B2 (en) 2003-12-12 2006-05-23 Francis M. Claessens Apparatus for electronically determining whether a tax for a product has been paid
US7126479B2 (en) 2004-08-17 2006-10-24 Francis M. Claessens Metal container closure having integral RFID tag
US7364089B2 (en) 2003-12-12 2008-04-29 Claessens Francis M Apparatus for electronically determining whether a tax for a product has been paid
US7702418B2 (en) 2001-06-13 2010-04-20 Advanced Technology Materials, Inc. Secure reader system
CN101829020A (en) * 2010-04-28 2010-09-15 河南海岩电子技术有限公司 Automatic sterile dispensing machine and control system thereof
EP2232084A1 (en) * 2008-01-07 2010-09-29 Bio-Rad Laboratories, Inc. Piston position detection for preparative chromatography column
WO2011001139A3 (en) * 2009-06-30 2011-04-28 Halliburton Energy Services, Inc. Improved methods and systems for integrated material processing
WO2011121372A1 (en) * 2010-03-29 2011-10-06 Ethimedix Sa Secure liquid drug dispenser and method for delivering liquid medication
US8336734B2 (en) 2006-06-13 2012-12-25 Advanced Technology Materials, Inc. Liquid dispensing systems encompassing gas removal
EP2803592A1 (en) * 2013-05-17 2014-11-19 Cirmeca Device and method for metering products and filling containers with said products
US9031683B2 (en) 2006-07-10 2015-05-12 Entegris, Inc. Systems and methods for managing material storage vessels having information storage elements
US20150344290A1 (en) * 2014-05-29 2015-12-03 L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. Precision liquid dispenser
US9395370B2 (en) 2009-07-08 2016-07-19 Bio-Rad Laboratories, Inc. Purification of monoclonal antibodies
FR3041427A1 (en) * 2015-09-18 2017-03-24 Agrolis Consulting PORTABLE DEVICE FOR THE VOLUMETRIC DETERMINATION OF A FLUID AND USE OF SUCH A DEVICE
US9637300B2 (en) 2010-11-23 2017-05-02 Entegris, Inc. Liner-based dispenser
WO2017049160A3 (en) * 2015-09-17 2017-05-11 Fillmaster Systems, LLC Automatic flavoring and water dispensing systems for medications
USD846146S1 (en) 2016-09-16 2019-04-16 Fillmaster Systems, LLC Medication flavoring dispenser
US10676341B2 (en) 2010-01-06 2020-06-09 Entegris, Inc. Liquid dispensing systems with gas removal and sensing capabilities

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US7664568B2 (en) 2001-06-13 2010-02-16 Advanced Technology Materials, Inc. Liquid handling system with electronic information storage
US6879876B2 (en) * 2001-06-13 2005-04-12 Advanced Technology Materials, Inc. Liquid handling system with electronic information storage
US8849448B2 (en) 2001-06-13 2014-09-30 Advanced Technology Materials, Inc. Liquid handling system with electronic information storage
US9618942B2 (en) 2001-06-13 2017-04-11 Entegris, Inc. Liquid handling system with electronic information storage
US7747344B2 (en) * 2001-06-13 2010-06-29 Advanced Technology Materials, Inc. Liquid handling system with electronic information storage
US8150549B2 (en) 2001-06-13 2012-04-03 Advanced Technology Materials, Inc. Liquid handling system with electronic information storage
US7702418B2 (en) 2001-06-13 2010-04-20 Advanced Technology Materials, Inc. Secure reader system
FR2852259A1 (en) * 2003-03-11 2004-09-17 Stedim Sa Apparatus for the preparation of fluids, as mixtures and solutions for nutrients or cell cultures or vaccines and the like, has a single multiple valve and a fluid syringe together with an air supply under sterile conditions
US7017807B2 (en) 2003-09-08 2006-03-28 Francis M. Claessens Apparatus and method for detecting tampering with containers and preventing counterfeiting thereof
WO2005043469A1 (en) * 2003-11-04 2005-05-12 L. Molteni & C. Dei Fratelli Alitti - Societa' Di Esercizio S.P.A. Dispenser for liquids equipped with electronic device for user identification
US7061382B2 (en) 2003-12-12 2006-06-13 Francis M. Claessens Apparatus for electronically verifying the authenticity of contents within a container
US7364089B2 (en) 2003-12-12 2008-04-29 Claessens Francis M Apparatus for electronically determining whether a tax for a product has been paid
US7048179B2 (en) 2003-12-12 2006-05-23 Francis M. Claessens Apparatus for electronically determining whether a tax for a product has been paid
WO2005099336A3 (en) * 2004-04-16 2005-11-17 Gonzalez Miguel Angel Perez Pharmaceutical dispenser
WO2005099336A2 (en) * 2004-04-16 2005-10-27 Perez Gonzalez Miguel Angel Pharmaceutical dispenser
EP1624303A3 (en) * 2004-08-04 2006-07-26 Imi Vision Limited In-Vitro diagnostics
EP1624303A2 (en) * 2004-08-04 2006-02-08 Imi Vision Limited In-Vitro diagnostics
US7126479B2 (en) 2004-08-17 2006-10-24 Francis M. Claessens Metal container closure having integral RFID tag
US8336734B2 (en) 2006-06-13 2012-12-25 Advanced Technology Materials, Inc. Liquid dispensing systems encompassing gas removal
US9120616B2 (en) 2006-06-13 2015-09-01 Advanced Technology Materials, Inc. Liquid dispensing systems encompassing gas removal
US9031683B2 (en) 2006-07-10 2015-05-12 Entegris, Inc. Systems and methods for managing material storage vessels having information storage elements
US10127094B2 (en) 2006-07-10 2018-11-13 Entegris, Inc Systems and methods for managing material storage vessels having information storage elements
EP2232084A4 (en) * 2008-01-07 2013-02-13 Bio Rad Laboratories Piston position detection for preparative chromatography column
EP2232084A1 (en) * 2008-01-07 2010-09-29 Bio-Rad Laboratories, Inc. Piston position detection for preparative chromatography column
WO2011001139A3 (en) * 2009-06-30 2011-04-28 Halliburton Energy Services, Inc. Improved methods and systems for integrated material processing
US9395370B2 (en) 2009-07-08 2016-07-19 Bio-Rad Laboratories, Inc. Purification of monoclonal antibodies
US10676341B2 (en) 2010-01-06 2020-06-09 Entegris, Inc. Liquid dispensing systems with gas removal and sensing capabilities
US9061879B2 (en) 2010-03-29 2015-06-23 Ethimedix Sa Secure liquid drug dispenser and method for delivering liquid medication
WO2011121372A1 (en) * 2010-03-29 2011-10-06 Ethimedix Sa Secure liquid drug dispenser and method for delivering liquid medication
CN101829020A (en) * 2010-04-28 2010-09-15 河南海岩电子技术有限公司 Automatic sterile dispensing machine and control system thereof
US9637300B2 (en) 2010-11-23 2017-05-02 Entegris, Inc. Liner-based dispenser
EP2803592A1 (en) * 2013-05-17 2014-11-19 Cirmeca Device and method for metering products and filling containers with said products
FR3005647A1 (en) * 2013-05-17 2014-11-21 Cirmeca DEVICE AND METHOD FOR DETERMINING PRODUCTS AND FILLING CONTAINERS WITH SAID PRODUCTS
US20150344290A1 (en) * 2014-05-29 2015-12-03 L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. Precision liquid dispenser
WO2017049160A3 (en) * 2015-09-17 2017-05-11 Fillmaster Systems, LLC Automatic flavoring and water dispensing systems for medications
US10150663B2 (en) 2015-09-17 2018-12-11 Fillmaster Systems, LLC Automatic flavoring and water dispensing systems for medications
US10926995B2 (en) 2015-09-17 2021-02-23 Fillmaster Systems, LLC Valve assemblies for use in automatic flavoring dispensing systems
US11905160B2 (en) 2015-09-17 2024-02-20 Fillmaster Systems, LLC Automatic reconstitution water dispensing systems for medications
FR3041427A1 (en) * 2015-09-18 2017-03-24 Agrolis Consulting PORTABLE DEVICE FOR THE VOLUMETRIC DETERMINATION OF A FLUID AND USE OF SUCH A DEVICE
USD846146S1 (en) 2016-09-16 2019-04-16 Fillmaster Systems, LLC Medication flavoring dispenser

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Publication number Publication date
EE200100462A (en) 2002-12-16
CN1596868A (en) 2005-03-23
EP1502567B1 (en) 2006-05-03
PL196346B1 (en) 2007-12-31
BG105882A (en) 2002-04-30
PL350280A1 (en) 2002-12-02
EP1165010A2 (en) 2002-01-02
CZ20013109A3 (en) 2002-01-16
ES2264086T3 (en) 2006-12-16
HUP0200364A2 (en) 2002-05-29
HUP0200364A3 (en) 2004-10-28
ITFI990052A0 (en) 1999-03-16
EP1165010B1 (en) 2005-01-12
HU228553B1 (en) 2013-03-28
ATE324854T1 (en) 2006-06-15
CN1345218A (en) 2002-04-17
DK1165010T3 (en) 2005-05-17
HRP20010680B1 (en) 2006-12-31
BG65557B1 (en) 2008-12-30
TR200704992T2 (en) 2007-09-21
CA2634655A1 (en) 2000-09-21
TR200102725T2 (en) 2002-08-21
EE04538B1 (en) 2005-10-17
PT1165010E (en) 2005-05-31
CA2366878C (en) 2008-08-19
BR0008981A (en) 2002-01-22
BG64689B1 (en) 2005-12-30
CA2366878A1 (en) 2000-09-21
RU2241433C2 (en) 2004-12-10
WO2000054724A3 (en) 2000-12-21
DE60017373D1 (en) 2005-02-17
IT1308253B1 (en) 2001-12-10
SK286699B6 (en) 2009-03-05
ITFI990052A1 (en) 2000-09-16
SI1165010T1 (en) 2005-08-31
CN1283221C (en) 2006-11-08
CZ299981B6 (en) 2009-01-14
EP1502567A2 (en) 2005-02-02
BG109177A (en) 2006-12-29
HRP20010680A2 (en) 2002-12-31
SK13002001A3 (en) 2002-01-07
IL145438A0 (en) 2002-06-30
DE60027799D1 (en) 2006-06-08
AU3810900A (en) 2000-10-04
ATE286705T1 (en) 2005-01-15
DE60027799T2 (en) 2007-04-05
CA2634655C (en) 2010-08-24
CN1326510C (en) 2007-07-18
UA69447C2 (en) 2004-09-15
ES2235849T3 (en) 2005-07-16
DE60017373T2 (en) 2006-01-12
EP1502567A3 (en) 2005-02-09

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