WO2000053245A1 - Dispositif comportant un orifice et permettant l'acces sous-cutane au systeme vasculaire d'un patient - Google Patents

Dispositif comportant un orifice et permettant l'acces sous-cutane au systeme vasculaire d'un patient Download PDF

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Publication number
WO2000053245A1
WO2000053245A1 PCT/US2000/006146 US0006146W WO0053245A1 WO 2000053245 A1 WO2000053245 A1 WO 2000053245A1 US 0006146 W US0006146 W US 0006146W WO 0053245 A1 WO0053245 A1 WO 0053245A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
catheter
needle
port device
patient
Prior art date
Application number
PCT/US2000/006146
Other languages
English (en)
Inventor
Brian K. Estabrook
Paul J. Smith
Harold M. Martins
Frank R. Prosl
Original Assignee
Biolink Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biolink Corporation filed Critical Biolink Corporation
Priority to AU56473/00A priority Critical patent/AU5647300A/en
Publication of WO2000053245A1 publication Critical patent/WO2000053245A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A61M39/12—Tube connectors; Tube couplings for joining a flexible tube to a rigid attachment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0208—Subcutaneous access sites for injecting or removing fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0208—Subcutaneous access sites for injecting or removing fluids
    • A61M2039/0211—Subcutaneous access sites for injecting or removing fluids with multiple chambers in a single site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A61M2039/1027—Quick-acting type connectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/04—Tools for specific apparatus

Definitions

  • Patent Application Serial No. 08/661,903, filed June 12, 1996 by Brian K. Estabrook et al. for DEVICE FOR SUBCUTANEOUS ACCESSIBILITY which in turn claims priority from (i) U.S. Patent Application Serial No. 08/485,498, filed June 7, 1995 for HEMODIALYSIS ACCESS APPARATUS, and (ii) U.S. Patent Application Serial No. 08/661,903, filed June 12, 1996 for IMPROVED DEVICE FOR SUBCUTANEOUS ACCESSIBILITY.
  • the disclosures of the aforementioned five (5) U.S. patent applications are hereby incorporated herein by reference.
  • the present invention relates generally to an apparatus that allows access to the vascular system of a human (or animal), and particularly for the high-volume fluid flow required in hemodialysis, plasmapheresis, and other fluid exchange therapies. More particularly, the present invention relates to a subcutaneously-implantable access device.
  • port devices for accessing fluid spaces and vessels within a human (or animal) body that are generally referred to as "ports".
  • vehicle is defined as any conduit carrying a fluid within the patient's body.
  • These prior art port devices generally comprise a chamber having an access opening sealed by means of a septum and having an egress from a second location leading to a catheter which is disposed within a fluid space or vessel.
  • the septum allows a hollow needle (or “cannula”) to pass into the port' s chamber, but then closes when the needle is removed, thereby preventing fluid leakage from within the bodily fluid space or vessel and also preventing anything from entering or exiting the port's chamber.
  • These port devices are usually implantable below the skin so as to prevent infection, other contamination and mishandling.
  • a problem associated with prior art port devices is that they tend to have a somewhat irregular external shape. This can create various problems. For one thing, it can make it harder for the body to form a fibrin pocket about the port after the port has been installed below the skin. Furthermore, when the port has been deployed in the body for a prolonged period of time, the irregular external shape of the port can cause undesirable tissue erosion.
  • Still another problem associated with prior art ports is that, even after knowing the orientation of the port within the body, it can be difficult for medical personnel to insert the hemodialysis needles
  • an object of the invention to provide a port device having a smooth, generally rounded configuration, lessening the likelihood of erosion of surrounding tissue and lessening impeding of formation of a fibrin pocket around the implanted device.
  • Another object of the invention is to provide a port device having an outboard tactile surface by which a surgeon, through feel of the surface residing beneath the skin, can substantially determine the location and orientation of the needle entrances of the device, so as to properly direct a needle or cannula (hereinafter “needle”) through the skin in the direction of the device's needle entrances.
  • needle needle or cannula
  • a still further object of the invention is to provide such a port device with needle receiving surfaces adapted to guide a needle into a needle entrance.
  • Still another object of the invention is to provide such a port device with means for securely locking catheters, of the type reinforced by coils of metal wire, to the port device, and means for effecting separation of the catheters from the device when desired.
  • Another object of the invention is to provide such a port device having means thereon to facilitate suturing of the device to tissue.
  • a still further object of the invention is to provide a port device which is useful for other liquid or fluid (including gases) transfer purposes into and out of human and animal bodies, including the transfer of externally-prepared solutions for cleaning, flushing, dialysis, chemical agent delivery, transfusions, blood donation, insufflation, wound drainage, and the like.
  • a feature of the present invention is the provision of a port device for implanting in a patient for subcutaneous access to the vascular system of the patient.
  • the device includes a housing having needle receiving apparatus, and apparatus for connecting a catheter to the housing, the housing being adapted to provide a flow path extending between a needle disposed in the needle receiving apparatus and the catheter.
  • the housing defines a groove therein for positioning under and adjacent the skin of the patient. The groove is of sufficient tactility to convey to an operator the subcutaneous location and orientation of the housing.
  • a port device for implanting in a patient for subcutaneous access to the vascular system of the patient.
  • the device includes a housing having needle receiving apparatus, and apparatus for connecting a catheter to the housing, the housing being adapted to provide a flow path extending between a needle disposed in the needle receiving apparatus and the catheter.
  • the housing defines a raised surface, aligned with the needle receiving apparatus, for positioning under and adjacent the skin of the patient. The raised surface is of sufficient tactility to convey to an operator the subcutaneous location of the needle receiving apparatus.
  • a port device for implanting in a patient for subcutaneous access to the vascular system of the patient.
  • the device includes a housing having needle receiving apparatus, and apparatus for connecting a catheter to the housing, the housing being adapted to provide a flow path extending between a needle disposed in the needle receiving apparatus and the catheter.
  • the needle receiving apparatus includes an opening in the housing and in communication with the flow path.
  • the housing defines needle guiding surfaces for guiding the needle from a first location removed from the opening to a second location coincident with the opening.
  • a device for implanting in a patient for subcutaneous access to the vascular system of the patient includes a housing having needle receiving apparatus, and apparatus for connecting a catheter to the housing.
  • the housing is adapted to provide a flow path extending between a needle disposed in the needle receiving apparatus and the catheter.
  • the housing defines a ledge within a profile of the housing and having a suture orifice therein and extending therethrough.
  • a port device for implanting in a patient for subcutaneous access to the vascular system of the patient.
  • the device includes a housing having needle receiving apparatus, and apparatus for connecting a catheter to the housing, the housing being adapted to provide a flow path extending between a needle disposed in the needle receiving apparatus and the catheter.
  • the housing is provided with a smooth, generally rounded exterior.
  • a port device for implanting in a patient for subcutaneous access to the vascular system of the patient.
  • the device includes a housing having needle receiving apparatus, and lock means for locking a catheter to the housing.
  • the lock means includes a collet for receiving the catheter when the collet is in an open condition, and a lock member responsive to application of a cam means to close the collet with the catheter therein, whereby to lock the catheter in the collet and thereby in the housing.
  • Fig. 1 is a diagrammatic view of one form of port device illustrative of an embodiment of the invention, shown in use;
  • Fig. 2 is a perspective view of the illustrative port device
  • Fig. 3 is a perspective view of the port device of Figs. 1 and 2;
  • Fig. 4 is a side elevational view thereof;
  • Fig. 5 is a side diagrammatic view of the port device showing preferred positioning and attitude of the device;
  • Fig. 6 is a further perspective view of the port device, showing a catheter locking feature
  • Fig. 7 is a generally sectional exploded view of the device
  • Fig. 8 is a generally sectional view of the device
  • Fig. 9 is a front elevational view of a locking tool for use in locking catheters to the port device
  • Fig'. 10 is a side elevational view thereof
  • Fig. 11 is a handle end view thereof
  • Fig. 12 is a camming end view thereof
  • Fig. 13 is a broken away, generally sectional view of the device with the locking tool of Figs. 9-12 shown in perspective;
  • Figs. 14 and 15 are perspective views of the device with the locking tool of Figs. 9-12 applied thereto;
  • Figs. 16 and 17 are similar to Figs. 8 and 13, respectively, but showing the device and catheters locked together;
  • Fig. 18 is an elevational view of an unlocking tool for use in unlocking catheters for separation from the port device;
  • Fig. 19 is a sectional view taken along line 19-19 of Fig. 18;
  • Figs. 20 and 21 are perspective views of the device, with the unlocking tool of Figs. 18 and 19 and the locking tool of Figs. 9-12 applied to the device for a catheter unlocking operation;
  • Fig. 22 is a side elevational view of a portion of the device and a portion of a catheter shown in section.
  • the port device 30 of the present invention is adapted to be disposed subcutaneously in the body of a patient, usually in the chest region.
  • the device includes a housing 32 having a pair of needle entrances 34a, 34b which are accessed subcutaneously by a pair of needles (not shown) connected to conduits (not shown) for flowing fluid, such as blood, from the housing 32 and to the housing.
  • a pair of needle entrances 34a, 34b which are accessed subcutaneously by a pair of needles (not shown) connected to conduits (not shown) for flowing fluid, such as blood, from the housing 32 and to the housing.
  • the housing 32 is provided with means for retaining the needles and with flow paths for channeling the flow therethrough of fluid received from, and directed toward, the needles, as discussed in detail in the ⁇ 956 patent application.
  • the port device 30 further includes lock means 36 for securely fixing to the housing 32 a pair of catheters 38a, 38b which may, in one application of the invention, extend through the jugular vein 40 of the patient, down the superior vena cava 41, and to a point in or near the right atrium of the heart of the patient.
  • a first one 38a of the catheters receives the flow of blood, or other selected fluid (hereinafter “blood”) from the housing 32 and directs the blood to the patient, while the other one 38b of the catheters flows blood from the patient and into the housing 32, or vice versa.
  • the housing 32 is provided with flow paths therethrough for flowing the blood in opposite directions.
  • the housing 32 typically is in communication with a dialysis machine, or the like, which receives blood from one 34b of the needle entrances by a needle and blood line connection (not shown) , and discharges blood to the other 34a of the needle entrances by another needle and blood line connection (not shown) .
  • the housing 32 is provided with a smooth, generally rounded exterior, or profile.
  • the profile is of a generally tear-drop configuration.
  • the smooth rounded profile devoid of sharp edges, accommodates to surrounding tissue and enables the tissue to more readily form a fibrin pocket around the device while minimizing erosion of surrounding tissue.
  • Figs. 2, 3 and 6 there is shown an axially-extending gently sloped groove 42 in a surface 44 of the housing 32 which, when the device is embedded in a patient, lies beneath and adjacent the patient's skin.
  • the groove 42 is of rounded configuration, devoid of sharp or pronounced edges.
  • the groove 42 is appropriately distinct to provide sufficient tactility to convey by "feel" to an operator the subcutaneous location and orientation of the housing 32.
  • raised surfaces 42a, 42b are preferably formed on either side of groove 42, in alignment with needle openings 34a, 34b, whereby the operator can locate, by "feel", the position of needle openings 34a, 34b.
  • the operator may feel the surface 44 of the device 30 through the skin, and feel the groove 42 to determine the location in which the device is disposed and the orientation of the device, and feel the raised surface 42a, 42b so as to determine approximately the location of the openings 34a and 34b. This enables the first penetration to place the needles in the vicinity of the needle openings, without repeated penetrations which can be disconcerting to the patient.
  • the device 30 is provided with needle receiving means 52 including the openings 34a, 34b, and including a needle guiding surface, or a "front porch", 60.
  • the axis a-a of the needle openings 34a, 34b extend at an angle A to the base surface 61 of port 30 (Fig. 4) .
  • the angle A is preferably less than about 30°, and preferably is about 15°.
  • the front porch 60 is also provided with guiding grooves 62, each aligned with one of the needle openings 34a, 34b. Extending over a portion of the front porch 60 is an overhang 64 in part constituting a portion of the surface 44 and having therein a portion of the groove 42.
  • the overhang 64 is provided with guiding grooves 66, each aligned with one of the needle openings 34a, 34b.
  • the front porch 60 and overhang 64 are of smooth and rounded configuration.
  • Fig. 5 there is illustrated diagrammatically a preferred disposition of the device 30 in a body.
  • the axes of the needle openings are generally parallel with the top and bottom surfaces of the port device, which are parallel to each other.
  • To gain entrance of a needle into the needle opening 34b it is necessary to penetrate the skin 72 at point B and move the needle distal end to point C, a distance represented by arrow b in Fig. 5.
  • the skin 72 is penetrated at point D and the needle distal end is moved to point E, a distance represented by the arrow d, substantially shorter than distance b.
  • the shorter distance d reduces discomfort to the patient and permits use of shorter needles which, in turn, increases flow rate.
  • the needle receiving means 52 assist in guiding needles to the openings 34a, 34b.
  • a needle striking the front porch 60 can be slid along the porch until the guiding grooves 62 are encountered. Needles may then follow along the guiding grooves 62 until the needles arrive at the needle openings 34a, 34b.
  • the needles are aimed too high, they will encounter a forward surface 68 and may be slid along the surface 68 to an undersurface 70, and then to the guiding grooves 66 and the needle openings 34a, 34b.
  • an operator may determine the general location of the needle openings 34a, 34b. By placing the penetrating needles in the correct location, the operator will generally move the needles into the needle receiving means 52, which help guide the needles into the needle openings 34a, 34b.
  • the device housing 32 is provided with recesses 46, each formed in part by a ledge 48 having an orifice 50 extending therethrough.
  • the orifices 50 facilitate suturing of the device 30 to tissue in the body, to hold the device in a selected location.
  • the recesses 46 and ledges 48 are within the housing profile, that is, the ledges 48 are wholly within the smooth and rounded boundary of the housing, so as to minimize irritation and/or erosion of the surrounding tissue.
  • Figs. 7 and 8 there is shown the lock means 36 for locking to the housing 32 the pair of reinforced catheters 38a, 38b.
  • the catheters 38a, 38b each include a flexible elastomeric tube 80 reinforced by a wire coil 82.
  • the reinforced catheter is shown and described in U.S. Patent Application Serial No. 09/251,572, filed February 17, 1999 by Harold M. Martins et al. for APPARATUS FOR THE DIALYSIS OF BLOOD, METHOD FOR FABRICATING THE SAME, AND METHOD FOR THE DIALYSIS OF BLOOD (Attorney's Docket No. PROSL-3 CIP), the disclosure of which is hereby incorporated herein by reference.
  • the lock means 36 include a collet 86 disposed around each of the outlet tubes 84. Annular spaces 88 are defined by the tubes 84 and collets 86.
  • a lock member 90 is provided with bores 92, each for housing a collet 86 and tube 84.
  • the lock member 90 is further provided with a third bore 94 having therein an annular ridge 96.
  • a locking bolt 98 is fixed at its proximal end in the housing 32 and extends through the bore 94. The bolt 98 is bifurcated at its distal end 100 (Fig.
  • FIG. 8 shows the catheters 38a, 38b removed from the housing 32, the lock means 36 unlocked, and the annular spaces 88 open.
  • a locking tool 120 for use in conjunction with the port device lock means 36 is shown in Figs. 9-12 and includes a rod 122 and a handle 124 fixed thereto. At the distal end 126 of the rod 122 is fixed an eccentric circular cam portion 128. Extending axially from the cam portion 128 is a pin portion 130 which may be centered with respect to the rod 122.
  • the catheters are moved in the direction of arrows 132 (Fig. 13) into the annular spaces 88 between the tubes 84 and collets 86.
  • the pin portion 130 of the locking tool 120 is inserted in the slot 106 in the lock member 90, with the cam portion 128 engaged with a distal wall 134 of the housing 32 (Figs. 13-15).
  • the outlet tubes 84 may be provided with slightly enlarged bands 112 to increase gripping between the outlet tubes and the catheters 38a, 38b.
  • the outlet tubes 84 may be provided with ribs 114 (Fig. 22) .
  • enlarged bands 112 and/or the ribs 114 are only modestly larger than the surrounding portions of the outlet tubes, so that the outer surfaces of the outlet tubes can form a smooth fit with the interiors of the catheters 38a, 38b without deforming the wire coils 82 of the catheters. It is possible to use such a construction, and still effectively secure the catheters to the outlet tubes, since collet-based lock means 36 are provided.
  • An unlocking tool 150 shown in Figs. 18 and 19, is used in conjunction with the locking tool 120 to unlock the lock means 36, for separating the device 30 and the catheters 38a, 38b.
  • the unlocking tool 150 includes a first planar portion 152. At a first end 154 thereof there is disposed a hook portion 156. At a second end 158 of first planar portion 152 there is disposed an aperture 160 extending through the first planar portion. Outwardly from the planar portion second end 158, a second planar portion 162 extends at an obtuse angle from the first planar portion 152.
  • the hook portion 156 of the unlocking tool 150 is placed on and around housing overhang 64, as shown in Fig. 20.
  • the first planar portion 152 of the unlocking tool 150 is placed on the housing surface 44.
  • the locking tool pin portion 130 is then extended through the unlocking tool aperture 160 until the locking tool cam portion 128 engages the unlocking tool first planar portion 152.
  • the operator may lever the locking tool pin 130 against the lock member 90 to push the lock member 90 from the position shown in Fig. 16 to the position shown in Fig. 8, releasing locking pressure on the collets 86, and thereby releasing locking pressure on the catheters 36a, 36b, permitting the catheters to be removed from the outlet tubes 84.
  • the aperture 160 is configured to permit the locking tool pin to pivot in the aperture so as to provide leverage.
  • seals 170 which receive the aforementioned incoming needles and serve to engage and retain the needles.
  • internal components defining flow paths 172, 174 There are shown internal components defining flow paths 172, 174.
  • the seals 170 serve to retain the needles in the device 30.
  • the flow path defining components serve to open and close the flow paths 172, 174, and also to retain the inserted needles.
  • the structure and operation of the seals 170 and components defining the flow paths 172, 174 are described in detail in the aforementioned x 956 patent application, incorporated herein by reference.
  • an improved port device having a profile which is more beneficially acceptable to body tissue and which permits tactile location of the needle entrances thereof, having needle receiving
  • PROSL-7 means which mechanically guide a needle from a point near the target entrance into the entrance, having a suturing facility within the device profile, and having means for securely locking reinforced catheters to the device and releasing the catheters to separate the device from the catheters. There are further provided specialized tools for performing the catheter locking and unlocking operations.
  • port device 30 as described as being disposed subcutaneously in the chest region of a patient. However, it could also be disposed in other regions of the patient with high flow vascular structures, such as femoral placement. In addition, port device 30 could also be used for peritoneal dialysis, with port placement in the abdomen of the patient and catheter access to the peritoneal cavity of the patient.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

Cette invention concerne un dispositif (30) comportant un orifice qui permet d'effectuer des implantations chez un patient, et qui permet l'accès sous-cutané au système vasculaire dudit patient. Ce dispositif comprend un boîtier (32) comportant des ouvertures (34a, 34b) qui permettent chacune de recevoir et de retenir une aiguille. Le boîtier est en outre doté d'une structure de verrouillage (36) qui permet d'y verrouiller des cathéters. L'intérieur du boîtier est conçu de manière à définir des voies d'écoulement qui vont des aiguilles placées dans les ouvertures jusqu'aux cathéters.
PCT/US2000/006146 1999-03-09 2000-03-09 Dispositif comportant un orifice et permettant l'acces sous-cutane au systeme vasculaire d'un patient WO2000053245A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU56473/00A AU5647300A (en) 1999-03-09 2000-03-09 Port device for subcutaneous access to the vascular system of a patient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12343299P 1999-03-09 1999-03-09
US60/123,432 1999-03-09

Publications (1)

Publication Number Publication Date
WO2000053245A1 true WO2000053245A1 (fr) 2000-09-14

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WO (1) WO2000053245A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10463845B2 (en) 2013-01-23 2019-11-05 C.R. Bard, Inc. Low-profile access port
USD870264S1 (en) 2017-09-06 2019-12-17 C. R. Bard, Inc. Implantable apheresis port
US11420033B2 (en) 2013-01-23 2022-08-23 C. R. Bard, Inc. Low-profile single and dual vascular access device
US11464960B2 (en) 2013-01-23 2022-10-11 C. R. Bard, Inc. Low-profile single and dual vascular access device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5253930A (en) * 1990-09-26 1993-10-19 Nippon Air Brake Co., Ltd. Air brake control system having an electromagnetic valve device which has two set points for establishing a lap position
US5336194A (en) * 1992-08-01 1994-08-09 Fresenius Ag Implantable apparatus
US5713859A (en) * 1994-01-18 1998-02-03 Vasca, Inc. Implantable vascular device
US5840063A (en) * 1995-06-07 1998-11-24 Programmable Pump Technologies, Inc. Septumless implantable treatment material device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5253930A (en) * 1990-09-26 1993-10-19 Nippon Air Brake Co., Ltd. Air brake control system having an electromagnetic valve device which has two set points for establishing a lap position
US5336194A (en) * 1992-08-01 1994-08-09 Fresenius Ag Implantable apparatus
US5713859A (en) * 1994-01-18 1998-02-03 Vasca, Inc. Implantable vascular device
US5840063A (en) * 1995-06-07 1998-11-24 Programmable Pump Technologies, Inc. Septumless implantable treatment material device

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10463845B2 (en) 2013-01-23 2019-11-05 C.R. Bard, Inc. Low-profile access port
US11420033B2 (en) 2013-01-23 2022-08-23 C. R. Bard, Inc. Low-profile single and dual vascular access device
US11464960B2 (en) 2013-01-23 2022-10-11 C. R. Bard, Inc. Low-profile single and dual vascular access device
USD870264S1 (en) 2017-09-06 2019-12-17 C. R. Bard, Inc. Implantable apheresis port
USD885557S1 (en) 2017-09-06 2020-05-26 C. R. Bard, Inc. Implantable apheresis port

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