WO2000051578A3 - Use of ceramides for the treatment of cystic fibrosis - Google Patents

Use of ceramides for the treatment of cystic fibrosis Download PDF

Info

Publication number
WO2000051578A3
WO2000051578A3 PCT/EP2000/001682 EP0001682W WO0051578A3 WO 2000051578 A3 WO2000051578 A3 WO 2000051578A3 EP 0001682 W EP0001682 W EP 0001682W WO 0051578 A3 WO0051578 A3 WO 0051578A3
Authority
WO
WIPO (PCT)
Prior art keywords
ceramides
treatment
cystic fibrosis
substances
relates
Prior art date
Application number
PCT/EP2000/001682
Other languages
German (de)
French (fr)
Other versions
WO2000051578A2 (en
Inventor
Florian Lang
Erich Gulbins
Lepple-Wienhues
Original Assignee
Florian Lang
Erich Gulbins
Lepple Wienhues
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florian Lang, Erich Gulbins, Lepple Wienhues filed Critical Florian Lang
Priority to EP00909267A priority Critical patent/EP1156854A2/en
Priority to CA002365290A priority patent/CA2365290A1/en
Priority to AU31613/00A priority patent/AU3161300A/en
Publication of WO2000051578A2 publication Critical patent/WO2000051578A2/en
Publication of WO2000051578A3 publication Critical patent/WO2000051578A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to the use of ceramides and/or substances which contain ceramides as a building block. Said ceramides and substances are used for the treatment of cystic fibrosis. The ceramides are especially C2 and/or C6 ceramides. The invention also relates to the use of the above-mentioned substances for the treatment of diseases which are linked to a disturbed regulation of transport processes at membranes.
PCT/EP2000/001682 1999-03-03 2000-02-29 Use of ceramides for the treatment of cystic fibrosis WO2000051578A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00909267A EP1156854A2 (en) 1999-03-03 2000-02-29 Use of ceramides for the treatment of cystic fibrosis
CA002365290A CA2365290A1 (en) 1999-03-03 2000-02-29 Use of ceramides for the treatment of cystic fibrosis
AU31613/00A AU3161300A (en) 1999-03-03 2000-02-29 Use of ceramides for the treatment of cystic fibrosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19909115A DE19909115A1 (en) 1999-03-03 1999-03-03 Use of ceramides to treat cystic fibrosis
DE19909115.3 1999-03-03

Publications (2)

Publication Number Publication Date
WO2000051578A2 WO2000051578A2 (en) 2000-09-08
WO2000051578A3 true WO2000051578A3 (en) 2001-01-04

Family

ID=7899443

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/001682 WO2000051578A2 (en) 1999-03-03 2000-02-29 Use of ceramides for the treatment of cystic fibrosis

Country Status (5)

Country Link
EP (1) EP1156854A2 (en)
AU (1) AU3161300A (en)
CA (1) CA2365290A1 (en)
DE (1) DE19909115A1 (en)
WO (1) WO2000051578A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2558429C (en) 2004-03-02 2011-02-01 Mcgill University Compositions and methods for preventing or treating an inflammatory response

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0074251A1 (en) * 1981-09-04 1983-03-16 Yeda Research And Development Company, Ltd. Novel lipid fraction, its preparation and pharmaceutical compositions containing same
WO1985003638A1 (en) * 1984-02-23 1985-08-29 Yeda Research And Development Ltd. Compositions containing active lipids
US4766111A (en) * 1985-10-31 1988-08-23 Trustees Of Boston University Lipids with plasmin inhibitory properties
EP0450991A2 (en) * 1990-02-20 1991-10-09 Synthelabo Use of phosphatidylglycerol(diC 18:10)in the treatment of obstructive airway diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3819870A1 (en) * 1987-06-12 1988-12-29 Hoerrmann Wilhelm Pharmaceuticals based on fatty amino alcohols
US5753613A (en) * 1994-09-30 1998-05-19 Inex Pharmaceuticals Corporation Compositions for the introduction of polyanionic materials into cells
ATE219660T1 (en) * 1994-09-30 2002-07-15 Inex Pharmaceuticals Corp AGENT FOR INTRODUCING POLYANIONIC MATERIALS INTO CELLS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0074251A1 (en) * 1981-09-04 1983-03-16 Yeda Research And Development Company, Ltd. Novel lipid fraction, its preparation and pharmaceutical compositions containing same
WO1985003638A1 (en) * 1984-02-23 1985-08-29 Yeda Research And Development Ltd. Compositions containing active lipids
US4766111A (en) * 1985-10-31 1988-08-23 Trustees Of Boston University Lipids with plasmin inhibitory properties
EP0450991A2 (en) * 1990-02-20 1991-10-09 Synthelabo Use of phosphatidylglycerol(diC 18:10)in the treatment of obstructive airway diseases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BURDGE G C ET AL: "PLASMA LIPID CONCENTRATIONS IN CHILDREN WITH CYSTIC FIBROSIS: THE VALUE OF A HIGH-FAT DIET AND PANCREATIC SUPPLEMENTATION", BRITISH JOURNAL OF NUTRITION,CAMBRIDGE,GB, vol. 71, no. 6, June 1994 (1994-06-01), pages 959 - 964, XP000951637 *
GIROD S ET AL: "PHOSPHOLIPID COMPOSITION AND SURFACE-ACTIVE PROPERTIES OF TRACHEOBRONCIAL SECRETIONS FROM PATIENTS WITH CYSTIC FIBROSIS AND CHRONIC OBSTRUCTIVE PULMONARY DISEASES", PEDIATRIC PULMONOLOGY,JOHN WILEY, NEW YORK, NY,US, vol. 13, no. 1, May 1992 (1992-05-01), pages 22 - 27, XP000952015, ISSN: 8755-6863 *
GRIESE M ET AL: "PULMONARY SURFACTANT IN CYSTIC FIBROSIS", EUROPEAN RESPIRATORY JOURNAL,DK,MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN, vol. 10, no. 9, September 1997 (1997-09-01), pages 1983 - 1988, XP000891384, ISSN: 0903-1936 *
KUIJCK VAN M A ET AL: "MOLECULAR CLONING AND EXPRESSION OF A CYCLIC AMP-ACTIVATED CHLORIDECONDUCTANCE REGULATOR: A NOVEL ATP-BINDING CASSETTE TRANSPORTER", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,NATIONAL ACADEMY OF SCIENCE. WASHINGTON,US, vol. 93, no. 11, May 1996 (1996-05-01), pages 5401 - 5406, XP000946726, ISSN: 0027-8424 *
SZABO I ET AL: "TYROSINE KINASE-DEPENDENT ACTIVATION OF A CHLORIDE CHANNEL IN CD95-INDUCED APOPTOSIS IN T LYMPHOCYTES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,NATIONAL ACADEMY OF SCIENCE. WASHINGTON,US, vol. 95, no. 11, 26 May 1998 (1998-05-26), pages 6169 - 6174, XP000946287, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
EP1156854A2 (en) 2001-11-28
DE19909115A1 (en) 2000-09-07
AU3161300A (en) 2000-09-21
CA2365290A1 (en) 2000-09-08
WO2000051578A2 (en) 2000-09-08

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