WO2000049990A3 - The process for manufacturing topical ophthalmic preparations without systemic effects - Google Patents

The process for manufacturing topical ophthalmic preparations without systemic effects Download PDF

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Publication number
WO2000049990A3
WO2000049990A3 PCT/IN2000/000008 IN0000008W WO0049990A3 WO 2000049990 A3 WO2000049990 A3 WO 2000049990A3 IN 0000008 W IN0000008 W IN 0000008W WO 0049990 A3 WO0049990 A3 WO 0049990A3
Authority
WO
WIPO (PCT)
Prior art keywords
systemic effects
topical ophthalmic
ophthalmic preparations
manufacturing
manufacturing topical
Prior art date
Application number
PCT/IN2000/000008
Other languages
French (fr)
Other versions
WO2000049990A2 (en
Inventor
Bakulesh Mafatlal Khamar
Original Assignee
Bakulesh Mafatlal Khamar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bakulesh Mafatlal Khamar filed Critical Bakulesh Mafatlal Khamar
Priority to IL13882400A priority Critical patent/IL138824A0/en
Priority to EA200000918A priority patent/EA200000918A1/en
Priority to CA002326690A priority patent/CA2326690A1/en
Priority to APAP/P/2000/001977A priority patent/AP2000001977A0/en
Priority to EP00925571A priority patent/EP1139970A2/en
Priority to BR0004530-6A priority patent/BR0004530A/en
Priority to AU44291/00A priority patent/AU4429100A/en
Publication of WO2000049990A2 publication Critical patent/WO2000049990A2/en
Publication of WO2000049990A3 publication Critical patent/WO2000049990A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to topical ophthalmic preperations resp. a process for manufacturing the same using polymers in such a way that they have desired topical effects but no systemic effects. The polymers (e.g. polyacrylic acids, hydroxyethyl cellulose, etc.) used for this purpose have pseudo-plastic, mucoadhesive and viscosity enhancing properties.
PCT/IN2000/000008 1999-02-03 2000-02-02 The process for manufacturing topical ophthalmic preparations without systemic effects WO2000049990A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IL13882400A IL138824A0 (en) 1999-02-03 2000-02-02 Process for manufacturing topical ophthalmic preparations without systemic effects
EA200000918A EA200000918A1 (en) 1999-02-03 2000-02-02 METHOD OF MANUFACTURING THE EYE DRUGS OF LOCAL APPLICATION WITHOUT GENERAL ACTIONS
CA002326690A CA2326690A1 (en) 1999-02-03 2000-02-02 The process for manufacturing topical ophthalmic preparations without systemic effects
APAP/P/2000/001977A AP2000001977A0 (en) 1999-02-03 2000-02-02 The process for manufacturing topical opthalmic preparations without systemic effects.
EP00925571A EP1139970A2 (en) 1999-02-03 2000-02-02 The process for manufacturing topical ophthalmic preparations without systemic effects
BR0004530-6A BR0004530A (en) 1999-02-03 2000-02-02 Process for manufacturing topical ophthalmic preparations without systemic effects
AU44291/00A AU4429100A (en) 1999-02-03 2000-02-02 The process for manufacturing topical ophthalmic preparations without systemic effects

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN90BO1999 IN185228B (en) 1999-02-03 1999-02-03
IN90/BOM/99 1999-02-03

Publications (2)

Publication Number Publication Date
WO2000049990A2 WO2000049990A2 (en) 2000-08-31
WO2000049990A3 true WO2000049990A3 (en) 2001-07-26

Family

ID=11077485

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2000/000008 WO2000049990A2 (en) 1999-02-03 2000-02-02 The process for manufacturing topical ophthalmic preparations without systemic effects

Country Status (11)

Country Link
EP (1) EP1139970A2 (en)
AP (1) AP2000001977A0 (en)
AU (1) AU4429100A (en)
BR (1) BR0004530A (en)
CA (1) CA2326690A1 (en)
EA (1) EA200000918A1 (en)
ID (1) ID28121A (en)
IL (1) IL138824A0 (en)
IN (1) IN185228B (en)
WO (1) WO2000049990A2 (en)
ZA (1) ZA200006252B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8858961B2 (en) 2000-07-14 2014-10-14 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
AU2005220199B2 (en) * 2000-07-14 2007-03-08 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
NZ521185A (en) * 2000-07-14 2005-02-25 Allergan Inc Compositions containing alpha-2-adrenergic agonist components
DE10132876A1 (en) * 2001-07-06 2003-01-30 Medproject Pharma Entwicklungs Two-phase, drop-onable hydrogels for use on the eye
US7439241B2 (en) 2003-05-27 2008-10-21 Galderma Laboratories, Inc. Compounds, formulations, and methods for treating or preventing rosacea
ES2647618T3 (en) 2004-05-25 2017-12-22 Galderma Pharma S.A. Compounds, formulations and procedures to treat or prevent inflammatory skin disorders
EP2329849B1 (en) 2009-11-18 2015-04-29 Galderma Research & Development Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder
FR2977493B1 (en) 2011-07-05 2014-02-14 Galderma Res & Dev NOVEL STABLE ANESTHETIC COMPOSITION FOR REDUCING SKIN REACTIONS
WO2014127243A1 (en) 2013-02-15 2014-08-21 Allergan, Inc. Sustained drug delivery implant
WO2014150899A1 (en) * 2013-03-15 2014-09-25 Chapin Matthew J Topical ophthalmic formulations for treating migraine
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
WO2016172712A2 (en) 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition
US11382909B2 (en) 2014-09-05 2022-07-12 Sydnexis, Inc. Ophthalmic composition
US11052094B2 (en) 2015-05-29 2021-07-06 Sydnexis, Inc. D2O stabilized pharmaceutical formulations
GB202110420D0 (en) * 2021-07-20 2021-09-01 Rosemont Pharmaceuticals Ltd Liquid pharmaceutical composition of clonidine

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD294174A5 (en) * 1990-05-04 1991-09-26 Sigrid Keipert OPHTHALMIKA WITH RESET EFFECT AND A NEW PROCESS FOR THEIR MANUFACTURE
WO1993000887A1 (en) * 1991-07-10 1993-01-21 Laboratoire Europhta S.A. Polyacrylic acid based ophthalmic compositions
WO1993002663A1 (en) * 1991-07-30 1993-02-18 Laboratoires Merck Sharp & Dohme-Chibret Ophthalmic compositions based on polyhydric alcohols
EP0801948A1 (en) * 1996-04-15 1997-10-22 Dr. GERHARD MANN chem.-pharm. Fabrik GmbH Ophthalmic composition having prolonged residence time in the eye

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6056684B2 (en) * 1977-11-07 1985-12-11 東興薬品工業株式会社 eye drops

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD294174A5 (en) * 1990-05-04 1991-09-26 Sigrid Keipert OPHTHALMIKA WITH RESET EFFECT AND A NEW PROCESS FOR THEIR MANUFACTURE
WO1993000887A1 (en) * 1991-07-10 1993-01-21 Laboratoire Europhta S.A. Polyacrylic acid based ophthalmic compositions
WO1993002663A1 (en) * 1991-07-30 1993-02-18 Laboratoires Merck Sharp & Dohme-Chibret Ophthalmic compositions based on polyhydric alcohols
EP0801948A1 (en) * 1996-04-15 1997-10-22 Dr. GERHARD MANN chem.-pharm. Fabrik GmbH Ophthalmic composition having prolonged residence time in the eye

Also Published As

Publication number Publication date
IN185228B (en) 2000-12-09
AU4429100A (en) 2000-09-14
ZA200006252B (en) 2001-11-29
EA200000918A1 (en) 2001-10-22
IL138824A0 (en) 2001-10-31
ID28121A (en) 2001-05-03
EP1139970A2 (en) 2001-10-10
WO2000049990A2 (en) 2000-08-31
AP2000001977A0 (en) 2000-12-31
BR0004530A (en) 2001-04-03
CA2326690A1 (en) 2000-08-31

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