WO2000049144A3 - Proteines fixatrices pyk2 - Google Patents

Proteines fixatrices pyk2 Download PDF

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Publication number
WO2000049144A3
WO2000049144A3 PCT/US2000/004647 US0004647W WO0049144A3 WO 2000049144 A3 WO2000049144 A3 WO 2000049144A3 US 0004647 W US0004647 W US 0004647W WO 0049144 A3 WO0049144 A3 WO 0049144A3
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WO
WIPO (PCT)
Prior art keywords
pyk2 binding
binding proteins
pyk2
protein
novel
Prior art date
Application number
PCT/US2000/004647
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English (en)
Other versions
WO2000049144A2 (fr
Inventor
Sima Lev
Joseph Schlessinger
Alon Chen
John Hernandez
Ricardo Martinez
Gregory D Plowman
Original Assignee
Sugen Inc
Sima Lev
Joseph Schlessinger
Alon Chen
John Hernandez
Ricardo Martinez
Gregory D Plowman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc, Sima Lev, Joseph Schlessinger, Alon Chen, John Hernandez, Ricardo Martinez, Gregory D Plowman filed Critical Sugen Inc
Priority to AU32422/00A priority Critical patent/AU3242200A/en
Priority to CA002362943A priority patent/CA2362943A1/fr
Priority to JP2000599869A priority patent/JP2003510010A/ja
Priority to EP00910308A priority patent/EP1157104A2/fr
Publication of WO2000049144A2 publication Critical patent/WO2000049144A2/fr
Publication of WO2000049144A3 publication Critical patent/WO2000049144A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne de nouvelles protéines fixatrices Pyk2, des séquences nucléotidiques codant pour ces nouvelles protéines, ainsi que divers produits et méthodes utilisés dans le diagnostic et le traitement de diverses maladies et divers états pathologiques liés à la protéine fixatrice Pyk2 et à la protéine kinase. Grâce à l'utilisation de systèmes bio-informatiques, deux membres mammaliens de la famille de la protéine fixatrice Pyk2 ont été identifiés et leur structure protéique déterminée.
PCT/US2000/004647 1999-02-22 2000-02-18 Proteines fixatrices pyk2 WO2000049144A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU32422/00A AU3242200A (en) 1999-02-22 2000-02-18 Pyk2 binding proteins
CA002362943A CA2362943A1 (fr) 1999-02-22 2000-02-18 Proteines fixatrices pyk2
JP2000599869A JP2003510010A (ja) 1999-02-22 2000-02-18 Ｐｙｋ２結合蛋白質
EP00910308A EP1157104A2 (fr) 1999-02-22 2000-02-18 Proteines fixatrices pyk2

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12112599P 1999-02-22 1999-02-22
US60/121,125 1999-02-22

Publications (2)

Publication Number Publication Date
WO2000049144A2 WO2000049144A2 (fr) 2000-08-24
WO2000049144A3 true WO2000049144A3 (fr) 2001-02-15

Family

ID=22394720

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/004647 WO2000049144A2 (fr) 1999-02-22 2000-02-18 Proteines fixatrices pyk2

Country Status (5)

Country Link
EP (1) EP1157104A2 (fr)
JP (1) JP2003510010A (fr)
AU (1) AU3242200A (fr)
CA (1) CA2362943A1 (fr)
WO (1) WO2000049144A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050059621A1 (en) * 2003-06-06 2005-03-17 Irene Griswold-Prenner Methods for using modulators of proline-rich tyrosine kinase 2
US7977462B2 (en) * 2007-04-19 2011-07-12 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007870A1 (fr) * 1996-08-23 1998-02-26 Beth Israel Deaconess Medical Center, Inc. Nouvelles molecules de signalisation raftk et leurs utilisations
WO1998016639A1 (fr) * 1996-10-11 1998-04-23 Sugen, Inc. Proteines rdgb
WO1998026054A2 (fr) * 1996-12-11 1998-06-18 Sugen, Inc. Produits et procedes en relation avec la pyk2
WO1998036065A1 (fr) * 1997-02-14 1998-08-20 Dana-Farber Cancer Institute Facteurs de stimulation de la differentiation et utilisations de ces facteurs

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007870A1 (fr) * 1996-08-23 1998-02-26 Beth Israel Deaconess Medical Center, Inc. Nouvelles molecules de signalisation raftk et leurs utilisations
WO1998016639A1 (fr) * 1996-10-11 1998-04-23 Sugen, Inc. Proteines rdgb
WO1998026054A2 (fr) * 1996-12-11 1998-06-18 Sugen, Inc. Produits et procedes en relation avec la pyk2
WO1998036065A1 (fr) * 1997-02-14 1998-08-20 Dana-Farber Cancer Institute Facteurs de stimulation de la differentiation et utilisations de ces facteurs

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANDREEV J ET AL.: "Identification of a new Pyk2 target protein with Arf-GAP activity", MOLECULAR AND CELLULAR BIOLOGY, vol. 19, no. 3, March 1999 (1999-03-01), pages 2338 - 2350, XP002145146 *
BROWN M T ET AL.: "Regulation, substrates and functions of src", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1287, no. 2-3, 7 June 1996 (1996-06-07), pages 121 - 149, XP000938413 *
DATABASE TREMBL EMBL; 1 June 1998 (1998-06-01), ISHIKAWA K ET AL.: "KIAA0400", XP002145148 *
ISHIKAWA K ET AL.: "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro", DNA RESEARCH, vol. 4, no. 5, 31 October 1997 (1997-10-31), pages 307 - 313, XP002066665 *
LEV S ET AL.: "Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein", MOLECULAR AND CELLULAR BIOLOGY, vol. 19, no. 3, March 1999 (1999-03-01), pages 2278 - 2288, XP002145147 *
SCHLAEPFER D D ET AL.: "Integrin signalling and tyrosine phosphorylation: just the FAKs?", TRENDS IN CELL BIOLOGY, vol. 8, no. 4, April 1998 (1998-04-01), pages 151 - 157, XP000938480 *
WENG Z ET AL.: "Identification of Src, Fyn, and Lyn SH3-binding proteins: Implications for a function of SH3 domains", MOLECULAR AND CELLULAR BIOLOGY, vol. 14, no. 7, 1 July 1994 (1994-07-01), pages 4509 - 4521, XP000652941 *

Also Published As

Publication number Publication date
CA2362943A1 (fr) 2000-08-24
AU3242200A (en) 2000-09-04
WO2000049144A2 (fr) 2000-08-24
EP1157104A2 (fr) 2001-11-28
JP2003510010A (ja) 2003-03-18

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