WO2000049002A1 - Processes and intermediates for the preparation of 1,3-oxazin-6-ones and uracils - Google Patents
Processes and intermediates for the preparation of 1,3-oxazin-6-ones and uracils Download PDFInfo
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- WO2000049002A1 WO2000049002A1 PCT/US2000/003731 US0003731W WO0049002A1 WO 2000049002 A1 WO2000049002 A1 WO 2000049002A1 US 0003731 W US0003731 W US 0003731W WO 0049002 A1 WO0049002 A1 WO 0049002A1
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- 0 C(C1C2)C1C1C2CC*C1 Chemical compound C(C1C2)C1C1C2CC*C1 0.000 description 14
- JUIVOFAXEWYJHQ-UHFFFAOYSA-N CC(NC(N1c(cc2)cc3c2[s]nc3Cl)=O)=CC1=O Chemical compound CC(NC(N1c(cc2)cc3c2[s]nc3Cl)=O)=CC1=O JUIVOFAXEWYJHQ-UHFFFAOYSA-N 0.000 description 1
- PNXVQYABDFYOFY-UHFFFAOYSA-N CC(c(cc(cc1)[N+]([O-])=O)c1Cl)=O Chemical compound CC(c(cc(cc1)[N+]([O-])=O)c1Cl)=O PNXVQYABDFYOFY-UHFFFAOYSA-N 0.000 description 1
- SBUYFICWQNHBCM-UHFFFAOYSA-N CCc1cc(C)c(C)cc1 Chemical compound CCc1cc(C)c(C)cc1 SBUYFICWQNHBCM-UHFFFAOYSA-N 0.000 description 1
- ONTNMJIKSMOICC-UHFFFAOYSA-N Cc(c(C(c1ccccc1)=O)c1)cc(F)c1[N+]([O-])=O Chemical compound Cc(c(C(c1ccccc1)=O)c1)cc(F)c1[N+]([O-])=O ONTNMJIKSMOICC-UHFFFAOYSA-N 0.000 description 1
- UNEZMMWAAMQSBE-UHFFFAOYSA-N Cc(c(C)c1)cc(C)c1OC Chemical compound Cc(c(C)c1)cc(C)c1OC UNEZMMWAAMQSBE-UHFFFAOYSA-N 0.000 description 1
- VZVKLQRLCVYZOV-UHFFFAOYSA-N Cc(c1c2)n[s]c1cc(F)c2N Chemical compound Cc(c1c2)n[s]c1cc(F)c2N VZVKLQRLCVYZOV-UHFFFAOYSA-N 0.000 description 1
- GBHMVHDHAURPFQ-UHFFFAOYSA-N Cc(c1c2)n[s]c1cc(F)c2[N+]([O-])=O Chemical compound Cc(c1c2)n[s]c1cc(F)c2[N+]([O-])=O GBHMVHDHAURPFQ-UHFFFAOYSA-N 0.000 description 1
- XGJBKVHUOUXGPH-UHFFFAOYSA-N NC(O1)=NC(C(F)(F)F)=CC1=O Chemical compound NC(O1)=NC(C(F)(F)F)=CC1=O XGJBKVHUOUXGPH-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Definitions
- 6- (Perfluoroalkyl ) uracil compounds are useful as herbicidal agents and methods for their preparation are known in the art.
- 6- (Perfluoroalkyl) uracil compounds may be prepared by reacting 2- (N,N-disubstituted) amino-4 - (perfluoroalkyl) -1, 3 -oxazin-6-one compounds with amine compounds .
- an object of the present invention to provide improved processes for the preparation of 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1, 3-oxazin-6- one compounds .
- the present invention provides a new process for the preparation of 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1, 3 -oxazin-6 -one compounds having the structural formula I
- Z and Z x are each independently or Z and Z 1 may be taken together with the atom to which they are attached to form a 4- to 7-membered ring wherein ZZ 1 is represented by - (CH 2 ) 2 0 (CH 2 ) 2 - or -(CH 2 ) m - where m is an integer of 3 , 4 , 5 or 6 ; and n is an integer of 1, 2, 3, 4, 5 or 6 , which comprises : (a) reacting a ⁇ -amino- ⁇ - (perfluoroalkyl) acrylate compound having the structural formula II
- n is as described above, and Z 2 is C- L -Cgalkyl or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C 1 -C 4 alkyl or C 1 -C 4 haloalkyl groups, with a base and a carbamoyl chloride compound having the structural formula III
- the present invention further provides a process for the preparation of 6- (perfluoroalkyl) uracil compounds having the structural formula V O
- n is an integer of 1 , 2 , 3 , 4 , 5 or 6 ;
- Z 3 is hydrogen or C 1 -C 6 alkyl; and
- Q is a C 1 -C 6 alkyl group or an optionally substituted phenyl , benzyl , heteroaryl or methyleneheteroaryl group , which process comprises :
- Z and Z are each independently or Z and Z may be taken together with the atom to which they are attached to form a 4- to 7-membered ring
- ZZ 1 is represented by - (CH 2 ) 2 0 (CH 2 ) 2 - or -(CH 2 ) m - where m is an integer of 3 , 4, 5 or 6
- Z 2 is Ci-C 8 alkyl or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C 1 -C 4 alkyl or C 1 -C 4 haloalkyl groups
- n is as described above, with a phosphorous pentahalide or oxalyl chloride to form a 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1,3- oxazin-6-one compound having the structural formula I
- Z and Z x are each independently Ci-Cgalkyl or Z and Z x may be taken together with the atom to which they are attached to form a 4- to 7-membered ring
- ZZ X is represented by - (CH 2 ) 2 0 (CH 2 ) 2 - or -(CH 2 ) m - where m is an integer of 3 , 4 , 5 or 6 ; n is an integer of 1 , 2 , 3 , , 5 or 6 ; and Z 2 is Ci-Cgalkyl or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C 1 -C 4 alkyl or C 1 -C 4 haloalkyl groups.
- the 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1,3- oxazin-6-one compounds of formula I are prepared by reacting a ⁇ -amino- ⁇ - (perfluoroalkyl) acrylate compound of formula II with a base and a carbamoyl chloride compound of formula III, preferably at a temperature ranging from about -20°C to 80°C, more preferably from about 0°C to 50°C, in the presence of a first solvent to form a urea compound of formula IV, and reacting the formula IV urea compound with a phosphorous pentahalide or oxalyl halide, preferably at a temperature ranging from about 0°C to 100°C, more preferably from about 20°C to 50°C, optionally in the presence of a second solvent.
- the present invention also provides a process for the preparation of 2- (N,N-disubstituted) amino-4- (per- fluoroalkyl) -1, 3-oxazin-6-one compounds of formula I which comprises reacting a urea compound of formula IV with a phosphorous pentahalide or oxalyl chloride, preferably at a temperature ranging from about 0°C to 100°C, more preferably from about 20°C to 50°C, optionally in the presence of a second solvent.
- the present invention provides improved processes for the preparation of 2- (N,N- disubstituted) amino-4- (perfluoroalkyl) -1, 3 -oxazin-6-one compounds which avoid the use of phosgene iminium chloride compounds .
- the present invention further relates to urea compounds having the structural formula IV which are utilized in the processes of this invention
- Z and Z x are each independently or Z and Z x may be taken together with the atom to which they are attached to form a 4- to 7-membered ring wherein ZZi is represented by - (CH 2 ) 2 0 (CH 2 ) 2 - or -(CH 2 ) m - where m is an integer of 3 , 4 , 5 or 6 ; n is an integer of 1, 2, 3, 4, 5 or 6 ; and Z 2 is C j ⁇ -C j alkyl or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C x -C 4 alkyl or C 1 -C 4 haloalkyl groups.
- Preferred formula IV compounds are those wherein Z and Z x are each independently Ci-Cgalkyl; Z 2 is C 1 -C 4 alkyl; and n is i.
- Z and Z x are the same and represent methyl or ethyl ;
- Z 2 is methyl or ethyl ; and
- n is 1.
- Representative formula IV compounds which are particularly useful in the processes of this invention include ethyl 3- [ (N,N-dimethylcarbamoyl) amino] -4,4,4- trifluorocrotonate, (Z) - ; methyl 3- [ (N,N-dimethylcarbamoyl) amino] -4,4,4- trifluorocrotonate, (Z) - ; ethyl 3- [ (N, N-diethylcarbamoyl) amino] -4,4,4- trifluorocrotonate, (Z) - ; methyl 3- [ (N,N-diethylcarbamoyl) amino] -4 , 4 , 4- trifluorocrotonate, (Z) - ; ethyl 3 - [ (N-pyrrolodine
- the double bond in the formula II and IV compounds is predominately in the (Z) - configuration.
- the product formula I compounds may be isolated by diluting the reaction mixture with water and extracting the product with a suitable extraction solvent.
- a suitable extraction solvent such as diethyl ether, ethyl acetate, toluene, methylene chloride, and the like, and mixtures thereof may be utilized.
- Bases suitable for use in the preparation of the formula IV urea compounds include, but are not limited to, alkali metal hydrides such as sodium hydride and the like; alkali metal C- L -Cgalkoxides such as potassium tert- butoxide, sodium tert-butoxide and the like; alkali metal hydroxides such as potassium hydroxide, sodium hydroxide and the like; alkali metal carbonates such as sodium carbonate, potassium carbonate and the like; alkaline earth metal hydroxides such as calcium hydroxide and the like; alkaline earth metal carbonates such as calcium carbonate and the like; and lithium bases such as alkyllithiums including - ⁇ -butyllithium, sec-butyllithium, tert-butyllithium, methyllithium and the like, lithium dialkylamides including lithium diisopropylamide and the like, and lithium cyclicamides including lithium tetramethylpiperidine and the like .
- Preferred first bases include alkali metal
- Phosphorous pentahalides suitable for use in the processes of this invention include phosphorous pentachloride, phosphorous pentabromide and phosphorous pentaiodide with phosphorous pentachloride being preferred.
- Oxalyl halides suitable for use in this invention include oxalyl chloride, oxalyl bromide and oxalyl iodide, with oxalyl chloride being preferred.
- First solvents useful in this invention include, but are not limited to, carboxylic acid amides such as N,N- dimethylfor amide, N,N-dimethylacetamide and the like; ethers such as diethyl ether, tetrahydrofuran, dioxane, 1, 2-dimethoxyethane and the like; nitriles such as acetonitrile, propionitrile and the like; dialkyl sulfoxides such as dimethyl sulfoxide and the like; and mixtures thereof.
- a preferred first solvent is N,N- dimethylformamide .
- Second solvents suitable for use in the present invention include, but are not limited to, phosphorous oxyhalides such as phosphorous oxychloride and the like; aromatic hydrocarbons such as toluene, benzene, xylenes, mesitylene and the like; halogenated aromatic hydro- carbons such as chlorobenzene, fluorobenzene and the like; carboxylic acid amides such as N,N-dimethyl- formamide, N,N-dimethylacetamide and the like; aliphatic hydrocarbons such as pentane, hexane, heptane and the like; halogenated aliphatic hydrocarbons such as methylene chloride, chloroform, carbon tetrachloride, 1, 2-dichloroethane and the like; and mixtures thereof.
- a preferred second solvent is phosphorous oxychloride .
- Preferred formula I compounds which may be prepared by the processes of this invention are those wherein Z and Z x are each independently C- L -Cgalkyl; and n is 1.
- the 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) - 1, 3 -oxazin-6-one compounds of formula I are useful for the preparation of herbicidal 6- (perfluoroalkyl) uracil compounds having the structural formula V
- n is an integer of 1, 2, 3, 4, 5 or 6 ;
- Z 3 is hydrogen or
- Q is a C 1 -C 6 alkyl group or an optionally substituted phenyl, benzyl, heteroaryl or methylenehetero- aryl group .
- formula V 6- (perfluoroalkyl) uracil compounds may be prepared by a process which comprises : (a) reacting a urea compound having the structural formula IV C ⁇ F r 2n+l co 2 z 2
- Z and Z are each independently or Z and Z may be taken together with the atom to which they are attached to form a 4- to 7-membered ring
- ZZ X is represented by - (CH 2 ) 2 0 (CH 2 ) 2 - or -(CH 2 ) m - where m is an integer of 3 , 4, 5 or 6
- Z 2 is C- L -Cgalkyl or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C 1 -C 4 alkyl or C 1 -C 4 haloalkyl groups
- n is as described above, with a phosphorous pentahalide or oxalyl halide to form a 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1, 3-oxazin- 6 -one compound having the structural formula I
- Acids suitable for use in the preparation of the formula V compounds include organic acids including, but not limited to, acids such as formic acid, acetic acid, propionic acid and the like; and mineral acids including, but not limited to, hydrochloric acid, sulfuric acid, phosphoric acid and the like.
- a preferred acid is acetic acid.
- Bases suitable for use in the preparation of the formula V compounds include, but are not limited to, tri (Ci-Cgalkyl) amines such as trimethylamine, triethylamine, tripropylamine, tributylamine, diisopropylethylamine and the like; heterocyclic tertiary amines such as 1, 8-diazazbicyclo [5.4.0] undec-7-ene (DBU) , 1, 5-diazabicyclo [4.3.0] non-5-ene (DBN) , 1,4- diazabicyclo [2.2.2] octane, pyridine, substituted pyridines, quinoline, substituted quinolines and the like; and alkali metal C- L -Cgalkoxides such as potassium tert-butoxide, sodium tert-butoxide and the like.
- tri (Ci-Cgalkyl) amines such as trimethylamine, triethylamine, tripropylamine,
- Preferred second bases include 1, 8-diazabicyclo [5.4.0] - undec-7-ene and 1, 5-diazabicyclo [4.3.0] non-5-ene .
- the 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1, 3- oxazin-6-one is reacted with the amine and the acid, preferably at a temperature ranging from about 20 °C to 150°C, in the presence of a third solvent.
- Third solvents suitable for use in this reaction include, but are not limited to, carboxylic acid amides such as N,N- dimethylformamide, N,N-dimethylacetamide and the like; dialkyl sulfoxides such as dimethyl sulfoxide and the like; aromatic hydrocarbons such as toluene, benzene, xylenes, mesitylene and the like; halogenated aromatic hydrocarbons such as chlorobenzene, fluorobenzene and the like; aliphatic hydrocarbons such as pentane, hexane, heptane and the like; halogenated aliphatic hydrocarbons such as methylene chloride, chloroform, carbon tetrachloride, 1, 2-dichloroethane and the like; alkanoic acids such as formic acid, acetic acid, propionic acid and the like; ketones such as acetone, methyl ethyl ketone and the like; ethers such as dieth
- Alkylation procedures suitable for use in this invention include conventional procedures known in the art.
- the alkylation procedure comprises reacting the formula V compound wherein Z 3 is hydrogen with an alkyl halide having the structural formula VII or a dialkylsulfate ester having the structural formula VIII
- X is chlorine, bromine or iodine
- Z 3 is C.-C 6 alkyl in the presence of a base.
- Bases suitable for use in the alkylation procedures of this invention include conventional bases known in the art including, but not limited to, alkali metal hydrides such as sodium hydride and the like; alkali metal such as potassium tert-butoxide, sodium tert-butoxide and the like; alkali metal hydroxides such as potassium hydroxide, sodium hydroxide and the like; alkali metal carbonates such as sodium carbonate, potassium carbonate and the like; alkaline earth metal hydroxides such as calcium hydroxide and the like; and alkaline earth metal carbonates such as calcium carbonate and the like.
- alkali metal hydrides such as sodium hydride and the like
- alkali metal hydroxides such as potassium hydroxide, sodium hydroxide and the like
- alkali metal carbonates such as sodium carbonate, potassium carbonate and the like
- alkaline earth metal hydroxides such as calcium hydroxide and the like
- alkaline earth metal carbonates such as calcium carbonate and the like.
- Preferred formula V compounds which may be prepared by the process of the present invention are those wherein n is 1 ; Z 3 is hydrogen or C 1 -C 4 alkyl;
- G is CH 2 or a bond;
- G x is CX 5 or N;
- G 2 is CX 4 or N;
- X is hydrogen, halogen or a C- ⁇ C g alkyl group optionally substituted with one epoxy group
- 1, 3-dioxolinone optionally substituted with one C.-C 3 alkoxy group or one or two C 1 -C 4 alkyl groups , or C 1 -C 4 alkyl optionally substituted with one C0 2 R 2 group and one halogen atom, and
- X 4 is hydrogen, halogen or OR 19 ;
- X s is hydrogen or halogen
- R, R S6 , R 64 , R 69 , R 70 , R 77 and R 91 are each independently hydrogen, S0 2 R 49 , C 1 -C 4 alkyl, C 3 -C 7 cycloalkyl , C 3 -C 3 alkenyl, C 3 -C 6 alkynyl, phenyl or benzyl;
- R is hydrogen, SO 2 R S0 , C(0)R 51/ amino or C 1 -C 4 alkyl optionally substituted with C0 2 R 52 or C(0)R S3 ; independently hydrogen, Ci-C 8 haloalkyl, C 3 -C 8 alkenyl, C 3 -C 6 alkynyl, phenyl, benzyl, furfuryl, pyridyl, thienyl , C ⁇ C g alkyl optionally substituted with C0 2 R 54 , morpholine or C(0)R S5 , or an alkali metal, an alkaline earth metal, ammonium or organic ammonium cation;
- R 3 , R 66 , R 67 , R 81 , R 85 and R 89 are each independently hydrogen , C 3 -C 3 alkenyl, C 3 -C 6 alkynyl, NR 56 R 57 , phenyl or benzyl;
- R 4 , R 18 , R 19 and R 65 are each independently hydrogen, Ci-C 8 alkyl, C 3 -C 3 alkenyl, C 3 -C 3 alkynyl , C 1 -C 4 haloalkyl,
- R s and R 72 are each independently C.-C 6 alkyl, C x - C g haloalkyl, NR g0 R 61 , imidazole or indazole;
- R 35 ' R 45 ' R 46 ' R s3 anc R so are each independently hydrogen or C 1 -C 4 alkyl;
- R 7 is hydrogen, C 3 -C 3 alkenyl, C 3 -C 6 alkynyl, benzyl, or C 1 -C 4 alkyl optionally substituted with cyano or
- C(0)R 62 ; R 8 and R 27 are each independently hydrogen, C 1 -C 4 alkyl or
- R 9 and R 90 are each independently C.-C 6 alkyl;
- R 10 is hydrogen, phenyl or benzyl;
- R 13 , R 24 and R 36 are each independently hydrogen, or halogen;
- R 23 is hydrogen or NR S3 R 64 ;
- R 34 is hydrogen, C 1 -C 4 alkyl or C ⁇ Chaloalkyl
- R 37 is hydrogen, C 1 -C 4 alkyl or C 2 -C 8 alkoxyalkyl ;
- R 38 and R 39 are each independently hydrogen, C 1 -C 4 alkyl
- each group is optionally substituted with any combination of one to six halogen atoms, one to three ⁇ -C ⁇ - alkoxy groups, one or two C ⁇ C g haloalkoxy groups, one or two NR 70 R 71 groups, one or two
- R 43 ' R 44 ' R 47 and R 48 are each independently hydrogen
- C 1 -C 4 alkyl, C--C 4 haloalkyl , C 3 -C 6 alkenyl, C 3 -C 6 alkynyl or C 3 -C 7 cycloalkyl, or R 43 and R 44 or R 47 and R 48 may be taken together with the atom to which they are attached to form a C 3 -C 7 cycloalkyl group;
- R 49 , R 50 and R 86 are each independently C- L -Cgalkyl, NR 93 R 94 , C 1 -C 4 haloakyl, C 3 -Cgalkenyl, C 3 -C 3 alkynyl or benzyl;
- R 78 , R 87 and R 92 are each independently hydrogen, C ⁇ -C 8 alkyl, C 3 -C 7 cycloalkyl, C- L -Cghaloalkyl,
- herbicidal agents which may be prepared by the process of this invention are those wherein n is 1; Z 3 is hydrogen or methyl;
- G is CH 2 or a bond;
- G x is CX 5 or N;
- G 2 is CX 4 or N;
- X is hydrogen, fluorine or C 1 -C 3 alkyl optionally substituted with one epoxy group
- X 3 is hydrogen, halogen, C 1 -C 4 haloalkyl, C0 2 R 17 , cyano,
- X 4 is hydrogen, halogen or 0R 19 ;
- X 5 is hydrogen or halogen;
- R, R 64 , R S9 and R 77 are each independently hydrogen, S0 2 R 49 or C 1 -C 4 alkyl;
- R- is hydrogen, SO 2 R S0 , C(0)R 51 , amino or C 1 -C 4 alkyl optionally substituted with C0 2 R 52 or C(0)R 53 ;
- R 2' i6' i7' 26' 3c 6 ⁇ ' R 75 ' 76 ' 82 an d Rg 8 are each independently hydrogen, C 3 -C 3 alkenyl or C 1 -C 4 alkyl optionally substituted with C0 2 R S4 , morpholine or C(0)R 55 ;
- R 3 , R g6 , R S7 , R 85 and R 89 are each independently hydrogen,
- R 4 , R 1S and R 19 are each independently hydrogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl , C(0)R 5B , C 3 -C 4 alkenyl or
- R 56 is S0 2 R 49 ;
- R 57 is hydrogen or C 1 -C 4 alkyl
- R 5 and R 72 are each independently NR g0 R sl or indazole
- Kg -t ⁇ ii / ⁇ 12 ' ⁇ 14' "'IS' ⁇ "•20 ' "21' ⁇ 22' "25' "-28' '”29' ⁇ "”31 ' "-32' "33'
- R 35 ' R 45 ' R 4 s an d R so are each independently hydrogen or methyl ;
- R 7 is C 1 -C 4 alkyl optionally substituted with cyano or C(0)R 62 ;
- R 8 is hydrogen or
- R 9 and R 90 are each independently C 1 -C 4 alkyl;
- R 10 is hydrogen or C x -C 3 alkyl;
- R 13 , R 24 and R 36 are each independently hydrogen or chlorine ;
- R 23 is NR 63 R 64 ;
- R 34 is C 1 -C 3 haloalkyl;
- R 37 is C 2 -C 4 alkoxyalkyl;
- R 38 and R 39 are each independently C 1 -C 3 haloalkyl, C- L -C j alkyl or propargyl ;
- C 1 -C 3 alkyl optionally substituted with any combination of one or two halogen atoms, one or two C 1 -C 3 alkoxy groups, one or two C 1 -C 3 haloalkoxy groups, one S0 2 R 72 group, one or two cyano groups, one C 3 -C 5 cycloalkyl group, one OS0 2 R 73 group, one C(0)R 74 group, one C0 2 R 75 group, one C(0)SR 76 group, one C(0)NR 77 R 78 group, one to two OR 79 groups, one P(0) (OR 80 ) 2 group, one 1,3- dioxolane group or one 1,3 -dioxane group, or phenyl optionally substituted with any combination of one halogen atom, one or two methyl groups, one methoxy group, one halomethyl group or one OR 83 group;
- R R 44 , R 47 and R 48 are each independently hydrogen or methyl, or R 43 and R 44 or R 47 and R 48 may be taken together with the atom to which they are attached to form a cyclopropyl group;
- R 86 are each independently C 1 -C 4 alkyl or NR 93 R 94 ;
- R, R ⁇ R ⁇ R c R, R, R 78 and R 87 are each independently hydrogen, C 1 -C 4 alkyl or C 1 -C 4 halo- alkyl ;
- R, and R 83 are each independently hydrogen, C(0)R 8S ,
- R 93 and R 94 are each independently hydrogen or C.-C 8 alkyl ; and p is 0, 1 or 2.
- the process of the present invention is especially useful for the preparation of 6- (trifluoromethyl) uracil compounds having the structural formula IX
- Z 3 is hydrogen or methyl
- X 5 is hydrogen or halogen
- R 40 is hydrogen, C(0)R 6S , C(S)R 67 , C0 2 R 68 ,
- Ci-C j alkyl optionally substituted with any combination of one or two halogen atoms, one or two C ⁇ C j alkoxy groups, one or two C 1 -C 3 haloalkoxy groups, one S0 2 R 72 group, one or two cyano groups, one C 3 -C 3 cycloalkyl group, one OS0 2 R 73 group, one or two OR 79 groups, one P(O) (OR 80 ) 2 group, one 1, 3-dioxolane group or one 1,3 -dioxane group, or phenyl optionally substituted with any combination of one halogen atom, one or two methyl groups, one methoxy group, one halomethyl group or one OR 83 group;
- R 66 , R S7 , R 85 and R 89 are each independently hydrogen
- R 57 is hydrogen or C 1 -C 4 alkyl
- R 49 and R 86 are each independently C 1 -C 4 alkyl or NR 93 R 94 ;
- R 93 and R 94 are each independently hydrogen or Ci-Cgalkyl;
- R 68 and R 88 are each independently hydrogen, C 3 -C 6 alkenyl or C 1 -C 4 alkyl optionally substituted with C0 2 R 54 , morpholine or C(0)R S5 ;
- R 54 , R 55 , R 60 , R 61 , R 73 and R 87 are each independently hydrogen, C j -C ⁇ j alkyl or C 1 -C 4 haloalkyl ;
- R 72 is NR 60 R 61 or indazole;
- R 79 and R 83 are each independently hydrogen C(0)R 85 , S0 2 R 86 , C 1 -C 4 haloalkyl, C 3 -C 4 alkenyl or C-_-C 3 alkyl substituted with one OC(0)R 87 , C0 2 R 88 ,
- R 80 is hydrogen or methyl
- R 90 is C 1 -C 4 alkyl.
- halogen hereinabove are fluorine, chlorine, bromine and iodine.
- ⁇ halomethyljg , 8 -C.haloalkylg , g C.-Cghaloalkylg , g C.-C 3 haloalkoxyg , ⁇ g C x -C 4 haloalkoxy$ and ⁇ Ci-Cghaloalkoxymethylg are defined as a methyl, C 1 -C 4 alkyl, C 1 -C 8 alkyl, C 1 -C 3 alkoxy,
- alkali metals include sodium, potassium and lithium
- alkaline earth metals include calcium and magnesium.
- Organic ammonium cations suitable for use in the present invention include, but are not limited to, a group consisting of a positively charged nitrogen atom joined to from one to four aliphatic groups, each containing from one to sixteen carbon atoms .
- 5- to 12-membered monocyclic or fused bicyclic, heterocyclic rings include, but are not limited to, benzimidazole, imidazole, imidazoline-2- thione, indole, isatoic anhydride, morpholine, piperazine, piperidine, purine, pyrazole, pyrrole, pyrrolidine and 1, 2,4-triazole rings wherein each ring is optionally substituted with one or more groups independently selected from halogen, cyano, nitro, amino, hydroxyl, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C x -C 4 alkoxy, C 1 -C 4 haloalkoxy, or C 1 -C 4 haloalkylsulfonyl groups.
- Starting formula II ⁇ -amino- ⁇ - (perfluoroalkyl) - acrylate compounds are known in the art and may be prepared according to the procedures described in U.S
- Carbamoyl chloride compounds of formula III are known in the art and may be prepared by conventional procedures . In addition, certain formula III carbamoyl chloride compounds are commercially available.
- X x , X 5 and R 40 are as described hereinabove, may be prepared, as shown in Flow Diagram I, by cyclizing a ketone of formula X with sulfur and ammonium hydroxide or ammonia to form a nitrobenzisothiazole of formula XI, and reducing the formula XI compound using conventional reducing agents such as iron in acetic acid.
- X , X 5 and R 41 are as described hereinabove, may be prepared, as illustrated in Flow Diagram II, by reacting a ketone of formula XII with hydroxylamine hydrochloride optionally in the presence of sodium acetate to form an oxi e of formula XIII, cyclizing the formula XIII compound with a base such as potassium hydroxide to form a nitrobenzisoxazole of formula XIV, and reducing the formula XIV compound using conventional reducing agents such as tin (II) chloride in acetic acid.
- a base such as potassium hydroxide
- formula XIV nitrobenzisoxazole compounds may be prepared, as shown in Flow Diagram III, by reacting a ketone of formula XV with hydroxylamine hydrochloride optionally in the presence of a base such as sodium acetate to form an oxime of formula XVI , cyclizing the formula XVI compound with 1, 1 ' -carbonyl- diimidazole in the presence of a base such as tri- ethylamine to form a benzisoxazole of formula XVII, and nitrating the formula XVII compound using conventional methods such as a nitric acid/sulfuric acid mixture.
- Formula XI and XIV intermediate compounds wherein R 40 and R 41 are Cl or Br may be prepared, as shown in Flow Diagram V, by reacting a 5-nitrobenzisoxazol-3-ol or 5- nitrobenzisothiazol-3-ol of formula XIX with phosphorous oxychloride, phosphorous oxybromide or phosphorous pentabromide .
- Ethyl 3 -amino-4, 4, 4 -trifluorocrotonate (18.4 g, 100 mmol) is added to a stirred solution of sodium hydride (60% in mineral oil, 9.6 g, 250 mmol) in N,N-dimethyl- formamide (60 tnL) at 5°C under nitrogen over a 60 minute period.
- the reaction mixture is allowed to warm to and held at room temperature for 15 minutes, cooled to 5°C, and treated with dimethylcarbamoylchloride (21.6g, 200 mmol) over a 60 minute period.
- the resultant solution is then warmed to and held at room temperature for 2 hours, diluted with water (150 mL) , and extracted with ethyl acetate (2 x 150 mL) .
- the combined organic layers are dried, filtered and concentrated, and the mineral oil layer is removed to obtain a residue.
- a mixture of aluminum chloride (33.3 g, 25.0 mmol) in methylene chloride is cooled to about 5 °C, treated over one hour with p-methylanisole (31.6 g, 25.0 mmol) while maintaining the reaction mixture temperature below 10 °C, treated over 20 minutes with a solution of 2-chloro-5-nitrobenzoyl chloride (50.0 g, 22.7 mmol) in methylene chloride while maintaining the reaction mixture temperature below 10 °C, warmed to and stirred at room temperature for 60 minutes, and poured onto ice.
- the resultant aqueous mixture is treated with concentrated hydrochloric acid (50 mL) and extracted with methylene chloride .
- Ammonium hydroxide (350 mL of a 30% solution, 270 mmol) is added to a mixture of 2 ' -chloro-2-methoxy-5- methyl-5 ' -nitrobenzophenone (68.7 g, 22.5 mmol) and sulfur (7.57 g, 23.6 mmol) in N, N-dimethylformamide .
- the resultant reaction mixture is stirred at 80 °C for 19.5 hours, cooled to 40 °C, treated with additional ammonium hydroxide (50 L of a 30% solution) , stirred at 80 °C for 25 hours, cooled, and poured onto ice.
- the resultant aqueous mixture is filtered to obtain the title product as a yellow solid (63.5 g, 93.9%) which is identified by NMR spectral analyses .
- Ammonia (45 g, 2,642 mmol) is bubbled into methanol at -40 °C in a steel bomb. Sulfur (30.5 g, 95.0 mmol) and 2 ' -chloro-5 ' -nitroacetophenone (19 g, 95.0 mmol) are then added. The bomb is sealed and heated at about 90 °C overnight. After cooling, the reaction mixture is removed from the bomb and concentrated in vacuo to obtain a residue. The residue is diluted with methylene chloride, passed through a plug of silica gel and concentrated in vacuo to give the title product as an orange solid (12.0 g) which is identified by NMR spectral analyses .
- the organic extract is diluted with hexanes, washed with water, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain the title product as an orange foam (163 g, 98.8%) which is identified by NMR spectral analyses .
- a mixture of 3- (6-methoxy-m-tolyl) -5-nitro-l, 2- benzisoxazole (20.0 g, 0.0703 mol) in acetic acid (380 mL) is warmed, treated with a warm solution of tin (II) chloride dihydrate (47.4 g, 0.210 mol) in concentrated hydrochloric acid (110 mL) , refluxed for one hour, cooled to 10 °C, and concentrated in vacuo to obtain a gum.
- the gum is added to water with stirring to obtain a slurry.
- the slurry is treated with 80 g of 50% sodium hydroxide solution, stirred at 60 °C to 80 °C over one hour, cooled, and decanted to obtain a residue.
- a mixture of the residue in ethanol is treated with potassium hydroxide (10 g) , heated overnight, cooled to room temperature, neutralized with hydrochloric acid, and concentrated in vacuo to obtain a residue.
- the residue is diluted with ethyl acetate and filtered.
- the filtrate is concentrated in vacuo and chromatographed using silica gel and a 2% ethyl acetate in methylene chloride solution to give the title products as semi-solids which are identified by elemental and mass spectral analyses.
- m-Fluorophenyl acetate (123 g, 0.798 mol) is cooled with an ice-bath, treated portionwise with . aluminum chloride (150 g, 1.12 mol), stirred at 190 °C for one hour, and cooled to obtain a solid. A mixture of ice, water and hydrochloric acid, and methylene chloride are added to the solid. The resultant mixture is stirred for several minutes, and the phases are separated. The organic phase is washed sequentially with water, saturated sodium hydrogen carbonate solution and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain the title product (99.0 g) which is identified by 1 H NMR spectral analysis.
- a mixture of 6-fluoro-3-methyl-l, 2 -benzisoxazole (23.5 g, 0.156 mol) in concentrated sulfuric acid is cooled with an ice-bath, treated dropwise with 90% nitric acid (8.50 mL) while maintaining the reaction mixture temperature below 15 °C, stirred for one hour at ice-bath temperature, treated with additional 90% nitric acid (5.80 mL) , warmed to and stirred at room temperature overnight, and poured onto ice.
- the resultant aqueous mixture is filtered to obtain a solid.
- the solid is air- dried and dissolved in methylene chloride.
- the resultant organic solution is dried over anhydrous magnesium sulfate, diluted with hexanes, and filtered to give the title product as a purple solid which is identified by 1 H NMR spectral analysis.
- the resultant aqueous mixture is filtered to obtain a solid which is recrystallized from a methylene chloride/hexanes solution to give the title product as a white solid (mp 158-159 °C) which is identified by NMR spectral analyses.
- H OCH(CH 3 ) 2 81- -83 H OCH 2 CH CH 2 70- -72 H OCH 3 101.5-103 Cl OCH(CH,)C0 2 CH, 98- 100
- a mixture of 5-nitro-l, 2-benzisoxazol-3-ol (4.00 g, 0.0220 mol) and phosphorus oxychloride (40.0 mL, 65.8 g, 0.429 mol) is placed in a glass bomb, heated at 150-155 °C for two hours, cooled overnight, concentrated in vacuo, diluted with methylene chloride, and brought to about pH 8 with sodium hydrogen carbonate solution.
- the phases are separated.
- the organic phase is washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a residue.
- a solution of chromium (VI) oxide (91.0 g, 0.919 mol) in a water/acetic acid solution (1:4) is added portionwise to 2-chloro-2 ' -methoxy-5-nitrobenzhydrol (64.2 g, 0.219 mol) while maintaining the reaction mixture temperature at 25 °C to 35 °C.
- the reaction mixture is then stirred at 25 °C to 35 °C for one hour, cooled, diluted with water, and concentrated in vacuo to obtain a residue.
- the residue is diluted with water, and extracted with methylene chloride.
- the organic extracts are combined, dried over anhydrous sodium sulfate, mixed with silica gel (10 g) , and filtered.
- the filtrate is concentrated in vacuo to obtain an oil.
- a solution of the oil in a methanol/water solution is decolorized with charcoal and concentrated in vacuo to yield a residue .
- Flash column chromatography of the solid using silica gel and a 10% to 50% ethyl acetate in hexanes gradient gives a yellow solid containing two components. Flash column chromatography of the yellow solid using silica gel and a 50% to 70% methylene chloride in hexanes gradient gives the title product as a pale, yellow solid (0.870 g, mp
- a sodium ethoxide solution (previously prepared from ethanol and sodium (1.00 g, 0.0430 mol)) is cooled with an ice-acetone bath, treated portionwise with ethyl cyanoacetate (4.51 g, 0.0398 mol), stirred at room temperature for 30 minutes, treated with 3-chloro-5- nitro-1, 2-benzisothiazole (4.27 g, 0.0199 mol), stirred at room temperature overnight, cooled to 0 °C, and treated dropwise with 10% hydrochloric acid (15.0 mL) . The resultant aqueous mixture is stirred at room temperature for one hour and filtered to obtain a solid. The solid is washed with ethanol and air-dried to give the title product as a yellow solid which is identified by NMR spectral analysis.
- a 10% acetic acid solution (31.0 mL) is stirred at 50 °C, treated with iron powder (0.656 g) , treated dropwise with a solution of ethyl 5-nitro-l, 2- benzisothiazole-3 -acetate (1.03 g, 3.88 mmol) in ethyl acetate, stirred at 50 °C for two hours, treated with additional iron powder (0.305 g) , stirred at 50 °C for 15 minutes, and poured into saturated sodium hydrogen carbonate solution. The resultant aqueous mixture is extracted with ethyl acetate.
- a solution of the foam in N,N- dimethylformamide is treated with potassium carbonate (0.312 g, 2.25 mmol), stirred for one hour, treated with iodomethane (0.420 mL, 6.70 mmol), stirred overnight at room temperature, and poured into an ice-water mixture containing 20 mL of concentrated hydrochloric acid.
- the resultant aqueous mixture is extracted with methylene chloride.
- the combined organic extracts are washed sequentially with 10% hydrochloric acid, water, saturated sodium hydrogen carbonate solution and water, dried over anhydrous sodium sulfate and concentrated in vacuo to obtain a brown oil .
- a mixture of iron powder (13.0 g, 0.233 mol) in a 5% acetic acid solution (65.0 mL) is heated to 50 °C, treated portionwise with a mixture of [ (5-nitro-l, 2-benzisothia- zol-3 -yl) oxy] acetonitrile (11.0 g, 0.047 mol), acetic acid (100 mL) and ethyl acetate (65.0 mL) , refluxed for two hours, cooled to 40 °C, and filtered to remove solids. The phases are separated and the aqueous phase is extracted with ethyl acetate.
- a suspension of 5-nitro-l, 2-benzisothiazole (271 g, 1.50 mol) in acetic acid is heated to 80 °C to form a solution.
- the heating source is removed and chlorine gas is added continuously over six hours at 70-80 °C until saturation of the mixture occurs .
- the mixture is cooled to room temperature and stirred overnight. Filtration affords the title compound as a yellow crystalline solid (237 g, 73.6%) which is identified by NMR spectral analysis .
- Oxalyl chloride (94.0 g, 0.739 mol) is added dropwise to a mixture of 2 , 4-difluoro-5-nitrobenzoic acid (100.0 g, 0.492 mol), methylene chloride and N,N- dimethylformamide (0.600 ml). The resultant mixture is stirred 3.25 hours at reflux, cooled to room temperature, and concentrated in vacuo to afford the title compound as a brown oil (111 g, 95.2%) .
- Ammonium hydroxide (330 ml) is added to a suspension of 2 ' , 4 ' -difluoro-2-methoxy-5-methyl-5 ' -nitrobenzophenone (60.0 g, 0.186 mol), sulfur (6.25 g, 0.195 mol) and N,N- dimethylformamide on an ice bath.
- the resultant mixture is allowed to warm to 35 °C, heated gradually to 81 °C over a two hour period, cooled to room temperature, and poured into water.
- the resultant solid is taken up in ethyl acetate and N,N-dimethylformamide, and washed with water.
- the organic layer is concentrated in vacuo to afford the title compound which is identified by NMR spectral analysis .
Abstract
An improved process and intermediate compounds (N) for the preparation of 2-(N,N-disubstituted)amino-4-(perfluoroalkyl)-1,3-oxazin-6-one compounds having structural formula (I) and an improved process for the preparation of 6-(perfluoroalkyl)uracil compounds having structural formula (V).
Description
PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF l,3-0XAZIN-6-0NES AND URACILS
BACKGROUND OF THE INVENTION
6- (Perfluoroalkyl ) uracil compounds are useful as herbicidal agents and methods for their preparation are known in the art. 6- (Perfluoroalkyl) uracil compounds may be prepared by reacting 2- (N,N-disubstituted) amino-4 - (perfluoroalkyl) -1, 3 -oxazin-6-one compounds with amine compounds .
Bull. Soc. Chem. Belg. , 102(4), pages 313-321 (1992) discloses that 2- (N,N-dialkyl) amino-4- (trifluoromethyl) - 1, 3-oxazin-6-one compounds are prepared by reacting ethyl 3 -amino-4, 4 ,4-trifluorocrotonate with phosgene iminium chloride compounds. However, this method is not entirely satisfactory for the preparation of 2- (N,N-disub- stituted) amino-4- (perfluoroalkyl) -1, 3 -oxazin-6-one compounds because the required phosgene iminium chloride compounds are difficult to handle and relatively expensive. Accordingly, a need exists in the art for an improved process for the preparation of 2- (N,N-disub- stituted) amino-4- (perfluoroalkyl) -1 , 3 -oxazin-6-one compounds which avoids the use of phosgene iminium chloride compounds .
It is, therefore, an object of the present invention to provide improved processes for the preparation of 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1, 3-oxazin-6- one compounds .
It is also an object of the present invention to provide intermediate compounds which are useful in the preparation of 2- (N,N-disubstituted) amino-4- (perfluoro- alkyl) -1, 3 -oxazin-6-one compounds.
It is a further object of the present invention to provide an improved process for the preparation of 6- (perfluoroalkyl) racil compounds .
Other objects and advantages of the present invention will be apparent to those skilled in the art from the description below and the appended claims .
SUMMARY OF THE INVENTION The present invention provides a new process for the preparation of 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1, 3 -oxazin-6 -one compounds having the structural formula I
-N>
( i :
wherein
Z and Zx are each independently
or Z and Z1 may be taken together with the atom to which they are attached to form a 4- to 7-membered ring wherein ZZ1 is represented by - (CH2) 20 (CH2) 2- or -(CH2)m- where m is an integer of 3 , 4 , 5 or 6 ; and n is an integer of 1, 2, 3, 4, 5 or 6 , which comprises : (a) reacting a β-amino-β- (perfluoroalkyl) acrylate compound having the structural formula II
NH.
( ID
wherein n is as described above, and Z2 is C-L-Cgalkyl or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C1-C4alkyl or C1-C4haloalkyl groups, with a base and a carbamoyl chloride compound having the structural formula III
(III)
wherein Z and _ are as described above to form a urea compound having the structural formula IV
CaFto+lV^co2za
( IV)
(b) reacting the formula IV urea with a phosphorous pentahalide or oxalyl halide.
The present invention further provides a process for the preparation of 6- (perfluoroalkyl) uracil compounds having the structural formula V
O
(V) wherein n is an integer of 1 , 2 , 3 , 4 , 5 or 6 ; Z3 is hydrogen or C1-C6alkyl; and Q is a C1-C6alkyl group or an optionally substituted phenyl , benzyl , heteroaryl or methyleneheteroaryl group , which process comprises :
(a) reacting a urea compound having the structural formula IV
,N
(IV)
wherein Z and Z are each independently
or Z and Z may be taken together with the atom to which they are attached to form a 4- to 7-membered ring wherein ZZ1 is represented by - (CH2) 20 (CH2) 2- or -(CH2)m- where m is an integer of 3 , 4, 5 or 6 ; Z2 is Ci-C8alkyl or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C1-C4alkyl or C1-C4haloalkyl groups; and
n is as described above, with a phosphorous pentahalide or oxalyl chloride to form a 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1,3- oxazin-6-one compound having the structural formula I
N^
Z Z,
(I)
(b) reacting the 2- (N,N-disubstituted) amino-4 - (perfluoroalkyl) -1, 3 -oxazin-6 -one with an amine compound having the structural formula VI
QNH2 (VI)
wherein Q is as described above in the presence of an acid or a base to form the 6- (perfluoroalkyl) uracil compound of formula V wherein Z3 is hydrogen; and
(c) optionally alkylating the formula V compound wherein Z3 is hydrogen. The present invention also relates to the novel urea compounds having the structural formula IV
HN
;
Z Z,
(IV) wherein
Z and Zx are each independently Ci-Cgalkyl or Z and Zx may be taken together with the atom to which they are attached to form a 4- to 7-membered ring wherein ZZX is represented by - (CH2) 20 (CH2) 2- or -(CH2)m- where m is an integer of 3 , 4 , 5 or 6 ; n is an integer of 1 , 2 , 3 , , 5 or 6 ; and Z2 is Ci-Cgalkyl or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C1-C4alkyl or C1-C4haloalkyl groups.
DETAILED DESCRIPTION OF THE INVENTION
In a preferred embodiment of the present invention, the 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1,3- oxazin-6-one compounds of formula I are prepared by reacting a β-amino-β- (perfluoroalkyl) acrylate compound of formula II with a base and a carbamoyl chloride compound of formula III, preferably at a temperature ranging from about -20°C to 80°C, more preferably from about 0°C to 50°C, in the presence of a first solvent to form a urea compound of formula IV, and reacting the formula IV urea compound with a phosphorous pentahalide or oxalyl halide, preferably at a temperature ranging from about 0°C to 100°C, more preferably from about 20°C to 50°C, optionally in the presence of a second solvent. The present invention also provides a process for the preparation of 2- (N,N-disubstituted) amino-4- (per- fluoroalkyl) -1, 3-oxazin-6-one compounds of formula I which comprises reacting a urea compound of formula IV with a phosphorous pentahalide or oxalyl chloride, preferably at a temperature ranging from about 0°C to 100°C, more preferably from about 20°C to 50°C, optionally in the presence of a second solvent.
Advantageously, the present invention provides improved processes for the preparation of 2- (N,N- disubstituted) amino-4- (perfluoroalkyl) -1, 3 -oxazin-6-one
compounds which avoid the use of phosgene iminium chloride compounds .
The present invention further relates to urea compounds having the structural formula IV which are utilized in the processes of this invention
Z zτ
(IV) wherein
Z and Zx are each independently
or Z and Zx may be taken together with the atom to which they are attached to form a 4- to 7-membered ring wherein ZZi is represented by - (CH2) 20 (CH2) 2- or -(CH2)m- where m is an integer of 3 , 4 , 5 or 6 ; n is an integer of 1, 2, 3, 4, 5 or 6 ; and Z2 is Cj^-Cjalkyl or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, Cx-C4alkyl or C1-C4haloalkyl groups. Preferred formula IV compounds are those wherein Z and Zx are each independently Ci-Cgalkyl; Z2 is C1-C4alkyl; and n is i.
More preferred formula IV urea compounds of this invention are those wherein
Z and Zx are the same and represent methyl or ethyl ; Z2 is methyl or ethyl ; and n is 1.
Representative formula IV compounds which are particularly useful in the processes of this invention include ethyl 3- [ (N,N-dimethylcarbamoyl) amino] -4,4,4- trifluorocrotonate, (Z) - ; methyl 3- [ (N,N-dimethylcarbamoyl) amino] -4,4,4- trifluorocrotonate, (Z) - ; ethyl 3- [ (N, N-diethylcarbamoyl) amino] -4,4,4- trifluorocrotonate, (Z) - ; methyl 3- [ (N,N-diethylcarbamoyl) amino] -4 , 4 , 4- trifluorocrotonate, (Z) - ; ethyl 3 - [ (N-pyrrolodinecarbonyl) amino] -4,4,4- trifluorocrotonate, (Z) - ; and methyl 3- [ (N-pyrrolodinecarbonyl) amino] -4,4,4- trifluorocrotonate, (Z)-, among others.
In another preferred embodiment of the present invention, the double bond in the formula II and IV compounds is predominately in the (Z) - configuration.
The product formula I compounds may be isolated by diluting the reaction mixture with water and extracting the product with a suitable extraction solvent. In the isolation procedure, conventional extraction solvents such as diethyl ether, ethyl acetate, toluene, methylene chloride, and the like, and mixtures thereof may be utilized.
Bases suitable for use in the preparation of the formula IV urea compounds include, but are not limited to, alkali metal hydrides such as sodium hydride and the like; alkali metal C-L-Cgalkoxides such as potassium tert- butoxide, sodium tert-butoxide and the like; alkali metal hydroxides such as potassium hydroxide, sodium hydroxide and the like; alkali metal carbonates such as sodium carbonate, potassium carbonate and the like; alkaline earth metal hydroxides such as calcium hydroxide and the like; alkaline earth metal carbonates such as calcium
carbonate and the like; and lithium bases such as alkyllithiums including -π-butyllithium, sec-butyllithium, tert-butyllithium, methyllithium and the like, lithium dialkylamides including lithium diisopropylamide and the like, and lithium cyclicamides including lithium tetramethylpiperidine and the like . Preferred first bases include alkali metal hydrides and alkali metal C-L-C3alko ides .
Phosphorous pentahalides suitable for use in the processes of this invention include phosphorous pentachloride, phosphorous pentabromide and phosphorous pentaiodide with phosphorous pentachloride being preferred. Oxalyl halides suitable for use in this invention include oxalyl chloride, oxalyl bromide and oxalyl iodide, with oxalyl chloride being preferred.
First solvents useful in this invention include, but are not limited to, carboxylic acid amides such as N,N- dimethylfor amide, N,N-dimethylacetamide and the like; ethers such as diethyl ether, tetrahydrofuran, dioxane, 1, 2-dimethoxyethane and the like; nitriles such as acetonitrile, propionitrile and the like; dialkyl sulfoxides such as dimethyl sulfoxide and the like; and mixtures thereof. A preferred first solvent is N,N- dimethylformamide . Second solvents suitable for use in the present invention include, but are not limited to, phosphorous oxyhalides such as phosphorous oxychloride and the like; aromatic hydrocarbons such as toluene, benzene, xylenes, mesitylene and the like; halogenated aromatic hydro- carbons such as chlorobenzene, fluorobenzene and the like; carboxylic acid amides such as N,N-dimethyl- formamide, N,N-dimethylacetamide and the like; aliphatic hydrocarbons such as pentane, hexane, heptane and the like; halogenated aliphatic hydrocarbons such as methylene chloride, chloroform, carbon tetrachloride,
1, 2-dichloroethane and the like; and mixtures thereof. A preferred second solvent is phosphorous oxychloride .
Preferred formula I compounds which may be prepared by the processes of this invention are those wherein Z and Zx are each independently C-L-Cgalkyl; and n is 1.
The processes of the present invention are also preferably used for the preparation of formula I compounds wherein Z and Zx are the same and represent methyl or ethyl ; and n is i.
The 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) - 1, 3 -oxazin-6-one compounds of formula I are useful for the preparation of herbicidal 6- (perfluoroalkyl) uracil compounds having the structural formula V
(V) wherein n is an integer of 1, 2, 3, 4, 5 or 6 ; Z3 is hydrogen or
and
Q is a C1-C6alkyl group or an optionally substituted phenyl, benzyl, heteroaryl or methylenehetero- aryl group .
Advantageously, formula V 6- (perfluoroalkyl) uracil compounds may be prepared by a process which comprises : (a) reacting a urea compound having the structural formula IV
CιFr 2n+l co2z2
HN 0
,Hk
(IV)
wherein
Z and Z are each independently
or Z and Z may be taken together with the atom to which they are attached to form a 4- to 7-membered ring wherein ZZX is represented by - (CH2) 20 (CH2) 2- or -(CH2)m- where m is an integer of 3 , 4, 5 or 6 ; Z2 is C-L-Cgalkyl or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C1-C4alkyl or C1-C4haloalkyl groups; and n is as described above, with a phosphorous pentahalide or oxalyl halide to form a 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1, 3-oxazin- 6 -one compound having the structural formula I
N^/O
Z Z. (I)
(b) reacting the 2- (N,N-disubstituted) amino-4-
(perfluoroalkyl) -1, 3 -oxazin-6-one with an amine compound having the structural formula VI
QNH2 (VI )
wherein Q is as described above in the presence of an acid or a base to form the 6- (perfluoroalkyl) uracil compound of formula V wherein Z3 is hydrogen; and
(c) optionally alkylating the formula V compound wherein Z3 is hydrogen.
Acids suitable for use in the preparation of the formula V compounds include organic acids including, but not limited to,
acids such as formic acid, acetic acid, propionic acid and the like; and mineral acids including, but not limited to, hydrochloric acid, sulfuric acid, phosphoric acid and the like. A preferred acid is acetic acid.
Bases suitable for use in the preparation of the formula V compounds include, but are not limited to, tri (Ci-Cgalkyl) amines such as trimethylamine, triethylamine, tripropylamine, tributylamine, diisopropylethylamine and the like; heterocyclic tertiary amines such as 1, 8-diazazbicyclo [5.4.0] undec-7-ene (DBU) , 1, 5-diazabicyclo [4.3.0] non-5-ene (DBN) , 1,4- diazabicyclo [2.2.2] octane, pyridine, substituted pyridines, quinoline, substituted quinolines and the like; and alkali metal C-L-Cgalkoxides such as potassium tert-butoxide, sodium tert-butoxide and the like.
Preferred second bases include 1, 8-diazabicyclo [5.4.0] - undec-7-ene and 1, 5-diazabicyclo [4.3.0] non-5-ene .
In a preferred embodiment of the present invention, the 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1, 3- oxazin-6-one is reacted with the amine and the acid, preferably at a temperature ranging from about 20 °C to 150°C, in the presence of a third solvent. Third solvents suitable for use in this reaction include, but are not limited to, carboxylic acid amides such as N,N-
dimethylformamide, N,N-dimethylacetamide and the like; dialkyl sulfoxides such as dimethyl sulfoxide and the like; aromatic hydrocarbons such as toluene, benzene, xylenes, mesitylene and the like; halogenated aromatic hydrocarbons such as chlorobenzene, fluorobenzene and the like; aliphatic hydrocarbons such as pentane, hexane, heptane and the like; halogenated aliphatic hydrocarbons such as methylene chloride, chloroform, carbon tetrachloride, 1, 2-dichloroethane and the like; alkanoic acids such as formic acid, acetic acid, propionic acid and the like; ketones such as acetone, methyl ethyl ketone and the like; ethers such as diethyl ether, tetrahydrofuran, dioxane, 1, 2 -dimethoxyethane and the like; nitriles such as acetonitrile, propionitrile and the like; and water; and mixtures thereof .
Alkylation procedures suitable for use in this invention include conventional procedures known in the art. In a preferred embodiment of this invention, the alkylation procedure comprises reacting the formula V compound wherein Z3 is hydrogen with an alkyl halide having the structural formula VII or a dialkylsulfate ester having the structural formula VIII
wherein X is chlorine, bromine or iodine, and Z3 is C.-C6alkyl in the presence of a base.
Bases suitable for use in the alkylation procedures of this invention include conventional bases known in the art including, but not limited to, alkali metal hydrides such as sodium hydride and the like; alkali metal
such as potassium tert-butoxide, sodium tert-butoxide and the like; alkali metal hydroxides such as potassium hydroxide, sodium hydroxide and the like; alkali metal carbonates such as sodium carbonate, potassium carbonate and the like; alkaline earth metal hydroxides such as calcium hydroxide and the like; and alkaline earth metal carbonates such as calcium carbonate and the like.
Preferred formula V compounds which may be prepared by the process of the present invention are those wherein n is 1 ; Z3 is hydrogen or C1-C4alkyl;
X is hydrogen, halogen or a C-^Cgalkyl group optionally substituted with one epoxy group, X2 is hydrogen, halogen NRR17 C02R2, C(0)R3, OR4, S02Rs, S02NR6R7, C(R8) (0R9)2, C (R10) =NOR11# C (R12) =C (R13) - C(0R14)=N0R15, CH20-NC02R16,
1, 3-dioxolane optionally substituted with one C-L-Cgalkoxy group or one or two C1-C4alkyl groups ,
1, 3-dioxolinone optionally substituted with one C.-C3alkoxy group or one or two C1-C4alkyl groups , or C1-C4alkyl optionally substituted with one C02R2 group and one halogen atom, and
X3 is hydrogen, halogen, C1-C4haloalkyl, C02R17, cyano,
C1-C4haloalkoxy, OR18 or C1-C4alkyl, or when Xx and X2 are taken together with the atoms to which they are attached, they may form a five- or six- membered ring wherein XXX2 or X2X- is represented by: -OC(R20) (R21)0-, -CH2S(0)pN(R22) -, -SC(R23)=N-, -CH=CH-
CH(R.-)0-, -OC(0)N-, -SC(R24)=N-, -ON (R25) C (0) - , -0C(C02R26)=C(R27)-, -NC(R28)=C(SR29)-, -CH=C (CO2R30) 0- , -CH2CH(R31)0- or -OC (R32) (R33) C (O) - , or when X2 and X3 are taken together with the atoms to which they are attached, they may form a five- or six- membered ring wherein X2X3 or X3X2 is represented by: -NC(R34)=NC(S)-, -N(R3S)N=C(R36) -, -N (R37) C (R38) =N- , -N(R38)C(0)CH20-, -N(R39)C(0)CH=CH-, -S-N=C (R40) - , -0-N=C(R41)-, -N=N-N(R42) -, -C (R43) (R44) C (0) N (R4S) - or -N(R46)C(0)C(R47) (R48) -;
X4 is hydrogen, halogen or OR19;
Xs is hydrogen or halogen;
R, RS6, R64, R69, R70, R77 and R91 are each independently hydrogen, S02R49, C1-C4alkyl, C3-C7cycloalkyl , C3-C3alkenyl, C3-C6alkynyl, phenyl or benzyl;
R is hydrogen, SO2RS0, C(0)R51/ amino or C1-C4alkyl optionally substituted with C02R52 or C(0)RS3;
independently hydrogen, Ci-C8haloalkyl, C3-C8alkenyl, C3-C6alkynyl, phenyl, benzyl, furfuryl, pyridyl, thienyl , C^Cgalkyl optionally substituted with C02R54, morpholine or C(0)RS5, or an alkali metal, an alkaline earth metal, ammonium or organic ammonium cation;
R3, R66, R67, R81, R85 and R89 are each independently hydrogen ,
C3-C3alkenyl, C3-C6alkynyl, NR56R57, phenyl or benzyl; R4, R18, R19 and R65 are each independently hydrogen,
Ci-C8alkyl, C3-C3alkenyl, C3-C3alkynyl , C1-C4haloalkyl,
C(0)Rε8 , C(S)RS9 or benzyl; Rs and R72 are each independently C.-C6alkyl, Cx- Cghaloalkyl, NRg0R61, imidazole or indazole;
"■6' "-11' •"■12' R-14 ' R1S ' R20' "21 ' ^22' "25' R28 ' "29' "31' ^32' "33'
R 35' R 45' R 46' Rs3 anc Rso are each independently hydrogen or C1-C4alkyl; R7 is hydrogen, C3-C3alkenyl, C3-C6alkynyl, benzyl, or C1-C4alkyl optionally substituted with cyano or
C(0)R62; R8 and R27 are each independently hydrogen, C1-C4alkyl or
C1-C4alkoxy; R9 and R90 are each independently C.-C6alkyl; R10 is hydrogen,
phenyl or benzyl;
R13, R24 and R36 are each independently hydrogen,
or halogen; R23 is hydrogen or NRS3R64;
R34 is hydrogen, C1-C4alkyl or C^Chaloalkyl ; R37 is hydrogen, C1-C4alkyl or C2-C8alkoxyalkyl ;
R38 and R39 are each independently hydrogen, C1-C4alkyl,
C1-C4haloalkyl, C3-C6alkenyl or C3-C6alkynyl ; R40, R41 and R42 are each independently hydrogen, halogen, cyano, OR65, C(0)R66, C(S)R67, C02R68, C(=NOR69) , a C.-C8alkyl, C3-C7cycloalkyl, C2-C8alkenyl or
C2-C8alkynyl group, wherein each group is optionally substituted with any combination of one to six halogen atoms, one to three ^-C^- alkoxy groups, one or two C^Cghaloalkoxy groups, one or two NR70R71 groups, one or two
3(0)^2 groups, one or two cyano groups, one or two C3-C7cycloalkyl groups, one OS02R73 group, one or two C(0)R74 groups, one or two C02R75 groups, one or two C(0)SR76 groups, one or two C(0)NR77R78 groups, one to three OR79 groups, one
or two P(O) (OR80)2 groups, one 1, 3-dioxolane optionally substituted with one to three C1-C4alkyl groups, or one 1,3-dioxane optionally substituted with one to three C1-C4alkyl groups, or phenyl or benzyl optionally substituted with any combination of one to three halogen atoms, one to three
groups, one to three C - C6alkoxy groups, one C3-C7cycloalkyl group, one Cx-C4haloalkyl group, one Cx-C4alkylthio group, one cyano group, one nitro group, one C(0)R81 group, one C02R82 group, one OR83 group, one SR84 group, one C-L-Cj-alkoxymethyl group, one hydroxymethyl group, one C3-C8alkenyloxymethyl group, or one
group;
R43' R44' R47 and R48 are each independently hydrogen,
C1-C4alkyl, C--C4haloalkyl , C3-C6alkenyl, C3-C6alkynyl or C3-C7cycloalkyl, or R43 and R44 or R47 and R48 may be taken together with the atom to which they are attached to form a C3-C7cycloalkyl group;
R49, R50 and R86 are each independently C-L-Cgalkyl, NR93R94, C1-C4haloakyl, C3-Cgalkenyl, C3-C3alkynyl or benzyl;
RS1 ' "52' R53 ' RS4 ' R55 ' "57' "58' "-59' R60 ' R61 ' "62' "71' 73 ' "74'
R78, R87 and R92 are each independently hydrogen, C^-C8alkyl, C3-C7cycloalkyl, C-L-Cghaloalkyl,
C3-C6alkenyl, C3-C6alkynyl, phenyl or benzyl; R79, R83 and R84 are each independently hydrogen, C(0)R85, S02R86,
C2-Cεalkenyl, C5-C8cycloalkenyl, C2-Cgalkynyl, phenyl, benzyl, or C^-C^alkyl optionally substituted with one hydroxyl, benzyloxy, 0C(0)R87, C^-C8alkoxy, C02R88, C(0)R89, C(OR90)2, C(0)NR91R92 or cyano group; R93 and R94 are each independently hydrogen, C1-C4haloalkyl, C2-C6alkenyl, C3-C8cycloalkyl, C.-C8alkyl optionally substituted with one or two
C1-C4alkoxy groups or one cyanoalkyl group, or benzyl or phenyl optionally substituted with any combination of one to three halogen atoms, one to three C-_-C4alkyl groups, one to three C1-C4haloalkyl groups, one to three C1-C4alkoxy groups, one to three C1-C4haloalkoxy groups, one cyano group or one nitro group, and when R93 and R94 are taken together with the atom to which they are attached, they form a 5- to 12- membered monocyclic or fused bicyclic, heterocyclic ring optionally substituted with one or more groups independently selected from halogen, cyano, nitro, amino, hydroxyl, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy and C.-C4haloalkylsulfonyl groups; and p and q are each independently 0, 1 or 2 ; and the optical isomers, diastereomers and/or tautomers thereof .
More preferred formula V herbicidal agents which may be prepared by the process of this invention are those wherein n is 1; Z3 is hydrogen or methyl;
G is CH2 or a bond; Gx is CX5 or N; G2 is CX4 or N;
X is hydrogen, fluorine or C1-C3alkyl optionally substituted with one epoxy group;
X2 is hydrogen, halogen NRR17 C02R2, C(0)R3, OR4, S02R5,
S02NR6R7, C(R8) (0R9)2, C (R10) =NOR11, C (R12) =C (R13) - C (OR14) =N0R1S, CH20-NC02R1S;
1, 3-dioxolane optionally substituted with one C-L-C8alkoxy group or one or two C1-C4alkyl groups ,
1, 3-dioxolinone optionally substituted with one C1-C6alkoxy group or one or two C1-C4alkyl groups , or C1-C4alkyl optionally substituted with one C02R2 group and one halogen atom, and
X3 is hydrogen, halogen, C1-C4haloalkyl, C02R17, cyano,
C1-C4haloalkoxy, OR18 or C1-C4alkyl, or when Xx and X2 are taken together with the atoms to which they are attached, they may form a five- or six- membered ring wherein X-X2 or X2XX is represented by.
-OC(R20) (R21)0-, -CH2S(0)pN(R22) -, -SC(R23)=N-, -CH=CH-CH(R11)0-, -OC(0)N-, -SC(R24)=N-, -ON (R2S) C (O) - , -OC(C02R26)=CH-, -NC(R28)=C(SR29) -, -CH=C (CO2R30) O- , -CH2CH(R31)0- or -OC (R32) (R33) C (0) - , or when X2 and X3 are taken together with the atoms to which they are attached, they may form a five- or six- membered ring wherein X2X3 or X3X2 is represented by: -NC(R34)=NC(S)-, -N(R35)N=C(R36) -, -N (R37) C (R38) =N- , -N(R38)C(0)CH20-, -N(R39)C(0)CH=CH-, -S-N=C (R40) - , -0-N=C(R41)-, -N=N-N(R42)-, -C (R43) (R44) C (0) N (R45) - or
-N(R46)C(0)C(R47) (R48)-; X4 is hydrogen, halogen or 0R19; X5 is hydrogen or halogen;
R, R64, RS9 and R77 are each independently hydrogen, S02R49 or C1-C4alkyl;
R-. is hydrogen, SO2RS0, C(0)R51, amino or C1-C4alkyl optionally substituted with C02R52 or C(0)R53;
R2' i6' i7' 26' 3c 6β ' R75 ' 76 ' 82 and Rg8 are each independently hydrogen, C3-C3alkenyl or C1-C4alkyl optionally substituted with C02RS4, morpholine or
C(0)R55; R3, Rg6, RS7, R85 and R89 are each independently hydrogen,
Cx-C4 alkyl or NR56R57; R4, R1S and R19 are each independently hydrogen, C1-C4alkyl, C1-C4haloalkyl , C(0)R5B, C3-C4alkenyl or
C3-C4alkynyl; R56 is S02R49;
R57 is hydrogen or C1-C4alkyl; R5 and R72 are each independently NRg0Rsl or indazole; Kg , -t^ii / ^12 ' ^14' "'IS' ■"•20 ' "21' ^22' "25' "-28' '"29' ■""31 ' "-32' "33'
R 35' R 45' R 4s and Rso are each independently hydrogen or methyl ; R7 is C1-C4alkyl optionally substituted with cyano or C(0)R62; R8 is hydrogen or
R9 and R90 are each independently C1-C4alkyl; R10 is hydrogen or Cx-C3alkyl;
R13, R24 and R36 are each independently hydrogen or chlorine ; R23 is NR63R64;
R34 is C1-C3haloalkyl; R37 is C2-C4alkoxyalkyl;
R38 and R39 are each independently C1-C3haloalkyl, C-L-Cjalkyl or propargyl ; R40, R41 and R42 are each independently hydrogen, C(0)Rg6, C(S)R67, C02R68, C(=NOR69) ,
C1-C3alkyl optionally substituted with any combination of one or two halogen atoms, one or two C1-C3alkoxy groups, one or two C1-C3haloalkoxy groups, one S02R72 group, one or two cyano groups, one C3-C5cycloalkyl group, one OS02R73 group, one C(0)R74 group, one C02R75 group, one C(0)SR76 group, one C(0)NR77R78 group, one to two OR79 groups, one P(0) (OR80)2 group, one 1,3- dioxolane group or one 1,3 -dioxane group, or
phenyl optionally substituted with any combination of one halogen atom, one or two methyl groups, one methoxy group, one halomethyl group or one OR83 group;
R R44, R47 and R48 are each independently hydrogen or methyl, or R43 and R44 or R47 and R48 may be taken together with the atom to which they are attached to form a cyclopropyl group;
"49 ' 50 and R86 are each independently C1-C4alkyl or NR93R94; R51' R-. R, Rκ Rβ Rc R, R, R78 and R87 are each independently hydrogen, C1-C4alkyl or C1-C4halo- alkyl ;
R, and R83 are each independently hydrogen, C(0)R8S,
S02R86/ C1-C4haloalkyl, C3-C4alkenyl or
C1-C3alkyl substituted with one OC(0)R87,
C02R88, C(0)R89, C(OR90)2 or cyano group; R93 and R94 are each independently hydrogen or C.-C8alkyl ; and p is 0, 1 or 2.
The process of the present invention is especially useful for the preparation of 6- (trifluoromethyl) uracil compounds having the structural formula IX
(IX)
wherein
Z3 is hydrogen or methyl ;
X5 is hydrogen or halogen;
R40 is hydrogen, C(0)R6S, C(S)R67, C02R68,
Ci-Cjalkyl optionally substituted with any combination of one or two halogen atoms, one or two C^Cjalkoxy groups, one or two C1-C3haloalkoxy groups, one S02R72 group, one or two cyano groups, one C3-C3cycloalkyl group, one OS02R73 group, one or two OR79 groups, one P(O) (OR80)2 group, one 1, 3-dioxolane group or one 1,3 -dioxane group, or phenyl optionally substituted with any combination of one halogen atom, one or two methyl groups, one methoxy group, one halomethyl group or one OR83 group;
R66, RS7, R85 and R89 are each independently hydrogen,
C1-C4alkyl or NR5gR57;
R57 is hydrogen or C1-C4alkyl; R49 and R86 are each independently C1-C4alkyl or NR93R94;
R93 and R94 are each independently hydrogen or Ci-Cgalkyl; R68 and R88 are each independently hydrogen, C3-C6alkenyl or C1-C4alkyl optionally substituted with C02R54, morpholine or C(0)RS5; R54, R55, R60, R61, R73 and R87 are each independently hydrogen, Cj-C^jalkyl or C1-C4haloalkyl ; R72 is NR60R61 or indazole;
R79 and R83 are each independently hydrogen C(0)R85, S02R86, C1-C4haloalkyl, C3-C4alkenyl or C-_-C3alkyl substituted with one OC(0)R87, C02R88,
C(0)R89, C(OR90)2 or cyano group; R80 is hydrogen or methyl; and R90 is C1-C4alkyl.
Exemplary of halogen hereinabove are fluorine, chlorine, bromine and iodine. The terms § halomethyljg , 8 -C.haloalkylg , g C.-Cghaloalkylg , g C.-C3haloalkoxyg , ξg Cx-C4haloalkoxy$ and § Ci-Cghaloalkoxymethylg are defined as a methyl, C1-C4alkyl, C1-C8alkyl, C1-C3alkoxy,
C1-C4alkoxy or C-L-Cgalkoxymethyl group substituted with one or more halogen atoms. In formula V above, alkali metals include sodium, potassium and lithium, and alkaline earth metals include calcium and magnesium. Organic ammonium cations suitable for use in the present invention include, but are not limited to, a group consisting of a positively charged nitrogen atom joined to from one to four aliphatic groups, each containing from one to sixteen carbon atoms . In formula V above, 5- to 12-membered monocyclic or fused bicyclic, heterocyclic rings include, but are not limited to, benzimidazole, imidazole, imidazoline-2- thione, indole, isatoic anhydride, morpholine, piperazine, piperidine, purine, pyrazole, pyrrole, pyrrolidine and 1, 2,4-triazole rings wherein each ring is optionally substituted with one or more groups independently selected from halogen, cyano, nitro, amino, hydroxyl, C1-C4alkyl, C1-C4haloalkyl, Cx-C4alkoxy, C1-C4haloalkoxy, or C1-C4haloalkylsulfonyl groups. Starting formula II β-amino-β- (perfluoroalkyl) - acrylate compounds are known in the art and may be prepared according to the procedures described in U.S. 5,777,154; Journal of Heterocyclic Chemistry, 9, pages
513-522 (1972) ; and Institute of Chemistry, Urals Scientific Center, Academy of Sciences of the USSR,
Sverdlovsk, pages 1442-1447 (1987) - English translation of Zhurnal Organicheskoi Khimii, 22(8), pages 1603-1609
(1986) .
Carbamoyl chloride compounds of formula III are known in the art and may be prepared by conventional
procedures . In addition, certain formula III carbamoyl chloride compounds are commercially available.
Amine compounds having the structural formula Via
(Via)
wherein Xx , X5 and R40 are as described hereinabove, may be prepared, as shown in Flow Diagram I, by cyclizing a ketone of formula X with sulfur and ammonium hydroxide or ammonia to form a nitrobenzisothiazole of formula XI, and reducing the formula XI compound using conventional reducing agents such as iron in acetic acid.
FLOW DIAGRAM I
(XI)
FLOW DIAGRAM I (cont.)
[H]
(Via)
Starting amine compounds having the structural formula VIb
(VIb)
wherein X , X5 and R41 are as described hereinabove, may be prepared, as illustrated in Flow Diagram II, by reacting a ketone of formula XII with hydroxylamine hydrochloride optionally in the presence of sodium acetate to form an oxi e of formula XIII, cyclizing the formula XIII compound with a base such as potassium hydroxide to form a nitrobenzisoxazole of formula XIV, and reducing the
formula XIV compound using conventional reducing agents such as tin (II) chloride in acetic acid.
FLOW DIAGRAM II
(XII)
NH2OH< HC1
(XIII)
Base
(XIV)
FLOW DIAGRAM II (cont . )
[H]
(vib)
Alternatively, formula XIV nitrobenzisoxazole compounds may be prepared, as shown in Flow Diagram III, by reacting a ketone of formula XV with hydroxylamine hydrochloride optionally in the presence of a base such as sodium acetate to form an oxime of formula XVI , cyclizing the formula XVI compound with 1, 1 ' -carbonyl- diimidazole in the presence of a base such as tri- ethylamine to form a benzisoxazole of formula XVII, and nitrating the formula XVII compound using conventional methods such as a nitric acid/sulfuric acid mixture.
FLOW DIAGRAM III
(XV)
NH2OH HC1
(XVII)
(XIV)
Intermediate compounds of formulas XI and XIV wherein R40 and R41 are ORss may be prepared, as shown in Flow Diagram IV, by nitrating a benzisoxazol-3-ol or benzisothiazol-3-ol of formula XVIII with a conventional nitrating agent such as a nitric acid/sulfuric acid mixture to form a 5-nitrobenzisoxazol-3-ol or 5- nitrobenzisothiazol-3-ol of formula XIX, and reacting the formula XIX compound with an electrophile of formula XX in the presence of a base such as potassium carbonate.
FLOW DIAGRAM IV
HN03/H2S04
(XIX)
FLOW DIAGRAM IV (cont.)
Formula XI and XIV intermediate compounds wherein R40 and R41 are Cl or Br may be prepared, as shown in Flow Diagram V, by reacting a 5-nitrobenzisoxazol-3-ol or 5- nitrobenzisothiazol-3-ol of formula XIX with phosphorous oxychloride, phosphorous oxybromide or phosphorous pentabromide .
FLOW DIAGRAM V
(XIX) (J = 0 or S)
P0C13 , POBr3 or PBr3
Other formula VI amine compounds are known in the art and may be prepared according to the procedures described in EP 561319-A; EP 540023-A; EP 545206-A; EP 542685-A; EP 473551-A; EP 476697-A; EP 489480-A; EP 496595-A; EP 420194-A; EP 648749-A; EP 705829-A; EP 714602-A; JP 9241245; JP 9301973; U.S. 5,169,430; U.S. 5,310,723; U.S. 5,324,854; U.S. 5,391,541; U.S. 5,399,543; U.S. 5,484,763; U.S. 5,523,278; U.S. 5,602,077; U.S. 5,661,108; WO 93/14073; WO 94/10155;
WO 94/24128 WO 91/07393 WO 91/107392; WO 95/04461; WO 95/05079 WO 95/05080 WO 95/17096; WO 95/25725, WO 95/29168 WO 95/32952 WO 95/33746; WO 96/02518 WO 96/08151 WO 96/14315 WO 96/28442; WO 96/34859, WO 96/35679 WO 97/01541 WO 97/01542; WO 97/05118, WO 97/07105 WO 97/08170 WO 97/08171; WO 97/08953 WO 97/12884 WO 97/12886 WO 97/29094; WO 97/29105, WO 97/34484 WO 97/35845 WO 97/42176; WO 97/42188 WO 97/45418 WO 97/47607 WO 98/02422; WO 98/06706, WO 98/08824 WO 98/27057 WO 98/27067; WO 98/27082, and WO 98/27088, among others.
In order to facilitate a further understanding of this invention, the following examples are presented primarily for the purpose of illustrating more specific details thereof. The scope of the invention should not be deemed limited by the examples but encompasses the entire subject matter defined in the claims.
EXAMPLE 1 Preparation of Ethyl 3- [ (N,N-dimethylcarbamoyl) amino] 4 , 4 , 4-trifluorocrotonate, (Z) -
CF,
NaH C02C2HS
/NN
H3C CH3
Ethyl 3 -amino-4, 4, 4 -trifluorocrotonate (18.4 g, 100 mmol) is added to a stirred solution of sodium hydride (60% in mineral oil, 9.6 g, 250 mmol) in N,N-dimethyl- formamide (60 tnL) at 5°C under nitrogen over a 60 minute period. The reaction mixture is allowed to warm to and held at room temperature for 15 minutes, cooled to 5°C, and treated with dimethylcarbamoylchloride (21.6g, 200 mmol) over a 60 minute period. The resultant solution is then warmed to and held at room temperature for 2 hours, diluted with water (150 mL) , and extracted with ethyl acetate (2 x 150 mL) . The combined organic layers are dried, filtered and concentrated, and the mineral oil layer is removed to obtain a residue. Flash column chromatography of the residue on silica gel using a 85:15 hexanes/ethyl acetate solution gives the title product as a yellow liquid (18.1 g, 71% yield) : XH NMR (DMSO-d6) δ 9.18 (s,lH), 5.85 (s, 1H) , 4.20 (q, 2H) , 2.89 (s, 6H) , 1.18 (t, 3H) ; 19F NMR δ -65.7 (s) .
Using essentially the same procedure, the following compounds are obtained :
CF, 02Z2
HN
-,0
Z Z,
(Z) - configuration
12 mo(°C) Yield (%)
C2H5 C2H5 C2H5 yellow oil 88
-(CH,). C2H5 54-57 37
CH, CH, CH3
C2H5 C2H5 CH3
(CHJ CH3
EXAMPLE 2 Preparation of 2 -Dimethylamino-4 - ( trif luoromethyl) - 6H- 1 , 3 -oxazin- 6 -one
A solution of ethyl 3- [N- (N,N-dimethylcarbamoyl) - amino] -4,4, 4-trifluorocrotonate (5.08 g, 0.02 mol) in phosphorus oxytrichloride (3 mL) is treated with phosphorus pentachloride (4.16 g, 0.02 mol) in three portions at 15 minute intervals, stirred for 30 minutes, and quenched with ice and water. The resultant aqueous mixture is extracted with ethyl acetate . The organic layer is washed sequentially with saturated sodium bicarbonate and water, and evaporated to give the title product as a white solid (3.9 g, 93.8% yield) which is identical by XE and 19F NMR to a sample prepared by the literature procedure (Bull . Soc . Chem . Belg . 101, 313,
1992) . The title product is further purified by crystallization from heptane (74.5% crystallized yield) . Using essentially the same procedure, but substituting 3- [N- (N,N-diethylcarbamoyl) amino] -4,4,4- trifluorocrotonate for 3- [N- (N,N-dimethylcarbamoyl) - amino] -4 , 4 , 4-trifluorocrotonate, 2-diethylamino-4- (trifluoromethyl) -6H-1, 3-oxazin-6-one is obtained as an oil (86% crude yield, 65% purified yield) .
EXAMPLE 3 Preparation of 3-Isopropyl-6- (trifluoromethvD - 2 , 4 (1H, 3H) -pyrimidinedione
O CH,
Isopropylamine (1.2 g, 20.3 mmol) and 1,8-diazabi- cyclo [5, 4 , 0] undec-7-ene (DBU, 6 mL) are added to a solution of 2-dimethylamino-4-trifluoromethyl-6H-1, 3- oxazin-6-one (4.0 g, 19.2 mmol) in xylene (34 mL) . The resultant reaction mixture is held at 100°C for 3 hours, cooled, washed with 5 wt . % HC1 (40 mL) , and extracted with ethyl acetate. The combined organic extracts are concentrated and triturated with heptane. The solids are filtered and dried to give the title product as a yellow powder (2.3g, 54% yield, mp 127°-129°C) which is identified by Ji NMR (DMSO-d6) δ 6.11 (1H, s) , 4.96 (1H, sp) , 1.35 (6H, d) ; and 19F NMR δ -68.9 (s) .
Using essentially the same procedure, but using the appropriate amine, the following compounds are obtained:
Preparation of 2' -Chloro-2-methoxy-5-methyl-5 nitrobenzophenone
CH.
A mixture of aluminum chloride (33.3 g, 25.0 mmol) in methylene chloride is cooled to about 5 °C, treated over one hour with p-methylanisole (31.6 g, 25.0 mmol) while maintaining the reaction mixture temperature below 10 °C, treated over 20 minutes with a solution of 2-chloro-5-nitrobenzoyl chloride (50.0 g, 22.7 mmol) in methylene chloride while maintaining the reaction mixture temperature below 10 °C, warmed to and stirred at room temperature for 60 minutes, and poured onto ice. The resultant aqueous mixture is treated with concentrated hydrochloric acid (50 mL) and extracted with methylene chloride . The organic extract is dried over anhydrous magnesium sulfate and concentrated in vacuo to give a yellow solid. After placing the solid in a Kugelrohr apparatus at 40 °C to remove residual p-methylanisole, the title product is obtained as a beige solid (68.8 g, 99.1%) which is identified by NMR spectral analyses.
Using essentially the same procedure, the following compounds are obtained:
H I H H OCH, 115-116.5 H H CH3 H OCH, H H C2H5 H H H CH3 CH3 H OCH3 H H OCH3 H H 108-112 H C2H5 H H OCH3 98-99.5 H H OCH3 H CH3 91-92 H H CH3 H H 95.5-96.5 H H SCH3 H H 127-128 H H CH3 H OCH3 91-92.5 H H C2H5 H H H H Cl H H 88.5-90.5 H H F H H 68-69.5 H Cl H H OCH3 124-126 H OCH3 H H OCH3 71-73 H H OCH3 H OCH3 98-100 H CH3 CH3 H OCH3 127-129 H H Cl H OCH3 96-99
CH3 H CH3 H OCH3 108.5-110 H H H CH3 OCH3 71-74 H H N(CH3)S02CH3 H H H CH, Cl H OCH, 126-128
H CH3 H CH3 OCH3 110-112
CH3 CH3 CH3 H OCH3 104-106
H CH(CH3)2 H H OCH3 69-71
H CH3 H H H
H H H H CN
H H H H OCH3
H OCH3 H H H
H F H H OCH3
H H F H OCH3
H H H H SCH3
H H H H CH3
H H H H F
H SCH3 H H H
H H OCH3 H H
H - (CH,) 7 — H OCH,
EXAMPLE 5 Preparation of 3- (6-Methoxγ--m-tolyl) -5-nitro-l, 2- benzisothiazole
Using essentially the same procedure, the following compounds are obtained:
H w2 w, H4 p °C
H H CH3 H OCH3 201-203 H CH3 CH3 H OCH3 199-200 H CH3 H H H 116.5-117.5 H H Cl H OCH3 229-231 H H H CH3 OCH3 134-136 H H H H CN 187.5-189 H H H H 0CH3 193-198 H H OCH3 H H 201-203 H OCH3 H H H 174-175 H F H H 0CH3 224-226 H C2HS H H OCH3 153-154.5 H H CH3 H H 188-189 H H N(CH3)S02CH3 H H
H CH3 Cl H OCH3 230-234
H I H H OCH3
H H SCH3 H H 177.5-178.5
H H OCH3 H CH3 131-135
H H F H H 226-228
H H Cl H H 217.5-219
H H F H OCH3 224-225
H H H H SCH3 114.5-115.5
H H CH3 H OCH3 201-203
H OCH3 H H 0CH3 195-196
H H H H CH3 145-146
H H H H F 181-182
H H OCH3 H OCH3 171-172.5
H SCH3 H H H 139-140.5
H CH3 H CH3 OCH3
CH3 CH3 CH3 H OCH3
H CH(CH3)2 H H OCH3
H H CH3 CH3 OCH3
H -(CH2)3- H OCH3
EXAMPLE 6
Preparation of 3 -Methyl - 5 -nitro-1, 2-benzisothiazole
Using essentially the same procedure, the following compounds are obtained:
H
C2H5
Preparation of 5-Amino-3- (6-methoxy--m-tolyl) -1, 2- benzisothiazole
Using essentially the same procedure, the following compounds are obtained:
H H H CN 118.5-120 H CH, 112-113.5
OCH,
OCH,
OCH.
OCH,
EXAMPLE 8
Preparation of 3- [3- (6-Methoxy-3 ,4-xylyl) -1, 2- benzisothiazol-5-yl] -6- (trifluoromethyl) -2,4 (1H.3H) pyri idinedione
A mixture of 5-amino-3- (6-methoxy-3 ,4-xylyl) -1, 2- benzisothiazole (8.53 g, 30.0 mmol), 2-dimethylamino-4- (trifluoromethyl) -6H-1 , 3 -oxazin-6-one (6.87 g, 33.0 mmol) and acetic acid is refluxed for 2 hours, cooled, and poured into water. The resultant aqueous mixture is filtered to obtain a solid. A solution of the solid in methylene chloride is washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain an oil . Column chromatography of the oil using silica gel and a 5% diethyl ether in methylene chloride solution gives the title product as a yellow foam (8.37 g, 62.0%) which is identified by NMR spectral analyses .
Using essentially the same procedure, the following compounds are obtained:
i χ5 ---40 mp °C
H H CN '255-258
H H H >260
H H CH3 273-274
H H C2H5
OCH
OCH 3.
OCH.
OCH.
SCH.
OCH,
OCH,
Br CH,
OCH,
H CH,
EXAMPLE 9
Preparation of 3- [3- (6-Methoxy-m-tolyl) -1, 2- benzisothiazol-5-yll -l-methyl-6- (trifluoromethyl) 2 , 4 (IH, 3H) -pyrimidinedione
Using essentially the same procedure, the following compounds are obtained:
H H CH3 H 223 - 225
H H CH3 CN 239 - 240
H H CH3 CH3 244 - 245
H H CH3 CH20CH2C02CH3 143 - 144
H H CH, C2H5 171 - 172
OCH.
OCH.
OCH,
OCH.
OCH.
OCH,
H F CH, CH,
OCH,
Br CH, CH 3 211 - 213
EXAMPLE 10
Preparation of 2-Chloro-27 -methoxy-5 -methyl-S- nitrobenzophenone, oxime
A mixture of 2-chloro-2 ' -methoxy-5 ' -methyl-5-nitro- benzophenone (90.0 g, 0.294 mol) in ethanol is treated with a solution of hydroxylamine hydrochloride (102.3 g, 1.47 mol) in water, refluxed overnight, and poured onto ice. The resultant aqueous mixture is filtered to obtain
a solid. The solid is washed with water and dried in a hot vacuum oven overnight to give the title product as a white solid (84.2 g) which is identified by XH NMR spectral analysis.
Using essentially the same procedure, the following compounds are obtained:
χ5 W W2 w3 p °C
H OCH3 H H 173- -178 H H H H 143- -145 H H OCH3 H 191-192.5 H OCH3 H F H H OCH2C02CH3 H 150- -155 H OCH3 H CH3 185.5- -186. 5 F OCH, H CH,
EXAMPLE 11
Preparation of 3- (6-Methoxy-.m-tolyl) -5-nitro-l, 2 - benzisoxazole
A mixture of 2-chloro-2 ' -methoxy-5 ' -methyl-5-nitro- benzophenone , oxime (84.0 g, 0.262 mol) in ethanol is warmed to 65 °C, treated with 150 mL of 10% potassium hydroxide solution over 25 minutes, heated to 78 °C over one hour, cooled, and poured onto ice. The resultant aqueous mixture is filtered to obtain a solid. The solid is washed with water, dried, recrystallized from N,N- dimethylformamide, washed sequentially with N,N-dimethyl- formamide and ethanol, and dried in a vacuum oven at 80 °C to give the title product as a solid (mp 225-226 °C) which is identified by XH NMR spectral analysis.
Using essentially the same procedure, the following compounds are obtained:
χ5 w & w2 mp °C
H OCH3 H H 170- -171
H H H H 138- -139
H H H OCH3 205- -207
F OCH3 CH3 H
EXAMPLE 12
Preparation of 5- -Amino- ■3- (6 -methoxy- -m-tolvl) • -1,2- benzisoxazole and 5- -Amino- - ■chloro -3- (6-methoxy -rn- -tolvl) -
1 , 2-benzisoxazole
EXAMPLE 13
Preparation of 3- [3- (6-Methoxy--m-tolyl) -1, 2- benzisoxazol-5-yl] -6- (trifluoromethyl) -2,4 (IH, 3H) pyrimidinedione
A mixture of 5-amino-3- (6-methoxy-m-tolyl) -1, 2-benz- isoxazole (8.40 g, 0.033 mol), 2 -dimethylamino-4- (trifluoromethyl) -6H-1, 3 -oxazin-6 -one (7.60 g, 0.036 mol), and acetic acid is refluxed for three hours, cooled, poured onto ice, and diluted with water. The resultant aqueous mixture is filtered to obtain a solid. The solid is washed with water and dried to give the title product as a pink solid which is identified by NMR spectral analyses . Using essentially the same procedure, the following compounds are obtained:
H H OCH3 H 214-216
H H H H
Cl H OCH3 CH3
H ' F OCH3 CH3
EXAMPLE 14
Preparation of 3- T3- (6- -Methoxy-m- -tolyl)-l,2- benzisoxazol-5 -yi]- 1-methyl- -6-( trifluoromethyl) -
2,4(1H. 3H) -pyrimidinedione
A mixture of 3- [3- (6-methoxy-m-tolyl) -1, 2-benz- isoxazol-5-yl] -6- (trifluoromethyl) -2,4 (1H,3H) -pyrimidinedione (10.5 g, 0.0255 mol) and potassium carbonate
(7.04 g, 0.051 mol) in N, N-dimethylformamide is stirred for 15 minutes, treated with methyl iodide (7.24 g, 0.051 mol), stirred overnight, and poured onto ice. The resultant aqueous mixture is extracted with methylene chloride. The organic extracts are combined, washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuo to obtain a brown glass . Dry column chromatography of the glass using silica gel and a hexanes/ethyl acetate solution (3:1) gives the title product as an off-white solid which is identified by NMR spectral analyses .
Using essentially the same procedure, the following compounds are obtained:
Xx κ w w3 mp °C
H H OCH3 H
H H H H 225 - 226 . 5
Cl H OCH3 CH3
H F OCH3 CH3
H F OCH, H
EXAMPLE 15 Preparation of m-Fluorophenyl acetate
A solution of 3-fluorophenol (100 g, 0.890 mol) in methylene chloride is cooled to 0 °C to 5 °C, treated with pyridine (75.0 mL, 0.930 mol), stirred for several minutes, treated dropwise with acetyl chloride (66.0 mL, 0.930 mol) while maintaining the reaction mixture temperature below 17 °C, stirred at ice-bath temperature for two hours, warmed to room temperature, and poured into an ice-water mixture. The organic phase is separated, washed with brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain the title product as a yellow oil which is identified by 1H NMR spectral analysis .
EXAMPLE 16 Preparation of 4 ' -Fluoro-2' -hvdroxyacetophenone
m-Fluorophenyl acetate (123 g, 0.798 mol) is cooled with an ice-bath, treated portionwise with . aluminum chloride (150 g, 1.12 mol), stirred at 190 °C for one hour, and cooled to obtain a solid. A mixture of ice, water and hydrochloric acid, and methylene chloride are added to the solid. The resultant mixture is stirred for several minutes, and the phases are separated. The organic phase is washed sequentially with water, saturated sodium hydrogen carbonate solution and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain the title product (99.0 g) which is identified by 1H NMR spectral analysis.
EXAMPLE 17 Preparation of 4 ' -Fluoro-2 ' -hydroxyacetophenone. oxime
A mixture of 4 ' -fluoro-2 ' -hydroxyacetophenone (99.0 g, 0.640 mol), hydroxylamine hydrochloride (89.0 g, 1.28 mol), and sodium acetate (79.0 g, 0.960 mol) in methanol is refluxed for one hour and poured into an ice-water mixture. The resultant aqueous mixture is filtered to obtain a solid. The solid is dissolved in methylene chloride, and the resultant organic solution is dried over anhydrous magnesium sulfate, concentrated in vacuo, diluted with hexanes, and filtered to give the title product as a solid (55.0 g, mp 112-114 °C) which is identified by 1H NMR spectral analysis.
EXAMPLE 18 Preparation of 6-Fluoro-3-methyl-l, 2 -benzisoxazole
A mixture of 4 ' -fluoro-2 ' -hydroxyacetophenone, oxime (47.0 g, 0.278 mol) in tetrahydrofuran is heated to just under reflux, treated with a solution of 1 , 1 ' -carbonyl- diimidazole (55.0 g, 0.340 mol) and triethylamine (39.0 g, 0.390 mol) in tetrahydrofuran, refluxed for one hour, cooled, concentrated in vacuo, and poured into an ice- water mixture. The resultant aqueous mixture is extracted with ether. The organic extracts are combined, washed sequentially with saturated ammonium chloride solution and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain an oil. Column chromatography of the oil using silica gel and a methylene chloride/hexanes solution (1:1) gives the title product as a yellow oil which is identified by XH NMR spectral analysis.
EXAMPLE 19
Preparation of 6-Fluoro-3-methyl-5-nitro-l,2-benz- isoxazole
A mixture of 6-fluoro-3-methyl-l, 2 -benzisoxazole (23.5 g, 0.156 mol) in concentrated sulfuric acid is cooled with an ice-bath, treated dropwise with 90% nitric acid (8.50 mL) while maintaining the reaction mixture temperature below 15 °C, stirred for one hour at ice-bath temperature, treated with additional 90% nitric acid (5.80 mL) , warmed to and stirred at room temperature overnight, and poured onto ice. The resultant aqueous mixture is filtered to obtain a solid. The solid is air- dried and dissolved in methylene chloride. The resultant organic solution is dried over anhydrous magnesium sulfate, diluted with hexanes, and filtered to give the title product as a purple solid which is identified by 1H NMR spectral analysis.
EXAMPLE 20
Preparation of 5-Amino-6-fluoro-3-methyl-l, 2-benzisoxazole and 5-Amino-4-chloro-6-fluoro-3-methyl-l, 2- benzisoxazole
A mixture of 6-fluoro-3 -methyl-5-nitro-1 , 2-benzisoxazole (3.00 g, 0.0153 mol) and acetic acid (85.0 mL) is heated to 40 °C, treated with a solution of tin (II) chloride dihydrate (9.70 g, 0.0430 mol) and concentrated hydrochloric acid (45.0 mL) , refluxed for 90 minutes, concentrated in vacuo, neutralized with 2N sodium hydroxide solution and filtered to obtain a solid. Column chromatography of the solid using silica gel and methylene chloride gives the title products as solids which are identified by NMR spectral analyses.
Using essentially the same procedure, but using an ethyl acetate/ethanol mixture instead of acetic acid, the following compounds are obtained:
H CH,
H Cl
H OCH2C02CH3
H OCH ( CH3 ) 2
H OCH (CH3) C02CH3
F 0CH2C02CH3
H OCH,
EXAMPLE 21
Preparation of 3- (6-Fluoro-3-methyl-l, 2-benzisox- azol-5-yl) -6- (trifluoromethyl) -2,4 (1H,3H) -pyrimidinedione
A mixture of 5-amino-6-fluoro-3 -methyl-1, 2 -benzisoxazole (4.85 g, 0.029 mol) and 2 -dimethylamino-4 - (trifluoromethyl) -6H-1, 3-oxazin-6-one (6.70 g, 0.0320 mol) in acetic acid is refluxed for 90 minutes, cooled to room temperature, and poured into an ice-water mixture. The resultant aqueous mixture is filtered to obtain a solid. The solid is air-dried and dissolved in ethyl acetate. The resultant organic solution is washed with
brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title product as a yellow solid (7.00 g, mp 235-237 °C) which is identified by NMR spectral analyses .
Using essentially the same procedure, the following compounds are obtained:
H H CH3 283-285
H H Cl
H H OCH2C02CH3 180-182
H H OCH(CH3)2 213-215
H H OCH3 230-235
Cl F CH, 125-130
EXAMPLE 22
Preparation of 3- (6-Fluoro-3-methyl-l, 2-benz- isoxazol-5-yl) -l-methyl-6- (trifluoromethyl) -2 , 4 (IH, 3H) pyrimidinedione
A mixture of 3- (6-fluoro-3-methyl-l, 2-benzisoxazol- 5-yl) -6- (trifluoromethyl) -2,4 (1H,3H) -pyrimidinedione (3.00 g, 9.12 mmol) and potassium carbonate (2.52 g, 18.2 mmol) in N,N-dimethylformamide is stirred for 15 minutes, treated with methyl iodide (2.58 g, 18.2 mmol), stirred at room temperature overnight, and poured into an ice- water mixture. The resultant aqueous mixture is filtered to obtain a solid which is recrystallized from a methylene chloride/hexanes solution to give the title product as a white solid (mp 158-159 °C) which is identified by NMR spectral analyses.
Using essentially the same procedure, the following compounds are obtained :
CH3
Xι mp_
H H CH, 196 - 198 H H Cl 168 . 5 - 170 H H OCH2C02CH3 156 - 157
H H OCH3 160-161 Cl F CH, 154-155
EXAMPLE 23 Preparation of 2 ' -Chloro-5/ -nitroacetophenone, oxime
A mixture of 2 ' -chloro-5 ' -nitroacetophenone (50.0 g, 0.250 mol) in ethanol is treated with a solution of hydroxylamine hydrochloride (83.0 g, 1.19 mol) in water, refluxed overnight, cooled to room temperature, and filtered to give the title product as a solid (mp 165-167 °C) which is identified by NMR spectral analyses .
EXAMPLE 24 Preparation of 3-Methyl-5-nitro-1, 2 -benzisoxazole
A mixture of 2 ' -chloro-5 ' -nitroacetophenone, oxime (30.0 g, 0.140 mol) in ethanol is treated dropwise with 10% potassium hydroxide solution (7.86 g KOH), stirred at room temperature for one hour, refluxed overnight, cooled, and poured into water. The resultant aqueous mixture is filtered to obtain a solid. Column chromatography of the solid using silica gel and methylene chloride gives the title product as a yellow solid (mp 84.5-86.5 °C) which is identified by NMR spectral analyses .
EXAMPLE 25 Preparation of 5-Nitro-l,2-benzisoxazol-3-ol
1, 2-Benzisoxazol-3-ol (19.7 g, 0.146 mol) is added portionwise to concentrated sulfuric acid. The resultant reaction mixture is treated dropwise with 70% nitric acid (11.3 mL) , stirred for 90 minutes, and poured onto ice. The resultant aqueous mixture is filtered to obtain a waxy paste. The paste is recrystallized from a methanol/water mixture to give the title product as a solid which is identified by XH NMR spectral analysis.
Using essentially the same procedure, the following compounds are obtained :
Xs
Cl
F
EXAMPLE 26 Preparation of Methyl [ (5-nitro-l, 2-benzisoxazol-3- yl) oxy] acetate
A mixture of 5-nitro-l, 2-benzisoxazol-3-ol (3.90 g, 0.0220 mol) and potassium carbonate (4.17 g, 0.0300 mol) in N,N-dimethylformamide is stirred for 30 minutes, treated with methyl bromoacetate (3.96 g, 0.0260 mol), stirred overnight at room temperature, and poured into an acidic ice-water mixture. The resultant aqueous mixture is extracted with ethyl acetate. The organic extracts are combined, washed sequentially with water and brine,
dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a yellow oil . Column chromatography of the oil using silica gel and a (1:1) to (4:1) methylene chloride/hexanes gradient gives the title product as a white solid (2.80 g, mp 72-73.5 °C) which is identified by NMR spectral analyses .
Using essentially the same procedure, the following compounds are obtained :
Xs R mp °C
H OCH(CH3)2 81- -83 H OCH2CH=CH2 70- -72 H OCH3 101.5-103 Cl OCH(CH,)C02CH, 98- 100
F OCH2C02CH3 104- -106
EXAMPLE 27 Preparation of 3 -Chloro-5-nitro-1,2 -benzisoxazole
A mixture of 5-nitro-l, 2-benzisoxazol-3-ol (4.00 g, 0.0220 mol) and phosphorus oxychloride (40.0 mL, 65.8 g, 0.429 mol) is placed in a glass bomb, heated at 150-155 °C for two hours, cooled overnight, concentrated in vacuo, diluted with methylene chloride, and brought to about pH
8 with sodium hydrogen carbonate solution. The phases are separated. The organic phase is washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a residue.
Column chromatography of the residue using silica gel and a methylene chloride/hexanes solution (1:1) gives the title product as an amber oil which is identified by NMR spectral analysis.
EXAMPLE 28
Preparation of 2 -Chloro-2 , -methoxy- 5 -nitrobenzophen- one
A solution of 2-bromoanisole (27.9 g, 145 mmol) in diethyl ether is cooled to -70 °C, treated with butyllithium (64.0 L, 160 mmol), stirred at -70 °C for
one hour, treated with 0.5 M zinc chloride in tetrahydrofuran solution (320 mL, 160 mmol) , stirred for one hour at -70 °C, warmed to about 0 °C, and concentrated in vacuo to obtain a yellow-green oil. A solution of the oil in tetrahydrofuran is treated sequentially with tetrakis (triphenylphosphine) palladium (0) (5.00 g, 4.35 mmol) and a solution of 2-chloro-5-nitrobenzoyl chloride (35.0 g, 159 mmol) in tetrahydrofuran, stirred for three days, and poured into 10% hydrochloric acid. The resultant aqueous mixture is extracted with methylene chloride. The organic extracts are combined, washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a semi-solid. The solid is triturated with diethyl ether to give the title product as a yellow solid which is identified by NMR spectral analyses .
Using essentially the same procedure, the following compounds are obtained :
H Cl H OCH3 96 - 99
H H CH3 OCH3 71 - 74
F H H 0CH3
Cl H H OCH3 124 - 126
0CH3 H H OCH3 71 - 73
H 0CH3 H * OCH, 98 - 100
H F H OCH,
H H CH3 H 65-66.5 H H SCH3 H 87-88 H H H F 118-120 H H H CH3 78-79.5 H H H SCH3 123-124.5 H F H H H H OCH3 H H H H OCH3 H CH, CH, OCH,
EXAMPLE 29 Preparation of Σ-Chloro-Σ -methoxy- 5 -nitrobenzhydrol
A solution of 2-bromoanisole (50.0 g, 0.267 mol) in ether is added portionwise to a mixture of magnesium (7.10 g, 0.293 mol) in ether. After the addition is complete, the reaction mixture is heated at reflux for one hour, diluted with ether, cooled to 0 °C, treated with a solution of 2-chloro-5-nitrobenzaldehyde (39.0 g, 0.210 mol) in tetrahydrofuran, warmed to room temperature, and diluted with an ice-water mixture. After acidifying the aqueous mixture with hydrochloric acid (pH 2 - pH 3) , the organic phase is separated and the aqueous phase is
extracted with ether. The organic extracts are combined, washed sequentially with 10% sodium hydrogen carbonate solution and brine, dried over anhydrous sodium sulfate, and concentrated in vacuo to give the title product as a brown gum.
Using essentially the same procedure, the following compounds are obtained:
W w, Λ
OCH3 H OCH3 CH, H OCH3
F H OCH3 H OCH, H
EXAMPLE 30 Preparation of 2-Chloro-2, -methoxy-5-nitrobenzo- phenone
A solution of chromium (VI) oxide (91.0 g, 0.919 mol) in a water/acetic acid solution (1:4) is added portionwise to 2-chloro-2 ' -methoxy-5-nitrobenzhydrol (64.2 g, 0.219 mol) while maintaining the reaction mixture temperature at 25 °C to 35 °C. The reaction mixture is then stirred at 25 °C to 35 °C for one hour, cooled, diluted with water, and concentrated in vacuo to obtain a residue. The residue is diluted with water, and extracted with methylene chloride. The organic extracts are combined, dried over anhydrous sodium sulfate, mixed with silica gel (10 g) , and filtered. The filtrate is concentrated in vacuo to obtain an oil. A solution of the oil in a methanol/water solution is decolorized with charcoal and concentrated in vacuo to yield a residue .
Column chromatography of the residue using silica gel and methylene chloride/hexanes solutions gives the title product as a white solid.
Using essentially the same procedure, the following compounds are obtained:
)CH3 H OCH3 H3 H OCH3 109 - 111
F H OCH, 94 - 95
H OCH. H 79 - 81
EXAMPLE 31
Preparation of 2-Chloro-4-fluoro-5-nitrobenzoyl chloride
A mixture of 2-chloro-4-fluoro-5-nitrobenzoic acid (50.0 g, 0.228 mol) and N,N-dimethylformamide (5 drops) in 1, 2-dichloroethane is treated dropwise with oxalyl chloride (30.8 mL, 0.353 mol), refluxed for 3 hours, cooled, and concentrated in vacuo to obtain the title
product as an orange solid which is identified by NMR spectral analyses .
EXAMPLE 32 Preparation of 2 ' -ChJoro-4 ' -f uoro-5' -nitroaceto- phenone
+ CH 3ZnCl Pd[P(C6H5)3]4
A 2 M solution of methylzinc chloride in tetrahydrofuran (5.00 mL, 10.1 mmol) is treated dropwise with a solution of 2-chloro-4-fluoro-5-nitrobenzoyl chloride (2.00 g, 8.40 mmol) in tetrahydrofuran, treated with tetrakis (triphenylphosphine) palladium (0) (0.400 g, 0.350 mmol) , stirred at room temperature for one hour, and poured into 3 N hydrochloric acid. The resultant aqueous mixture is extracted with ethyl acetate . The organic extracts are combined, washed sequentially with water and saturated sodium hydrogen carbonate solution, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a dark liquid. Flash column chromatography of the liquid using silica gel and a methylene chloride in hexanes solution (6:4) gives the title product as an off- white solid (mp 66-68 °C) which is identified by NMR spectral analyses .
EXAMPLE 33
Preparation of 6-Amino-3-methyl-5-nitro-1,2- benzisothiazole
A mixture of 2 ' -chloro-4 ' -fluoro-5 ' -nitroacetophenone (12.0 g, 0.0552 mol), sulfur (1.77 g, 0.0552 mol), 30% ammonium hydroxide solution (100 mL, 0.856 mol) , and methanol is placed in a steel bomb, heated at 85 °C overnight, cooled, treated with additional sulfur (0.270 g) and 30% ammonium hydroxide solution (50 mL) , heated at 85 °C overnight, cooled, filtered to remove solids, and extracted with ethyl acetate. The organic extracts are combined, washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a solid. Flash column chromatography of the solid using silica gel, and 0%, 1% and 2% diethyl ether in methylene chloride solutions gives the title product as an orange solid (4.19 g, mp 189-191 °C) which is identified by NMR spectral analyses. Using essentially the same procedure, the following compound is obtained:
EXAMPLE 34
Preparation of 6-Chloro-3 -methyl-5-nitro-l, 2- benzis thi zole
A mixture of tert-butyl nitrite (3.30 mL, 0.0278 mol) and copper (II) chloride (2.98 g, 0.0222 mol) in acetonitrile is heated to 65 °C, treated portionwise with 6 -amino-3 -methyl-5-nitro-l, 2-benzisothiazole (3.88 g, 0.0185 mol), stirred at 65 °C, cooled to room temperature, and poured into 20% hydrochloric acid. The resultant aqueous mixture is extracted with ethyl acetate. The organic extracts are combined, washed with 20% hydrochloric acid, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a solid. Flash column chromatography of the solid using silica gel and methylene chloride/hexanes solutions (1:1 and 3:1) gives the title product as a pale, yellow solid (2.54 g, mp 156-158 °C) which is identified by NMR spectral analyses. Using essentially the same procedure, the following compound is obtained:
EXAMPLE 35
Preparation of 6-Fluoro-3 -methyl-5-nitro-l, 2- benzisothiazole
A mixture of 6-chloro-3-methyl-5-nitro-l, 2- benzisothiazole (2.25 g, 9.80 mmol), potassium fluoride (2.85 g, 49.0 mmol), and 18-crown-6 (1.50 g, 5.70 mmol) in acetonitrile is heated in a sealed tube for 29 days, filtered to remove solids, and partially concentrated in vacuo to obtain a liquid. The liquid is diluted with ethyl acetate, washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a dark, brown solid. Flash column chromatography of the solid using silica gel and a 10% to 50% ethyl acetate in hexanes gradient gives a yellow solid containing two components. Flash column chromatography of the yellow solid using silica gel and a 50% to 70% methylene chloride in hexanes gradient gives the title product as a pale, yellow solid (0.870 g, mp
118-119 °C) which is identified by NMR spectral analyses. Using essentially the same procedure, the following compound is obtained:
EXAMPLE 36
Preparation of 5-Amino-6-fluoro-3 -methyl-1,2 -benz isothiazole
A solution of 6-fluoro-3-methyl-5-nitro-l, 2- benzisothiazole (0.740 g, 3.50 mmol), 5% acetic acid (25.0 mL) and ethyl acetate is heated to 65 °C, treated with iron powder (0.980 g, 17.5 mmol), stirred at 65 °C for one hour, cooled to room temperature, and filtered to remove solids. The organic phase is separated, washed sequentially with water, saturated sodium hydrogen carbonate solution and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title product as an orange solid (0.610 g) which is identified by NMR spectral analyses.
Using essentially the same procedure, the following compound is obtained:
EXAMPLE 37 Preparation of 2-Chloro-4-fluoro-5-nitrobenzophenone
A solution of 2-chloro-4-fluoro-5-nitrobenzoyl chloride (26.7 g, 0.112 mol) and benzene (12.0 mL, 0.134 mol) in 1, 1, 2 , 2-tetrachloroethane is cooled to 0 °C to 5 °C, treated with aluminum chloride (18.1 g, 0.136 mol), stirred for 15 minutes at about 8 °C, heated to and stirred at 50 °C for one hour, cooled to room temperature, and diluted sequentially with an ice-water mixture and concentrated hydrochloric acid. The organic phase is separated, washed sequentially with water and saturated sodium hydrogen carbonate solution, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a solid. Flash column chromatography of the solid using silica gel and methylene chloride gives the title product as an orange solid (30.8 g) which is identified by NMR spectral analyses .
EXAMPLE 38 Preparation of 2 , 2 ' -Dithiobis [5 -nitrobenzoic acid]
A mixture of 2-chloro-5-nitrobenzoic acid (100 g, 0.496 mol) in ethanol is treated portionwise with potassium tert-butoxide (55.5 g, 0.495 mol), diluted with additional ethanol, heated to reflux, treated portionwise with a solution prepared from sodium sulfide nonahydrate (60.0 g, 0.249 mol), sulfur (8.80 g, 0.274 mol) and water, refluxed for two hours, cooled to room temperature, and treated with concentrated hydrochloric acid. The resultant acidic mixture is stirred for one hour and filtered to obtain a solid. The solid is washed with water and air-dried to give the title product as a yellow powder which is identified by NMR spectral analysis .
EXAMPLE 39 Preparation of 5-Nitro-l, 2-benzisothiazol-3 (2H) -one
A mixture of 2 , 2 ' -dithiobis [5-nitrobenzoic acid] (44.6 g, 0.113 mol) and thionyl chloride (49.0 mL, 0.670 mol) in methylene chloride is treated with N,N- dimethylformamide (0.800 mL) , refluxed overnight, concentrated in vacuo, and diluted with 1,2- dichloroethane . The resultant organic solution is treated with bromine (22.5 mL, 0.436 mol), stirred at room temperature for 20 minutes, refluxed for 3.5 hours, and concentrated in vacuo to obtain a residue. A solution of the residue in 1, 2-dichloroethane is cooled with an ice-water bath, treated with concentrated ammonia (112 mL) over 15 minutes, stirred at room temperature for 16 hours, cooled with an ice-water bath, and treated with concentrated hydrochloric acid. The resultant aqueous mixture is stirred at room temperature for one hour and filtered to obtain a solid. The solid is washed with
water and air-dried to give the title product as a yellow solid which is identified by NMR spectral analysis.
EXAMPLE 40 Preparation of 3-Chloro-5-nitro-l, 2-benzisothiazole
A mixture of 5-nitro-l, 2-benzisothiazol-3 (2H) -one (10.0 g, 0.0510 mol), phosphorus oxychloride (40.0 mL, 0.429 mol) and tributylamine (12.0 mL, 0.050 mol) is heated at 103-115 °C for six hours, stirred at room temperature overnight, and poured into an ice-water mixture . The resultant aqueous mixture is extracted with methylene chloride. The combined organic extracts are washed sequentially with water and saturated sodium hydrogen carbonate solution, dried over anhydrous sodium sulfate, and concentrated in vacuo to obtain a gum.
Column chromatography of the gum using silica gel and methylene chloride gives the title product as an orange- yellow solid which is identified by NMR spectral analysis.
EXAMPLE 41
Preparation of Ethyl α-cvano- 5 -nitro- l , 2 -benziso- thiazole-3 -acetate
0"Na + CH2 ( CN) C02C2H5
A sodium ethoxide solution (previously prepared from ethanol and sodium (1.00 g, 0.0430 mol)) is cooled with an ice-acetone bath, treated portionwise with ethyl cyanoacetate (4.51 g, 0.0398 mol), stirred at room temperature for 30 minutes, treated with 3-chloro-5- nitro-1, 2-benzisothiazole (4.27 g, 0.0199 mol), stirred at room temperature overnight, cooled to 0 °C, and treated dropwise with 10% hydrochloric acid (15.0 mL) . The resultant aqueous mixture is stirred at room temperature for one hour and filtered to obtain a solid. The solid is washed with ethanol and air-dried to give the title product as a yellow solid which is identified by NMR spectral analysis.
EXAMPLE 42
Preparation of Ethyl 5-nitro-l, 2-benzisothiazole-3- acetate
Ethyl α-cyano-5-nitro-l, 2-benzisothiazole-3-acetate (6.67 g, 0.0229 mol) is added to a solution of acetyl chloride (67.0 mL) in ethanol. The reaction mixture is refluxed overnight, cooled, and filtered to remove solids. The resultant filtrate is concentrated in vacuo to obtain a brown semi-solid. A mixture of the semi- solid in diethyl ether is stirred for two hours and filtered to obtain a solid. The solid is washed with diethyl ether and air-dried to give the title product as yellow crystals (1.04 g, mp 91-92 °C) .
EXAMPLE 43
Preparation of Ethyl 5-amino-l, 2 -benzisothiazole-3 acetate
A 10% acetic acid solution (31.0 mL) is stirred at 50 °C, treated with iron powder (0.656 g) , treated dropwise with a solution of ethyl 5-nitro-l, 2- benzisothiazole-3 -acetate (1.03 g, 3.88 mmol) in ethyl acetate, stirred at 50 °C for two hours, treated with additional iron powder (0.305 g) , stirred at 50 °C for 15 minutes, and poured into saturated sodium hydrogen carbonate solution. The resultant aqueous mixture is extracted with ethyl acetate. The combined organic extracts are washed sequentially with water and brine, dried over anhydrous sodium sulfate, and concentrated in vacuo to obtain an oil . Column chromatography of the oil using silica gel and methylene chloride gives the title product as a yellow oil .
EXAMPLE 44
Preparation of Ethyl 5- [3 , 6-dihvdro-2 , 6-dioxo-4- (trifluoromethyl) -K2H) -pyrimidinyl] -1, 2-benzisothiazole- 3 -acetate
C2H5
A mixture of ethyl 5-amino-1, 2 -benzisothiazole-3 - acetate (0.748 g, 3.16 mmol) and 2 -dimethylamino-4- (trifluoromethyl) -6H-1, 3 -oxazin-6-one (0.660 g, 3.17 mmol) in acetic acid is refluxed for three hours, concentrated in vacuo, and diluted with saturated sodium hydrogen carbonate solution. The resultant mixture is extracted with methylene chloride . The combined organic extracts are washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuo to give the title product as a tan solid which is identified by NMR spectral analysis.
EXAMPLE 45
Preparation of Ethyl 5- [3 , 6-dihydro-3-methyl-2 , 6- dioxo-4- (trifluoromethyl) -1 (2H) -pyrimidinyl] -1, 2-benz- isothiazole-3 -acetate
A mixture of ethyl 5- [3 , 6-dihydro-2 , 6-dioxo-4- (trifluoromethyl) -1 (2H) -pyrimidinyl] -1, 2-benzisothiazole-3- acetate (0.643 g, 0.00160 mol) and potassium carbonate (0.243 g, 0.00170 mol) in N,N-dimethylformamide is stirred at room temperature for 90 minutes, treated with iodomethane (0.320 mL, 0.00500 mol), stirred at room temperature overnight, and diluted with water. The resultant aqueous mixture is extracted with methylene chloride. The organic extract is washed with water, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a brown oil . Column chromatography of the oil using silica gel and a 10% ethyl acetate in hexanes solution gives the title product as a tan solid (0.362 g, mp 150-152 °C) .
EXAMPLE 46
Preparation of 5-Nitro-l, 2 -benzisothiazole-3 -acetonitrile
A mixture of ethyl 5-nitro-l, 2 -benzisothiazole-3 - acetate (5.00 g, 17.2 mmol), water (1.00 mL) , and methyl sulfoxide (35.0 mL) is stirred at 107 °C for 24 hours, stirred at room temperature for two days, and poured into an ice-water mixture. The resultant aqueous mixture is stirred for two hours and filtered to obtain a solid. The solid is washed with water and air-dried to give the title product as a tan solid.
EXAMPLE 47
Preparation of α,α-Dimethyl-5-nitro-l, 2-benziso- thiazole-3 -acetonitrile
A mixture of 5-nitro-l, 2-benzisothiazole-3-aceto- nitrile (1.29 g, 5.89 mmol) in N,N-dimethylformamide is cooled to -9 °C, treated with sodium hydride (1.00 g of a 60% dispersion in oil) , stirred at -3 °C for 20 minutes, treated with iodomethane (5.00 mL) , stirred at room temperature for four hours, and poured onto ice. The resultant aqueous mixture is treated with 10% hydrochloric acid and extracted with methylene chloride . The combined organic extracts are washed sequentially with water, saturated sodium hydrogen carbonate solution and water, dried over anhydrous sodium sulfate, and concentrated in vacuo to obtain a solid. column chromatography of the solid using silica gel and methylene chloride gives the title product as a yellow solid which is identified by NMR spectral analysis.
EXAMPLE 48
Preparation of Ethyl α,α-dimethyl-5-nitro-l, 2-benzisothiazole-3 -acetate
A mixture of α,α-dimethyl-5-nitro-1, 2 -benzisothiazole-3 -acetonitrile (0.913 g, 3.69 mmol), water (0.450 mL) , concentrated sulfuric acid (4.55 mL) and ethanol (9.10 mL) is refluxed for one hour, cooled, and poured onto ice. The resultant aqueous mixture is neutralized with saturated sodium bicarbonate solution and extracted with methylene chloride . The organic extract is washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuo to obtain a solid. Column chromatography of the solid using silica gel and methylene chloride gives the title product as pale yellow crystals .
EXAMPLE 49
Preparation of Ethyl 5-amino-α,α-dimethyl-l, 2-benzisothiazole-3 -acetate
A mixture of ethyl α,α-dimethyl-5-nitro-1 , 2-benziso- thiazole-3-acetate (0.714 g, 2.42 mmol), iron powder (0.500 g) , 10% acetic acid (23.0 mL) and ethyl acetate (23.0 mL) is stirred at 54-58 °C for one hour, cooled, and poured into saturated sodium hydrogen carbonate solution. The resultant aqueous mixture is extracted with ethyl acetate. The combined organic extracts are washed sequentially with water and brine, dried over anhydrous sodium sulfate, and concentrated in vacuo to obtain a yellow oil. Column chromatography of the oil using silica gel and a 10% ethyl acetate in methylene chloride solution gives the title product as a light brown oil which is identified by NMR spectral analysis.
EXAMPLE 50
Preparation of Ethyl 5- [3 , 6-dihvdro-3-methyl-2 , 6- dioxo-4- (trifluoromethyl) -1 (2H) -pyrimidinyl] -α,α- dimethyl-1, 2 -benzisothiazole-3 -acetate
A mixture of ethyl 5-amino-α,α-dimethyl-1, 2-benziso- thiazole-3-acetate (0.546 g, 2.06 mmol) and 2-dimethyl- amino-4- (trifluoromethyl) -6H-1, 3 -oxazin-6-one (0.430 g, 2.06 mmol) in acetic acid is refluxed for 4.5 hours, concentrated in vacuo, and diluted with saturated sodium hydrogen carbonate solution. The resultant aqueous mixture is extracted with methylene chloride . The combined organic extracts are washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuo to obtain a brown foam. A solution of the foam in N,N-
dimethylformamide is treated with potassium carbonate (0.312 g, 2.25 mmol), stirred for one hour, treated with iodomethane (0.420 mL, 6.70 mmol), stirred overnight at room temperature, and poured into an ice-water mixture containing 20 mL of concentrated hydrochloric acid. The resultant aqueous mixture is extracted with methylene chloride. The combined organic extracts are washed sequentially with 10% hydrochloric acid, water, saturated sodium hydrogen carbonate solution and water, dried over anhydrous sodium sulfate and concentrated in vacuo to obtain a brown oil . Column chromatography of the oil using silica gel and a 33% ethyl acetate in methylene chloride solution affords a pink foam which is recrystal- lized from ethanol to give the title product as pink crystals, mp 164-167 °C.
EXAMPLE 51 Preparation of 5-Amino-3-chloro-l, 2-benzisothiazole
A solution of 3-chloro-5-nitro-l, 2-benzisothiazole (2.00 g) in toluene is treated with iron powder (8.40 g, 325 mesh) and concentrated hydrochloric acid (8 drops) , heated to reflux, treated dropwise with water (8.00 mL) , refluxed for 35 minutes, cooled to room temperature, and filtered through diatomaceous earth. The resultant
filtrate is concentrated in vacuo to obtain a residue. Flash column chromatography of the residue using silica gel and an ethyl acetate/hexanes solution (1:1) gives the title product.
EXAMPLE 52
Preparation of 3 - (3 -Chloro-l , 2 -benzisothiazol- 5-yl) - 6 - ( trifluoromethyl) -2 , 4 (IH, 3H) -pyrimidinedione
A mixture of 5-amino-3-chloro-l, 2-benzisothiazole (1.10 g) and 2-dimethylamino-4- (trifluoromethyl) -6H-1, 3- oxazin-6-one (1.38 g) in acetic acid (15.1 mL) is stirred at 90-105 °C for two hours, cooled to room temperature, and filtered to obtain 0.500 g of the title product as a solid. The resultant filtrate is diluted with water and filtered to obtain an additional 1.11 g of the title product .
EXAMPLE 53
Preparation of 3- (3-Chloro-l, 2-benzisothiazol-5-yl) 1 -methyl- 6- (trifluoromethyl) -2,4 (1H,3H) -pyrimidinedione
A mixture of 3- (3-chloro-l, 2-benzisothiazol-5-yl) -6- (trifluoromethyl) -2,4 (IH, 3H) -pyrimidinedione (1.06 g) , potassium carbonate (0.470 g) and iodomethane (0.500 mL) in N,N-dimethylformamide is stirred at room temperature for 90 minutes, treated with additional iodomethane (0.500 mL) , stirred at room temperature for 15 minutes, and diluted with water. The resultant aqueous mixture is filtered to obtain a solid. The solid is washed with water and dried-in a vacuum oven at room temperature to give the title product as a solid which is identified by NMR spectral analysis.
EXAMPLE 54
Preparation of [ (5-Nitro-l, 2-benzisothiazol-3-yl) oxy] cetonitrile
CN
A mixture of 5-nitro-l, 2-benzisothiazol-3 (2H) -one (17.5 g, 89.2 mmol) in N,N-dimethylformamide is treated with potassium carbonate (18.5 g, 134 mmol), stirred at room temperature for 30 minutes, treated with bromoaceto- nitrile (16.0 g, 133 mmol), stirred at room temperature overnight, and poured onto ice. The resultant aqueous mixture is acidified to pH 3 with hydrochloric acid and extracted with ethyl acetate . The combined organic extracts are washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a solid. Column chromatography of the solid using silica gel and methylene chloride gives the title product as a yellow solid (15.0 g, mp 123-124.5 °C) .
Using essentially the same procedure, the following compounds are obtained :
OCH3 108 - 109
OCH ( CH3 ) 2
OCH2CH=CH2
OCH2CsCH 115 - 117
OCH2C02CH3
EXAMPLE 55
Preparation of [ ( 5 -Amino- l , 2 -benzisothiazol - 3 -yl ) oxy] acetonitrile
A mixture of iron powder (13.0 g, 0.233 mol) in a 5% acetic acid solution (65.0 mL) is heated to 50 °C, treated portionwise with a mixture of [ (5-nitro-l, 2-benzisothia- zol-3 -yl) oxy] acetonitrile (11.0 g, 0.047 mol), acetic acid (100 mL) and ethyl acetate (65.0 mL) , refluxed for two hours, cooled to 40 °C, and filtered to remove solids. The phases are separated and the aqueous phase is extracted with ethyl acetate. The organic phase and the organic extracts are combined, washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title product as an oil which is identified by NMR spectral analysis.
- Ill -
Using essentially the same procedure, the following compounds are obtained:
OCH,
OCH ( CH,
OCH2CH=CH2 OCH2C≡CH
OCH2C02CH3
EXAMPLE 56
Preparation of {{5- [3 , 6-Dihvdro-2 , 6-dioxo-4- (trifluoromethyl) -1(2H) -pyrimidinyl] -1, 2-benzisothiazol-3- yl}oxy}acetonitrile
A mixture of [ (5-amino-l, 2-benzisothiazol-3-yl) oxy] acetonitrile (4.30 g, 21.0 mmol) and 2-dimethylamino-4-
(trifluoromethyl) -6H-1, 3-oxazin-6-one (4.37 g, 21.0 mmol) in acetic acid is refluxed for three hours, stirred overnight at room temperature, and poured into an ice- water mixture. The resultant aqueous mixture is filtered to obtain a solid. The solid is washed with water and dried overnight in a vacuum oven at 55 °C to give the title product as a brown solid (2.63 g, mp 254-258 °C) .
Using essentially the same procedure, the following compounds are obtained:
mβ_
OCH,
OCH ( CH, 180-185
OCH2CH=CH2 210-212
OCH2C≡CH 212-215
OCH2C02CH3
EXAMPLE 57
Preparation of {{5- [3 , 6-Dihydro-3-methyl-2 , 6-dioxo- 4- (trif uoromethyl) -1(2H) -pyrimidinyl] -1,2-benziso- thiazol-3-yl}oxy}acetonitrile
A mixture of { {5- [3 , 6-dihydro-2 , 6-dioxo-4- (trifluoromethyl) -1(2H) -pyrimidinyl] -1, 2-benzisothiazol-3- yl}oxy} acetonitrile (2.63 g, 7.15 mmol) and potassium carbonate (1.97 g, 14.3 mmol) in N,N-dimethylformamide is stirred for 30 minutes, treated with iodomethane (2.03 g, 14.3 mmol), stirred overnight at room temperature, and poured into an ice-water mixture. The resultant aqueous mixture is filtered to obtain a solid. The solid is dissolved in ethyl acetate and the resultant solution is washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a brown solid. Column chromatography of the solid using silica gel and methylene chloride affords a yellow solid. The yellow solid is recrystallized from a methylene chloride/hexanes solution to give the title product as an off-white solid, mp 265-266 °C.
Using essentially the same procedure, the following compounds are obtained:
mp °C
OCH3 198- -199
OCH(CH3)2 125- -127
OCH2CH=CH2 184- -185
OCH2C≡CH 201-202.5
OCH,CO,CH, 181- -183
EXAMPLE 58 Preparation of 5-Nitro-1, 2-benzisothiazole
To a mixture of ammonium hydroxide (1000 ml) and N,N-dimethylformamide is added 2 -chloro-5-nitrobenz- aldehyde (300 g, 1.62 mol) and sulfur (54.4 g, 1.70 mol) The mixture is heated slowly to and stirred at 90 °C for
one hour, cooled to room temperature, poured onto ice, and diluted with water. Filtration affords the title compound as a yellow solid (277.1 g, 94.9%) .
EXAMPLE 59 Preparation of 3 -Chloro-5-nitro-l, 2-benzisothiazole
A suspension of 5-nitro-l, 2-benzisothiazole (271 g, 1.50 mol) in acetic acid is heated to 80 °C to form a solution. The heating source is removed and chlorine gas is added continuously over six hours at 70-80 °C until saturation of the mixture occurs . The mixture is cooled to room temperature and stirred overnight. Filtration affords the title compound as a yellow crystalline solid (237 g, 73.6%) which is identified by NMR spectral analysis .
EXAMPLE 60 Preparation of 2 ' -Chloro-2-methyl-2-carboethoxy propiophenone
A mixture of 2-chlorobenzoyl chloride (52.2 g, 0.298 mol), ethyl 2-bromoisobutyrate (58.2 g, 0.298 mol) and ether is added in portions to zinc foil (19.5 g, 0.298 mol) and the resultant mixture stirred at reflux for three hours and overnight at room temperature. The mixture is poured into cold, dilute sulfuric acid and the organic layer is washed with saturated sodium bicarbonate and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to a yellow oil. The oil is chromatographed on silica gel with hexanes : ethyl acetate to afford the title compound as a colorless oil (41.8 g, 55.1%) .
EXAMPLE 61 Preparation of 2 ' -Chloro-5' -nitro-2 -methyl-2- carboethoxypropiophenone
To concentrated sulfuric acid (15.0 ml) at 5 °C is added 2 ' -chloro-2 -methyl -2 -carboethoxypropiophenone (4.00 g, 0.01570 mol) followed by dropwise addition of concentrated nitric acid (90%, 0.740 ml, 0.0204 mol). After stirring 5 minutes, the mixture is poured onto ice and extracted with ethyl acetate . The organic layers are washed with saturated sodium bicarbonate and brine, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to afford the title compound as a yellow oil (3.90 g, 83.0%) which is identified by NMR spectral analysis.
EXAMPLE 62 Preparation of Ethyl ,α-dimethyl-5-nitro-l, 2- benzisothiazole-3 -acetate
A mixture of 2 ' -chloro-5 ' -nitro-2-methyl-2- carboethoxypropiophenone (3.24 g, 0.00108 mol), N,N- dimethylformamide and sulfur (0.350 g, 0.00109 mol) is treated dropwise with ammonium hydroxide (9 ml) , heated to and stirred at 70-80 °C for two hours, cooled to room temperature, and diluted with water. Filtration affords the title compound as a solid (2.49 g, 78.3%, mp 75-77 °C) which is identified by NMR spectral analysis.
EXAMPLE 63 Preparation of l-Benzothiophen-2 , 3-dione
To a solution of thiophenol (100 g, 0.907 mol) in ether is added dropwise a solution of oxalyl chloride (175 g, 1.38 mol) in ether. The mixture is stirred two hours at reflux and concentrated in vacuo . The residue
is taken up in methylene chloride and cooled to 0 °C. Aluminum chloride (145 g, 1.09 mol) is added in portions such that the temperature does not exceed 25 °C. The resultant mixture is stirred 30 minutes at reflux, cooled to room temperature and poured into ice water with stirring. The organic layer is washed with saturated sodium bicarbonate, water and brine, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to an orange solid which is recrystallized from methylene chloride: hexanes to afford the title compound (102 g, 69.0%) which is identified by NMR spectral analysis.
EXAMPLE 64 Preparation of 1, 2 -Benzisothiazole-3 -carboxamide
To ammonium hydroxide (1.78 1) is added 1- benzothiophen-2, 3-dione (87.0 g, 0.530 mol) at 5-10 °C, followed by hydrogen peroxide (30% aqueous, 178 ml) . The resultant mixture is filtered to obtain a yellow solid which is dried (77.0 g, 81.7%) and identified as the title compound by NMR and IR spectral analysis.
EXAMPLE 65 Preparation of 3-Cyano-5-nitro-1, 2-benzisothiazole
2) POC1,
A solution of 1, 2 -benzisothiazole-3 -carboxamide (12.0 g, 0.0674 mol) in concentrated sulfuric acid at 0-5 °C is treated dropwise with nitric acid (90%, 4.12 ml) such that the temperature does not exceed 10 °C, stirred one hour at 5 °C, and poured into ice water with vigorous stirring. The resultant suspension is filtered to obtain a solid. The solid is dried and recrystallized from acetonitrile to afford a white solid (10.0 g) which is treated with phosphorus oxychloride (60.0 ml) . The resultant mixture is stirred at 90-100 °C for 90 minutes, cooled to room temperature, slowly poured into ice water with stirring, and filtered to obtain a solid. Recrystallization of the solid from methylene chloride : hexanes gives the title compound as an orange solid (8.00 g, 87.9%, mp 168-170 °C) which is identified by NMR and IR spectral analyses .
EXAMPLE 66 Preparation of 2 , 4-Difluoro-5-nitrobenzoyl chloride
Oxalyl chloride (94.0 g, 0.739 mol) is added dropwise to a mixture of 2 , 4-difluoro-5-nitrobenzoic acid (100.0 g, 0.492 mol), methylene chloride and N,N- dimethylformamide (0.600 ml). The resultant mixture is stirred 3.25 hours at reflux, cooled to room temperature, and concentrated in vacuo to afford the title compound as a brown oil (111 g, 95.2%) .
EXAMPLE 67 Preparation of 2 ' , 4' -Difluoro-2-methoxy-5-methyl-5' nitrobenzophenone
CH,
A mixture of aluminum chloride (62.3 g, 0.467 mol) and methylene chloride is cooled to -20 °C to -10 °C, treated with 4-methylanisole (60.1 g, 0.492 mol), treated dropwise with a mixture of 2 , 4-difluoro-5-nitrobenzoyl chloride (111 g, 0.468 mol) and methylene chloride over a 10 minute period, warmed to 0 °C, stirred overnight at ambient temperature, slowly poured onto ice with stirring, and diluted with methylene chloride. The organic layer is washed with water and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to a solid. The solid is recrystallized from acetonitrile to afford the title compound as a yellow solid (82.1 g, 54.0%) which is identified by NMR spectral analysis.
EXAMPLE 68
Preparation of 3- (6-Mβ hoxy-_m-tolyl) -6-amino-5- nitro-1, 2 -benzisothiazole
Ammonium hydroxide (330 ml) is added to a suspension of 2 ' , 4 ' -difluoro-2-methoxy-5-methyl-5 ' -nitrobenzophenone (60.0 g, 0.186 mol), sulfur (6.25 g, 0.195 mol) and N,N- dimethylformamide on an ice bath. The resultant mixture is allowed to warm to 35 °C, heated gradually to 81 °C over a two hour period, cooled to room temperature, and poured into water. The resultant solid is taken up in ethyl acetate and N,N-dimethylformamide, and washed with water. The organic layer is concentrated in vacuo to afford the title compound which is identified by NMR spectral analysis .
EXAMPLE 69 Preparation of 3- (6-Methoxy-m-tolyl) -6-chloro-5- nitro-1, 2-benzisothiazole
nitrite + CuCl.
A mixture of tert-butyl nitrite (5.90 g, 0.0571 mol), copper chloride (6.20 g, 0.0457 mol) and acetonitrile is heated to 65-75 °C, treated with 3- (6- methoxy-m-tolyl) -6-amino-5-nitro-l, 2-benzisothiazole
(12.0 g, 0.0381 mol) over 10 minutes, stirred for two hours at 67-75 °C, treated with tert-butyl nitrite (1.50 ml) and copper chloride (1.00 g) , stirred 40 minutes at 67-75°C, cooled to room temperature, and diluted with ethyl acetate. The organic layer is washed with 10% hydrochloric acid and filtered. The filtrate is washed with water and concentrated in vacuo to afford the title compound as a solid (10.6 g, 83.1%) which is identified by NMR and IR spectral analyses .
EXAMPLE 70 Preparation of 3- (6-Methoxy--m-tolyl) -6-fluoro-5- nitro-1, 2-benzisothiazole
+ KF + 18-crown-6
A mixture of 3- (6-methoxy-m-tolyl) -6-chloro-5-nitro- 1, 2-benzisothiazole (7.30 g, 0.0218 mol), potassium fluoride (6.33 g, 0.109 mol) 18-crown-6 (2.31 g, 0.0872 mol) and sulfolane is stirred 19 hours at 154°C, cooled to room temperature, and poured into ice water. The resultant solid is filtered and chromatographed on silica gel with methylene chloride to afford a solid which is recrystallized from acetonitrile to afford a tan powder. The powder is recrystallized from ethyl acetate to give the title compound as a tan solid (2.09 g, 29.9%) which is identified by NMR spectral analysis.
EXAMPLE 71 Preparation of 5-Amino-4-bromo-6-fluoro-3-methyl- 1 , 2 -benzisothiazole
To a solution of 5-amino-6-fluoro-3-methyl-l, 2- benzisothiazole (0.600 g, 0.00329 mol) in 1,2- dichloroethane is added N-bromosuccinimide (0.586 g, 0.00329 mol) followed by 1, 1 ' -azobis (cyclohexanecarbo- nitrile) (0.0200 g) . The mixture is stirred two hours at 70 °C, additional N-bromosuccinimide (0.240 g, 0.00135 mol) is added, and the mixture is stirred 40 minutes at 70°C. The mixture is then cooled to room temperature, filtered and concentrated in vacuo to obtain a residue.
The residue is chromatographed on silica gel to give the title compound (0.870 g, 100%) which is identified by NMR spectral analysis.
Claims
1. A process for the preparation of a 2-(N,N- disubstituted) amino-4- (perfluoroalkyl) -1, 3 -oxazin-6 -one compound having the structural formula I
N^^0
^N^ Z Z,
(I)
wherein
Z and Zx are each independently C-^-C8alkyl or Z and Zx may be taken together with the atom to which they are attached to form a 4- to 7-membered ring wherein ZZX is represented by - (CH2) 20 (CH2) 2- or -(CH2)m- where m is an integer of 3 , 4 , 5 or 6 ; and n is an integer of 1, 2, 3, 4, 5 or 6, which process comprises:
(a) reacting a β-amino-β- (perfluoroalkyl) acrylate compound having the structural formula II
NH2
( i i :
wherein n is as described above, and Z2 is Cx-C6alkyl or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, Cx-C4alkyl or C1-C4haloalkyl groups, with a base and a carbamoyl chloride compound having the structural formula III 
( III )
wherein Z and Zx are as described above to form a urea compound having the structural formula IV
Z Zχ • and
(IV)
(b) reacting the formula IV urea with a phosphorous pentahalide or oxalyl halide.
2. The process according to claim 1 wherein the double bond in the formula II and IV compounds is predominately in the (Z) - configuration.
3. The process according to claim 1 wherein the base is selected from the group consisting of an alkali metal hydride, an alkali metal Cj-Cgalkoxide, an alkali metal hydroxide, an alkali metal carbonate, an alkaline earth metal hydroxide, an alkaline earth metal carbonate and a lithium base.
4. The process according to claim 3 wherein the base is selected from the group consisting of an alkali metal hydride and an alkali metal Cx-C6alkoxide.
5. The process according to claim 4 wherein the base is selected from the group consisting of sodium hydride, sodium tert-butoxide and potassium tert- butoxide .
6. The process according to claim 1 wherein the phosphorus pentahalide is phosphorus pentachloride, and the oxalyl halide is oxalyl chloride.
7. The process according to claim 1 wherein the β- amino-β- (perfluoroalkyl) acrylate is reacted with the base and carbamoyl chloride in the presence of a first solvent, and the urea is reacted with the phosphorus pentahalide or oxalyl halide in the presence of a second solvent .
8. The process according to claim 7 wherein the first solvent is selected from the group consisting of a carboxylic acid amide, an ether, a nitrile and a dialkyl sulfoxide and mixtures thereof; and the second solvent is selected from the group consisting of a phosphorus oxyhalide, an aromatic hydrocarbon, a halogenated aromatic hydrocarbon, a carboxylic acid amide, an aliphatic hydrocarbon and a halogenated aliphatic hydrocarbon and mixtures thereof .
9. The process according to claim 8 wherein the first solvent is N,N-dimethylformamide .
10. The process according to claim 1 wherein the β-amino-β- (perfluoroalkyl) acrylate is reacted with the base and carbamoyl chloride at a temperature of about -20°C to 80°C, and the urea is reacted with the phosphorus pentahalide or oxalyl halide at a temperature of about 0°C to 100°C.
11. The process according to claim 10 wherein the β-amino-β- (perfluoroalkyl) acrylate is reacted with the base and carbamoyl chloride at a temperature of about 0°C to 50°C, and the urea is reacted with the phosphorus pentahalide or oxalyl halide at a temperature of about 20°C to 50°C.
12. The process according to claim 1 wherein Z and Zx are each independently Cj-Cgal yl;
Z2 is C1-C4alkyl; and n is 1.
13. The process according to claim 12 wherein Z and Zx are the same and represent methyl or ethyl ; Z2 is methyl or ethyl ; and n is i.
14. A process for the preparation of a 2- (N,N- disubstituted) amino-4- (perfluoroalkyl) -1, 3-oxazin-6-one compound having the structural formula I
N^/0
z z.
(I)
wherein
Z and Zx are each independently C.-C8alkyl or Z and Zx may be taken together with the atom to which they are attached to form a 4- to 7-membered ring wherein ZZX is represented by - (CH2) 20 (CH2) 2- or -(CH2)m- where m is an integer of 3 , 4 , 5 or 6 ; and n is an integer of 1, 2, 3, 4, 5 or 6, which process comprises reacting a urea compound having the structural formula IV
HN 0
^N^ Z Z,
( IV)
wherein n, Z and Zx are as described above, and Z2 is 
or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C1-C4alkyl or C1-C4haloalkyl groups, with a phosphorous pentahalide or oxalyl halide.
15. The process according to claim 14 wherein the double bond in the formula IV compound is predominately in the (Z) - configuration.
16. The process according to claim 14 wherein the phosphorus pentahalide is phosphorus pentachloride, and the oxalyl halide is oxalyl chloride.
17. The process according to claim 14 wherein the urea is reacted with the phosphorus pentahalide or oxalyl halide in the presence of a solvent.
18. The process according to claim 17 wherein the solvent is selected from the group consisting of a phosphorus oxyhalide, an aromatic hydrocarbon, a halogenated aromatic hydrocarbon, a carboxylic acid amide, an aliphatic hydrocarbon and a halogenated aliphatic hydrocarbon and mixtures thereof.
19. A process according to claim 14 wherein the urea is reacted with the phosphorus pentahalide or oxalyl chloride at a temperature of about 0°C to 100°C.
20. The process according to claim 19 wherein the urea is reacted with the phosphorus pentahalide or oxalyl chloride at a temperature of about 20°C to 50°C.
21. The process according to claim 14 wherein Z and Zx are each independently C-L-Cgalkyl;
Z2 is C1-C4alkyl; and n is 1.
22. The process according to claim 21 wherein
Z and Zx are the same and represent methyl or ethyl ; and Z2 is methyl or ethy; and n is 1.
23. A urea compound having the structural formula IV
HN
-.0
/N^ z z.
:ιv) wherein
Z and Zx are each independently 
or Z and Zx may be taken together with the atom to which they are attached to form a 4- to 7-membered ring wherein ZZX is represented by - (CH2) 20 (CH2) 2- or -(CH2)ra- where m is an integer of 3 , 4 , 5 or 6 ; n is an integer of 1, 2, 3, 4, 5 or 6 ; and
Z2 is C1-C6alkyl or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C1-C4alkyl or C1-C4haloalkyl groups.
24. A compound according to claim 23 wherein the double bond is predominately in the (Z) - configuration.
25. A compound according to claim 23 wherein Z and Zx are each independently C-L-Cgalkyl;
Z2 is C1-C4alkyl; and n is 1.
26. A compound according to claim 25 wherein
Z and Z are the same and represent methyl or ethyl ; and Z2 is methyl or ethyl .
27. A- compound according to claim 23 selected from the group consisting of ethyl 3- [ (N,N-dimethylcarbamoyl) amino] -4,4,4- trifluorocrotonate, (Z) - ; methyl 3- [ (N,N-dimethylcarbamoyl) amino] -4,4,4- trifluorocrotonate, (Z) - ,- ethyl 3- [ (N,N-diethylcarbamoyl) amino] -4,4,4- trifluorocrotonate, (Z) - ; methyl 3- [ (N,N-diethylcarbamoyl) amino] -4,4,4- trifluorocrotonate, (Z) - ; ethyl 3- [ (N-pyrrolodinecarbonyl) amino] -4,4,4- trifluorocrotonate, (Z) - ; and methyl 3- [ (N-pyrrolodinecarbonyl) amino] -4,4,4- trifluorocrotonate, (Z) - .
28. A process for the preparation of a 6- (per- fluoroalkyl) uracil compound having the structural formula V
0 (V)
wherein n is an integer of 1, 2, 3, 4, 5 or 6 ;
Z3 is hydrogen or C1-C6alkyl; and
Q is a C-L-Cgalkyl group or an optionally substituted phenyl, benzyl, heteroaryl or methyleneheteroaryl group , which process comprises :
(a) reacting a urea compound having the structural formula IV
HN
O
-N
(IV)
wherein
Z and Z, are each independently C^Cgalkyl or Z and Zx may be taken together with the atom to which they are attached to form a 4- to 7-membered ring wherein ZZj. is represented by - (CH2) 20 (CH2) 2- or -(CH2)m- where is an integer of 3 , 4, 5 or 6 ; Z2 is C.-C6alkyl or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C1-C4alkyl or C1-C4haloalkyl groups; and n is as described above, with a phosphorous pentahalide or oxalyl halide to form a 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1,3-oxazin- 6-one compound having the structural formula I
C F - y\ ^o
N^.^0
Z Z,
(I)
(b) reacting the 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1, 3 -oxazin-6-one with an amine compound having the structural formula VI
QNH2 (VI)
wherein Q is as described above in the presence of an acid or a base to form the 6- (perfluoroalkyl) uracil compound of formula V wherein Z3 is hydrogen; and
(c) optionally alkylating the formula V compound wherein Z3 is hydrogen.
29. The process according to claim 28 wherein the double bond in the formula IV compound is predominately in the (Z) - configuration.
30. The process according to claim 28 wherein the phosphorus pentahalide is phosphorus pentachloride, and the oxalyl halide is oxalyl chloride.
31. The process according to claim 28 wherein the acid is selected from the group consisting of an organic acid and a mineral acid.
32. The process according to claim 31 wherein the organic acid is a C1-C6alkanoic acid, and the mineral acid is selected from the group consisting of hydrochloric acid, sulfuric acid and phosphoric acid.
33. The process according to claim 31 wherein the acid is acetic acid.
34. The process according to claim 28 wherein the base is selected from the group consisting of a tri- 
amine, a heterocyclic tertiary amine and an alkali metal Cj-Cgalkoxide.
35. The process according to claim 34 wherein the base is selected from the group consisting of 1,8- diazabicyclo [5.4.0] undec-7-ene and 1, 5-diazabicyclo-
[4.3.0] non-5-ene.
36. The process according to claim 28 wherein the urea is reacted with the phosphorus pentahalide or oxalyl halide optionally in the presence of a first solvent, and the 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1,3- oxazin-6-one is reacted with the amine and the acid in the presence of a second solvent .
37. The process according to claim 36 wherein the first solvent is selected from the group consisting of a phosphorus oxyhalide, an aromatic hydrocarbon, a halogenated aromatic hydrocarbon, a carboxylic acid amide, an aliphatic hydrocarbon and a halogenated aliphatic hydrocarbon and mixtures thereof, and the second solvent is selected from the group consisting of a carboxylic acid amide, a dialkyl sulfoxide, an aromatic hydrocarbon, a halogenated aromatic hydrocarbon, an aliphatic hydrocarbon, a halogenated aliphatic hydrocarbon, an alkanoic acid, a ketone, an ether, a nitrile and water and mixtures thereof .
38. The process according to claim 28 wherein the urea is reacted with the phosphorus pentahalide or oxalyl chloride at a temperature of about 0°C to 100°C, and the 2- (N,N-disubstituted) amino-4- (perfluoroalkyl) -1, 3-oxazin- 6 -one is reacted with the amine and the acid at a temperature of about 20°C to 150°C.
39. The process according to claim 28 wherein step (c) comprises reacting the formula V compound wherein Z3 is hydrogen with an alkyl halide having the structural formula VII or a dialkylsulfate ester having the structural formula VIII
(VIII; ■13!
wherein X is chlorine, bromine or iodine, and Z3 is C-L-Cgalkyl, in the presence of a base.
40. The process according to claim 28 wherein n is 1 ; Z3 is hydrogen or C1-C4alkyl;
G is CH2 or a bond;
Gx is CX5 or N;
G2 is CX4 or N;
X is hydrogen, halogen or a 
group optionally substituted with one epoxy group, X2 is hydrogen, halogen NRR1# C02R2, C(0)R3, OR4, S02Rs,
S02NR6R7, C(R8) (OR9)2, C (R10) =NOR11, C (R12) =C (R13) -
C (OR14) =NORx5 , CH20-NC02R16 ,
1 , 3 -dioxolane optionally substituted with one Ci-Cgalkoxy group or one or two C1-C4alkyl groups ,
1 , 3 -dioxolinone optionally substituted with one C-L-Cgalkoxy group or one or two C1-C4alkyl groups , or
Cx-C4alkyl optionally substituted with one C02R2 group and one halogen atom, and X3 is hydrogen, halogen, C1-C4haloalkyl , C02R17 , cyano ,
C1-C4haloalkoxy, OR18 or C1-C4alkyl , or when Xx and X2 are taken together with the atoms to which they are attached, they may form a five- or six- membered ring wherein XXX2 or X2XX is represented by:
-OC(R20) (R21)0-, -CH2S(0)pN(R22)-, -SC(R23)=N-, -CH=CH-
CH(R11)0-, -OC(0)N-, -SC(R24)=N-, -ON (R2S) C (0) - ,
-OC(C02R26)=C(R27)-, -NC(R28)=C(SR29) -, -CH=C (CO2R30) 0- ,
-CH2CH(R31)0- or -OC (R32) (R33) C (0) - , or when X2 and X3 are taken together with the atoms to which they are attached, they may form a five- or six- membered ring wherein X2X3 or X3X2 is represented by: -NC(R34)=NC(S)-, -N(R35)N=C(R36)-, -N (R37) C (R38) =N- , -N(R38)C(0)CH20-, -N(R39)C(0)CH=CH-, -S-N=C (R40) - , -0-N=C(R41)-, -N=N-N(R42) -, -C (R43) (R44) C (O) N (R45) - or -N(R46)C(0)C(R47) (R48)-;
X4 is hydrogen, halogen or OR19;
X5 is hydrogen or halogen;
R, RS6, R64, R69, R70, R77 and R91 are each independently hydrogen, S02R49, C1-C4alkyl, C3-C7cycloalkyl , C3-C6alkenyl, C3-C6alkynyl, phenyl or benzyl;
Rx is hydrogen, SO2R50, C(0)R51, amino or C1-C4alkyl optionally substituted with C02RS2 or C(0)R53;
K-2 ' i6 ' ^-17' ^-26' ^-30' ^68» R-75 ' ^76 ^82 and R88 are each independently hydrogen, 
C3-C8alkenyl,
C3-C6alkynyl, phenyl, benzyl, furfuryl, pyridyl, thienyl ,
C-L-C8alkyl optionally substituted with C02RS4, morpholine or C(0)RS5, or an alkali metal, an alkaline earth metal, ammonium or organic ammonium cation; R3, R66, R67, R81, R85 and R89 are each independently hydrogen , 
C3-C6alkenyl , C3-Cεalkynyl, NR5gR57, phenyl or benzyl; R4, R18, R19 and R65 are each independently hydrogen,
C^Cgalkyl, C3-C6alkenyl, C3-Cεalkynyl, C.-C4haloalkyl ,
C(0)R58 , C(S)RS9 or benzyl; R5 and R72 are each independently Cx-Cgalkyl, Cx- Cghaloalkyl ,
NRg0R61, imidazole or indazole; β ' ll ' l2 ' ^"li ' -^15' ∑O R-21 ' ^22 ∑5 ' ^28' \29 ' °31 / ^32' ^33 '
R35/ R45/ R46/ R63 and- R80 are each independently hydrogen or C1-C4alkyl; R7 is hydrogen, C3-C3alkenyl, C3-C6alkynyl, benzyl, or Cx-C4alkyl optionally substituted with cyano or C(0)R62;
R8 and R27 are each independently hydrogen, C1-C4alkyl or Cx -C4 alkoxy ;
R9 and R90 are each independently 
R10 is hydrogen, Cx-C6alkyl, phenyl or benzyl;
R13, R24 and R36 are each independently hydrogen, 
or halogen;
R23 is hydrogen or NR63R64;
R34 is hydrogen, Cx-C4alkyl or C1-C4haloalkyl;
R37 is hydrogen, Cx-C4alkyl or C2-C8alkoxyalkyl ;
R38 and R39 are each independently hydrogen, C1-C4alkyl, C1-C4haloalkyl, C3-C6alkenyl or C3-C6alkynyl;
R40, R41 and R42 are each independently hydrogen, halogen, cyano, ORS5, C(0)RgS, C(S)RS7, C02R68, C(=N0R69), a 
C3-C7cycloalkyl, C2-C8alkenyl or
C2-C8alkynyl group, wherein each group is optionally substituted with any combination of one to six halogen atoms, one to three Cx-C10- alkoxy groups, one or two Ci-Cghaloalkoxy groups, one or two NR70R71 groups, one or two S (O) ^.72 groups, one or two cyano groups, one or two C3-C7cycloalkyl groups, one OS02R73 group, one or two C(0)R74 groups, one or two C02R75 groups, one or two C(0)SR76 groups, one or two C(0)NR77R78 groups, one to three 0R79 groups, one or two P(O) (OR80)2 groups, one 1, 3-dioxolane optionally substituted with one to three C-L-Calkyl groups, or one 1,3-dioxane optionally substituted with one to three C1-C4alkyl groups, or phenyl or benzyl optionally substituted with any combination of one to three halogen atoms, one to three Ci-Cgalkyl groups, one to three C^ C6alkoxy groups, one C3-C7cycloalkyl group, one C1-C4haloalkyl group, one C.-C4alkylthio group, one cyano group, one nitro group, one C(0)R81 group, one C02R82 group, one OR83 group, one SR84 group, one Ci-Cgalkoxymethyl group, one hydroxymethyl group, one C3 - C8alkenyloxymethyl group, or one Ci-Cghaloalkoxymethyl group; R43/ R44/ R4 and R48 are each independently hydrogen,
C1-C4alkyl, C1-C4haloalkyl, C3-C6alkenyl, C3-C6alkynyl or C3-C7cycloalkyl, or R43 and R44 or R47 and R48 may be taken together with the atom to which they are attached to form a C3-C7cycloalkyl group; R49, Rso and RBe are each independently C1-C6alkyl, NR93R94, C1-C4haloakyl, C3-C6alkenyl, C3-C6alkynyl or benzyl;
"•51' 52 ' R-S3 ' ^54' "-5S ' 57 ' "-S8 ' R-59 ' "'SO* R-61 ' R-62 ' 71 ' ^73' ^74'
R78, R87 and R92 are each independently hydrogen, C1-C6alkyl, C3-C7cycloalkyl, 
C3-C6alkenyl, C3-C6alkynyl, phenyl or benzyl; R79, R83 and R84 are each independently hydrogen, C(0)R8S, S02R86/ 
C2-C6alkenyl, C5-C8cycloalkenyl, C2-Cεalkynyl, phenyl, benzyl, or C1-C10alkyl optionally substituted with one hydroxyl, benzyloxy, OC(0)R87, C02Rg8, C(0)R89, C(OR90)2, C(0)NR91R92 or cyano group; R93 and R94 are each independently hydrogen, C1-C4haloalkyl, C2-C3alkenyl, C3-C8cycloalkyl, C1-C8alkyl optionally substituted with one or two
C1-C4alkoxy groups or one cyanoalkyl group, or benzyl or phenyl optionally substituted with any combination of one to three halogen atoms, one to three C1-C4alkyl groups, one to three C1-C4haloalkyl groups, one to three C.-C4alkoxy groups, one to three Cx-C4haloalkoxy groups, one cyano group or one nitro group, and when R93 and R94 are taken together with the atom to which they are attached, they form a 5- to 12- membered monocyclic or fused bicyclic, heterocyclic ring optionally substituted with one or more groups independently selected from halogen, cyano, nitro, amino, hydroxyl, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy and C1-C4haloalkylsulfonyl groups ; p and q are each independently 0, 1 or 2;
Z and Zx are each independently 
and
Z2 is C1-C4alkyl.
41. The process according to claim 40 wherein Z3 is hydrogen or methyl ; X is hydrogen, fluorine or C1-C3alkyl optionally substituted with one epoxy group; X2 is hydrogen, halogen NRR17 C02R2, C(0)R3, 0R4, S02R5, S02NR6R7, C(R8) (OR9)2, C (R10) =NORlx, C (R12) =C (R13) - C (OR14) =N0R1S, CH20-NC02R16,
1, 3-dioxolane optionally substituted with one C1-C6alkoxy group or one or two Cx-C4alkyl groups , 1, 3-dioxolinone optionally substituted with one 
group or one or two C1-C4alkyl groups , or C.-C4alkyl optionally substituted with one C02R2 group and one halogen atom, and X3 is hydrogen, halogen, Cx-C4haloalkyl, C02R17, cyano,
C1-C4haloalkoxy, 0R18 or C1-C4alkyl, or when Xx and X2 are taken together with the atoms to which they are attached, they may form a five- or six- membered ring wherein XXX2 or X2XX is represented by: -OC(R20) (R21)0-, -CH2S(0)pN(R22)-, -SC(R23)=N-, -CH=CH-CH(R11)0-, -0C(0)N-, -SC(R24)=N-, -ON (R25) C (0) - , -0C(C02R2ε)=CH-, -NC(R28)=C(SR29) -, -CH=C (CO2R30) 0- , -CH2CH(R31)0- or -OC (R32) (R33) C (0) - , or when X2 and X3 are taken together with the atoms to which they are attached, they may form a five- or six- membered ring wherein X2X3 or X3X2 is represented by: -NC(R34)=NC(S)-, -N(R3S)N=C(R36)-, -N (R37) C (R38) =N- , -N(R38)C(0)CH20-, -N(R39)C(0)CH=CH-, -S-N=C (R40) - , -0-N=C(R41)-, -N=N-N(R42) -, -C (R43) (R44) C (0) N (R45) - or -N(R4ε)C(0)C(R47) (R48)-;
X4 is hydrogen, halogen or OR19;
Xε is hydrogen or halogen;
R, R64, R69 and R77 are each independently hydrogen, S02R49 or C1-C4alkyl;
Rx is hydrogen, SO2RS0, C(0)Rsl, amino or Cx-C4alkyl optionally substituted with C02RE2 or C(0)R53; 
independently hydrogen, C3-Cεalkenyl or C1-C4alkyl optionally substituted with C02RS4, morpholine or C(0)RS5;
R3, R66/ RS7, R8S and R89 are each independently hydrogen, C1-C4alkyl or NRSgR57;
R4, R18 and R19 are each independently hydrogen,
C1-C4alkyl, C1-C4haloalkyl, C(0)R58, C3-C4alkenyl or C3-C4alkynyl;
R56 is S02R49;
R57 is hydrogen or C1-C4alkyl;
R5 and R72 are each independently NR60Rει or indazole;
"6 ' "ll ' "12 ' 14 ' "15 ' "20 ' "21 ' "22 ' "25 ' "28 ' "29 ' "31 ' "32 ' "33 '
R 35' R 45' R 46 anti Rso are each independently hydrogen or methyl ,- R7 is C1-C4alkyl optionally substituted with cyano or
C(0)R62; R8 is hydrogen or C--C4alkoxy; R9 and R90 are each independently Cx-C4alkyl; R10 is hydrogen or C1-C3alkyl; R13, R24 and R36 are each independently hydrogen or chlorine ; R23 is NRS3R64; R34 is C1-C3haloalkyl;
R37 is C2-C4alkoxyalkyl;
R38 and R39 are each independently C1-C3haloalkyl, C--C3alkyl or propargyl; R40, R41 and R42 are each independently hydrogen, C(0)RS6, C(S)R67, C02Rε8, C(=NOR69) ,
Cx-C3alkyl optionally substituted with any combination of one or two halogen atoms, one or two C1-C3alkoxy groups, one or two C1-C3haloalkoxy groups, one S02R72 group, one or two cyano groups, one C3-C5cycloalkyl group, one OS02R73 group, one C(0)R74 group, one C02R7E group, one C(0)SR7ε group, one C(0)NR77R78 group, one to two 0R79 groups, one P(O) (OR80)2 group, one 1,3- dioxolane group or one 1,3 -dioxane group, or phenyl optionally substituted with any combination of one halogen atom, one or two methyl groups, one methoxy group, one halomethyl group or one OR83 group; R43/ R44/ R47 and R48 are each independently hydrogen or methyl, or R43 and R44 or R47 and R48 may be taken together with the atom to which they are attached to form a cyclopropyl group; R49, R50 and R8g are each independently Cx-C4alkyl or NR93R94;
R5I/ K-52' "S3' "54' ^55' ^58' ^60' ^61' ^62' ^73' "74' "78 a R87 are each independently hydrogen, C1-C4alkyl or Cx-C4halo- alkyl ,- R79 and R83 are each independently hydrogen, C(0)R85,
S02R86, C1-C4haloalkyl, C3-C4alkenyl or
C1-C3alkyl substituted with one OC(0)R87,
C02R88, C(0)R89, C(OR90)2 or cyano group; R93 and R94 are each independently hydrogen or C--C8alkyl; p is 0, 1 or 2; Z and Zx are the same and represent methyl or ethyl; and Z2 is methyl or ethyl .
42. The process according to claim 28 for the preparation of a 6- (trifluoromethyl) uracil compound having the structural formula IX
(IX)
wherein
Z3 is hydrogen or methyl;
X5 is hydrogen or halogen,-
R40 is hydrogen, C(0)Rεε, C(S)R67, C02R68,
C1-C3alkyl optionally substituted with any combination of one or two halogen atoms, one or two Cx-C3alkoxy groups, one or two C1-C3haloalkoxy groups, one S02R72 group, one or two cyano groups, one C3-C5cycloalkyl group, one OS02R73 group, one or two OR79 groups, one P(O) (OR80)2 group, one 1, 3-dioxolane group or one 1,3-dioxane group, or phenyl optionally substituted with any combination of one halogen atom, one or two methyl groups, one methoxy group, one halomethyl group or one
OR83 group ;
R, 66 ' R 67 ' R85 and R89 are each independently hydrogen,
Cx-C4alkyl or NRsεR, 57 '
R56 is S02R49 ; R57 is hydrogen or C1-C4alkyl;
R49 and R86 are each independently Cx-C4alkyl or NR93R94; R93 and R94 are each independently hydrogen or Cx-C8alkyl; R68 and R88 are each independently hydrogen, C3-C6alkenyl or
Cx-C4alkyl optionally substituted with C02RS4, morpholine or C(0)RS5; R 54' R s5' Rso' Rei' R73 and R 87 are each independently hydrogen, Cx-C4alkyl or C1-C4haloalkyl; R72 is NRggRg! or indazole; R79 and R83 are each independently hydrogen C(0)R85, S02R86,
C1-C4haloalkyl, C3-C4alkenyl or
C1-C3alkyl substituted with one OC(0)R87, C02R88, C(0)R89, C(OR90)2 or cyano group; R80 is hydrogen or methyl; and R90 is Cx-C4alkyl.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020017010391A KR20020000140A (en) | 1999-02-16 | 2000-02-14 | Processes And Intermediates For The Preparation Of 1,3-Oxazin-6-ones And Uracils |
| EP00906032A EP1169308A1 (en) | 1999-02-16 | 2000-02-14 | Processes and intermediates for the preparation of 1,3-oxazin-6-ones and uracils |
| JP2000599742A JP4619542B2 (en) | 1999-02-16 | 2000-02-14 | Processes and intermediates for the preparation of 1,3-oxazin-6-ones and uracils |
| MXPA01008188A MXPA01008188A (en) | 1999-02-16 | 2000-02-14 | Processes and intermediates for the preparation of 1,3-oxazin-6-ones and uracils. |
| IL14477600A IL144776A0 (en) | 1999-02-16 | 2000-02-14 | Processes and intermediates for the preparation of 1,3-oxazin-6-ones and uracils |
| AU27598/00A AU2759800A (en) | 1999-02-16 | 2000-02-14 | Processes and intermediates for the preparation of 1,3-oxazin-6-ones and uracils |
| CA002364281A CA2364281A1 (en) | 1999-02-16 | 2000-02-14 | Processes and intermediates for the preparation of 1,3-oxazin-6-ones and uracils |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25066099A | 1999-02-16 | 1999-02-16 | |
| US09/250,660 | 1999-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2000049002A1 true WO2000049002A1 (en) | 2000-08-24 |
Family
ID=22948652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2000/003731 WO2000049002A1 (en) | 1999-02-16 | 2000-02-14 | Processes and intermediates for the preparation of 1,3-oxazin-6-ones and uracils |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1169308A1 (en) |
| JP (1) | JP4619542B2 (en) |
| KR (1) | KR20020000140A (en) |
| CN (1) | CN1344259A (en) |
| AU (1) | AU2759800A (en) |
| CA (1) | CA2364281A1 (en) |
| CZ (1) | CZ20012948A3 (en) |
| HU (1) | HUP0201942A3 (en) |
| IL (1) | IL144776A0 (en) |
| MX (1) | MXPA01008188A (en) |
| WO (1) | WO2000049002A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017202768A1 (en) | 2016-05-24 | 2017-11-30 | Basf Se | Herbicidal uracilpyrid |
| WO2019101533A1 (en) | 2017-11-27 | 2019-05-31 | Basf Se | Crystalline forms of ethyl 2-[[3-[[3-chloro-5-fluoro-6-[3-methyl-2,6-dioxo-4-(trifluoromethyl)pyrimidin-1-yl]-2-pyridyl]oxy]-2-pyridyl]oxy]acetate |
| EP4230621A1 (en) | 2022-02-22 | 2023-08-23 | Bayer AG | Substituted n-benzoic acid uracils, their salts and use of said compounds as herbicidal agents |
| EP4230620A1 (en) | 2022-02-22 | 2023-08-23 | Bayer Aktiengesellschaft | Substituted n-amino-n-benzoic acid uracils, their salts and use of said compounds as herbicidal agents |
| WO2023161172A1 (en) | 2022-02-22 | 2023-08-31 | Bayer Aktiengesellschaft | Substituted n-benzoic acid uracils and salts thereof, and use thereof as herbicidal active substances |
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| CN105330654A (en) * | 2015-11-01 | 2016-02-17 | 许自协 | Compound for inhibiting growth of white rust bacteria of sunflowers |
| CN105211078A (en) * | 2015-11-01 | 2016-01-06 | 许自协 | A kind of compound suppressing larch pin spoting disease bacteria growing |
| CN105211079A (en) * | 2015-11-02 | 2016-01-06 | 许自协 | A kind of compound suppressing brown stem rot bacteria growing |
| CN105165848A (en) * | 2015-11-02 | 2015-12-23 | 许自协 | Compound for inhibiting growth of banana bacterial wilt |
| CN105165849A (en) * | 2015-11-02 | 2015-12-23 | 许自协 | Compound for inhibiting growth of tilletia controversa kuhn |
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| DE19750195A1 (en) * | 1997-11-13 | 1999-05-20 | Bayer Ag | Production of aryl and aralkyl substituted uracil derivatives useful as herbicides |
| EP0985670A1 (en) * | 1998-08-13 | 2000-03-15 | American Cyanamid Company | 1-(3-Heterocyclylphenyl)isothiourea, -isourea, -guanidine and -amidine compounds as herbicides |
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2000
- 2000-02-14 HU HU0201942A patent/HUP0201942A3/en unknown
- 2000-02-14 CZ CZ20012948A patent/CZ20012948A3/en unknown
- 2000-02-14 IL IL14477600A patent/IL144776A0/en unknown
- 2000-02-14 WO PCT/US2000/003731 patent/WO2000049002A1/en not_active Application Discontinuation
- 2000-02-14 JP JP2000599742A patent/JP4619542B2/en not_active Expired - Fee Related
- 2000-02-14 EP EP00906032A patent/EP1169308A1/en not_active Withdrawn
- 2000-02-14 MX MXPA01008188A patent/MXPA01008188A/en unknown
- 2000-02-14 CA CA002364281A patent/CA2364281A1/en not_active Abandoned
- 2000-02-14 KR KR1020017010391A patent/KR20020000140A/en not_active Application Discontinuation
- 2000-02-14 CN CN00805231A patent/CN1344259A/en active Pending
- 2000-02-14 AU AU27598/00A patent/AU2759800A/en not_active Abandoned
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017202768A1 (en) | 2016-05-24 | 2017-11-30 | Basf Se | Herbicidal uracilpyrid |
| WO2019101533A1 (en) | 2017-11-27 | 2019-05-31 | Basf Se | Crystalline forms of ethyl 2-[[3-[[3-chloro-5-fluoro-6-[3-methyl-2,6-dioxo-4-(trifluoromethyl)pyrimidin-1-yl]-2-pyridyl]oxy]-2-pyridyl]oxy]acetate |
| EP4230621A1 (en) | 2022-02-22 | 2023-08-23 | Bayer AG | Substituted n-benzoic acid uracils, their salts and use of said compounds as herbicidal agents |
| EP4230620A1 (en) | 2022-02-22 | 2023-08-23 | Bayer Aktiengesellschaft | Substituted n-amino-n-benzoic acid uracils, their salts and use of said compounds as herbicidal agents |
| WO2023161172A1 (en) | 2022-02-22 | 2023-08-31 | Bayer Aktiengesellschaft | Substituted n-benzoic acid uracils and salts thereof, and use thereof as herbicidal active substances |
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA01008188A (en) | 2003-07-21 |
| JP2002537289A (en) | 2002-11-05 |
| KR20020000140A (en) | 2002-01-04 |
| IL144776A0 (en) | 2002-06-30 |
| CN1344259A (en) | 2002-04-10 |
| CZ20012948A3 (en) | 2002-07-17 |
| HUP0201942A3 (en) | 2002-12-28 |
| HUP0201942A2 (en) | 2002-09-28 |
| JP4619542B2 (en) | 2011-01-26 |
| EP1169308A1 (en) | 2002-01-09 |
| CA2364281A1 (en) | 2000-08-24 |
| AU2759800A (en) | 2000-09-04 |
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