WO2000047560A3 - Process for the preparation of asymmetrical 1,4-dihydro-pyridine-dicarboxylic acid esters - Google Patents

Process for the preparation of asymmetrical 1,4-dihydro-pyridine-dicarboxylic acid esters Download PDF

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Publication number
WO2000047560A3
WO2000047560A3 PCT/HU2000/000012 HU0000012W WO0047560A3 WO 2000047560 A3 WO2000047560 A3 WO 2000047560A3 HU 0000012 W HU0000012 W HU 0000012W WO 0047560 A3 WO0047560 A3 WO 0047560A3
Authority
WO
WIPO (PCT)
Prior art keywords
stands
asymmetrical
dihydro
pyridine
preparation
Prior art date
Application number
PCT/HU2000/000012
Other languages
French (fr)
Other versions
WO2000047560A2 (en
Inventor
Daniel Bozsing
Lax Gyoergyi Kovanyine
Gyula Simig
Peter Toempe
Gabor Blasko
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Daniel Bozsing
Lax Gyoergyi Kovanyine
Gyula Simig
Peter Toempe
Gabor Blasko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Daniel Bozsing, Lax Gyoergyi Kovanyine, Gyula Simig, Peter Toempe, Gabor Blasko filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to AU28195/00A priority Critical patent/AU2819500A/en
Publication of WO2000047560A2 publication Critical patent/WO2000047560A2/en
Publication of WO2000047560A3 publication Critical patent/WO2000047560A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The invention relates to an improved process for the preparation of asymmetrical 1,4-dihydro-pyridine-dicarboxylic acid esters of general Formula (I) (wherein R?1 and R2¿ each stands for lower alkyl or an ethyl group substituted by methosy or cyano, with the proviso that R?1 and R2¿ are different; R¿3? stands for lower alkyl optionally substituted by hydroxy or halogen, or a benzyloxymethyl group or a group of the general Formula -CH2-O-CH2-CH2-X; X stands for halogen, azido or -NR?4R5; R4 and R5¿ are identical or different and each stands for hydrogen or lower alkyl, or R?4 and R5¿ together with the nitrogen atom, they are attached to, form a phthaloyl group; A is nitro or halogen and n is 1 or 2).
PCT/HU2000/000012 1999-02-15 2000-02-15 Process for the preparation of asymmetrical 1,4-dihydro-pyridine-dicarboxylic acid esters WO2000047560A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU28195/00A AU2819500A (en) 1999-02-15 2000-02-15 Process for the preparation of asymmetrical 1,4-dihydro-pyridine-dicarboxylic acid esters

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9900353A HUP9900353A3 (en) 1999-02-15 1999-02-15 Process for producing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acids
HUP9900353 1999-02-15

Publications (2)

Publication Number Publication Date
WO2000047560A2 WO2000047560A2 (en) 2000-08-17
WO2000047560A3 true WO2000047560A3 (en) 2000-11-02

Family

ID=89997785

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2000/000012 WO2000047560A2 (en) 1999-02-15 2000-02-15 Process for the preparation of asymmetrical 1,4-dihydro-pyridine-dicarboxylic acid esters

Country Status (3)

Country Link
AU (1) AU2819500A (en)
HU (1) HUP9900353A3 (en)
WO (1) WO2000047560A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1975167A1 (en) 2007-03-30 2008-10-01 Esteve Quimica, S.A. Acetone solvate of phthaloyl amlodipine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3907508A1 (en) * 1988-03-08 1989-09-21 Egyt Gyogyszervegyeszeti Gyar PROCESS AND INTERMEDIATE PRODUCTS, IF N N SUBSTITUTED, (2- (NITRO) -PHENYL) METHYLENIMINE FOR THE PRODUCTION OF 1,4-DI- (HYDRO) -2,6-DI- (METHYL) -4- (2 '- ( NITRO) -PHENYL) -PYRIDINE-3,5-DI- (CARBONIC ACID DIMETHYL ESTER) AND METHOD FOR PRODUCING THIS INTERMEDIATE PRODUCTS
EP0534520A2 (en) * 1991-09-13 1993-03-31 Merck & Co. Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3907508A1 (en) * 1988-03-08 1989-09-21 Egyt Gyogyszervegyeszeti Gyar PROCESS AND INTERMEDIATE PRODUCTS, IF N N SUBSTITUTED, (2- (NITRO) -PHENYL) METHYLENIMINE FOR THE PRODUCTION OF 1,4-DI- (HYDRO) -2,6-DI- (METHYL) -4- (2 '- ( NITRO) -PHENYL) -PYRIDINE-3,5-DI- (CARBONIC ACID DIMETHYL ESTER) AND METHOD FOR PRODUCING THIS INTERMEDIATE PRODUCTS
EP0534520A2 (en) * 1991-09-13 1993-03-31 Merck & Co. Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LEVAI, L. ET AL: "Nucleophilic substitution in the azomethine series: an improved synthesis of 1,4- dihydropyridines", SYNTH. COMMUN. (1992), 22(1), 47-61, XP000929356 *

Also Published As

Publication number Publication date
AU2819500A (en) 2000-08-29
HUP9900353A2 (en) 2001-03-28
HU9900353D0 (en) 1999-04-28
WO2000047560A2 (en) 2000-08-17
HUP9900353A3 (en) 2002-01-28

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