WO2000045857A3 - Metallmakrozyklen für zweischritt-strahlentherapieformen - Google Patents

Metallmakrozyklen für zweischritt-strahlentherapieformen Download PDF

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Publication number
WO2000045857A3
WO2000045857A3 PCT/EP2000/000473 EP0000473W WO0045857A3 WO 2000045857 A3 WO2000045857 A3 WO 2000045857A3 EP 0000473 W EP0000473 W EP 0000473W WO 0045857 A3 WO0045857 A3 WO 0045857A3
Authority
WO
WIPO (PCT)
Prior art keywords
radiotherapy
step forms
meaning
metal macrocycles
macrocycles
Prior art date
Application number
PCT/EP2000/000473
Other languages
English (en)
French (fr)
Other versions
WO2000045857A2 (de
Inventor
Ruediger Lawaczeck
Johannes Platzek
Bernd Raduechel
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Priority to AU26658/00A priority Critical patent/AU2665800A/en
Publication of WO2000045857A2 publication Critical patent/WO2000045857A2/de
Publication of WO2000045857A3 publication Critical patent/WO2000045857A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0085—Mossbauer effect therapy based on mossbauer effect of a material, i.e. re-emission of gamma rays after absorption of gamma rays by the material; selective radiation therapy, i.e. involving re-emission of ionizing radiation upon exposure to a first ionizing radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Es wird die Verwendung von mindestens einer physiologisch verträglichen Verbindung der allgemeinen Formel (I), worin U für -CH2-CH(OH)-CH2- oder -CHR-CO-NH-(CH2)n-CO mit R in der Bedeutung eines Wasserstoffatoms oder einer Methylgruppe und n in der Bedeutung der Ziffern 1 bis 10, und T für einen tumorspezifischen Rest biologischen oder synthetischen Ursprungs stehen, für die Herstellung von Präparaten für die Neutroneneinfang- und Photonenaktivierungstherapie beschrieben.
PCT/EP2000/000473 1999-02-01 2000-01-21 Metallmakrozyklen für zweischritt-strahlentherapieformen WO2000045857A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU26658/00A AU2665800A (en) 1999-02-01 2000-01-21 Metal macrocycles for two-step forms of radiotherapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19905094.5 1999-02-01
DE1999105094 DE19905094C1 (de) 1999-02-01 1999-02-01 Gadolinium (III)-Komplexe sowie ihre Verwendung für Zweischritt Strahlentherapieformen und diese enthaltende pharmazeutische Mittel

Publications (2)

Publication Number Publication Date
WO2000045857A2 WO2000045857A2 (de) 2000-08-10
WO2000045857A3 true WO2000045857A3 (de) 2001-04-05

Family

ID=7896791

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/000473 WO2000045857A2 (de) 1999-02-01 2000-01-21 Metallmakrozyklen für zweischritt-strahlentherapieformen

Country Status (3)

Country Link
AU (1) AU2665800A (de)
DE (1) DE19905094C1 (de)
WO (1) WO2000045857A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739313A (en) 1995-11-13 1998-04-14 Regents Of The University Of Minnesota Radionuclide labeling of vitamin B12 and coenzymes thereof
KR20020032421A (ko) * 1999-04-16 2002-05-03 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 항암제로서 유용한 코발라민 컨쥬게이트
US7591995B2 (en) 1999-10-15 2009-09-22 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
EP1239887A1 (de) 1999-10-15 2002-09-18 Mayo Foundation For Medical Education And Research Cobalamin-konjugate geeignet zur verwendung wie bilderzeugungs- oder therapeutische mitteln
AU2002239719A1 (en) * 2000-10-25 2002-06-03 Mayo Foundation For Medical Education And Research Transcobalamin receptor binding conjugates for neutron capture therapy
EP1754712A3 (de) * 2000-10-25 2009-01-14 Mayo Foundation For Medical Education And Research Transcobalamin-bindende Konjugate zur Behandlung abnormaler zellulärer Proliferation
EP1334114A2 (de) * 2000-10-25 2003-08-13 Mayo Foundation For Medical Education And Research Transcobalamin-bindende konjugate zur behandlung abnormaler zellulärer proliferation
DE10135355C1 (de) * 2001-07-20 2003-04-17 Schering Ag Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie
WO2003026674A1 (en) * 2001-09-28 2003-04-03 Mayo Foundation For Medical Education And Research Coadministration of transport protein with conjugated cobalamin to deliver agents
US20030176326A1 (en) * 2002-03-15 2003-09-18 Ceramoptec Industries Inc. Photosensitzers for photodynamic therapy of microbial infections
US9050378B2 (en) 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
WO2006014530A2 (en) * 2004-07-07 2006-02-09 The General Hospital Corporation Imaging of enzyme activity
US20080305049A1 (en) * 2005-01-31 2008-12-11 Hadassa Degani Mri Contrast Agents for Diagnosis and Prognosis of Tumors
SE528407C2 (sv) 2005-08-19 2006-11-07 Hammercap Ab Borföreningar användbara vid BNCT
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
CN109867635A (zh) * 2019-02-14 2019-06-11 华东师范大学 一种t1型胶束磁共振成像造影剂及其制备方法
CN112358494B (zh) * 2020-04-09 2021-09-28 南京大学 一种基于吖啶的碳硼烷衍生物及其在生物显影中的应用
CN112442095B (zh) * 2020-12-01 2022-07-22 上海科黛生物科技有限公司 一种维生素b12的精制方法及所得产品的应用

Citations (9)

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Publication number Priority date Publication date Assignee Title
EP0240990A2 (de) * 1985-03-19 1987-10-14 Randell L. Mills Verfahren und Vorrichtung zur selektiven Bestrahlung von biologischen Materialien
WO1988009152A1 (en) * 1985-03-19 1988-12-01 Mills Randell L Apparatus providing diagnosis and selective tissue necrosis
WO1989000062A1 (en) * 1987-07-07 1989-01-12 The Cancer Institute Board Radiotherapy
WO1989010758A1 (en) * 1988-05-02 1989-11-16 Zynaxis Technologies, Inc. Compounds, compositions and method for binding bio-affecting substances to surface membranes of bio-particles
WO1991001144A1 (en) * 1989-07-20 1991-02-07 Sandoz Ltd Labeled polypeptide derivatives
CA2005039A1 (en) * 1989-12-08 1991-06-08 Randell L. Mills Pharmaceuticals and apparatus providing diagnosis and selective tissue necrosis
US5286853A (en) * 1992-09-11 1994-02-15 Boron Biologicals, Inc. Boron-gadolinium compounds and method of conducting imaging and/or neutron capture therapy with same
WO1998024775A1 (de) * 1996-12-04 1998-06-11 Schering Aktiengesellschaft Verfahren zur herstellung von metallkomplexcarbonsäureamiden
WO1999029302A1 (en) * 1997-12-05 1999-06-17 Katarina Edwards Drug delivery system with two-step targeting

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240990A2 (de) * 1985-03-19 1987-10-14 Randell L. Mills Verfahren und Vorrichtung zur selektiven Bestrahlung von biologischen Materialien
WO1988009152A1 (en) * 1985-03-19 1988-12-01 Mills Randell L Apparatus providing diagnosis and selective tissue necrosis
WO1989000062A1 (en) * 1987-07-07 1989-01-12 The Cancer Institute Board Radiotherapy
WO1989010758A1 (en) * 1988-05-02 1989-11-16 Zynaxis Technologies, Inc. Compounds, compositions and method for binding bio-affecting substances to surface membranes of bio-particles
WO1991001144A1 (en) * 1989-07-20 1991-02-07 Sandoz Ltd Labeled polypeptide derivatives
CA2005039A1 (en) * 1989-12-08 1991-06-08 Randell L. Mills Pharmaceuticals and apparatus providing diagnosis and selective tissue necrosis
US5286853A (en) * 1992-09-11 1994-02-15 Boron Biologicals, Inc. Boron-gadolinium compounds and method of conducting imaging and/or neutron capture therapy with same
WO1998024775A1 (de) * 1996-12-04 1998-06-11 Schering Aktiengesellschaft Verfahren zur herstellung von metallkomplexcarbonsäureamiden
WO1999029302A1 (en) * 1997-12-05 1999-06-17 Katarina Edwards Drug delivery system with two-step targeting

Non-Patent Citations (6)

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Title
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MILLS, RANDELL L.: "Pharmaceuticals and apparatus based on Moessbauer isotopic resonant absorption of.gamma. emission (MIRAGE) providing diagnosis and selective tissue necrosis", XP002148584, retrieved from STN Database accession no. 116:37120 *
JONO, KAORI ET AL: "Preparation of lecithin microcapsules by a dilution method using the Wurster process for intraarterial administration in gadolinium neutron capture therapy", CHEM. PHARM. BULL. (1999), 47(1), 54-63, XP000801702 *
MEHTA S C ET AL: "TARGETED DRUG DELIVERY FOR BORON NEUTRON CAPTURE THERAPY", PHARMACEUTICAL RESEARCH,US,NEW YORK, NY, vol. 13, no. 3, March 1996 (1996-03-01), pages 344 - 351, XP000874361, ISSN: 0724-8741 *
MIYAMOTO M ET AL: "DESIGN AND PREPARATION OF GADOLINIUM-RESERVOIR MICROCAPSULES FOR NEUTRON-CAPTURE THERAPY BY MEANS OF THE WURSTER PROCESS", CHEMICAL AND PHARMACEUTICAL BULLETIN,JP,PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, vol. 45, no. 12, 1 December 1997 (1997-12-01), pages 2043 - 2050, XP000731370, ISSN: 0009-2363 *
R. LAWACZECK: "BIMODALE TUMORTHEAPIEN-PHOTONEN- UND NEUTRONENAKTIVERUNG", KLINISCHE NEURORADIOLOGIE, vol. 5, no. 1, 1995, pages 39 - 45, XP002148581 *
TOKUMITSU, HIROYUKI ET AL: "Preparation of gadopentetic acid-loaded chitosan microparticles for gadolinium neutron - capture therapy of cancer by a novel emulsion-droplet coalescence technique", CHEM. PHARM. BULL. (1999), 47(6), 838-842, XP000834009 *

Also Published As

Publication number Publication date
WO2000045857A2 (de) 2000-08-10
AU2665800A (en) 2000-08-25
DE19905094C1 (de) 2000-10-12

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