WO2000044363A3 - Desmethylsildenafil compositions and uses for treating angina and erectile dysfunctions - Google Patents

Desmethylsildenafil compositions and uses for treating angina and erectile dysfunctions Download PDF

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Publication number
WO2000044363A3
WO2000044363A3 PCT/US2000/001470 US0001470W WO0044363A3 WO 2000044363 A3 WO2000044363 A3 WO 2000044363A3 US 0001470 W US0001470 W US 0001470W WO 0044363 A3 WO0044363 A3 WO 0044363A3
Authority
WO
WIPO (PCT)
Prior art keywords
desmethylsildenafil
compositions
treating angina
erectile dysfunctions
sildenafil
Prior art date
Application number
PCT/US2000/001470
Other languages
French (fr)
Other versions
WO2000044363A2 (en
Inventor
William E Yelle
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Priority to AU33473/00A priority Critical patent/AU3347300A/en
Publication of WO2000044363A2 publication Critical patent/WO2000044363A2/en
Publication of WO2000044363A3 publication Critical patent/WO2000044363A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Methods and compositions are disclosed utilizing desmethylsildenafil for the treatment of sexual dysfunction in humans. Desmethylsildenafil exhibits a lessened liability toward drug-drug interactions than sildenafil and a more predictable dosing regimen than sildenafil. Desmethylsildenafil is also useful for the treatment of angina, hypertension, heart failure or atherosclerosis.
PCT/US2000/001470 1999-01-28 2000-01-21 Desmethylsildenafil compositions and uses for treating angina and erectile dysfunctions WO2000044363A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33473/00A AU3347300A (en) 1999-01-28 2000-01-21 Desmethylsildenafil compositions and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11761199P 1999-01-28 1999-01-28
US60/117,611 1999-01-28

Publications (2)

Publication Number Publication Date
WO2000044363A2 WO2000044363A2 (en) 2000-08-03
WO2000044363A3 true WO2000044363A3 (en) 2001-08-23

Family

ID=22373861

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/001470 WO2000044363A2 (en) 1999-01-28 2000-01-21 Desmethylsildenafil compositions and uses for treating angina and erectile dysfunctions

Country Status (2)

Country Link
AU (1) AU3347300A (en)
WO (1) WO2000044363A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT512084A1 (en) 2011-10-20 2013-05-15 Univ Wien Tech DIAZABICYCLO AND DIAZASPIRO ALKAN DERIVATIVES AS PHOSPHODIESTERASE-5 INHIBITORS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463756A1 (en) * 1990-06-20 1992-01-02 Pfizer Limited Pyrazolopyrimidinone antianginal agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463756A1 (en) * 1990-06-20 1992-01-02 Pfizer Limited Pyrazolopyrimidinone antianginal agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BR. J. CLIN. PHARMACOL., vol. 42, no. 2, 1996, pages 268p, XP000950005 *

Also Published As

Publication number Publication date
AU3347300A (en) 2000-08-18
WO2000044363A2 (en) 2000-08-03

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