WO2000043028A2 - Method of treating chronic cardiac disease - Google Patents

Method of treating chronic cardiac disease Download PDF

Info

Publication number
WO2000043028A2
WO2000043028A2 PCT/US2000/001515 US0001515W WO0043028A2 WO 2000043028 A2 WO2000043028 A2 WO 2000043028A2 US 0001515 W US0001515 W US 0001515W WO 0043028 A2 WO0043028 A2 WO 0043028A2
Authority
WO
WIPO (PCT)
Prior art keywords
cardiac disease
bpi
chronic cardiac
chronic
bpi protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/001515
Other languages
English (en)
French (fr)
Other versions
WO2000043028A9 (en
WO2000043028A3 (en
Inventor
Brett P. Giroir
Patrick J. Scannon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Xoma Technology Ltd USA
University of Texas at Austin
Original Assignee
University of Texas System
Xoma Technology Ltd USA
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002359681A priority Critical patent/CA2359681A1/en
Application filed by University of Texas System, Xoma Technology Ltd USA, University of Texas at Austin filed Critical University of Texas System
Priority to AT00905696T priority patent/ATE239492T1/de
Priority to DE60002552T priority patent/DE60002552T2/de
Priority to AU27341/00A priority patent/AU778001B2/en
Priority to EP00905696A priority patent/EP1143996B1/en
Priority to MXPA01007031A priority patent/MXPA01007031A/es
Priority to NZ513087A priority patent/NZ513087A/xx
Priority to JP2000594481A priority patent/JP2002535282A/ja
Publication of WO2000043028A2 publication Critical patent/WO2000043028A2/en
Publication of WO2000043028A3 publication Critical patent/WO2000043028A3/en
Anticipated expiration legal-status Critical
Publication of WO2000043028A9 publication Critical patent/WO2000043028A9/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Definitions

  • Chronic congestive heart failure can result as a consequence of coronary artery disease, cardiomyopathy, myocarditis, aortic stenosis, hypertension, idiopathic asymmetrical septal hypertrophy, coarctation of the aorta, aortic regurgitation, mitral regurgitation, left-to-right shunts, hypertrophied muscle, pericardial tamponade, constrictive pericarditis, mitral stenosis, left atrial mzxoma, left atrial thrombus, cor triatriatum and numerous other conditions.
  • BPI protein products are also useful in antithrombotic methods, as described in U.S. Patent No. 5,741,779 and U.S. Application Serial No. 09/063,465 filed April 20, 1998 and corresponding WO 97/42967 (PCT US7/0801 ), all of which are incorporated herein by reference.
  • BPI fragments include biologically active molecules that have the same or similar amino acid sequence as a natural human BPI holoprotein, except that the fragment molecule lacks amino-terminal amino acids, internal amino acids, and/or carboxy-terminal amino acids of the holoprotein.
  • Nonlimiting examples of such fragments include an N-terminal fragment of natural human BPI of approximately 25 kD, described in Ooi et al., J. Exp. Med., 174:649 (1991 ), and the recombinant expression product of DNA encoding N-terminal amino acids from 1 to about 193 to 199 of natural human BPI, described in Gazzano-Santoro et al, Infect. Immun.
  • BPI protein products are preferably accomplished with a pharmaceutical composition comprising a BPI protein product and a pharmaceutically acceptable diluent, adjuvant, or carrier.
  • the BPI protein product may be administered without or in conjunction with known surfactants or other therapeutic agents.
  • Blood samples for the determination of LPS, LBP, and IL-6 were obtained prior to surgery and at 1, 8, 24, 48 and 72 hours after completion of cardiopulmonary bypass.
  • the pre-operative sample was obtained from a newly placed central venous catheter, immediately after the induction of anesthesia and endotracheal intubation.
  • blood samples were collected into heparinized VacutainerTM tubes (Becton-Dickson, Rutherford NJ) selected for low endotoxin content (BioWhitaker, Walkersville, MD), immediately placed on ice, and walked to the laboratory by an investigator. Platelet-rich plasma was obtained by centrifugation (180 x g, 10 min, 2-8°C). Samples were stored at -70°C until assay.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PCT/US2000/001515 1999-01-22 2000-01-21 Method of treating chronic cardiac disease Ceased WO2000043028A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2000594481A JP2002535282A (ja) 1999-01-22 2000-01-21 慢性心臓疾患を処置する方法
AT00905696T ATE239492T1 (de) 1999-01-22 2000-01-21 Verwendung von einem bpi protein zur herstellung eines medikamentes zur behandlung von chronischen herzerkrankungen
DE60002552T DE60002552T2 (de) 1999-01-22 2000-01-21 Verwendung von einem bpi protein zur herstellung eines medikamentes zur behandlung von chronischen herzerkrankungen
AU27341/00A AU778001B2 (en) 1999-01-22 2000-01-21 Method of treating chronic cardiac disease
EP00905696A EP1143996B1 (en) 1999-01-22 2000-01-21 Use of a bpi protein for the preparation of a medicament for treating chronic cardiac disease
CA002359681A CA2359681A1 (en) 1999-01-22 2000-01-21 Method of treating chronic cardiac disease
NZ513087A NZ513087A (en) 1999-01-22 2000-01-21 Bactericidal/permability -increasing protein (BPI) for treating chronic heart disease
MXPA01007031A MXPA01007031A (es) 1999-01-22 2000-01-21 Metodo para tratar enfermedades acrdiacas cronicas.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11673699P 1999-01-22 1999-01-22
US60/116,736 1999-01-22

Publications (3)

Publication Number Publication Date
WO2000043028A2 true WO2000043028A2 (en) 2000-07-27
WO2000043028A3 WO2000043028A3 (en) 2000-11-30
WO2000043028A9 WO2000043028A9 (en) 2001-09-20

Family

ID=22368911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/001515 Ceased WO2000043028A2 (en) 1999-01-22 2000-01-21 Method of treating chronic cardiac disease

Country Status (11)

Country Link
US (3) US6509317B1 (enExample)
EP (1) EP1143996B1 (enExample)
JP (2) JP2002535282A (enExample)
CN (1) CN1353614A (enExample)
AT (1) ATE239492T1 (enExample)
AU (1) AU778001B2 (enExample)
CA (1) CA2359681A1 (enExample)
DE (1) DE60002552T2 (enExample)
MX (1) MXPA01007031A (enExample)
NZ (1) NZ513087A (enExample)
WO (1) WO2000043028A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002055099A3 (en) * 2000-12-01 2002-12-27 Xoma Technology Ltd. Modulation of pericyte proliferation using bpi protein products or bpi inhibitors
US10450348B2 (en) 2013-11-06 2019-10-22 Norwegian University Of Science And Technology Antimicrobial agents and their use in therapy
US10517923B2 (en) 2013-11-06 2019-12-31 Norwegian University Of Science And Technology Immunosuppressive agents and their use in therapy

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062738A1 (en) * 2008-11-03 2010-06-03 Ut-Battelle, Llc Diagnosis and treatment of congenital heart defects using nell 1
US9974759B2 (en) * 2013-05-31 2018-05-22 Indiana University Research And Technology Corporation Beta 2 adrenoceptor antagonists for treating orthostatic hypotension
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643875A (en) 1994-01-24 1997-07-01 Friedmann; Nadav Human therapeutic uses of bactericidal/permeability increasing (BPI) protein products
US5578568A (en) 1994-04-22 1996-11-26 Xoma Corporation Method of treating conditions associated with intestinal ischemia/reperfusion
US5646114A (en) * 1994-07-11 1997-07-08 Xoma Corporation Anti-protozoan methods
DK0914144T3 (da) * 1996-05-10 2001-04-09 Univ Texas Terapeutiske anvendelser af BPI-protein-produkter til human meningokokæmi

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002055099A3 (en) * 2000-12-01 2002-12-27 Xoma Technology Ltd. Modulation of pericyte proliferation using bpi protein products or bpi inhibitors
US7291451B2 (en) 2000-12-01 2007-11-06 Xoma Technology Ltd. Modulation of pericyte proliferation
US10450348B2 (en) 2013-11-06 2019-10-22 Norwegian University Of Science And Technology Antimicrobial agents and their use in therapy
US10517923B2 (en) 2013-11-06 2019-12-31 Norwegian University Of Science And Technology Immunosuppressive agents and their use in therapy
US11246907B2 (en) 2013-11-06 2022-02-15 Norwegian University Of Science And Technology Immunosuppressive agents and their use in therapy
US11337427B2 (en) 2013-11-06 2022-05-24 Norwegian University Of Science And Technology Antimicrobial agents and their use in therapy

Also Published As

Publication number Publication date
JP2002535282A (ja) 2002-10-22
US6509317B1 (en) 2003-01-21
AU2734100A (en) 2000-08-07
DE60002552D1 (de) 2003-06-12
DE60002552T2 (de) 2004-02-26
EP1143996A2 (en) 2001-10-17
CA2359681A1 (en) 2000-07-27
EP1143996A4 (de) 2002-04-24
US20030216312A1 (en) 2003-11-20
CN1353614A (zh) 2002-06-12
WO2000043028A9 (en) 2001-09-20
JP2007126479A (ja) 2007-05-24
AU778001B2 (en) 2004-11-11
US20060171937A1 (en) 2006-08-03
ATE239492T1 (de) 2003-05-15
MXPA01007031A (es) 2004-08-12
EP1143996B1 (en) 2003-05-07
NZ513087A (en) 2003-02-28
WO2000043028A3 (en) 2000-11-30
US7045501B2 (en) 2006-05-16

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