WO2000041472A3 - Binding partners for 5-ht5-receptors for the treatment of migraine - Google Patents

Binding partners for 5-ht5-receptors for the treatment of migraine Download PDF

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Publication number
WO2000041472A3
WO2000041472A3 PCT/EP2000/000142 EP0000142W WO0041472A3 WO 2000041472 A3 WO2000041472 A3 WO 2000041472A3 EP 0000142 W EP0000142 W EP 0000142W WO 0041472 A3 WO0041472 A3 WO 0041472A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding partners
migraine
receptors
treatment
methods
Prior art date
Application number
PCT/EP2000/000142
Other languages
German (de)
French (fr)
Other versions
WO2000041472A2 (en
Inventor
Francisco Javier Garcia-Ladona
Original Assignee
Knoll Ag
Garcia Ladona Francisco Javier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag, Garcia Ladona Francisco Javier filed Critical Knoll Ag
Priority to CA2359360A priority Critical patent/CA2359360C/en
Priority to AU22891/00A priority patent/AU2289100A/en
Priority to MXPA01006986A priority patent/MXPA01006986A/en
Priority to EP00901526A priority patent/EP1144050A2/en
Priority to JP2000593096A priority patent/JP2002540063A/en
Publication of WO2000041472A2 publication Critical patent/WO2000041472A2/en
Publication of WO2000041472A3 publication Critical patent/WO2000041472A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to selective binding partners for 5-HT5-receptors, methods, in particular screening methods, for identifying and characterizing such binding partners, as well as pharmaceutical compositions containing said binding partners and their use in the treatment of cerebrovascular diseases such as migraine.
PCT/EP2000/000142 1999-01-11 2000-01-11 Binding partners for 5-ht5-receptors for the treatment of migraine WO2000041472A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2359360A CA2359360C (en) 1999-01-11 2000-01-11 In vitro screening method for identifying selective binding partners for 5-ht5-receptors
AU22891/00A AU2289100A (en) 1999-01-11 2000-01-11 Binding partners for 5-ht5-receptors for the treatment of migraine
MXPA01006986A MXPA01006986A (en) 1999-01-11 2000-01-11 Binding partners for 5-ht5-receptors for the treatment of migraine.
EP00901526A EP1144050A2 (en) 1999-01-11 2000-01-11 Binding partners for 5-ht5-receptors for the treatment of migraine
JP2000593096A JP2002540063A (en) 1999-01-11 2000-01-11 Binding partner for 5-HT5 receptor for migraine treatment

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19900674A DE19900674A1 (en) 1999-01-11 1999-01-11 Binding partner for 5-HT5 receptors for migraine treatment
DE19900674.1 1999-01-11

Publications (2)

Publication Number Publication Date
WO2000041472A2 WO2000041472A2 (en) 2000-07-20
WO2000041472A3 true WO2000041472A3 (en) 2001-10-11

Family

ID=7893919

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/000142 WO2000041472A2 (en) 1999-01-11 2000-01-11 Binding partners for 5-ht5-receptors for the treatment of migraine

Country Status (8)

Country Link
EP (1) EP1144050A2 (en)
JP (1) JP2002540063A (en)
CN (1) CN1321635C (en)
AU (1) AU2289100A (en)
CA (1) CA2359360C (en)
DE (1) DE19900674A1 (en)
MX (1) MXPA01006986A (en)
WO (1) WO2000041472A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004008141A1 (en) 2004-02-19 2005-09-01 Abbott Gmbh & Co. Kg Guanidine compounds and their use as binding partners for 5-HT5 receptors
WO2007022947A2 (en) 2005-08-21 2007-03-01 Abbott Gmbh & Co. Kg 5-ring heteroaromatic compounds and their use as binding partners for 5-ht5 receptors
US9296697B2 (en) 2005-08-24 2016-03-29 Abbott Laboratories Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2105192A (en) * 1981-08-27 1983-03-23 Shaun R Coughlin Composition for use in treating atherosclerosis
WO1994001555A1 (en) * 1992-07-01 1994-01-20 Institut National De La Sante Et De La Recherche Medicale (Inserm) Polypeptides having serotoninergique activity (5ht5a), nucleic acids coding for these polypeptides and uses thereof
WO1994018319A1 (en) * 1993-02-09 1994-08-18 Institut National De La Sante Et De La Recherche Medicale Novel polypeptides having serotoninergic receptor activity, nucleic acids coding therefor and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360735A (en) * 1992-01-08 1994-11-01 Synaptic Pharmaceutical Corporation DNA encoding a human 5-HT1F receptor, vectors, and host cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2105192A (en) * 1981-08-27 1983-03-23 Shaun R Coughlin Composition for use in treating atherosclerosis
WO1994001555A1 (en) * 1992-07-01 1994-01-20 Institut National De La Sante Et De La Recherche Medicale (Inserm) Polypeptides having serotoninergique activity (5ht5a), nucleic acids coding for these polypeptides and uses thereof
WO1994018319A1 (en) * 1993-02-09 1994-08-18 Institut National De La Sante Et De La Recherche Medicale Novel polypeptides having serotoninergic receptor activity, nucleic acids coding therefor and use thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Martindale", PHARMACEUTICAL PRESS, LONDON, XP002140026, 1993 *
CARSON: "the 5ht5a...", GLIA, vol. 17, no. 4, 1996, pages 317 - 326, XP000913723 *
See also references of EP1144050A2 *
SHIMRON: "human 5ht5...", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 233, no. 1, 1997, pages 6 - 9, XP000907456 *
WEISS: "expression of...", METHODS IN MOLECULAR BIOLOGY, vol. 103, 1998, pages 227 - 239, XP002140017 *

Also Published As

Publication number Publication date
CN1342070A (en) 2002-03-27
CN1321635C (en) 2007-06-20
CA2359360A1 (en) 2000-07-20
EP1144050A2 (en) 2001-10-17
MXPA01006986A (en) 2002-09-18
JP2002540063A (en) 2002-11-26
CA2359360C (en) 2012-11-27
WO2000041472A2 (en) 2000-07-20
AU2289100A (en) 2000-08-01
DE19900674A1 (en) 2000-07-13

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