WO2000040759A3 - Uses of flavivirus rna-dependent rna polymerases - Google Patents

Uses of flavivirus rna-dependent rna polymerases Download PDF

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Publication number
WO2000040759A3
WO2000040759A3 PCT/US2000/000152 US0000152W WO0040759A3 WO 2000040759 A3 WO2000040759 A3 WO 2000040759A3 US 0000152 W US0000152 W US 0000152W WO 0040759 A3 WO0040759 A3 WO 0040759A3
Authority
WO
WIPO (PCT)
Prior art keywords
rna
flavivirus
polymerases
dependent
dependent rna
Prior art date
Application number
PCT/US2000/000152
Other languages
French (fr)
Other versions
WO2000040759A9 (en
WO2000040759A2 (en
Inventor
C Cheng Kao
Original Assignee
Advanced Res & Tech Inst
C Cheng Kao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Res & Tech Inst, C Cheng Kao filed Critical Advanced Res & Tech Inst
Priority to AU24053/00A priority Critical patent/AU2405300A/en
Publication of WO2000040759A2 publication Critical patent/WO2000040759A2/en
Publication of WO2000040759A3 publication Critical patent/WO2000040759A3/en
Publication of WO2000040759A9 publication Critical patent/WO2000040759A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses

Abstract

An isolated recombinant viral polymerase is provided that is useful in diagnostic and anti-viral compound screening applications.
PCT/US2000/000152 1999-01-05 2000-01-05 Uses of flavivirus rna-dependent rna polymerases WO2000040759A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU24053/00A AU2405300A (en) 1999-01-05 2000-01-05 Uses of flavivirus rna-dependent rna polymerases

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11477999P 1999-01-05 1999-01-05
US60/114,779 1999-01-05
US47484799A 1999-12-30 1999-12-30
US09/474,847 1999-12-30

Publications (3)

Publication Number Publication Date
WO2000040759A2 WO2000040759A2 (en) 2000-07-13
WO2000040759A3 true WO2000040759A3 (en) 2000-11-23
WO2000040759A9 WO2000040759A9 (en) 2001-10-11

Family

ID=26812534

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/000152 WO2000040759A2 (en) 1999-01-05 2000-01-05 Uses of flavivirus rna-dependent rna polymerases

Country Status (2)

Country Link
AU (1) AU2405300A (en)
WO (1) WO2000040759A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000033635A2 (en) * 1998-12-10 2000-06-15 Eli Lilly And Company Primer-independent rna synthesis catalyzed by hcv polymerase
ES2345053T3 (en) 2004-03-24 2010-09-14 Achillion Pharmaceuticals, Inc. QUANTITATIVE TEST FOR THE RECENTLY SYNTHESIZED RNA DETECTION IN A CELL-FREE SYSTEM AND IDENTIFICATION OF RNA SYNTHESIS INHIBITORS.
WO2018191275A1 (en) * 2017-04-10 2018-10-18 The Penn State Research Foundation Compositions and methods comprising viral reverse transcriptase
WO2021231891A1 (en) * 2020-05-15 2021-11-18 Quidel Corporation Method for direct amplification and detection of rna

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364760A (en) * 1986-04-16 1994-11-15 The Salk Institute For Biological Studies Replicative RNA reporter systems
WO1998031789A1 (en) * 1997-01-16 1998-07-23 Scriptgen Pharmaceuticals, Inc. Nucleic acid encoding m. tuberculosis algu protein

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364760A (en) * 1986-04-16 1994-11-15 The Salk Institute For Biological Studies Replicative RNA reporter systems
WO1998031789A1 (en) * 1997-01-16 1998-07-23 Scriptgen Pharmaceuticals, Inc. Nucleic acid encoding m. tuberculosis algu protein

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KAO C C &SUN J-H: "Initiation of minus-strand RNA synthesis by the brome mosaic virus RNA-dependent RNA polymerase: use of oligoribonucleotide primers", JOURNAL OF VIROLOGY,US,THE AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 70, no. 10, October 1996 (1996-10-01), pages 6826 - 6830-6830, XP002110170, ISSN: 0022-538X *
KAO C C ET AL: "De novo initiation of RNA synthesis by a recombinant flaviridae RNA-dependent RNA polymerase", VIROLOGY,US,ACADEMIC PRESS,ORLANDO, vol. 253, no. 253, 1999, pages 1 - 7-7, XP002110174, ISSN: 0042-6822 *
LOHMAN V. ET AL.,: "Biochemical and kinetic analyses of NS5B RNA-dependent RNA polymerase of the hepatitis C virus", VIROLOGY, vol. 249, - 1998, pages 108 - 118, XP002141668 *
LOHMANN V ET AL: "BIOCHEMICAL PROPERTIES OF HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE AND IDENTIFICATION OF AMINO ACID SEQUENCE MOTIFS ESSENTIAL FOR ENZYMATIC ACTIVITY", JOURNAL OF VIROLOGY,US,THE AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 71, no. 11, November 1997 (1997-11-01), pages 8416 - 8428, XP000877461, ISSN: 0022-538X *

Also Published As

Publication number Publication date
WO2000040759A9 (en) 2001-10-11
AU2405300A (en) 2000-07-24
WO2000040759A2 (en) 2000-07-13

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