WO2000040272A3 - P450 / acetaminophen gdept for cancer treatment - Google Patents

P450 / acetaminophen gdept for cancer treatment Download PDF

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Publication number
WO2000040272A3
WO2000040272A3 PCT/GB1999/004269 GB9904269W WO0040272A3 WO 2000040272 A3 WO2000040272 A3 WO 2000040272A3 GB 9904269 W GB9904269 W GB 9904269W WO 0040272 A3 WO0040272 A3 WO 0040272A3
Authority
WO
WIPO (PCT)
Prior art keywords
acetaminophen
gdept
cancer treatment
vectors
nabqi
Prior art date
Application number
PCT/GB1999/004269
Other languages
French (fr)
Other versions
WO2000040272A2 (en
Inventor
Donald Davies
Original Assignee
Ml Lab
Donald Davies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ml Lab, Donald Davies filed Critical Ml Lab
Priority to AU18700/00A priority Critical patent/AU1870000A/en
Publication of WO2000040272A2 publication Critical patent/WO2000040272A2/en
Publication of WO2000040272A3 publication Critical patent/WO2000040272A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

The invention herein described relates to a form of cancer therapy which exploits the cytotoxic properties of acetaminophen when converted to NABQI by the metabolic activity of tumour cell specific P450; vectors for use in the delivery of P450 to tumour cells; and therapeutic compositions comprising said vectors.
PCT/GB1999/004269 1999-01-04 1999-12-30 P450 / acetaminophen gdept for cancer treatment WO2000040272A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU18700/00A AU1870000A (en) 1999-01-04 1999-12-30 Gene therapy-2

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9900009.3A GB9900009D0 (en) 1999-01-04 1999-01-04 Gene therapy
GB9900009.3 1999-01-04

Publications (2)

Publication Number Publication Date
WO2000040272A2 WO2000040272A2 (en) 2000-07-13
WO2000040272A3 true WO2000040272A3 (en) 2000-11-02

Family

ID=10845482

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/004269 WO2000040272A2 (en) 1999-01-04 1999-12-30 P450 / acetaminophen gdept for cancer treatment

Country Status (3)

Country Link
AU (1) AU1870000A (en)
GB (1) GB9900009D0 (en)
WO (1) WO2000040272A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040073958A1 (en) * 2001-02-23 2004-04-15 Motoya Katsuki Transgenic animal having drug metabolism enzyme gene and utilization thereof
WO2005084713A2 (en) * 2004-03-06 2005-09-15 Innovata Plc Enzyme-prodrug therapy for prosthetic joint repair
US7740847B2 (en) * 2004-08-04 2010-06-22 Applied Molecular Evolution, Inc. Variant Fc regions
CN102876716B (en) * 2012-09-28 2015-07-01 深圳市疾病预防控制中心 Lentiviral expression vector for specifically promoting hepatic cell CYP2E1 gene high expression, construction method of vector and application of vector

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997035994A2 (en) * 1996-03-27 1997-10-02 Bavarian Nordic Research Institute A/S Cytochrome p450 transducing retroviral vectors
US5760008A (en) * 1991-11-04 1998-06-02 Co Enzyme Technology Ltd. Method and compositions for treating malignant tumors and inhibiting metastases of malignant tumors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760008A (en) * 1991-11-04 1998-06-02 Co Enzyme Technology Ltd. Method and compositions for treating malignant tumors and inhibiting metastases of malignant tumors
WO1997035994A2 (en) * 1996-03-27 1997-10-02 Bavarian Nordic Research Institute A/S Cytochrome p450 transducing retroviral vectors

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
AMERICAN JOURNAL OF PHYSIOLOGY, vol. 263, no. 2 PART 2, 1992, pages R348 - R352, ISSN: 0002-9513 *
CANCER (PHILADELPHIA), vol. 72, no. 3, 1993, pages 783 - 787, ISSN: 0008-543X *
CELL BIOCHEMISTRY AND FUNCTION, vol. 9, no. 2, 1991, pages 125 - 134, ISSN: 0263-6484 *
CHEMICAL RESEARCH IN TOXICOLOGY, vol. 6, no. 4, 1993, pages 511 - 518, ISSN: 0893-228X *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1991, PRINCIPE P ET AL: "CELLULAR THIOLS IN RAT LIVER CELL LINES POSSESSING DIFFERENT GROWTH CHARACTERISTICS", XP002140945, Database accession no. PREV199192050788 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1992, AEBI S ET AL: "DIVERGENT EFFECTS OF INTRAVENOUS GSH AND CYSTEINE ON RENAL AND HEPATIC GSH", XP002140944, Database accession no. PREV199294112166 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1993, PATTEN CHRIS J ET AL: "Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics.", XP002140947, Database accession no. PREV199396085381 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1993, PERRY ROGER R ET AL: "Glutathione levels and variability in breast tumors and normal tissue.", XP002140946, Database accession no. PREV199396089335 *

Also Published As

Publication number Publication date
GB9900009D0 (en) 1999-02-24
AU1870000A (en) 2000-07-24
WO2000040272A2 (en) 2000-07-13

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