UA89363C2 - Nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents - Google Patents

Nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents

Info

Publication number
UA89363C2
UA89363C2 UAA200605988A UAA200605988A UA89363C2 UA 89363 C2 UA89363 C2 UA 89363C2 UA A200605988 A UAA200605988 A UA A200605988A UA A200605988 A UAA200605988 A UA A200605988A UA 89363 C2 UA89363 C2 UA 89363C2
Authority
UA
Ukraine
Prior art keywords
cytotoxic agents
corresponding phosphates
targeted cytotoxic
nitrophenylaziridine
alcohols
Prior art date
Application number
UAA200605988A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Уилльям Александер Денни
Грехем Джон Этвелл
Шанцзинь Ян
Уилльям Роберт Уилсон
Адам Ворн Петтерсон
Нуала Анн Хелзби
Original Assignee
Окленд Юнисервисиз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Окленд Юнисервисиз Лимитед filed Critical Окленд Юнисервисиз Лимитед
Publication of UA89363C2 publication Critical patent/UA89363C2/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumours, and to their use in cell ablation, including gene-directed enzyme-prodrug therapy (GDEPT) and antibody-directed enzymeprodrug therapy (ADEPT), in conjunction with nitrorcductase enzymes.
UAA200605988A 2003-10-31 2004-10-29 Nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents UA89363C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NZ529249A NZ529249A (en) 2003-10-31 2003-10-31 Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic

Publications (1)

Publication Number Publication Date
UA89363C2 true UA89363C2 (en) 2010-01-25

Family

ID=36292631

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200605988A UA89363C2 (en) 2003-10-31 2004-10-29 Nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents

Country Status (4)

Country Link
CN (1) CN1902159B (en)
NZ (1) NZ529249A (en)
UA (1) UA89363C2 (en)
ZA (1) ZA200603105B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ536107A (en) 2004-10-22 2007-06-29 Auckland Uniservices Ltd Nitrobenzindoles and their use in cancer therapy
CN101723932B (en) * 2008-10-31 2013-11-20 北京以岭生物工程技术有限公司 Nitropyridine ethylenimine compound, medicinal composition, preparation method and application thereof
CN108113989A (en) * 2012-08-23 2018-06-05 健康创新企业私人有限责任公司 Novel prodrug and its application method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ240785A (en) * 1991-11-28 1995-08-28 Cancer Res Campaign Tech Substituted nitro aniline derivatives and medicaments
GB9819472D0 (en) * 1998-09-07 1998-10-28 Cancer Soc Auckland Div Nz Inc Novel nitrophenylaziridine compounds and their use as prodrugs

Also Published As

Publication number Publication date
CN1902159B (en) 2010-06-09
ZA200603105B (en) 2007-09-26
NZ529249A (en) 2006-04-28
CN1902159A (en) 2007-01-24

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