WO2000040084A2 - Medaille pour animaux de compagnie - Google Patents

Medaille pour animaux de compagnie Download PDF

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Publication number
WO2000040084A2
WO2000040084A2 PCT/US2000/000392 US0000392W WO0040084A2 WO 2000040084 A2 WO2000040084 A2 WO 2000040084A2 US 0000392 W US0000392 W US 0000392W WO 0040084 A2 WO0040084 A2 WO 0040084A2
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WO
WIPO (PCT)
Prior art keywords
invention according
tag
insecticide
ticks
resin base
Prior art date
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PCT/US2000/000392
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English (en)
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WO2000040084A3 (fr
Inventor
Joe D. Kellerby
Michael G. Fletcher
Original Assignee
Y-Tex Corporation
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Filing date
Publication date
Application filed by Y-Tex Corporation filed Critical Y-Tex Corporation
Priority to AU29610/00A priority Critical patent/AU2961000A/en
Publication of WO2000040084A2 publication Critical patent/WO2000040084A2/fr
Publication of WO2000040084A3 publication Critical patent/WO2000040084A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K27/00—Leads or collars, e.g. for dogs
    • A01K27/007—Leads or collars, e.g. for dogs with insecticide-dispensing means
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K13/00—Devices for grooming or caring of animals, e.g. curry-combs; Fetlock rings; Tail-holders; Devices for preventing crib-biting; Washing devices; Protection against weather conditions or insects
    • A01K13/003—Devices for applying insecticides or medication

Definitions

  • the present invention relates generally to insecticide compositions and, more particularly, to compositions, methods and devices containing or employing a mixture of zeta-cypermethrin and piperonyl butoxide which together provide a synergistic effect as an insecticide.
  • the present invention is particularly useful as an insecticide either applied topically or in a sustained release delivery system, such as a resin base, for tick and flea infestation control and prevention. 2 • Discussion
  • Insects are the most numerous of living organisms and nearly one million described species constitute approximately 70% of all animal species. Of these, about 1% are considered significant pests. These pests attack humans and/or their domestic animals; transmit human, animal, and plant diseases; destroy structures; and compete for available supplies of food and other natural resources. In the United States, at least 600 species of insects are important pests.
  • Pesticides are generally defined as any substance or chemical designed or formulated to kill or control weeds or animal pests, and include algicides, herbicides, insecticides, acaricides, and rodenticides .
  • Insecticides are generally defined as any substance or chemical formulated to either kill or control insects.
  • Acaricides are generally defined as any substance or chemical formulated to either kill or control mites or ticks.
  • control is achieved by oral ingestion of stomach poisons, contact poisons that penetrate through the cuticle, or fumigants that penetrate through the respiratory system.
  • Ancillary chemicals are also employed in insect control and include attractants and repellants, which influence insect behavior, and chemosterilants, which influence reproduction.
  • the widespread use of chemical insecticides has resulted in increasing difficulties in practical pest control.
  • the difficulties include genetic selection under chemical pressure of strains of more than 400 arthropod (insect and acarine pests) that are resistant to one or more classes of pesticides and some to every available material; resurgences of pests and outbreaks of secondary pests that result from elimination of natural enemies by the use of broad-spectrum pesticides; adverse human-health effects from injudicious use of highly toxic insecticides; and exponentially increasing costs of developing new insecticides.
  • hornflies Haematobia irri tans
  • organophosphates such as diazinon (i.e, a pyrimidine organothiophosphate) and chlorpyrifos (i.e., a pyridine organothiophosphate)
  • the insecticide mixture is slowly released from the resin base onto the hair of the animal and exhibits good contact toxicity results with respect to various pests, including hornflies, stable flies, and house flies.
  • a complete discussion of this technology can be found in commonly-assigned U.S. Patent No. 5,472,955, the entire disclosure being incorporated herein by reference.
  • An ear tag containing a mixture of diazinon and chlorpyrifos is readily commercially available from Y-Tex Corporation (Cody, Wyoming) and is being marketed under the trademark WARRIORTM. Recently, another ear tag has been developed by
  • PYTHONTM Y-Tex Corporation and is being marketed under the trademark PYTHONTM.
  • This ear tag is similar to the WARRIORTM ear tag in that a synergized insecticide is impregnated into a resin base.
  • the PYTHONTM ear tag differs primarily from the WARRIORTM ear tag in that the impregnated insecticide is an enriched-isomer, synthetic pyrethroid compound, as opposed to an organothiophosphate compound.
  • a synthetic pyrethroid compound is generally defined as a synthetic pesticide that mimics pyrethrin, the original botanical pesticide derived from certain species of chrysanthemum flowers.
  • pyrethroid compounds include, without limitation, allethrins, resmethrins, permethrins, and fenvalerates .
  • the synthetic pyrethroids have the marked advantages of low to moderate toxicity to humans and domestic animals and high effectiveness at low application rates, often one-tenth of those required for organophosphorus and carbamate insecticides.
  • the PYTHONTM ear tag utilizes zeta-cypermethrin (empirical formula: C 22 H 19 C1 2 N0 3 ) as the insecticide. Zeta-cypermethrin (readily commercially available from FMC Corporation, Philadelphia,
  • the PYTHONTM ear tag exhibits excellent contact toxicity against horn flies (including horn flies with moderate pyrethroid resistance) , face flies
  • Fleas are very important pests, especially during the summer months when heat and humidity levels are high.
  • Adult fleas are not only a nuisance, but can cause medical problems including flea allergy dermatitis, tapeworms, secondary skin irritations, and anemia. It is estimated that pet owners spend over one billion dollars each year controlling fleas, especially the cat flea ⁇ Ctenocephalides felis) and the dog flea ( Ctenocephalides canis) .
  • Fleas pass through a complete life cycle consisting of egg, larvae, pupa, and adult. A typical flea population consists of 50 percent eggs, 35 percent larvae, 10 percent pupae, and 5 percent adults.
  • Ticks are blood feeding external parasites of mammals, birds, and reptiles throughout the world. Approximately 850 species have been described worldwide. Ticks transmit the widest variety of pathogens of any blood sucking arthropod, including bacteria, rickettsiae, protozoa, and viruses.
  • tick-borne pathogens Some animal diseases of current interest in the United States caused by tick-borne pathogens include Babesiosis, Ehr1 i chios i s , Haemobartonellosis , Rocky Mountain spotted fever, Lyme disease, Hepatozoonosis, and Cytauxzoonosis .
  • Ixodidae hard ticks
  • Argasidae soft ticks
  • Hard ticks have three distinct life stages. Larvae which emerge from the egg have six legs. After obtaining a blood meal from a vertebrate host, they molt to the nymphal stage and acquire eight legs. Nymphs feed and molt to the next and final stage - the adult, which also has eight legs. After feeding once more, the adult female hard ticks lay one batch of thousands of eggs and then die. Only one blood meal is taken during each of the three life stages. The time to completion of the entire life cycle may vary from less than a year in tropical regions to over three years in cold climates, where certain stages may enter diapause until hosts are again available. Many hard ticks can go for several months without feeding if not unduly stressed by environmental conditions. An example of the hard tick is the American Dog Tick (Dermacentor variabilis) .
  • the life stages of soft ticks are not readily distinguishable.
  • the first life stage to come out of the e ⁇ 3Q i a six-legged larva, takes a blood meal from a host, and molts to the first nymphal stage.
  • many soft ticks go through multiple nymphal stages, gradually increasing in size until the final molt to the adult stage.
  • Some soft ticks pass through up to seven nymphal molts before they become adults.
  • Soft ticks feed several times during each life stage, and females lay multiple small batches of eggs between blood meals during their lives.
  • the time to completion of the entire life cycle is generally much longer than that of hard ticks, lasting over several years.
  • many soft ticks have an uncanny resistance to starvation, and can survive for over two years without a blood meal .
  • An example of such is the Spinose Ear Tick (Oto-bius megnini ) .
  • the treatment and prevention of flea and tick infestation in dogs and cats has typically been accomplished through various methods, including: (1) neck collars having a releasable impregnated insecticide composition; (2) the use of topically applied insecticide- containing compositions in the form of "spot-ons", shampoos, aerosols, dips, sprays, and powders; and (3) orally administered insecticide compositions which are systemically active, such as a pill for flea control.
  • Neck collars having a releasable impregnated insecticide composition are well known.
  • the neck collar also commonly referred to as a flea collar, is comprised of some type of plasticized thermoplastic polymer that is extruded, coextruded or injection molded, or compounded with an insecticide, typically an organophosphate or carbamate compound. These compounds usually have objectionable odors, and the insecticide employed is typically effective against the parasitic life stages of fleas and/or ticks.
  • Another active ingredient used in collars is an insect growth regulator (IGR) which is active against the eggs and larval fleas.
  • IGR insect growth regulator
  • the neck collar is placed around the neck of the animal and adjusted to fit snugly about the animal's neck; thus, it is not considered to be free-swinging.
  • the neck collar typically was employed in addition to the animal's pre-existing collar that may have contained identification tags, vaccinations tags, and the like.
  • the insecticide then diffuses out of the collar in the form of either a viscous liquid or a powder, depending on the melting point of the particular insecticide.
  • the insecticidal residues are then transferred to the animal's hair.
  • the efficacy of the insecticide released from neck collars has been always been problematic. There are two primary reasons for this difficulty: (1) limited mobility of the collar which limits application of insecticide residues; and (2) low release rate because of the requirement to make the collar durable.
  • ADVANTAGETM is comprised of a solution of imidacloprid (chemical formula: 1- [ (6-Chloro-3- pyridinyl) methyl] -N-nitro-2 -imidazolidinimine) , a chloronicotinyl nitroguanidine synthesized from the nitromethylene class of compounds .
  • imidacloprid chemical formula: 1- [ (6-Chloro-3- pyridinyl) methyl] -N-nitro-2 -imidazolidinimine
  • Imidacloprid is supposedly selectively active against adult fleas and flea larvae; however, it has no effect against flea eggs, nor does it have any acaricidal properties.
  • Imidacloprid binds to the nicotinyl receptor site in the post-synaptic region of the adult flea's nerve, thus interfering with normal nerve transmissions and causing eventual death.
  • the imidacloprid solution is topically applied (i.e., spot-on) once a month between the shoulder blades of the animal and is spread to the other parts of the animal by a process known as translocation.
  • topically applied insecticide composition is marketed under the trademark
  • FRONTLINETM by Merial (Lyon, France) .
  • FRONTLINETM is comprised of a solution of fipronil (chemical formula: 5- amino-1- [2 , 6-dichloro-4- (trifluoromethyl)phenyl] -4- [ (1R, S) -
  • Fipronil is supposedly selectively active against adult fleas and ticks; however, it has no effect against the other life stages of fleas or ticks. Fipronil acts on the gamma aminobutyric acid (GABA) mediated chloride channels of invertebrates. Fipronil blocks the passage of chloride ions in the adult flea or tick thus blocking nerve transmission and causing eventual death.
  • GABA gamma aminobutyric acid
  • the fipronil solution is topically applied (i.e., spot-on) between the shoulder blades of the animal and is spread to the other parts of the animal by translocation.
  • DEFENDTM Still another example of a topically applied insecticide composition is marketed under the trademark DEFENDTM by Schering-Plough (Madison, New Jersey) .
  • DEFENDTM is comprised of a high concentrate solution (about 60 vol. %) of permethrin (chemical formula: 3-phenoxybenzyl) .
  • Permethrin is active against fleas, ticks, flies, and mosquitoes.
  • the permethrin solution is applied (i.e., spot-on) between the shoulder blades of the animal, typically a dog, and is spread to the other parts of the animal by translocation.
  • permethrin is relatively toxic to cats, and therefore is not recommended to be applied in a topical solution to cats.
  • Monthly applications to dogs are required throughout the flea and tick seasons.
  • PROGRAMTM An example of an orally administered insecticide composition is marketed under the trademark PROGRAMTM by Ciba-Geigy (Greensboro, North Carolina) .
  • PROGRAMTM is comprised of lufenuron (chemical formula: N- [2 , 5-dichloro- 4- (1,1,2,3,3,3, -hexafluoropropoxy) -phenylaminocarbonyl] - 2 , 6-difluorobenzamide) , a benzoylphenyl-urea derivative.
  • Lufenuron is supposedly selectively active against flea eggs; however, it has no effect on the other life stages of fleas, nor does it have any acaricidal properties.
  • Lufenuron interferes with chitin synthesis, polymerization, and deposition in the flea egg. Eliminating the availability of chitin prevents the flea from completing its development. Additionally, if development did occur, the emerging flea would quickly desiccate due to the lack of chitin in the body shell. Lufenuron is orally administered in tablet form on a monthly basis, with a suggested treatment period of six months.
  • topically applied insecticide-containing compositions are generally oily and slightly toxic to humans as well as animals, thus requiring the need for a high degree of care when applying to the animal. Even after application is complete, these topically applied insecticide-containing compositions may take more than a day to completely dry. Orally administered insecticide compositions are sometimes very difficult to administer to an uncooperative animal, especially cats, and may not be well tolerated by the animal's digestive system. Further, the pest still has to bite the animal in order to receive a toxic dose.
  • a free-swinging, slow-release insecticidal tag is designed for attachment to the neck collar of a domesticated animal for the prevention and treatment of tick and flea infestation.
  • the insecticide includes at least one pyrethroid compound, such as, but not limited to zeta-cypermethrin.
  • a synergist such as, but not limited to piperonyl butoxide is combined with the zeta- cypermethrin to produce a synergized insecticide.
  • the synergized insecticide is then impregnated into a resin base, such as, but not limited to polyvinyl chloride, acrylonitrile-butadiene copolymer, polyurethane, and chlorinated polyethylene, and then formed into the shape of a tag or medallion.
  • a resin base such as, but not limited to polyvinyl chloride, acrylonitrile-butadiene copolymer, polyurethane, and chlorinated polyethylene
  • the tag is then attached to the neck collar of the animal in such a manner so as to allow the tag to physically contact various parts of the animal's body, for example, during the grooming process.
  • the synergized insecticide is released from the tag over the course of several months and is particularly effective against all of the parasitic life stages of various domestic animal pests, such as, but not limited to ticks and fleas.
  • FIG. 1 is a perspective view of an insecticidal tag, in accordance with the general teachings of the present invention.
  • Figure 2 is a side elevational view of an attachment means for use with the insecticidal tag depicted in Figure 1;
  • Figure 3 is a perspective view of a collar incorporating the insecticidal tag depicted in Figure 1 and the attachment means depicted in Figure 2;
  • Figure 4 is a perspective view of an intended use of the insecticidal tag depicted in Figure 1.
  • the present invention is primarily directed to the use of a free-swinging, slow release insecticidal neck tag or medallion for the prevention and treatment of flea and tick infestation of domestic animals, such as, but not limited to dogs and cats.
  • free-swinging as that term is used herein, it is meant that the tag is allowed substantially unfettered freedom of movement in all directions.
  • slow release as that term is used herein, it is meant that the insecticide is released from the tag over a period of several months .
  • neck tag or medallion as that term is used herein, it is meant any shaped object that is capable of being attached, either directly or indirectly, to the neck collar of a domestic animal .
  • the insecticide composition of the present invention preferably includes at least one releasable oil- soluble contact-effective insecticide.
  • the releasable oil-soluble contact-effective insecticide is at least one pyrethroid compound, such as, but not limited to zeta-cypermethrin (preferably a mixture of stereoisomers comprising high concentrations of s-isomers of cypermethrin) in combination with at least one synergist such as, but not limited to piperonyl butoxide (preferably technical grade) .
  • the insecticide composition of the present invention preferably contains up to about 10 weight percent zeta-cypermethrin and up to about 20 weight percent piperonyl butoxide, which could be varied by several percentage points without substantially affecting efficacy. These weight percents are based on the total weight of the tag. Preferably, the ratio of zeta-cypermethrin to piperonyl butoxide is about 1:2 by weight.
  • pyrethroid compounds that have demonstrated insecticidal and/or acaricidal activity may also be used, including but not limited to deltamethrin, alphacypermethrin, pe'rmethrin, bifenthrin, flumethrin, cyfluthrin, beta-cyfluthrin, fenvalerate, esfenvalerate , cyhalothrin, lambdacyhalothrin, tralomethrin, fenpropathrin, fenfluthrin, fluvalinate, tetramethrin, tefluthrin, flucythrinate, and etofenprox.
  • deltamethrin alphacypermethrin, pe'rmethrin, bifenthrin, flumethrin, cyfluthrin, beta-cyfluthrin, fenvalerate, esfenvalerate
  • the insecticide composition of the present invention is preferably releasably impregnated into a resin base.
  • the impregnation can be accomplished by any number of suitable means, such as, but not limited to co- extrusion, compounding, or blending.
  • the resin base is capable of allowing the insecticide composition to be slowly released from the resin base over an extended period of time, such as several months.
  • the impregnated resin base is substantially odorless.
  • the impregnated resin base is then formed by suitable means, such as injection molding or profile extrusion and stamping processes, into a desired shape such as, but not limited to a tag or medallion 10 as depicted in Figure 1.
  • suitable means such as injection molding or profile extrusion and stamping processes
  • the exact shape and dimensions of the tag 10 are not thought to be critical to the success of the present invention. Rather, it is the free-swinging characteristic that is thought to be critical .
  • the size of the tag 10 will be dependent in part on the size of the animal that is to be treated. For example, a 5 pound cat may require a smaller and lighter tag than a 150 pound dog.
  • the tag 10 weighs about 2.5 to about 7 grams, to allow for different sizes of tags to be manufactured for different sizes of animals.
  • the tag 10 may be provided with an area defining an aperture 12 for mounting a fastener to be used for attachment to the animal's pre-existing collar.
  • the tag 10 may be easily mounted by hand to the animal's pre-existing neck collar. Thus, there is no need for an additional collar, as is required with conventional flea collars.
  • the tag 10 of the present invention may be formed to include an integrated attachment means, such as a hook-shaped appendage, for direct mounting to the animal's neck collar, it may be preferable to use a separate attachment means.
  • a separate attachment means 20 formed of a substantially durable material (e.g., metal or hard plastic) may used to attach the tag 10 to the neck collar, thus allowing the tag 10 to hang freely down about the animal's chest area.
  • the attachment means 20 may be placed or folded over the neck collar and then employ a snap assembly 22 that fits through the aperture 12 provided on the upper part of the tag 10. In this manner, the tag 10 is securely, but not rigidly, affixed to the attachment means 20 and the attachment means 20 is securely, but not rigidly, affixed to the neck collar 30 as depicted in Figure 3.
  • this insecticide composition when impregnated into a free- swinging, resin-based tag, is effective against both fleas and ticks, especially the Brown Dog tick ⁇ Rhipicephalus sanguineus) , the American Dog tick (Dermacentor variabilis) , the Lone Star tick (Amblyomma americanum) , and the Deer tick ( Ixodes scapularis) .
  • the resin base employed may be thermosetting or thermoplastic, although the latter is more readily employed in the manufacture of a tag of the present invention.
  • suitable substances are polyolefins (e.g., polyethylene, polypropylene and copolymers of ethylene and propylene) ; halogenated polyolefins (e.g., chlorinated polyethylene); polyacrylates (e.g., polymers and copolymers of methyl acrylate, ethyl acrylate, methyl methacrylate and ethyl methacrylate); polymers of vinyl compounds (e.g., polystyrene and polymerized divinylbenzene) ; polyvinyl halides (e.g., polyvinyl chloride); polyvinyl acetals (e.g., polyvinyl butyryl) ; polyvinylidene compounds (e.g., polyvinylidene chloride) ; synthetic and natural elastomers (e.g., rubber obtained from hevea brasiliensis, cis-1,4- polyisoprene, acrylonitrile-
  • the choice of the resin base will depend both on the particular insecticide mixture with which it is to be formulated and the conditions under which the final formulation will be employed.
  • the resin base is preferably insoluble in water and presents a hydrophobic surface, thus resisting the absorption of moisture on its surface which could dilute the active ingredients.
  • the resin base may include a polymer or a copolymer of a vinyl compound, for example, polyvinyl halides (e.g., polyvinyl chloride and polyvinyl fluoride); polyacrylate and polymethacrylate esters (e.g., polymethyl acrylate, polymethyl acrylate and polymethyl methacrylate) ; and polymers of vinyl benzenes (e.g., polystyrene and polymer polymerized vinyl toluene) . Because it possesses desirable physical properties with desirable release rate characteristics for the insecticide, one of the preferred macromolecular substances is a polymer of vinyl chloride.
  • polyvinyl halides e.g., polyvinyl chloride and polyvinyl fluoride
  • polyacrylate and polymethacrylate esters e.g., polymethyl acrylate, polymethyl acrylate and polymethyl methacrylate
  • vinyl benzenes e.g., polystyrene and polymer poly
  • plasticizers are phthalates (e.g., di (2-ethylhexyl) phthalate, diethylglycol phthalate, dioctyl phthalate, diphenyl phthalate, dicyclohexyl phthalate, dimethyl phthalate, diethyl phthalate, dihexyl phthalate, di(2- ethylhexyl) isophthalate , and di (2 -ethylhexyl) hexahydrophthalate) ; sebacates (e.g., di (2-ethylhexyl) sebacate, dipentyl sebacate, n-butyl benzyl sebacate, dimethyl sebacate, and dibenzyl sebacate); adipates (e.g., isobutyl adipate, di (2-ethylhexyl)
  • plasticizers are, for example, hydrogenated polyphenols ; alkylated aromatic hydrocarbons; polyester plasticizers, for example, polyesters of polyols, such as hexanediol; polycarboxylic acids, such as sebacic or adipic acid, having molecular weights of about 2000; and epoxide plasticizers such as epoxidized soybean oil, epoxidized linseed oil and epoxidized tall oils (such as octyl epoxy tallate) .
  • polyester plasticizers for example, polyesters of polyols, such as hexanediol
  • polycarboxylic acids such as sebacic or adipic acid, having molecular weights of about 2000
  • epoxide plasticizers such as epoxidized soybean oil, epoxidized linseed oil and epoxidized tall oils (such as octyl epoxy tallate) .
  • a relatively softer resin base as opposed to a relatively harder resin base, will enhance the delivery of the insecticide composition when the tag 10 contacts the animal's body. It is believed that higher concentrations of plasticizers, which cause a softer resin base, enable higher release rates of impregnated insecticides.
  • compositions such as dyes, pigments, colorants, fluorescents, lubricants, fillers, anti-oxidants and ultraviolet stabilizers may be included in the formulation.
  • materials such as dyes, pigments, colorants, fluorescents, lubricants, fillers, anti-oxidants and ultraviolet stabilizers may be included in the formulation.
  • the stability of the formulation is extended if amounts of 0.10% to about 0.25% by weight, of each one or more suitable chemical stabilizers are included.
  • hydroxycinnamates such as IRGANOX ® 1076, octadecyl 3,5 -di - tert -butyl -4 -hydroxyhydrocinnamate
  • benzotriazoles such as TINUVIN ® P, 2 - (2 ' -hydroxy-5 ' - methylphenyl) benzotriazole
  • FIG 4 there is illustrated an intended use of the tag 10 of the present invention.
  • a cat is wearing a collar 30 having the tag 10 of the present invention attached thereto by an attachment means 20 (as previously depicted in Figure 3) .
  • the tag 10 is brushed up against various parts of the cat's body, thus releasing the insecticide composition onto those parts of the cat's body. In this manner, the entire body of the cat is exposed to the insecticide composition.
  • Test data has indicated that the free-swinging, insecticidal tag 10 of the present invention is effective against the parasitic life stages of ticks for about 2 to 3 months. Additionally, test data indicated that the free- swinging, insecticidal tag 10 of the present invention is effective against the parasitic life stages of fleas for over 5 months.
  • the asterisk denotes that, on the day proceeding the day indicated, each of the dogs were challenged with 100 fleas. Visual counts were made on the day denoted with an asterisk. The fleas were then combed off and counted two days later, i.e., those days not denoted with an asterisk. Thus, all days without an asterisk are three days post-challenge.
  • Table I indicates, the insecticidal tag 10 of the present invention was highly efficacious in the prevention and treatment of flea infestation in the treated group of dogs .
  • insecticidal tag produced in accordance with the general teachings of the present invention (e.g., a mixture comprising up to about 10 weight percent zeta-cypermethrin and up to about 20 weight percent piperonyl butoxide) , were exposed to brown dog ticks, Rhipicephalus sanguineus , over a 79 day period.
  • Table II The results of the experiment are presented in Table II, below:
  • the asterisk denotes that, on the day proceeding the day indicated, each of the dogs were challenged with 50 ticks. Visual counts were made on the day denoted with an asterisk. The ticks were then counted and removed two days later, i.e., those days not denoted with an asterisk. Thus, all days without an asterisk are three days post-challenge.
  • the insecticidal tag 10 of the present invention was highly efficacious in the prevention and treatment of tick infestation in the treated groups of dogs .
  • the insecticidal tags of the present invention were applied to the collars of the non-control dogs.
  • the dogs were then examined to estimate the number of ticks present, with a light infestation (i.e., less than 10 ticks) denoted as L, a moderate infestation (i.e., 10 to 50 ticks) denoted as M, a heavy infestation (i.e., 50 to 100 ticks) denoted as H, and a very heavy infestation (i.e., greater than 100 ticks) denoted as VH.
  • the term NA i.e., not available refers to the fact that control dog number 3 (C3) had to be removed from the experimental study due to anemia and weakness.
  • tick counts for Days 14, 21, 28, 35, and 42 could not be taken for this particular dog.
  • Table III indicates that the insecticidal tag 10 of the present invention was highly efficacious in the prevention and treatment of tick infestation in the treated groups of dogs .
  • an experiment was conducted to determine the efficacy of the insecticidal tag 10 of the present invention against both flea and tick infestation.
  • a treated group of dogs wearing a 7 gram insecticidal tag (Ref. No.
  • YT-1601-M1 produced in accordance with the general teachings of the present invention (e.g., a mixture comprising up to about 10 weight percent zeta-cypermethrin and up to about 20 weight percent piperonyl butoxide) , were exposed to fleas and ticks over an 85 day period.
  • the dogs were infested with fleas for one day and ticks for two days prior to evaluation, at which time all of the pests were removed from each dog, whereupon, the efficacy of the tag against flea and tick infestation was determined.
  • Table IV The results of the experiment are presented in Table IV, below:
  • the insecticidal tag 10 of the present invention was highly efficacious in the prevention and treatment of both flea and tick infestation in the treated groups of dogs .

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  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Cette invention concerne une plaque (10), destinée à être attachée au collier (30) d'un animal de compagnie, pouvant se balancer librement, et diffusant lentement un produit de prévention et de traitement des infestations par les tiques et les puces. L'insecticide comprend au moins un composé pyréthroïde, notamment, mais pas exclusivement, de la zêta-cyperméthrine. On combine un agent synergique, notamment, mais pas exclusivement, du butoxyde de pipéronyle avec la zêta-cyperméthrine pour produire un insecticide synergique. On utilise alors cet insecticide synergique pour imprégner une résine, notamment, mais pas exclusivement, du polychlorure de vinyle. Le tout est ensuite formé pour obtenir un dispositif à diffusion continue sans odeur en forme de plaque ou de médaille. La plaque (10) est alors attachée au collier (30) de l'animal de manière à ce qu'elle entre en contact avec différentes parties du corps de l'animal, quand il fait sa toilette par exemple. La plaque (10) diffuse pendant plusieurs mois l'insecticide synergique, et constitue un moyen efficace de lutte contre toutes les différentes phases du cycle vital des parasites, notamment, mais pas exclusivement les tiques et les puces, touchant les animaux domestiques.
PCT/US2000/000392 1999-01-08 2000-01-07 Medaille pour animaux de compagnie WO2000040084A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU29610/00A AU2961000A (en) 1999-01-08 2000-01-07 Pet medallion

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11522299P 1999-01-08 1999-01-08
US60/115,222 1999-01-08

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WO2000040084A2 true WO2000040084A2 (fr) 2000-07-13
WO2000040084A3 WO2000040084A3 (fr) 2000-09-28

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WO (1) WO2000040084A2 (fr)

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Publication number Priority date Publication date Assignee Title
WO2009059607A2 (fr) 2007-11-05 2009-05-14 Vestergaard Frandsen Sa Pièce comportant deux objets insecticides qui permettent de lutter contre les insectes résistants
WO2014089277A1 (fr) * 2012-12-06 2014-06-12 Y-Tex Corporation Porte-étiquette
US10111430B2 (en) 2008-08-06 2018-10-30 Vestergaard Sa Insecticidal polymer matrix comprising PBO and DM
CN109662958A (zh) * 2017-10-13 2019-04-23 魏先华 一种预防或治疗动物体外寄生生物的方法

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US3318769A (en) * 1963-05-31 1967-05-09 Shell Oil Co Resin compositions comprising organo-phosphorus pesticides
US3852416A (en) * 1971-05-27 1974-12-03 L Grubb Tick and flea collar of solid solution plasticized vinylic resin-carbamate insecticide
US3904746A (en) * 1973-10-17 1975-09-09 Robert Aries Synergized carbamic acid ester insecticidal collar
US4189467A (en) * 1977-04-07 1980-02-19 Bayer Aktiengesellschaft Polyurethanes having ectoparasiticidal activity
US4562794A (en) * 1984-01-30 1986-01-07 Bend Research, Inc. Pest control in animals
US5373815A (en) * 1994-01-21 1994-12-20 Sagebiel; Audrey C. Fly collar

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2462689A (en) * 1944-08-03 1949-02-22 Ernest A Stretz Insecticide dispensing device
US3318769A (en) * 1963-05-31 1967-05-09 Shell Oil Co Resin compositions comprising organo-phosphorus pesticides
US3852416A (en) * 1971-05-27 1974-12-03 L Grubb Tick and flea collar of solid solution plasticized vinylic resin-carbamate insecticide
US3904746A (en) * 1973-10-17 1975-09-09 Robert Aries Synergized carbamic acid ester insecticidal collar
US4189467A (en) * 1977-04-07 1980-02-19 Bayer Aktiengesellschaft Polyurethanes having ectoparasiticidal activity
US4562794A (en) * 1984-01-30 1986-01-07 Bend Research, Inc. Pest control in animals
US5373815A (en) * 1994-01-21 1994-12-20 Sagebiel; Audrey C. Fly collar

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009059607A2 (fr) 2007-11-05 2009-05-14 Vestergaard Frandsen Sa Pièce comportant deux objets insecticides qui permettent de lutter contre les insectes résistants
US10111430B2 (en) 2008-08-06 2018-10-30 Vestergaard Sa Insecticidal polymer matrix comprising PBO and DM
WO2014089277A1 (fr) * 2012-12-06 2014-06-12 Y-Tex Corporation Porte-étiquette
US9226549B2 (en) 2012-12-06 2016-01-05 Y-Tex Corporation Tag hanger
CN109662958A (zh) * 2017-10-13 2019-04-23 魏先华 一种预防或治疗动物体外寄生生物的方法

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AU2961000A (en) 2000-07-24

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