WO2000039301A3 - Methods for using mycobacterium tuberculosis molecules as immunological adjuvants - Google Patents

Methods for using mycobacterium tuberculosis molecules as immunological adjuvants Download PDF

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Publication number
WO2000039301A3
WO2000039301A3 PCT/US1999/030975 US9930975W WO0039301A3 WO 2000039301 A3 WO2000039301 A3 WO 2000039301A3 US 9930975 W US9930975 W US 9930975W WO 0039301 A3 WO0039301 A3 WO 0039301A3
Authority
WO
WIPO (PCT)
Prior art keywords
mycobacterium tuberculosis
methods
immunological adjuvants
proteins
antigen
Prior art date
Application number
PCT/US1999/030975
Other languages
French (fr)
Other versions
WO2000039301A9 (en
WO2000039301A2 (en
Inventor
Yasir Skeiky
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU25945/00A priority Critical patent/AU2594500A/en
Application filed by Corixa Corp filed Critical Corixa Corp
Priority to EP99968552A priority patent/EP1141312A2/en
Priority to CA002356669A priority patent/CA2356669A1/en
Publication of WO2000039301A2 publication Critical patent/WO2000039301A2/en
Publication of WO2000039301A3 publication Critical patent/WO2000039301A3/en
Publication of WO2000039301A9 publication Critical patent/WO2000039301A9/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

Abstract

The present invention relates to immunological adjuvants. In particular, it relates to Mycobacterium tuberculosis proteins which stimulate interleukin-12 (IL-12) and interferon gamma production. These proteins and fragments thereof may be used in combination with an antigen for inducing and/or enhancing an immune response to the antigen. Alternatively, polynucleotides encoding such proteins may be ligated with an antigen coding sequence to produce a fusion protein as an immunogen.
PCT/US1999/030975 1998-12-24 1999-12-23 Methods for using mycobacterium tuberculosis molecules as immunological adjuvants WO2000039301A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU25945/00A AU2594500A (en) 1998-12-24 1999-12-21 Methods for using mycobacterium tuberculosis molecules as immunological adjuvants
EP99968552A EP1141312A2 (en) 1998-12-24 1999-12-23 Methods for using mycobacterium tuberculosis molecules as immunological adjuvants
CA002356669A CA2356669A1 (en) 1998-12-24 1999-12-23 Methods for using mycobacterium tuberculosis molecules as immunological adjuvants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22041698A 1998-12-24 1998-12-24
US09/220,416 1998-12-24

Publications (3)

Publication Number Publication Date
WO2000039301A2 WO2000039301A2 (en) 2000-07-06
WO2000039301A3 true WO2000039301A3 (en) 2001-05-03
WO2000039301A9 WO2000039301A9 (en) 2001-10-18

Family

ID=22823460

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/030975 WO2000039301A2 (en) 1998-12-24 1999-12-23 Methods for using mycobacterium tuberculosis molecules as immunological adjuvants

Country Status (4)

Country Link
EP (1) EP1141312A2 (en)
AU (1) AU2594500A (en)
CA (1) CA2356669A1 (en)
WO (1) WO2000039301A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0003082D0 (en) * 2000-02-10 2000-03-29 Glaxo Group Ltd Vaccine
AU2001271963A1 (en) * 2000-07-10 2002-01-21 Colorado State University Research Foundation Mid-life vaccine and methods for boosting anti-mycobacterial immunity
NZ519667A (en) * 2002-06-19 2005-02-25 Univ Massey A putative 23kDa lipoprotein from Mycobacterium paratuberculosis and its use in Johne's disease
DE60325586D1 (en) * 2003-08-22 2009-02-12 Axenoll Ag Mycobacterial protein antigens for cancer therapy and vaccination
NZ581306A (en) 2004-11-16 2011-03-31 Crucell Holland Bv Multivalent vaccines comprising recombinant viral vectors
EP2368568A1 (en) * 2006-11-01 2011-09-28 Immport Therapeutics, INC. Compositions and methods for immunodominant antigens

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599545A (en) * 1990-05-07 1997-02-04 University College London Mycobacterium as adjuvant for antigens
WO1997009428A2 (en) * 1995-09-01 1997-03-13 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
WO1998016646A2 (en) * 1996-10-11 1998-04-23 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
WO1998044119A1 (en) * 1997-04-02 1998-10-08 Statens Serum Institut NUCLEIC ACID FRAGMENTS AND POLYPEPTIDE FRAGMENTS DERIVED FROM $i(M. TUBERCULOSIS)

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599545A (en) * 1990-05-07 1997-02-04 University College London Mycobacterium as adjuvant for antigens
WO1997009428A2 (en) * 1995-09-01 1997-03-13 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
WO1998016646A2 (en) * 1996-10-11 1998-04-23 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
WO1998044119A1 (en) * 1997-04-02 1998-10-08 Statens Serum Institut NUCLEIC ACID FRAGMENTS AND POLYPEPTIDE FRAGMENTS DERIVED FROM $i(M. TUBERCULOSIS)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LAUNOIS P ET AL: "T-CELL-EPITOPE MAPPING OF THE MAJOR SECRETED MYCOBACTERIAL ANTIGEN AG85A IN TUBERCULOSIS AND LEPROSY", INFECTION AND IMMUNITY,US,AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, vol. 62, no. 9, 1 September 1994 (1994-09-01), pages 3679 - 3687, XP000572211, ISSN: 0019-9567 *
SINHA R K ET AL: "Immunobiological properties of a 30 kDa secretory protein of Mycobacterium tuberculosis H37Ra", VACCINE,GB,BUTTERWORTH SCIENTIFIC. GUILDFORD, vol. 15, no. 6-7, 1 April 1997 (1997-04-01), pages 689 - 699, XP004064532, ISSN: 0264-410X *
SKEIKY ET AL: "LeIF: a recombinant Leishmania protein that induces and IL-12-mediated Th cytokine profile", JOURNAL OF IMMUNOLOGY,US,THE WILLIAMS AND WILKINS CO. BALTIMORE, 1998, pages 6171 - 6179, XP002103156, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
AU2594500A (en) 2000-07-31
CA2356669A1 (en) 2000-07-06
WO2000039301A9 (en) 2001-10-18
EP1141312A2 (en) 2001-10-10
WO2000039301A2 (en) 2000-07-06

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