WO2000036081A3 - Materials and methods for the modification of isoprenoid content, composition and metabolism - Google Patents

Materials and methods for the modification of isoprenoid content, composition and metabolism Download PDF

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Publication number
WO2000036081A3
WO2000036081A3 PCT/NZ1999/000219 NZ9900219W WO0036081A3 WO 2000036081 A3 WO2000036081 A3 WO 2000036081A3 NZ 9900219 W NZ9900219 W NZ 9900219W WO 0036081 A3 WO0036081 A3 WO 0036081A3
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WO
WIPO (PCT)
Prior art keywords
metabolism
methods
content
modification
composition
Prior art date
Application number
PCT/NZ1999/000219
Other languages
French (fr)
Other versions
WO2000036081A2 (en
Inventor
Ilkka Jaakko Havukkala
Original Assignee
Genesis Res & Dev Corp Ltd
Fletcher Challenge Forests Ltd
Ilkka Jaakko Havukkala
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genesis Res & Dev Corp Ltd, Fletcher Challenge Forests Ltd, Ilkka Jaakko Havukkala filed Critical Genesis Res & Dev Corp Ltd
Priority to EP99962594A priority Critical patent/EP1151081A2/en
Priority to AU19001/00A priority patent/AU1900100A/en
Priority to BR9917002-7A priority patent/BR9917002A/en
Priority to MXPA01006009A priority patent/MXPA01006009A/en
Priority to JP2000588332A priority patent/JP2002541764A/en
Priority to CA002353910A priority patent/CA2353910A1/en
Publication of WO2000036081A2 publication Critical patent/WO2000036081A2/en
Publication of WO2000036081A3 publication Critical patent/WO2000036081A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8255—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving lignin biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Nutrition Science (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Novel isolated polynucleotides associated with plant isoprenoid biosynthetic pathways are provided, together with genetic constructs comprising such sequences. Methods for the modulation of the content, structure and metabolism of polypeptides involved in an isoprenoid biosynthetic pathway in target organisms are also disclosed, the methods comprising incorporating one or more of the polynucleotides or genetic constructs of the present invention into the genome of a target organism. Modulation of the content, structure and metabolism of such polypeptides produces modifications in the content, structure and metabolism of isoprenoids in the target organism.
PCT/NZ1999/000219 1998-12-17 1999-12-16 Materials and methods for the modification of isoprenoid content, composition and metabolism WO2000036081A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP99962594A EP1151081A2 (en) 1998-12-17 1999-12-16 Materials and methods for the modification of isoprenoid content, composition and metabolism
AU19001/00A AU1900100A (en) 1998-12-17 1999-12-16 Materials and methods for the modification of isoprenoid content, composition and metabolism
BR9917002-7A BR9917002A (en) 1998-12-17 1999-12-16 Materials and processes for the modification of isoprenoid content, composition and metabolism
MXPA01006009A MXPA01006009A (en) 1998-12-17 1999-12-16 Materials and methods for the modification of isoprenoid content, composition and metabolism.
JP2000588332A JP2002541764A (en) 1998-12-17 1999-12-16 Materials and methods for modifying isoprenoid content, composition and metabolism
CA002353910A CA2353910A1 (en) 1998-12-17 1999-12-16 Materials and methods for the modification of isoprenoid content, composition and metabolism

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21550498A 1998-12-17 1998-12-17
US09/215,504 1998-12-17
US14644199P 1999-07-29 1999-07-29
US60/146,441 1999-07-29

Publications (2)

Publication Number Publication Date
WO2000036081A2 WO2000036081A2 (en) 2000-06-22
WO2000036081A3 true WO2000036081A3 (en) 2000-08-03

Family

ID=26843909

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NZ1999/000219 WO2000036081A2 (en) 1998-12-17 1999-12-16 Materials and methods for the modification of isoprenoid content, composition and metabolism

Country Status (10)

Country Link
EP (1) EP1151081A2 (en)
JP (1) JP2002541764A (en)
CN (1) CN1334866A (en)
AR (1) AR021636A1 (en)
AU (1) AU1900100A (en)
BR (1) BR9917002A (en)
CA (1) CA2353910A1 (en)
ID (1) ID29580A (en)
MX (1) MXPA01006009A (en)
WO (1) WO2000036081A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1826265B1 (en) 1998-10-09 2011-01-12 Arborgen, Llc Materials and methods for the modification of plant lignin content
CN100372939C (en) 2000-10-06 2008-03-05 札幌啤酒株式会社 Farnesyl pyrophosphate synthase protein, nucleic acid and promoter region thereof
DE10057755A1 (en) 2000-11-22 2002-05-23 Bayer Ag New nucleic acid encoding plant phosphomevalonate kinase, useful for identifying modulators, potentially useful as herbicides and growth regulators
US20030217384A1 (en) * 2002-02-05 2003-11-20 Harvell Leslie T. Obtusifoliol 14a-demethylase
US20040010818A1 (en) * 2002-05-09 2004-01-15 Mcgonigle Brian Transgenic plants with a suppressed triterpene level
US7402428B2 (en) 2004-09-22 2008-07-22 Arborgen, Llc Modification of plant lignin content
EP2182888A4 (en) * 2007-09-04 2010-09-08 Affinergy Inc Methods and compositions for delivery of growth factor to fibrous connective tissue
CN105671108A (en) 2010-06-02 2016-06-15 沃维公司 Recombinant production of steviol glycosides
EP3009508B1 (en) 2011-08-08 2020-11-25 Evolva SA Recombinant production of steviol glycosides
CN105051195B (en) 2013-02-06 2019-09-06 埃沃尔瓦公司 Method for improving the generation of Rebaudiodside A D and Rebaudiodside A M
CA2900882A1 (en) 2013-02-11 2014-08-14 Evolva Sa Efficient production of steviol glycosides in recombinants hosts
MX2017001859A (en) 2014-08-11 2017-04-11 Evolva Sa Production of steviol glycosides in recombinant hosts.
AU2015314251A1 (en) 2014-09-09 2017-03-16 Evolva Sa Production of steviol glycosides in recombinant hosts
SG11201705606PA (en) 2015-01-30 2017-08-30 Evolva Sa Production of steviol glycosides in recombinant hosts
CA2979931A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
AU2016307066A1 (en) 2015-08-07 2018-02-08 Evolva Sa Production of steviol glycosides in recombinant hosts
AU2017251462B2 (en) 2016-04-13 2022-02-03 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3458599A1 (en) 2016-05-16 2019-03-27 Evolva SA Production of steviol glycosides in recombinant hosts
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2463799A (en) * 1998-01-22 1999-08-09 Washington State University Research Foundation Sesquiterpene synthases from grand fir abies grandis, and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2463799A (en) * 1998-01-22 1999-08-09 Washington State University Research Foundation Sesquiterpene synthases from grand fir abies grandis, and methods of use

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Also Published As

Publication number Publication date
CN1334866A (en) 2002-02-06
MXPA01006009A (en) 2002-04-15
EP1151081A2 (en) 2001-11-07
ID29580A (en) 2001-09-06
AR021636A1 (en) 2002-07-31
CA2353910A1 (en) 2000-06-22
JP2002541764A (en) 2002-12-10
AU1900100A (en) 2000-07-03
BR9917002A (en) 2001-12-04
WO2000036081A2 (en) 2000-06-22

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