WO2000035490A3 - Contrast agent for facilitating ocular identification and inspection of lymph nodes - Google Patents

Contrast agent for facilitating ocular identification and inspection of lymph nodes Download PDF

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Publication number
WO2000035490A3
WO2000035490A3 PCT/EP1999/009783 EP9909783W WO0035490A3 WO 2000035490 A3 WO2000035490 A3 WO 2000035490A3 EP 9909783 W EP9909783 W EP 9909783W WO 0035490 A3 WO0035490 A3 WO 0035490A3
Authority
WO
WIPO (PCT)
Prior art keywords
dyes
contrast agent
inspection
lymph nodes
reactive
Prior art date
Application number
PCT/EP1999/009783
Other languages
French (fr)
Other versions
WO2000035490A2 (en
Inventor
Christer Busch
Original Assignee
Christer Busch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Christer Busch filed Critical Christer Busch
Priority to AU22824/00A priority Critical patent/AU2282400A/en
Publication of WO2000035490A2 publication Critical patent/WO2000035490A2/en
Publication of WO2000035490A3 publication Critical patent/WO2000035490A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery

Abstract

A contrast agent, and a method, for facilitating ocular identification and inspection of lymph nodes are disclosed. The contrast agent comprises a non-carcinogenic non-toxic biodegradable conjugate of a macromolecule and a reactive dye. Preferably the macromolecule is selected from hyaluronan, dextrans, glycogens, denaturated albumin molecules, and so-called sulfur colloids, and the reactive dye is selected from triazine based reactive dyes, such as Cibachron dyes or Procion dyes, and pyrimidinyl based reactive dyes, such as Rectone dyes, and reactive alkene dyes, such as Ramazol dyes, patent violet, trypan blue, and isosulfan blue.
PCT/EP1999/009783 1998-12-15 1999-12-10 Contrast agent for facilitating ocular identification and inspection of lymph nodes WO2000035490A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU22824/00A AU2282400A (en) 1998-12-15 1999-12-10 Contrast agent for facilitating ocular identification and inspection of lymph nodes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9804328-4 1998-12-15
SE9804328A SE9804328D0 (en) 1998-12-15 1998-12-15 Contrast agent for facilitating ocular identification and inspection of lymph nodes

Publications (2)

Publication Number Publication Date
WO2000035490A2 WO2000035490A2 (en) 2000-06-22
WO2000035490A3 true WO2000035490A3 (en) 2000-09-21

Family

ID=20413661

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/009783 WO2000035490A2 (en) 1998-12-15 1999-12-10 Contrast agent for facilitating ocular identification and inspection of lymph nodes

Country Status (3)

Country Link
AU (1) AU2282400A (en)
SE (1) SE9804328D0 (en)
WO (1) WO2000035490A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1419787A1 (en) * 2002-11-18 2004-05-19 Uwe Prof. Dr. Till Contrast agent for the identification of lymph nodes
US20080308744A1 (en) * 2003-11-18 2008-12-18 Beth Israel Deaconess Medical Center Serum Albumin Conjugated to Fluorescent Substances for Imaging
US20080064954A1 (en) 2006-08-24 2008-03-13 Baylor College Of Medicine Method of measuring propulsion in lymphatic structures
KR20160008206A (en) 2013-04-26 2016-01-21 마이렉서스 바이오테크놀로지스 인코퍼레이티드 Monodisperse glycogen and phytoglycogen nanoparticles and use thereof as additives in cosmetics, pharmaceuticals, and food products
CN113730605A (en) * 2016-07-21 2021-12-03 波士顿科学国际有限公司 Injectable composition

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS557245A (en) * 1978-06-30 1980-01-19 Dai Ichi Seiyaku Co Ltd Colorant for lymph system
WO1994021303A1 (en) * 1993-03-16 1994-09-29 Alliance Pharmaceutical Corp. Fluorocarbon compositions containing a visible or fluorescent label
RU2020963C1 (en) * 1989-06-26 1994-10-15 Центр по химии лекарственных средств Medicinal preparation for diagnosing lymphatic system disorders
WO1996004922A1 (en) * 1994-08-10 1996-02-22 Davis, Joanne, T. Method of using hyaluronic acid for the detection, location and diagnosis of tumors
WO1996017628A1 (en) * 1994-12-07 1996-06-13 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin In-vivo diagnostic process by near infrared radiation
WO1998048845A1 (en) * 1997-04-29 1998-11-05 Nycomed Imaging As Method of demarcating tissue

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS557245A (en) * 1978-06-30 1980-01-19 Dai Ichi Seiyaku Co Ltd Colorant for lymph system
RU2020963C1 (en) * 1989-06-26 1994-10-15 Центр по химии лекарственных средств Medicinal preparation for diagnosing lymphatic system disorders
WO1994021303A1 (en) * 1993-03-16 1994-09-29 Alliance Pharmaceutical Corp. Fluorocarbon compositions containing a visible or fluorescent label
WO1996004922A1 (en) * 1994-08-10 1996-02-22 Davis, Joanne, T. Method of using hyaluronic acid for the detection, location and diagnosis of tumors
WO1996017628A1 (en) * 1994-12-07 1996-06-13 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin In-vivo diagnostic process by near infrared radiation
WO1998048845A1 (en) * 1997-04-29 1998-11-05 Nycomed Imaging As Method of demarcating tissue

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 198009, Derwent World Patents Index; Class B04, AN 1980-15380C, XP002900982 *
DATABASE WPI Section Ch Week 199524, Derwent World Patents Index; Class B04, AN 1995-183770, XP002900981 *

Also Published As

Publication number Publication date
WO2000035490A2 (en) 2000-06-22
SE9804328D0 (en) 1998-12-15
AU2282400A (en) 2000-07-03

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