SE9804328D0 - Contrast agent for facilitating ocular identification and inspection of lymph nodes - Google Patents
Contrast agent for facilitating ocular identification and inspection of lymph nodesInfo
- Publication number
- SE9804328D0 SE9804328D0 SE9804328A SE9804328A SE9804328D0 SE 9804328 D0 SE9804328 D0 SE 9804328D0 SE 9804328 A SE9804328 A SE 9804328A SE 9804328 A SE9804328 A SE 9804328A SE 9804328 D0 SE9804328 D0 SE 9804328D0
- Authority
- SE
- Sweden
- Prior art keywords
- dyes
- contrast agent
- inspection
- lymph nodes
- reactive
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title abstract 3
- 238000007689 inspection Methods 0.000 title abstract 2
- 210000001165 lymph node Anatomy 0.000 title abstract 2
- 239000000975 dye Substances 0.000 abstract 5
- 239000000985 reactive dye Substances 0.000 abstract 4
- 229920002521 macromolecule Polymers 0.000 abstract 2
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 abstract 1
- RTLULCVBFCRQKI-UHFFFAOYSA-N 1-amino-4-[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfoanilino]-9,10-dioxoanthracene-2-sulfonic acid Chemical compound C1=2C(=O)C3=CC=CC=C3C(=O)C=2C(N)=C(S(O)(=O)=O)C=C1NC(C=1)=CC=C(S(O)(=O)=O)C=1NC1=NC(Cl)=NC(Cl)=N1 RTLULCVBFCRQKI-UHFFFAOYSA-N 0.000 abstract 1
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- 229920002527 Glycogen Polymers 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 abstract 1
- 150000001336 alkenes Chemical class 0.000 abstract 1
- 239000000084 colloidal system Substances 0.000 abstract 1
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 abstract 1
- 229940099552 hyaluronan Drugs 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 229940074320 iso-sulfan blue Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 231100001223 noncarcinogenic Toxicity 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- NLUFDZBOHMOBOE-UHFFFAOYSA-M sodium;2-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzene-1,4-disulfonate Chemical compound [Na+].C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC=C(C=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1 NLUFDZBOHMOBOE-UHFFFAOYSA-M 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Landscapes
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oncology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Abstract
A contrast agent, and a method, for facilitating ocular identification and inspection of lymph nodes are disclosed. The contrast agent comprises a non-carcinogenic non-toxic biodegradable conjugate of a macromolecule and a reactive dye. Preferably the macromolecule is selected from hyaluronan, dextrans, glycogens, denaturated albumin molecules, and so-called sulfur colloids, and the reactive dye is selected from triazine based reactive dyes, such as Cibachron dyes or Procion dyes, and pyrimidinyl based reactive dyes, such as Rectone dyes, and reactive alkene dyes, such as Ramazol dyes, patent violet, trypan blue, and isosulfan blue.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9804328A SE9804328D0 (en) | 1998-12-15 | 1998-12-15 | Contrast agent for facilitating ocular identification and inspection of lymph nodes |
| AU22824/00A AU2282400A (en) | 1998-12-15 | 1999-12-10 | Contrast agent for facilitating ocular identification and inspection of lymph nodes |
| PCT/EP1999/009783 WO2000035490A2 (en) | 1998-12-15 | 1999-12-10 | Contrast agent for facilitating ocular identification and inspection of lymph nodes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9804328A SE9804328D0 (en) | 1998-12-15 | 1998-12-15 | Contrast agent for facilitating ocular identification and inspection of lymph nodes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE9804328D0 true SE9804328D0 (en) | 1998-12-15 |
Family
ID=20413661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9804328A SE9804328D0 (en) | 1998-12-15 | 1998-12-15 | Contrast agent for facilitating ocular identification and inspection of lymph nodes |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2282400A (en) |
| SE (1) | SE9804328D0 (en) |
| WO (1) | WO2000035490A2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1419787A1 (en) * | 2002-11-18 | 2004-05-19 | Uwe Prof. Dr. Till | Contrast agent for the identification of lymph nodes |
| WO2005082423A2 (en) * | 2003-11-18 | 2005-09-09 | Beth Israel Deaconess Medical Center | Serum albumin conjugated to fluorescent substances for imaging |
| US20080064954A1 (en) * | 2006-08-24 | 2008-03-13 | Baylor College Of Medicine | Method of measuring propulsion in lymphatic structures |
| KR102214865B1 (en) | 2013-04-26 | 2021-02-15 | 마이렉서스 바이오테크놀로지스 인코퍼레이티드 | Phytoglycogen nanoparticles and methods of manufacture thereof |
| WO2018017861A1 (en) * | 2016-07-21 | 2018-01-25 | Boston Scientific Scimed, Inc. | Injectable compositions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS557245A (en) * | 1978-06-30 | 1980-01-19 | Dai Ichi Seiyaku Co Ltd | Colorant for lymph system |
| RU2020963C1 (en) * | 1989-06-26 | 1994-10-15 | Центр по химии лекарственных средств | Medicinal preparation for diagnosing lymphatic system disorders |
| AU6365894A (en) * | 1993-03-16 | 1994-10-11 | Alliance Pharmaceutical Corporation | Fluorocarbon compositions containing a visible or fluorescent label |
| CA2196408A1 (en) * | 1994-08-10 | 1996-02-22 | Roderick T. Coward | Method of using hyaluronic acid for the detection, location and diagnosis of tumors |
| DE4445065A1 (en) * | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Methods for in-vivo diagnostics using NIR radiation |
| DE69820867T2 (en) * | 1997-04-29 | 2004-11-18 | Amersham Health As | LIGHT IMAGING CONTRAST AGENTS |
-
1998
- 1998-12-15 SE SE9804328A patent/SE9804328D0/en unknown
-
1999
- 1999-12-10 WO PCT/EP1999/009783 patent/WO2000035490A2/en active Application Filing
- 1999-12-10 AU AU22824/00A patent/AU2282400A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000035490A3 (en) | 2000-09-21 |
| AU2282400A (en) | 2000-07-03 |
| WO2000035490A2 (en) | 2000-06-22 |
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