WO2000034294A3 - Tumor necrosis factor receptor homologue-1 ('trh1') - Google Patents

Tumor necrosis factor receptor homologue-1 ('trh1') Download PDF

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Publication number
WO2000034294A3
WO2000034294A3 PCT/US1999/029400 US9929400W WO0034294A3 WO 2000034294 A3 WO2000034294 A3 WO 2000034294A3 US 9929400 W US9929400 W US 9929400W WO 0034294 A3 WO0034294 A3 WO 0034294A3
Authority
WO
WIPO (PCT)
Prior art keywords
trh1
necrosis factor
tumor necrosis
factor receptor
receptor homologue
Prior art date
Application number
PCT/US1999/029400
Other languages
French (fr)
Other versions
WO2000034294A2 (en
Inventor
Michael A Bowen
Nathan Siemers
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to EP99968873A priority Critical patent/EP1135412A2/en
Priority to JP2000586737A priority patent/JP2002531112A/en
Priority to CA002354612A priority patent/CA2354612A1/en
Priority to AU27080/00A priority patent/AU2708000A/en
Publication of WO2000034294A2 publication Critical patent/WO2000034294A2/en
Publication of WO2000034294A3 publication Critical patent/WO2000034294A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention discloses the identification of the new human tumor necrosis factor receptor homologue ('TRH1'), as identified by its nucleic acid and amino acid sequences disclosed herein. The invention also includes methods of using the nucleic acid sequence, the TRH1 protein, a monoclonal antibody specific for the novel tumor necrosis factor receptor, a ligand for the novel tumor necrosis factor receptor, and fusion proteins comprising all or a portion of the TRH1 disclosed herein.
PCT/US1999/029400 1998-12-11 1999-12-10 Tumor necrosis factor receptor homologue-1 ('trh1') WO2000034294A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99968873A EP1135412A2 (en) 1998-12-11 1999-12-10 Tumor necrosis factor receptor homologue-1 (trh1)
JP2000586737A JP2002531112A (en) 1998-12-11 1999-12-10 Tumor necrosis factor receptor homolog-1
CA002354612A CA2354612A1 (en) 1998-12-11 1999-12-10 Tumor necrosis factor receptor homologue-1 ("trh1")
AU27080/00A AU2708000A (en) 1998-12-11 1999-12-10 Tumor necrosis factor receptor homologue-1 ("trh1")

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11182698P 1998-12-11 1998-12-11
US60/111,826 1998-12-11

Publications (2)

Publication Number Publication Date
WO2000034294A2 WO2000034294A2 (en) 2000-06-15
WO2000034294A3 true WO2000034294A3 (en) 2000-10-26

Family

ID=22340643

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/029400 WO2000034294A2 (en) 1998-12-11 1999-12-10 Tumor necrosis factor receptor homologue-1 ('trh1')

Country Status (5)

Country Link
EP (1) EP1135412A2 (en)
JP (1) JP2002531112A (en)
AU (1) AU2708000A (en)
CA (1) CA2354612A1 (en)
WO (1) WO2000034294A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358508B1 (en) 1997-06-11 2002-03-19 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor TR9
CN1329086A (en) * 2000-06-21 2002-01-02 上海博德基因开发有限公司 A novel polypeptide-human TNFR/NGFR protein 15 contaiing cytochrome C structural domain and polynucleotide for coding this polypeptide

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0869179A1 (en) * 1997-04-02 1998-10-07 Smithkline Beecham Corporation Tumor necrosis related receptor, TR7
WO1998056892A1 (en) * 1997-06-11 1998-12-17 Human Genome Sciences, Inc. Human tumor necrosis factor receptor tr9

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0869179A1 (en) * 1997-04-02 1998-10-07 Smithkline Beecham Corporation Tumor necrosis related receptor, TR7
WO1998056892A1 (en) * 1997-06-11 1998-12-17 Human Genome Sciences, Inc. Human tumor necrosis factor receptor tr9

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EST, ADAMS ET AL.: "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotide of cDNA sequence" *
DATABASE EST, HILLIER ET AL.: "Generation and analysis of 280,000 human expressed sequence tags" *
DATABASE GENEMBL, (PATHOLOGY, UNIVERSITY OF MICHIGAN MEDICAL SCHOOL, ANN ARBOR, MI, USA),; PAN ET AL.: "Identification and Functional Characterization of DR6 a Novel Death Domain-containing TNF Receptor" *
GENE SEQUENCE, 5 September 1998 (1998-09-05) *
GENE SEQUENCE, GENOME RES.,, vol. 6, no. 9, 11 December 1996 (1996-12-11), pages 807 - 828 *
GENE SEQUENCE, NATURE,, vol. 377, no. 6547 SUPPL., 21 April 1997 (1997-04-21), pages 3 - 174 *

Also Published As

Publication number Publication date
AU2708000A (en) 2000-06-26
JP2002531112A (en) 2002-09-24
CA2354612A1 (en) 2000-06-15
EP1135412A2 (en) 2001-09-26
WO2000034294A2 (en) 2000-06-15

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