WO2000034285A3 - Indenoindoles et benzofuranoindoles substitues utilises comme nouveaux elements d'ouverture de canaux potassiques - Google Patents

Indenoindoles et benzofuranoindoles substitues utilises comme nouveaux elements d'ouverture de canaux potassiques Download PDF

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Publication number
WO2000034285A3
WO2000034285A3 PCT/US1999/028619 US9928619W WO0034285A3 WO 2000034285 A3 WO2000034285 A3 WO 2000034285A3 US 9928619 W US9928619 W US 9928619W WO 0034285 A3 WO0034285 A3 WO 0034285A3
Authority
WO
WIPO (PCT)
Prior art keywords
potassium channel
benzofuranoindoles
indenoindoles
substituted
channel openers
Prior art date
Application number
PCT/US1999/028619
Other languages
English (en)
Other versions
WO2000034285A2 (fr
Inventor
Schuyler A Antane
John A Butera
Joseph R Lennox
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Priority to AU21636/00A priority Critical patent/AU2163600A/en
Priority to EP99965977A priority patent/EP1135393A2/fr
Priority to CA002350590A priority patent/CA2350590A1/fr
Priority to JP2000586730A priority patent/JP2002531569A/ja
Priority to BR9915900-7A priority patent/BR9915900A/pt
Publication of WO2000034285A2 publication Critical patent/WO2000034285A2/fr
Publication of WO2000034285A3 publication Critical patent/WO2000034285A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des composés représentés par la formule (I) et (II), dans lesquelles R1, R2, R3, X, Y et Z sont tels que définis dans le descriptif, ces composés étant utilisés dans le traitement des troubles associés à la contraction des muscles lisses, par la modulation des canaux calciques.
PCT/US1999/028619 1998-12-04 1999-12-03 Indenoindoles et benzofuranoindoles substitues utilises comme nouveaux elements d'ouverture de canaux potassiques WO2000034285A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU21636/00A AU2163600A (en) 1998-12-04 1999-12-03 Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
EP99965977A EP1135393A2 (fr) 1998-12-04 1999-12-03 Indenoindoles et benzofuranoindoles substitues utilises comme nouveaux elements d'ouverture de canaux potassiques
CA002350590A CA2350590A1 (fr) 1998-12-04 1999-12-03 Indenoindoles et benzofuranoindoles substitues utilises comme nouveaux elements d'ouverture de canaux potassiques
JP2000586730A JP2002531569A (ja) 1998-12-04 1999-12-03 新規なカリウムチャンネル開放物質としての置換ベンゾフラノインドール及びインデノインドール
BR9915900-7A BR9915900A (pt) 1998-12-04 1999-12-03 Composto, composição farmacêutica, e, processo para tratar ou inibir distúrbios associados com contração da musculatura lisa.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20577098A 1998-12-04 1998-12-04
US09/205,770 1998-12-04

Publications (2)

Publication Number Publication Date
WO2000034285A2 WO2000034285A2 (fr) 2000-06-15
WO2000034285A3 true WO2000034285A3 (fr) 2000-11-16

Family

ID=22763580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/028619 WO2000034285A2 (fr) 1998-12-04 1999-12-03 Indenoindoles et benzofuranoindoles substitues utilises comme nouveaux elements d'ouverture de canaux potassiques

Country Status (7)

Country Link
EP (1) EP1135393A2 (fr)
JP (1) JP2002531569A (fr)
CN (1) CN1333774A (fr)
AU (1) AU2163600A (fr)
BR (1) BR9915900A (fr)
CA (1) CA2350590A1 (fr)
WO (1) WO2000034285A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006034090A1 (fr) * 2004-09-20 2006-03-30 Janssen Pharmaceutica N.V. Nouveaux derives contenant des heteroatomes tetracycliques modulateurs des recepteurs des hormones steroidiennes sexuelles
KR100659498B1 (ko) 2005-03-10 2006-12-20 애니젠 주식회사 벤조퓨로인돌계 칼륨 채널 개시제
WO2007009120A2 (fr) 2005-07-14 2007-01-18 Irm Llc Composes et compositions utilises comme mimetiques de la tpo
JP6091445B2 (ja) * 2013-02-07 2017-03-08 富士フイルム株式会社 有機薄膜トランジスタ、有機半導体薄膜および有機半導体材料
DK3292116T3 (da) 2015-02-02 2022-01-10 Valo Health Inc 3-aryl-4-amido-bicykliske [4,5,0]hydroxamsyrer som hdac-inhibitorer
WO2016126726A1 (fr) 2015-02-02 2016-08-11 Forma Therapeutics, Inc. Acides hydroxamiques bicycliques [4,6,0] en tant qu'inhibiteurs hdac6
US10555935B2 (en) 2016-06-17 2020-02-11 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors
CN106632360A (zh) * 2016-09-27 2017-05-10 上海道亦化工科技有限公司 基于苯并呋喃并吲哚的化合物及其有机电致发光器件
CN109942545A (zh) * 2019-04-15 2019-06-28 中国药科大学 含吲哚结构的钾离子竞争性酸阻滞剂及其制备方法与用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015799A1 (fr) * 1989-06-22 1990-12-27 University Of Bath Composes d'indenoindole ii
WO1990015800A1 (fr) * 1989-06-22 1990-12-27 University Of Bath Composes d'indenoindole
WO1991014688A1 (fr) * 1990-03-20 1991-10-03 The Wellcome Foundation Limited Composes biocides heteropolycycliques et utilisation de ces composes en medecine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015799A1 (fr) * 1989-06-22 1990-12-27 University Of Bath Composes d'indenoindole ii
WO1990015800A1 (fr) * 1989-06-22 1990-12-27 University Of Bath Composes d'indenoindole
WO1991014688A1 (fr) * 1990-03-20 1991-10-03 The Wellcome Foundation Limited Composes biocides heteropolycycliques et utilisation de ces composes en medecine

Also Published As

Publication number Publication date
WO2000034285A2 (fr) 2000-06-15
BR9915900A (pt) 2001-08-21
EP1135393A2 (fr) 2001-09-26
JP2002531569A (ja) 2002-09-24
CA2350590A1 (fr) 2000-06-15
CN1333774A (zh) 2002-01-30
AU2163600A (en) 2000-06-26

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