WO2000031258A3 - Human orphan g protein-coupled receptors - Google Patents

Human orphan g protein-coupled receptors Download PDF

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Publication number
WO2000031258A3
WO2000031258A3 PCT/US1999/023687 US9923687W WO0031258A3 WO 2000031258 A3 WO2000031258 A3 WO 2000031258A3 US 9923687 W US9923687 W US 9923687W WO 0031258 A3 WO0031258 A3 WO 0031258A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
coupled receptors
human orphan
orphan
human
Prior art date
Application number
PCT/US1999/023687
Other languages
French (fr)
Other versions
WO2000031258A2 (en
Inventor
Ruoping Chen
Huong T Dang
Chen W Liaw
I-Lin Lin
Original Assignee
Arena Pharm Inc
Ruoping Chen
Huong T Dang
Chen W Liaw
Lin I Lin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES99972682T priority Critical patent/ES2243095T3/en
Application filed by Arena Pharm Inc, Ruoping Chen, Huong T Dang, Chen W Liaw, Lin I Lin filed Critical Arena Pharm Inc
Priority to DE69926650T priority patent/DE69926650T8/en
Priority to JP2000584067A priority patent/JP2003534767A/en
Priority to AU37904/00A priority patent/AU770056B2/en
Priority to AT99972682T priority patent/ATE301673T1/en
Priority to IL14253899A priority patent/IL142538A0/en
Priority to CA002348377A priority patent/CA2348377C/en
Priority to DK07008841T priority patent/DK1849866T3/en
Priority to EP99972682A priority patent/EP1133559B1/en
Priority to NZ511087A priority patent/NZ511087A/en
Priority to DK05003040T priority patent/DK1584683T3/en
Publication of WO2000031258A2 publication Critical patent/WO2000031258A2/en
Publication of WO2000031258A3 publication Critical patent/WO2000031258A3/en
Priority to IL142538A priority patent/IL142538A/en
Priority to HK01108607A priority patent/HK1037675A1/en
Priority to AU2004202147A priority patent/AU2004202147A1/en
Priority to AU2007202241A priority patent/AU2007202241A1/en
Priority to AU2009202228A priority patent/AU2009202228B2/en
Priority to IL205658A priority patent/IL205658A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors.
PCT/US1999/023687 1998-11-20 1999-10-13 Human orphan g protein-coupled receptors WO2000031258A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
DK07008841T DK1849866T3 (en) 1998-11-20 1999-10-13 Human orphan G protein-coupled receptor RUP3
DE69926650T DE69926650T8 (en) 1998-11-20 1999-10-13 HUMAN RUP3 RECIPE RING WITH A G-PROTEIN WITHOUT BELIGAND
JP2000584067A JP2003534767A (en) 1998-11-20 1999-10-13 Human orphan G protein-coupled receptor
AU37904/00A AU770056B2 (en) 1998-11-20 1999-10-13 Human orphan G protein coupled receptors
AT99972682T ATE301673T1 (en) 1998-11-20 1999-10-13 HUMAN RUP3 RECEPTOR COUPLED TO A G-PROTEIN WITHOUT KNOWN LIGAND
IL14253899A IL142538A0 (en) 1998-11-20 1999-10-13 Human orphan g protein-coupled receptors
NZ511087A NZ511087A (en) 1998-11-20 1999-10-13 Human orphan G protein-coupled receptors
EP99972682A EP1133559B1 (en) 1998-11-20 1999-10-13 Human orphan g protein-coupled receptor rup3
CA002348377A CA2348377C (en) 1998-11-20 1999-10-13 Human orphan g protein-coupled receptors
ES99972682T ES2243095T3 (en) 1998-11-20 1999-10-13 RECEPTORS COUPLED TO PROTEINA G HUMANOS HUERFANOS.
DK05003040T DK1584683T3 (en) 1998-11-20 1999-10-13 Human G protein-coupled orphan receptor RUP3
IL142538A IL142538A (en) 1998-11-20 2001-04-11 Use of a g protein-coupled receptor to screen candidate compounds as pharmacetical agents
HK01108607A HK1037675A1 (en) 1998-11-20 2001-12-07 Human orphan g protein-coupled receptor rup3.
AU2004202147A AU2004202147A1 (en) 1998-11-20 2004-05-12 Human Orphan G protein-Coupled receptors
AU2007202241A AU2007202241A1 (en) 1998-11-20 2007-05-11 Human Orphan G protein-coupled receptor hRUP3
AU2009202228A AU2009202228B2 (en) 1998-11-20 2009-06-04 Human Orphan G protein-Coupled receptor hRUP3
IL205658A IL205658A0 (en) 1998-11-20 2010-05-10 The use of a g protein-coupled receptor to screen candidate compounds as pharmaceutical agents

Applications Claiming Priority (46)

Application Number Priority Date Filing Date Title
US10921398P 1998-11-20 1998-11-20
US60/109,213 1998-11-20
US12041699P 1999-02-16 1999-02-16
US60/120,416 1999-02-16
US12185299P 1999-02-26 1999-02-26
US60/121,852 1999-02-26
US12394699P 1999-03-12 1999-03-12
US12394999P 1999-03-12 1999-03-12
US60/123,949 1999-03-12
US60/123,946 1999-03-12
US13643699P 1999-05-28 1999-05-28
US13713199P 1999-05-28 1999-05-28
US13643999P 1999-05-28 1999-05-28
US13656799P 1999-05-28 1999-05-28
US13712799P 1999-05-28 1999-05-28
US13643799P 1999-05-28 1999-05-28
US60/136,437 1999-05-28
US60/136,436 1999-05-28
US60/137,127 1999-05-28
US60/136,567 1999-05-28
US60/137,131 1999-05-28
US60/136,439 1999-05-28
US14144899P 1999-06-29 1999-06-29
US60/141,448 1999-06-29
US15663499P 1999-09-29 1999-09-29
US15663399P 1999-09-29 1999-09-29
US15655599P 1999-09-29 1999-09-29
US15665399P 1999-09-29 1999-09-29
US60/156,555 1999-09-29
US60/156,653 1999-09-29
US60/156,634 1999-09-29
US60/156,633 1999-09-29
US15728099P 1999-10-01 1999-10-01
US15728299P 1999-10-01 1999-10-01
US15729499P 1999-10-01 1999-10-01
US15728199P 1999-10-01 1999-10-01
US15729399P 1999-10-01 1999-10-01
US60/157,281 1999-10-01
US60/157,294 1999-10-01
US60/157,282 1999-10-01
US60/157,280 1999-10-01
US60/157,293 1999-10-01
US41704499A 1999-10-12 1999-10-12
US41676099A 1999-10-12 1999-10-12
US09/417,044 1999-10-12
US09/416,760 1999-10-12

Publications (2)

Publication Number Publication Date
WO2000031258A2 WO2000031258A2 (en) 2000-06-02
WO2000031258A3 true WO2000031258A3 (en) 2000-10-05

Family

ID=27586698

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/023687 WO2000031258A2 (en) 1998-11-20 1999-10-13 Human orphan g protein-coupled receptors

Country Status (13)

Country Link
EP (8) EP1580271A3 (en)
JP (5) JP2003534767A (en)
KR (5) KR100926208B1 (en)
AT (3) ATE301673T1 (en)
AU (2) AU770056B2 (en)
CA (2) CA2645717A1 (en)
DK (3) DK1584683T3 (en)
ES (3) ES2308759T3 (en)
HK (2) HK1037675A1 (en)
IL (2) IL142538A0 (en)
NZ (3) NZ537625A (en)
PT (3) PT1133559E (en)
WO (1) WO2000031258A2 (en)

Cited By (2)

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US8883714B2 (en) 2008-04-07 2014-11-11 Arena Pharmaceuticals, Inc. Pharmaceutical compositions comprising GPR119 agonists which act as peptide YY (PYY) secretagogues
US8933083B2 (en) 2003-01-14 2015-01-13 Arena Pharmaceuticals, Inc. 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia

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