WO2000031092A3 - Benzyllactobionamides as inhibitors of smooth muscle cell proliferation - Google Patents

Benzyllactobionamides as inhibitors of smooth muscle cell proliferation Download PDF

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Publication number
WO2000031092A3
WO2000031092A3 PCT/US1999/027774 US9927774W WO0031092A3 WO 2000031092 A3 WO2000031092 A3 WO 2000031092A3 US 9927774 W US9927774 W US 9927774W WO 0031092 A3 WO0031092 A3 WO 0031092A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell proliferation
smooth muscle
muscle cell
inhibitors
benzyllactobionamides
Prior art date
Application number
PCT/US1999/027774
Other languages
French (fr)
Other versions
WO2000031092A2 (en
Inventor
Scott Christian Mayer
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU57066/99A priority Critical patent/AU5706699A/en
Application filed by American Home Prod filed Critical American Home Prod
Priority to CA002351061A priority patent/CA2351061A1/en
Priority to JP2000583920A priority patent/JP2002530417A/en
Priority to EP99944107A priority patent/EP1133507A2/en
Priority to BR9915641-5A priority patent/BR9915641A/en
Publication of WO2000031092A2 publication Critical patent/WO2000031092A2/en
Publication of WO2000031092A3 publication Critical patent/WO2000031092A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

This invention provides smooth muscle cell proliferation inhibitors of formula (I) having the structure or a pharmaceutically acceptable salt thereof.
PCT/US1999/027774 1998-11-24 1999-11-23 Benzyllactobionamides as inhibitors of smooth muscle cell proliferation WO2000031092A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU57066/99A AU5706699A (en) 1998-11-24 1999-02-04 Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
CA002351061A CA2351061A1 (en) 1998-11-24 1999-11-23 Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
JP2000583920A JP2002530417A (en) 1998-11-24 1999-11-23 Benzyl lactobionamide as an inhibitor of smooth muscle cell proliferation
EP99944107A EP1133507A2 (en) 1998-11-24 1999-11-23 Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
BR9915641-5A BR9915641A (en) 1998-11-24 1999-11-23 Benzyl lactobionamides as inhibitors of smooth muscle cell proliferation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19898298A 1998-11-24 1998-11-24
US09/198,982 1998-11-24

Publications (2)

Publication Number Publication Date
WO2000031092A2 WO2000031092A2 (en) 2000-06-02
WO2000031092A3 true WO2000031092A3 (en) 2001-01-18

Family

ID=22735720

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/027774 WO2000031092A2 (en) 1998-11-24 1999-11-23 Benzyllactobionamides as inhibitors of smooth muscle cell proliferation

Country Status (7)

Country Link
EP (1) EP1133507A2 (en)
JP (1) JP2002530417A (en)
CN (1) CN1333779A (en)
AU (1) AU5706699A (en)
BR (1) BR9915641A (en)
CA (1) CA2351061A1 (en)
WO (1) WO2000031092A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2576131C (en) * 2004-08-05 2012-04-24 Ivax Drug Research Institute Ltd. Polysulfated glycosides and salts thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0312086A2 (en) * 1987-10-14 1989-04-19 LUITPOLD PHARMA GmbH Polysulfuric esters of amides of bis-aldonic acids and their derivatives, a method for their preparation and a drug
WO1996014325A1 (en) * 1994-11-07 1996-05-17 American Home Products Corporation Acylated benzylglycosides as inhibitors of smooth muscle cell proliferation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0312086A2 (en) * 1987-10-14 1989-04-19 LUITPOLD PHARMA GmbH Polysulfuric esters of amides of bis-aldonic acids and their derivatives, a method for their preparation and a drug
US5008247A (en) * 1987-10-14 1991-04-16 Luitpold-Werk Chemisch-Pharmazeutische Fabrik Gmbh & Co. Polysulfuric acid esters of bis-aldonamides and their derivatives, process for their preparation and medicaments
WO1996014325A1 (en) * 1994-11-07 1996-05-17 American Home Products Corporation Acylated benzylglycosides as inhibitors of smooth muscle cell proliferation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
OHNO, KOHJI ET AL: "Free-radical polymerization of a sugar residue-carrying styryl monomer with a lipophilic alkoxyamine initiator. Synthesis of a well-defined novel glycolipid", MACROMOL. CHEM. PHYS. (1998), 199(10), 2193-2197, XP000787909 *
OUARI, OLIVIER ET AL: "Synthesis and spin-trapping behavior of glycosylated nitrones", J. CHEM. SOC., PERKIN TRANS. 2 (1998), (10), 2299-2308, XP002149958 *

Also Published As

Publication number Publication date
CN1333779A (en) 2002-01-30
WO2000031092A2 (en) 2000-06-02
AU5706699A (en) 2000-06-13
EP1133507A2 (en) 2001-09-19
BR9915641A (en) 2001-08-07
JP2002530417A (en) 2002-09-17
CA2351061A1 (en) 2000-06-02

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