WO2000031094A3 - Benzylglycosylamides as inhibitors of smooth muscle cell proliferation - Google Patents

Benzylglycosylamides as inhibitors of smooth muscle cell proliferation Download PDF

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Publication number
WO2000031094A3
WO2000031094A3 PCT/US1999/027823 US9927823W WO0031094A3 WO 2000031094 A3 WO2000031094 A3 WO 2000031094A3 US 9927823 W US9927823 W US 9927823W WO 0031094 A3 WO0031094 A3 WO 0031094A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell proliferation
smooth muscle
muscle cell
inhibitors
benzylglycosylamides
Prior art date
Application number
PCT/US1999/027823
Other languages
French (fr)
Other versions
WO2000031094A2 (en
Inventor
Robert Emmett Mcdevitt
Folake Oluwemimo Adebayo
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Priority to AU18293/00A priority Critical patent/AU1829300A/en
Priority to EP99961783A priority patent/EP1144426A2/en
Priority to BR9915606-7A priority patent/BR9915606A/en
Priority to CA002350755A priority patent/CA2350755A1/en
Priority to JP2000583922A priority patent/JP2002530419A/en
Publication of WO2000031094A2 publication Critical patent/WO2000031094A2/en
Publication of WO2000031094A3 publication Critical patent/WO2000031094A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

This invention provides smooth muscle cell proliferation inhibitors of formula (I) having the structure (a) wherein Y is C or N; where n is 0 - 3; X is (II); or a pharmaceutically acceptable salt thereof.
PCT/US1999/027823 1998-11-24 1999-11-23 Benzylglycosylamides as inhibitors of smooth muscle cell proliferation WO2000031094A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU18293/00A AU1829300A (en) 1998-11-24 1999-11-23 Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
EP99961783A EP1144426A2 (en) 1998-11-24 1999-11-23 Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
BR9915606-7A BR9915606A (en) 1998-11-24 1999-11-23 Benzylglycosylamides as inhibitors of cell proliferation in smooth muscle
CA002350755A CA2350755A1 (en) 1998-11-24 1999-11-23 Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
JP2000583922A JP2002530419A (en) 1998-11-24 1999-11-23 Benzylglycosylamide as an inhibitor of smooth muscle cell proliferation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19843398A 1998-11-24 1998-11-24
US09/198,433 1998-11-24

Publications (2)

Publication Number Publication Date
WO2000031094A2 WO2000031094A2 (en) 2000-06-02
WO2000031094A3 true WO2000031094A3 (en) 2000-12-21

Family

ID=22733363

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/027823 WO2000031094A2 (en) 1998-11-24 1999-11-23 Benzylglycosylamides as inhibitors of smooth muscle cell proliferation

Country Status (7)

Country Link
EP (1) EP1144426A2 (en)
JP (1) JP2002530419A (en)
CN (1) CN1333780A (en)
AU (1) AU1829300A (en)
BR (1) BR9915606A (en)
CA (1) CA2350755A1 (en)
WO (1) WO2000031094A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339064B1 (en) 1998-11-24 2002-01-15 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
WO2000031093A2 (en) * 1998-11-24 2000-06-02 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
US6362170B1 (en) 1998-11-24 2002-03-26 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07304788A (en) * 1994-05-09 1995-11-21 Mitsui Toatsu Chem Inc Styrene derivative having oligo saccharide chain and method for production the same
EP0714903A1 (en) * 1994-10-10 1996-06-05 Hoechst Aktiengesellschaft New carbohydrate conjugates as cell adhesion inhibitors
WO2000031093A2 (en) * 1998-11-24 2000-06-02 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07304788A (en) * 1994-05-09 1995-11-21 Mitsui Toatsu Chem Inc Styrene derivative having oligo saccharide chain and method for production the same
EP0714903A1 (en) * 1994-10-10 1996-06-05 Hoechst Aktiengesellschaft New carbohydrate conjugates as cell adhesion inhibitors
WO2000031093A2 (en) * 1998-11-24 2000-06-02 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 199604, Derwent World Patents Index; Class A11, AN 1996-035887, XP002149382 *
DEFERRARI, JORGE O. ET AL: "Reaction of ammonia with acylated disaccharides. X. Octa-O-benzoyllactose and other benzoyl derivatives of lactose", CARBOHYD. RES. (1973), 29 (1), 141-6, XP000938501 *
NG, KEN ET AL: "Specificity of binding of.beta.-glucoside activators of ryegrass (1.fwdarw.3)-.beta.-glucan synthase and the synthesis of some potential photoaffinity activators", PLANT PHYSIOL. (1996), 111(4), 1227-1231, XP002149381 *

Also Published As

Publication number Publication date
CN1333780A (en) 2002-01-30
CA2350755A1 (en) 2000-06-02
BR9915606A (en) 2001-08-14
EP1144426A2 (en) 2001-10-17
WO2000031094A2 (en) 2000-06-02
JP2002530419A (en) 2002-09-17
AU1829300A (en) 2000-06-13

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