WO2000029400A3 - Procedure for synthesis of n-[2[[[5- [(dialkilamino) methyl]-2- furanyl] methyl]thyo] ethyl]-n'- alkyl-2-nitro1,1 alkenediamines and their hydrochlorides - Google Patents

Procedure for synthesis of n-[2[[[5- [(dialkilamino) methyl]-2- furanyl] methyl]thyo] ethyl]-n'- alkyl-2-nitro1,1 alkenediamines and their hydrochlorides Download PDF

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Publication number
WO2000029400A3
WO2000029400A3 PCT/YU1999/000011 YU9900011W WO0029400A3 WO 2000029400 A3 WO2000029400 A3 WO 2000029400A3 YU 9900011 W YU9900011 W YU 9900011W WO 0029400 A3 WO0029400 A3 WO 0029400A3
Authority
WO
WIPO (PCT)
Prior art keywords
methyl
furanyl
alkenediamines
nitro1
hydrochlorides
Prior art date
Application number
PCT/YU1999/000011
Other languages
French (fr)
Other versions
WO2000029400A2 (en
Inventor
Slobodan Stankovi
Nebojsa Stojanovic
Stanislava Stojicic
Dragan Milenovic
Original Assignee
Dd Zdravlje Farmaceutsko Hemij
Slobodan Stankovi
Nebojsa Stojanovic
Stanislava Stojicic
Milenovic Dragane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dd Zdravlje Farmaceutsko Hemij, Slobodan Stankovi, Nebojsa Stojanovic, Stanislava Stojicic, Milenovic Dragane filed Critical Dd Zdravlje Farmaceutsko Hemij
Priority to AU14798/00A priority Critical patent/AU1479800A/en
Publication of WO2000029400A2 publication Critical patent/WO2000029400A2/en
Publication of WO2000029400A3 publication Critical patent/WO2000029400A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Abstract

This invention is related to the procedure for obtaining of the therapeutically active N-[2[[[5-[(dialkylamino methyl]-2-furanyl] methyl] thio] ethyl]-N'-alky-2-nitro1,1 alkenediamines) of formula (I) and their hydrochlorides of formula (II), where R1, R2 and R3 are alkyl groups (C1-C4), and X is nitro-alkenic group by reaction of 2[[[5-[(dimethylamino-methyl-2-furanyl]methyl]thio]-ethanamine-hydrochloride) and N-methyl-1(methylthio-2-nitroethenamine) in the aqueous environment at the mild temperature.
PCT/YU1999/000011 1998-11-19 1999-11-18 Procedure for synthesis of n-[2[[[5- [(dialkilamino) methyl]-2- furanyl] methyl]thyo] ethyl]-n'- alkyl-2-nitro1,1 alkenediamines and their hydrochlorides WO2000029400A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU14798/00A AU1479800A (en) 1998-11-19 1999-11-18 Procedure for synthesis of N-(2(((5-((dialkilamino) methyl)-2- furanyl) methyl)thyo) ethyl)-N'- alkyl-2-nitro1,1 alkenediamines and their hydrochlorides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
YUP-525/98 1998-11-19
YU52598A YU52598A (en) 1998-11-19 1998-11-19 Procedure for synthesis of n-[2[[[5-[ (dialkylamino)methyl] -2-furanil]methyl]thi0]etyl]-n'-alkyl-2-nitro 1,1 alkendiamine and its hydrochloride

Publications (2)

Publication Number Publication Date
WO2000029400A2 WO2000029400A2 (en) 2000-05-25
WO2000029400A3 true WO2000029400A3 (en) 2000-07-20

Family

ID=25550316

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/YU1999/000011 WO2000029400A2 (en) 1998-11-19 1999-11-18 Procedure for synthesis of n-[2[[[5- [(dialkilamino) methyl]-2- furanyl] methyl]thyo] ethyl]-n'- alkyl-2-nitro1,1 alkenediamines and their hydrochlorides

Country Status (3)

Country Link
AU (1) AU1479800A (en)
WO (1) WO2000029400A2 (en)
YU (1) YU52598A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107382922A (en) * 2017-08-03 2017-11-24 江苏汉斯通药业有限公司 The preparation method of high-transmittance ranitidine hydrochloride

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2734070A1 (en) * 1976-08-04 1978-02-09 Allen & Hanburys Ltd AMINOALKYLFURA DERIVATIVES, PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
EP0055625A1 (en) * 1980-12-30 1982-07-07 Glaxo Group Limited Process for the preparation of a furan derivative
CH642072A5 (en) * 1976-08-04 1984-03-30 Allen & Hanburys Ltd Process for the preparation of aminoalkylfuran derivatives
GB2160204A (en) * 1984-06-15 1985-12-18 Glaxo Group Ltd Preparation of N-methyl-1-alkylthio-2-nitroethenamines
EP0697411A1 (en) * 1994-06-24 1996-02-21 Ranbaxy Laboratories Limited Process for the manufacture of pharmaceutical grade ranitidine base

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2734070A1 (en) * 1976-08-04 1978-02-09 Allen & Hanburys Ltd AMINOALKYLFURA DERIVATIVES, PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
CH642072A5 (en) * 1976-08-04 1984-03-30 Allen & Hanburys Ltd Process for the preparation of aminoalkylfuran derivatives
EP0055625A1 (en) * 1980-12-30 1982-07-07 Glaxo Group Limited Process for the preparation of a furan derivative
GB2160204A (en) * 1984-06-15 1985-12-18 Glaxo Group Ltd Preparation of N-methyl-1-alkylthio-2-nitroethenamines
EP0697411A1 (en) * 1994-06-24 1996-02-21 Ranbaxy Laboratories Limited Process for the manufacture of pharmaceutical grade ranitidine base

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107382922A (en) * 2017-08-03 2017-11-24 江苏汉斯通药业有限公司 The preparation method of high-transmittance ranitidine hydrochloride

Also Published As

Publication number Publication date
YU52598A (en) 2001-05-28
AU1479800A (en) 2000-06-05
WO2000029400A2 (en) 2000-05-25

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