WO2000028574A3 - Mass spectrometer including multiple mass analysis stages and method of operation, to give improved resolution - Google Patents

Mass spectrometer including multiple mass analysis stages and method of operation, to give improved resolution Download PDF

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Publication number
WO2000028574A3
WO2000028574A3 PCT/CA1999/001062 CA9901062W WO0028574A3 WO 2000028574 A3 WO2000028574 A3 WO 2000028574A3 CA 9901062 W CA9901062 W CA 9901062W WO 0028574 A3 WO0028574 A3 WO 0028574A3
Authority
WO
WIPO (PCT)
Prior art keywords
rod sets
operated
resolution
mass
rod
Prior art date
Application number
PCT/CA1999/001062
Other languages
French (fr)
Other versions
WO2000028574A2 (en
Inventor
Donald J Douglas
Zhaohui Du
Bruce A Collings
Original Assignee
Univ British Columbia
Donald J Douglas
Zhaohui Du
Bruce A Collings
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia, Donald J Douglas, Zhaohui Du, Bruce A Collings filed Critical Univ British Columbia
Priority to EP99953499A priority Critical patent/EP1129469A2/en
Priority to CA002350568A priority patent/CA2350568A1/en
Priority to AU10252/00A priority patent/AU1025200A/en
Publication of WO2000028574A2 publication Critical patent/WO2000028574A2/en
Publication of WO2000028574A3 publication Critical patent/WO2000028574A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/421—Mass filters, i.e. deviating unwanted ions without trapping
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/28—Static spectrometers
    • H01J49/284—Static spectrometers using electrostatic and magnetic sectors with simple focusing, e.g. with parallel fields such as Aston spectrometer
    • H01J49/286—Static spectrometers using electrostatic and magnetic sectors with simple focusing, e.g. with parallel fields such as Aston spectrometer with energy analysis, e.g. Castaing filter
    • H01J49/288—Static spectrometers using electrostatic and magnetic sectors with simple focusing, e.g. with parallel fields such as Aston spectrometer with energy analysis, e.g. Castaing filter using crossed electric and magnetic fields perpendicular to the beam, e.g. Wien filter
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/427—Ejection and selection methods
    • H01J49/429—Scanning an electric parameter, e.g. voltage amplitude or frequency

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Electron Tubes For Measurement (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

A method is provided of operating a mass spectrometer apparatus comprising a pair of quadrupole rod sets. Each quadrupole rod set is operated in a mass resolving mode. They may be operated in the same or different stability regions. The rod sets are operated to select essentially ions of the same mass to charge ratio, and are operated such that the combined resolution of the two rod sets is greater than the resolution of either rod set. The rod sets can be operated at relatively low resolution, with the combined peak shape from the two rod sets showing high resolution. This can make up for mechanical imperfections in the rod sets, losses due to high gas pressures, etc. A mass shift can be provided to give the desired resolution. The rod sets can be close coupled, and for this purpose neutralizing capacitors can be provided to prevent electrical interference between adjacent rod sets. The rod sets can be provided with the same frequency signal, which preferably is a phase locked and shifted, to give enhanced sensitivity.
PCT/CA1999/001062 1998-11-10 1999-11-09 Mass spectrometer including multiple mass analysis stages and method of operation, to give improved resolution WO2000028574A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99953499A EP1129469A2 (en) 1998-11-10 1999-11-09 Mass spectrometer including multiple mass analysis stages and method of operation, to give improved resolution
CA002350568A CA2350568A1 (en) 1998-11-10 1999-11-09 Mass spectrometer including multiple mass analysis stages and method of operation, to give improved resolution
AU10252/00A AU1025200A (en) 1998-11-10 1999-11-09 Mass spectrometer including multiple mass analysis stages and method of operation, to give improved resolution

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/188,352 1998-11-10
US09/188,352 US6191417B1 (en) 1998-11-10 1998-11-10 Mass spectrometer including multiple mass analysis stages and method of operation, to give improved resolution

Publications (2)

Publication Number Publication Date
WO2000028574A2 WO2000028574A2 (en) 2000-05-18
WO2000028574A3 true WO2000028574A3 (en) 2000-11-16

Family

ID=22692781

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1999/001062 WO2000028574A2 (en) 1998-11-10 1999-11-09 Mass spectrometer including multiple mass analysis stages and method of operation, to give improved resolution

Country Status (5)

Country Link
US (1) US6191417B1 (en)
EP (1) EP1129469A2 (en)
AU (1) AU1025200A (en)
CA (1) CA2350568A1 (en)
WO (1) WO2000028574A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9820210D0 (en) 1998-09-16 1998-11-11 Vg Elemental Limited Means for removing unwanted ions from an ion transport system and mass spectrometer
US6340814B1 (en) * 1999-07-15 2002-01-22 Sciex, A Division Of Mds Inc. Mass spectrometer with multiple capacitively coupled mass analysis stages
US6410924B1 (en) * 1999-11-16 2002-06-25 Schlumberger Technologies, Inc. Energy filtered focused ion beam column
US20050203578A1 (en) * 2001-08-15 2005-09-15 Weiner Michael L. Process and apparatus for treating biological organisms
US6797950B2 (en) * 2002-02-04 2004-09-28 Thermo Finnegan Llc Two-dimensional quadrupole ion trap operated as a mass spectrometer
GB0210930D0 (en) * 2002-05-13 2002-06-19 Thermo Electron Corp Improved mass spectrometer and mass filters therefor
EP3147935B1 (en) * 2008-05-22 2020-08-05 Shimadzu Corporation Quadrupole mass spectrometer
US9587292B2 (en) * 2009-10-01 2017-03-07 Advanced Applied Physics Solutions, Inc. Method and apparatus for isolating the radioisotope molybdenum-99
WO2011057415A1 (en) * 2009-11-16 2011-05-19 Dh Technologies Development Pte. Ltd. Apparatus for providing power to a multipole in a mass spectrometer
GB201103854D0 (en) * 2011-03-07 2011-04-20 Micromass Ltd Dynamic resolution correction of quadrupole mass analyser
US9236231B2 (en) * 2012-05-18 2016-01-12 Dh Technologies Development Pte. Ltd. Modulation of instrument resolution dependant upon the complexity of a previous scan
DE102013208959A1 (en) * 2013-05-15 2014-11-20 Carl Zeiss Microscopy Gmbh Apparatus for the mass-selective determination of an ion
US8921770B1 (en) 2013-07-05 2014-12-30 Bruker Daltonics, Inc. Reduction of cross-talk between RF components in a mass spectrometer
GB201804386D0 (en) * 2018-03-19 2018-05-02 Thermo Fisher Scient Bremen Gmbh Mass Spectrometer
US11798797B2 (en) 2018-12-13 2023-10-24 Dh Technologies Development Pte Ltd Effective potential matching at boundaries of segmented quadrupoles in a mass spectrometer
GB2622400A (en) * 2022-09-14 2024-03-20 Thermo Fisher Scient Bremen Gmbh Analysing a field of a mass spectrometer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4988869A (en) * 1989-08-21 1991-01-29 The Regents Of The University Of California Method and apparatus for electron-induced dissociation of molecular species

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234791A (en) 1978-11-13 1980-11-18 Research Corporation Tandem quadrupole mass spectrometer for selected ion fragmentation studies and low energy collision induced dissociator therefor
US4329582A (en) 1980-07-28 1982-05-11 French J Barry Tandem mass spectrometer with synchronized RF fields
JP4018186B2 (en) 1997-01-30 2007-12-05 アロカ株式会社 Isotope analyzer
WO1998052209A1 (en) * 1997-05-12 1998-11-19 Mds Inc. Rf-only mass spectrometer with auxiliary excitation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4988869A (en) * 1989-08-21 1991-01-29 The Regents Of The University Of California Method and apparatus for electron-induced dissociation of molecular species

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DOUGLAS D J: "Applications of Collision Dynamics in Quadrupole Mass Spectrometry - Techniques and Applications of Tandem Mass Spectrometry", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,US,ELSEVIER SCIENCE INC, vol. 9, no. 2, 1 February 1998 (1998-02-01), pages 101 - 113, XP004114918, ISSN: 1044-0305 *

Also Published As

Publication number Publication date
AU1025200A (en) 2000-05-29
CA2350568A1 (en) 2000-05-18
WO2000028574A2 (en) 2000-05-18
US6191417B1 (en) 2001-02-20
EP1129469A2 (en) 2001-09-05

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