WO2000028315B1 - Practical device for controlling ultrasmall volume flow - Google Patents

Practical device for controlling ultrasmall volume flow

Info

Publication number
WO2000028315B1
WO2000028315B1 PCT/US1999/026724 US9926724W WO0028315B1 WO 2000028315 B1 WO2000028315 B1 WO 2000028315B1 US 9926724 W US9926724 W US 9926724W WO 0028315 B1 WO0028315 B1 WO 0028315B1
Authority
WO
WIPO (PCT)
Prior art keywords
capillary channel
integrated external
longitudinal
flow
control
Prior art date
Application number
PCT/US1999/026724
Other languages
French (fr)
Other versions
WO2000028315A1 (en
Inventor
Mark A Hayes
Nolan A Polson
Original Assignee
Univ Arizona
Mark A Hayes
Nolan A Polson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arizona, Mark A Hayes, Nolan A Polson filed Critical Univ Arizona
Priority to JP2000581444A priority Critical patent/JP2002529235A/en
Priority to CA002348864A priority patent/CA2348864A1/en
Priority to EP99958906A priority patent/EP1129345A1/en
Publication of WO2000028315A1 publication Critical patent/WO2000028315A1/en
Publication of WO2000028315B1 publication Critical patent/WO2000028315B1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44752—Controlling the zeta potential, e.g. by wall coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Electrostatic Separation (AREA)
  • Flow Control (AREA)

Abstract

A device for control of ultrasmall volume fluid flow used in the fields of electrophoretic separation, chemical analysis, and microchemical reactions has a substrate defining a capillary channel and integrated external electrodes to control electroosmotic flow. The channel geometry and integrated external electrode proximity reduce the voltage required for control of flow. Longitudinal electrodes provide electrophoretic separation of components. High dielectric material between the integrated external electrode and capillary reduces the voltage required for the control of flow. Real-time flow monitoring and capillary channel surface coating enhance the control of flow.

Claims

AMENDED CLAIMS
[received by the International Bureau on 12 May 2000 (12.05.00); new claims 17-19 added; remaining claims unchanged (2 pages)]
14. The process of claim 13, wherein the voltage applied to the integrated external electrodes is less than about 200 volts.
15. A fluid flow process using the device of claim 1 , comprising the
steps of: (1) introducing a fluid into the capillary channel;
(2) applying a voltage of less than about 2000 volts to the integrated external electrodes to control fluid How; and
(3) applying a voltage difference to the longitudinal electrodes, thereby causing fluid flow to occur.
16. The process of claim 15, wherein the voltage applied to the integrated external electrodes is less than about 200 volts.
17. A device for performing fluid flow having an efficiency factor I\ comprising: a substrate defining a capillary channel, 'wherein the capillary channel comprises an inner wall surface, first and second ends, and a cross section of less than about 200 x 10'9 square meters; and at least one integrated external electrode spaced apart from the inner wall surface of the capillary channel by a distance d of less than about 160 x 10"* meters, wherein the integrated external electrode is positioned to provide a perpendicular voltage field to the capillary channel; and first and second longitudinal electrodes, the first longitudinal electrode being positioned at the first end of the capillary channel and the second
longitudinal electrode being positioned at the second end of the capillary channel, wherein the longitudinal electrodes are positioned at the immediate ends of the capillary channel and are positioned to provide a longitudinal voltage field selectively through the capillary channel, wherein the efficiency factor T is greater than 2 x 10"6 (cm2/Ns)/(V/micrometer).
18. The device of claim 17, in which the efficiency factor T is greater than 5 x 10"* (cm2/Ns)/(V/micrometer).
19. The device of claim 17, in which the efficiency factor T is equal o or greater than 3.3 x 10"s (cm2/Vs)/(V/micrometer).
PCT/US1999/026724 1998-11-12 1999-11-10 Practical device for controlling ultrasmall volume flow WO2000028315A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2000581444A JP2002529235A (en) 1998-11-12 1999-11-10 Practical equipment for controlling micro flow
CA002348864A CA2348864A1 (en) 1998-11-12 1999-11-10 Practical device for controlling ultrasmall volume flow
EP99958906A EP1129345A1 (en) 1998-11-12 1999-11-10 Practical device for controlling ultrasmall volume flow

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10808698P 1998-11-12 1998-11-12
US60/108,086 1998-11-12

Publications (2)

Publication Number Publication Date
WO2000028315A1 WO2000028315A1 (en) 2000-05-18
WO2000028315B1 true WO2000028315B1 (en) 2000-07-06

Family

ID=22320213

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/026724 WO2000028315A1 (en) 1998-11-12 1999-11-10 Practical device for controlling ultrasmall volume flow

Country Status (4)

Country Link
EP (1) EP1129345A1 (en)
JP (1) JP2002529235A (en)
CA (1) CA2348864A1 (en)
WO (1) WO2000028315A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7465382B2 (en) * 2001-06-13 2008-12-16 Eksigent Technologies Llc Precision flow control system
EP1362827B1 (en) * 2002-05-16 2008-09-03 Micronit Microfluidics B.V. Method of fabrication of a microfluidic device
NL1021269C2 (en) * 2002-08-14 2004-02-17 Lionix B V Electrode system, for electro hydraulic microsystems, used for chemical analysis, includes hydraulic constriction filled with second electrically conductive liquid
JP2004276224A (en) * 2003-03-17 2004-10-07 Toyo Technol Inc Electro-osmotic pump filled with fiber
JP4880944B2 (en) * 2005-08-11 2012-02-22 セイコーインスツル株式会社 Liquid transfer device, microreactor, and microreactor system
JP4986504B2 (en) * 2006-05-23 2012-07-25 愛知時計電機株式会社 Electromagnetic flow measuring device
GB2477287B (en) * 2010-01-27 2012-02-15 Izon Science Ltd Control of particle flow in an aperture
SE534488C2 (en) 2010-02-22 2011-09-06 Lunavation Ab A system for electrokinetic flow technology
FR3025440A1 (en) * 2014-09-05 2016-03-11 Centre Nat Rech Scient DEVICE AND METHOD FOR MICROFLUIDIC ANALYSIS
US11090660B2 (en) 2016-08-10 2021-08-17 Arizona Board Of Regents On Behalf Of Arizona State University Hyper efficient separations device
WO2019003230A1 (en) * 2017-06-29 2019-01-03 Technion Research & Development Foundation Limited Devices and methods for flow control using electro-osmotic flow
EP3792623A1 (en) * 2019-09-16 2021-03-17 Imec VZW Cyclic capillary electrophoresis device

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5092972A (en) * 1990-07-12 1992-03-03 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Field-effect electroosmosis
US5180475A (en) * 1991-09-04 1993-01-19 Hewlett-Packard Company System and method for controlling electroosmotic flow
US5358618A (en) * 1993-01-22 1994-10-25 The Penn State Research Foundation Capillary electrophoresis apparatus with improved electroosmotic flow control
US5415747A (en) * 1993-08-16 1995-05-16 Hewlett-Packard Company Capillary electrophoresis using zwitterion-coated capillary tubes
US5624539A (en) * 1995-06-19 1997-04-29 The Penn State Research Foundation Real time monitoring of electroosmotic flow in capillary electrophoresis
GB9805301D0 (en) * 1998-03-12 1998-05-06 Imperial College Detector

Also Published As

Publication number Publication date
WO2000028315A1 (en) 2000-05-18
CA2348864A1 (en) 2000-05-18
EP1129345A1 (en) 2001-09-05
JP2002529235A (en) 2002-09-10

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