WO2000028033A3 - Nucleic acids and polypeptides having altered expression in the t84 gut barrier model - Google Patents

Nucleic acids and polypeptides having altered expression in the t84 gut barrier model Download PDF

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Publication number
WO2000028033A3
WO2000028033A3 PCT/US1999/026788 US9926788W WO0028033A3 WO 2000028033 A3 WO2000028033 A3 WO 2000028033A3 US 9926788 W US9926788 W US 9926788W WO 0028033 A3 WO0028033 A3 WO 0028033A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
nucleic acids
altered expression
gut barrier
barrier model
Prior art date
Application number
PCT/US1999/026788
Other languages
French (fr)
Other versions
WO2000028033A2 (en
Inventor
Peter Robert Baum
Robert Finley Dubose
John E Sims
Adel Youakim
Karl W Hasel
Brian S Hilbush
Original Assignee
Digital Gene Tech Inc
Peter Robert Baum
Robert Finley Dubose
John E Sims
Adel Youakim
Karl W Hasel
Brian S Hilbush
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Digital Gene Tech Inc, Peter Robert Baum, Robert Finley Dubose, John E Sims, Adel Youakim, Karl W Hasel, Brian S Hilbush filed Critical Digital Gene Tech Inc
Priority to AU20238/00A priority Critical patent/AU2023800A/en
Priority to MXPA01004745A priority patent/MXPA01004745A/en
Priority to EP99963894A priority patent/EP1131431A2/en
Priority to CA002351167A priority patent/CA2351167A1/en
Publication of WO2000028033A2 publication Critical patent/WO2000028033A2/en
Publication of WO2000028033A3 publication Critical patent/WO2000028033A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The invention is directed to purified and isolated polypeptides, the nucleic acids encoding such polypeptides that have altered expression characteristics in the T84 gut barrier model, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses to study inflammatory bowel diseas (IBD).
PCT/US1999/026788 1998-11-10 1999-11-10 Nucleic acids and polypeptides having altered expression in the t84 gut barrier model WO2000028033A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU20238/00A AU2023800A (en) 1998-11-10 1999-11-10 Novel dnas and polypeptides
MXPA01004745A MXPA01004745A (en) 1998-11-10 1999-11-10 NOVEL DNAs AND POLYPEPTIDES.
EP99963894A EP1131431A2 (en) 1998-11-10 1999-11-10 Nucleic acids and polypeptides having altered expression in the t84 gut barrier model
CA002351167A CA2351167A1 (en) 1998-11-10 1999-11-10 Nucleic acids and polypeptides having altered expression in the t84 gut barrier model

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10782198P 1998-11-10 1998-11-10
US60/107,821 1998-11-10

Publications (2)

Publication Number Publication Date
WO2000028033A2 WO2000028033A2 (en) 2000-05-18
WO2000028033A3 true WO2000028033A3 (en) 2000-11-09

Family

ID=22318664

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/026788 WO2000028033A2 (en) 1998-11-10 1999-11-10 Nucleic acids and polypeptides having altered expression in the t84 gut barrier model

Country Status (5)

Country Link
EP (1) EP1131431A2 (en)
AU (1) AU2023800A (en)
CA (1) CA2351167A1 (en)
MX (1) MXPA01004745A (en)
WO (1) WO2000028033A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7029895B2 (en) 1999-09-27 2006-04-18 Millennium Pharmaceuticals, Inc. 27411, a novel human PGP synthase
US6451994B1 (en) * 1999-09-27 2002-09-17 Millennium Pharmaceuticals, Inc. 23413, a novel human ubiquitin protease
US20020156238A1 (en) * 1999-12-09 2002-10-24 Peyman John A. Novel polypeptides and polynucleotides encoding same
KR20080029963A (en) * 2005-05-12 2008-04-03 아테뉴온, 엘엘씨 Treatment of inflammatory bowel disease (ibd) with anti-angiogenic compounds
NL2015130B1 (en) 2015-07-09 2017-02-01 Mimetas B V Barrier function measurements.

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
A. YOUAKIM ET AL: "Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 276, no. 5, May 1999 (1999-05-01), pages G1279 - G1288, XP000906855 *
D. LLOYD: "Human DNA sequence from clone RP1-6802 on chromosome 22 contains the 5' end of the APOL2 gene for apolipoprotein L2, the APOLgene for apolipoprotein L, the MYH9 for nonmuscletype myosin heavy chain 9. ESTs, STSs and GSSs", EMBL DATABASE ENTRY HS6802, ACCESSION NUMBER Z82215, 8 November 1996 (1996-11-08), XP002136975 *
F. BESANÇON ET AL: "Interferon-gamma downregulates CFTR gene expression in epithelial cells", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 267, no. 5, November 1994 (1994-11-01), pages C1398 - C1404, XP000906853 *
J.L. MADARA ET AL: "Interferon-gamma directly affects barrier function of cultured epithelial monolayers", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 83, no. 2, February 1989 (1989-02-01), pages 724 - 727, XP000906849 *
J.L. MADARA ET AL: "Occluding junction structure-function relationships in a cultured epithelial monolayer", THE JOURNAL OF CELL BIOLOGY, vol. 101, December 1985 (1985-12-01), pages 2124 - 2133, XP000906833 *
K.DHARMASATHAPHORN ET AL: "A human colonic tumor cell line that maintains vectorial electrolyte transport", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 9, no. 2, February 1984 (1984-02-01), pages G204 - G208, XP002136976 *
L. HILLIER ET AL: "washU-Merck EST project 1997. zx87d07.r1 Soares tumor NbHOT Homo sapiens cDNA clone IMAGE:810733 5', mRNA sequence", EMBL DATABASE ENTRY HS1272990, ACCESSION NUMBER AA480830, 24 June 1997 (1997-06-24), XP002136972 *
P.N. DUCHATEAU ET AL: "Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 272, no. 41, 1997, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD., US, pages 25576 - 25582, XP002136974, ISSN: 0021-9258 *
P.N. DUCHATEAU ET AL: "Homo sapiens apolipoprotein L mRNA, complete cds", EMBL DATABASE ENTRY AF019225, ACCESSION NUMBER AF019225, 29 September 1997 (1997-09-29), XP002136973 *
UNPUBLISHED *

Also Published As

Publication number Publication date
EP1131431A2 (en) 2001-09-12
WO2000028033A2 (en) 2000-05-18
CA2351167A1 (en) 2000-05-18
AU2023800A (en) 2000-05-29
MXPA01004745A (en) 2003-06-09

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