WO2000028011A3 - Regulation fondee sur fk506 d'evenements biologiques - Google Patents

Regulation fondee sur fk506 d'evenements biologiques Download PDF

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Publication number
WO2000028011A3
WO2000028011A3 PCT/US1999/025766 US9925766W WO0028011A3 WO 2000028011 A3 WO2000028011 A3 WO 2000028011A3 US 9925766 W US9925766 W US 9925766W WO 0028011 A3 WO0028011 A3 WO 0028011A3
Authority
WO
WIPO (PCT)
Prior art keywords
cab
ligand
domain
protein
cyclophilin
Prior art date
Application number
PCT/US1999/025766
Other languages
English (en)
Other versions
WO2000028011A2 (fr
Inventor
Paul A Clemons
Brian G Gladstone
Abhinav Seth
Stuart L Schreiber
Original Assignee
Harvard College
Paul A Clemons
Brian G Gladstone
Abhinav Seth
Stuart L Schreiber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Paul A Clemons, Brian G Gladstone, Abhinav Seth, Stuart L Schreiber filed Critical Harvard College
Priority to EP99958742A priority Critical patent/EP1127140A2/fr
Priority to AU16039/00A priority patent/AU1603900A/en
Priority to CA002346962A priority patent/CA2346962A1/fr
Priority to JP2000581178A priority patent/JP2002529081A/ja
Publication of WO2000028011A2 publication Critical patent/WO2000028011A2/fr
Publication of WO2000028011A3 publication Critical patent/WO2000028011A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

On décrit des matières et des procédés qui permettent de réguler des événements biologiques tels que la transcription de gènes cibles et la croissance, la prolifération ou la différenciation de cellules génétiquement modifiées.
PCT/US1999/025766 1998-11-06 1999-11-05 Regulation fondee sur fk506 d'evenements biologiques WO2000028011A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99958742A EP1127140A2 (fr) 1998-11-06 1999-11-05 Regulation fondee sur fk506 d'evenements biologiques
AU16039/00A AU1603900A (en) 1998-11-06 1999-11-05 Fk506-based regulation of biological events
CA002346962A CA2346962A1 (fr) 1998-11-06 1999-11-05 Regulation fondee sur fk506 d'evenements biologiques
JP2000581178A JP2002529081A (ja) 1998-11-06 1999-11-05 生物学的事象のｆｋ５０６に基づく調節

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10747398P 1998-11-06 1998-11-06
US60/107,473 1998-11-06

Publications (2)

Publication Number Publication Date
WO2000028011A2 WO2000028011A2 (fr) 2000-05-18
WO2000028011A3 true WO2000028011A3 (fr) 2000-11-23

Family

ID=22316797

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/025766 WO2000028011A2 (fr) 1998-11-06 1999-11-05 Regulation fondee sur fk506 d'evenements biologiques

Country Status (5)

Country Link
EP (1) EP1127140A2 (fr)
JP (1) JP2002529081A (fr)
AU (1) AU1603900A (fr)
CA (1) CA2346962A1 (fr)
WO (1) WO2000028011A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2449747C (fr) 2001-06-22 2010-04-13 F. Hoffmann-La Roche Ag Utilisation de chaperones fkbp comme instrument d'expression
US7094757B2 (en) 2001-06-22 2006-08-22 Roche Diagnostics Corporation Complexes comprising a prion protein and a peptidyl prolyl isomerase chaperone, and method for producing and using them
ATE491947T1 (de) * 2006-01-27 2011-01-15 Univ Wuerzburg J Maximilians Peptid zur hemmung von calcineurin
CN105785027A (zh) * 2015-12-30 2016-07-20 海口奇力制药股份有限公司 一种组合试剂及其应用、含有该组合试剂的试剂盒及检测方法
EP3914599A4 (fr) * 2019-01-23 2022-10-19 The Johns Hopkins University Analogues de fk506 non-immunosuppresseurs et utilisation associée

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018317A1 (fr) * 1993-02-12 1994-08-18 The Board Of Trustees Of The Leland Stanford Junior University Transcription regulee de genes cibles et d'autres evenements biologiques
EP0618227A1 (fr) * 1993-04-01 1994-10-05 Amgen Inc. Dimères de fusionspolypeptidiques biologiquement actifs
WO1996012806A1 (fr) * 1994-10-24 1996-05-02 The Board Of Trustees Of The Leland Stanford Junior University Compositions de proteines ayant une interaction avec la calcineurine et procedes
WO1996016172A2 (fr) * 1994-11-23 1996-05-30 Icos Corporation Modulateurs de la fonction des proteines d'ancrage
WO1997006246A2 (fr) * 1995-08-09 1997-02-20 Vertex Pharmaceuticals Incorporated Molecules comportant une poche de liaison de type calcineurine et support de donnees code capable de les afficher graphiquement

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018317A1 (fr) * 1993-02-12 1994-08-18 The Board Of Trustees Of The Leland Stanford Junior University Transcription regulee de genes cibles et d'autres evenements biologiques
EP0618227A1 (fr) * 1993-04-01 1994-10-05 Amgen Inc. Dimères de fusionspolypeptidiques biologiquement actifs
WO1996012806A1 (fr) * 1994-10-24 1996-05-02 The Board Of Trustees Of The Leland Stanford Junior University Compositions de proteines ayant une interaction avec la calcineurine et procedes
WO1996016172A2 (fr) * 1994-11-23 1996-05-30 Icos Corporation Modulateurs de la fonction des proteines d'ancrage
WO1997006246A2 (fr) * 1995-08-09 1997-02-20 Vertex Pharmaceuticals Incorporated Molecules comportant une poche de liaison de type calcineurine et support de donnees code capable de les afficher graphiquement

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
M.T. KENNEDY ET AL.,: "Contributions of Myristoylation to Calcineurin Structure/Function", J. BIOL. CHEM., vol. 271, no. 43, 25 October 1996 (1996-10-25), US, pages 26517 - 26521, XP002140377 *
Q. WEI AND E.Y. LEE: "Expression and reconstitution of calcineurin A and B subunits", BIOCHEM. MOL. BIOL. INT., vol. 41, no. 1, January 1997 (1997-01-01), pages 169 - 177, XP000915910 *

Also Published As

Publication number Publication date
WO2000028011A2 (fr) 2000-05-18
CA2346962A1 (fr) 2000-05-18
JP2002529081A (ja) 2002-09-10
AU1603900A (en) 2000-05-29
EP1127140A2 (fr) 2001-08-29

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