WO2000026262A3 - Functionalized polymeric substrates for binding molecular moieties - Google Patents

Functionalized polymeric substrates for binding molecular moieties Download PDF

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Publication number
WO2000026262A3
WO2000026262A3 PCT/US1999/026289 US9926289W WO0026262A3 WO 2000026262 A3 WO2000026262 A3 WO 2000026262A3 US 9926289 W US9926289 W US 9926289W WO 0026262 A3 WO0026262 A3 WO 0026262A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymeric substrates
functionalized polymeric
molecular moieties
binding molecular
substrates
Prior art date
Application number
PCT/US1999/026289
Other languages
French (fr)
Other versions
WO2000026262A8 (en
WO2000026262A2 (en
Inventor
Chinh T Bui
Andrew Bray
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of WO2000026262A2 publication Critical patent/WO2000026262A2/en
Publication of WO2000026262A3 publication Critical patent/WO2000026262A3/en
Publication of WO2000026262A8 publication Critical patent/WO2000026262A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/04—Reduction, e.g. hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/10—Acylation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/12—Hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/18—Introducing halogen atoms or halogen-containing groups
    • C08F8/20—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/26—Removing halogen atoms or halogen-containing groups from the molecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C08F8/32—Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Novel functionalized polymeric substrates useful as supports in solid phase synthetic reactions are provided. Substrates comprised of base polymers having backbone and/or pendant aromatic groups are derivatized to form linkers having improved characteristics for use as a support.
PCT/US1999/026289 1998-11-05 1999-11-05 Functionalized polymeric substrates for binding molecular moieties WO2000026262A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10751198P 1998-11-05 1998-11-05
US60/107,511 1998-11-05
US43229499A 1999-11-02 1999-11-02
US09/432,294 1999-11-02

Publications (3)

Publication Number Publication Date
WO2000026262A2 WO2000026262A2 (en) 2000-05-11
WO2000026262A3 true WO2000026262A3 (en) 2000-07-27
WO2000026262A8 WO2000026262A8 (en) 2001-07-12

Family

ID=26804868

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/026289 WO2000026262A2 (en) 1998-11-05 1999-11-05 Functionalized polymeric substrates for binding molecular moieties

Country Status (1)

Country Link
WO (1) WO2000026262A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787635B2 (en) 2001-04-05 2004-09-07 3M Innovative Properties Company Solid phase synthesis supports and methods
US7691968B2 (en) 2002-05-03 2010-04-06 Avecia Biologics Limited Process for the synthesis of peptides amides by side-chain attachment to a solid phase

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1162218A (en) * 1965-10-22 1969-08-20 Monsanto Co Long Cain Alcohols
FR2157628A5 (en) * 1971-10-21 1973-06-01 Hoffmann La Roche
EP0274998A2 (en) * 1986-12-24 1988-07-20 Monsanto Company Resin support for solid phase peptide synthesis
US4868256A (en) * 1988-08-02 1989-09-19 Hoechst Celanese Process for the production of 3-mono or 3,5-disubstituted-4-acetoxystyrene its polymerization, and hydrolysis
WO1992022591A1 (en) * 1991-06-14 1992-12-23 Research & Diagnostic Antibodies Polymeric resin for peptide synthesis
WO1995034813A1 (en) * 1994-06-14 1995-12-21 Smithkline Beecham Corporation Resins for solid state synthesis
US5723599A (en) * 1990-10-26 1998-03-03 Genta Incorporated Organic polymer reagents for solid phase synthesis of oligonucleotides
USH1729H (en) * 1996-05-09 1998-05-05 Bristol-Myers Squibb Company Method for preparing compounds employing solid phase synthesis and novel linker-resin

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1162218A (en) * 1965-10-22 1969-08-20 Monsanto Co Long Cain Alcohols
FR2157628A5 (en) * 1971-10-21 1973-06-01 Hoffmann La Roche
EP0274998A2 (en) * 1986-12-24 1988-07-20 Monsanto Company Resin support for solid phase peptide synthesis
EP0274999A2 (en) * 1986-12-24 1988-07-20 Monsanto Company Resin support for solid phase peptide synthesis
US4868256A (en) * 1988-08-02 1989-09-19 Hoechst Celanese Process for the production of 3-mono or 3,5-disubstituted-4-acetoxystyrene its polymerization, and hydrolysis
US5723599A (en) * 1990-10-26 1998-03-03 Genta Incorporated Organic polymer reagents for solid phase synthesis of oligonucleotides
WO1992022591A1 (en) * 1991-06-14 1992-12-23 Research & Diagnostic Antibodies Polymeric resin for peptide synthesis
WO1995034813A1 (en) * 1994-06-14 1995-12-21 Smithkline Beecham Corporation Resins for solid state synthesis
USH1729H (en) * 1996-05-09 1998-05-05 Bristol-Myers Squibb Company Method for preparing compounds employing solid phase synthesis and novel linker-resin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
F. E. K. KROLL: "RESIN-IMMOBILISED BENZYL AND ARYL VINYL SULFONES: NEW VERSATILE TRACELESS LINKERS FOR SOLID-PHASE ORGANIC SYNTHESIS.", TETRAHEDRON LETTERS, vol. 38, no. 49, 1997, pages 8573 - 8576, XP004096002 *

Also Published As

Publication number Publication date
WO2000026262A8 (en) 2001-07-12
WO2000026262A2 (en) 2000-05-11

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