WO2000026262A8 - Functionalized polymeric substrates for binding molecular moieties - Google Patents

Functionalized polymeric substrates for binding molecular moieties

Info

Publication number
WO2000026262A8
WO2000026262A8 PCT/US1999/026289 US9926289W WO0026262A8 WO 2000026262 A8 WO2000026262 A8 WO 2000026262A8 US 9926289 W US9926289 W US 9926289W WO 0026262 A8 WO0026262 A8 WO 0026262A8
Authority
WO
WIPO (PCT)
Prior art keywords
polymeric substrates
functionalized polymeric
molecular moieties
binding molecular
substrates
Prior art date
Application number
PCT/US1999/026289
Other languages
French (fr)
Other versions
WO2000026262A3 (en
WO2000026262A2 (en
Inventor
Chinh T Bui
Andrew Bray
Original Assignee
Mitokor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitokor filed Critical Mitokor
Publication of WO2000026262A2 publication Critical patent/WO2000026262A2/en
Publication of WO2000026262A3 publication Critical patent/WO2000026262A3/en
Publication of WO2000026262A8 publication Critical patent/WO2000026262A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/04—Reduction, e.g. hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/10—Acylation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/12—Hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/18—Introducing halogen atoms or halogen-containing groups
    • C08F8/20—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/26—Removing halogen atoms or halogen-containing groups from the molecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C08F8/32—Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines

Abstract

Novel functionalized polymeric substrates useful as supports in solid phase synthetic reactions are provided. Substrates comprised of base polymers having backbone and/or pendant aromatic groups are derivatized to form linkers having improved characteristics for use as a support.
PCT/US1999/026289 1998-11-05 1999-11-05 Functionalized polymeric substrates for binding molecular moieties WO2000026262A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10751198P 1998-11-05 1998-11-05
US60/107,511 1998-11-05
US43229499A 1999-11-02 1999-11-02
US09/432,294 1999-11-02

Publications (3)

Publication Number Publication Date
WO2000026262A2 WO2000026262A2 (en) 2000-05-11
WO2000026262A3 WO2000026262A3 (en) 2000-07-27
WO2000026262A8 true WO2000026262A8 (en) 2001-07-12

Family

ID=26804868

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/026289 WO2000026262A2 (en) 1998-11-05 1999-11-05 Functionalized polymeric substrates for binding molecular moieties

Country Status (1)

Country Link
WO (1) WO2000026262A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787635B2 (en) 2001-04-05 2004-09-07 3M Innovative Properties Company Solid phase synthesis supports and methods
ATE342273T1 (en) 2002-05-03 2006-11-15 Avecia Ltd METHOD FOR PRODUCING PEPTIDE AMIDES BY SIDE CHAIN ATTACHMENT TO A SOLID PHASE

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3429936A (en) * 1965-10-22 1969-02-25 Monsanto Co Novel polyalkyl alcohols
US3814732A (en) * 1971-10-21 1974-06-04 Hoffmann La Roche Modified solid supports for solid phase synthesis
ES2003864A4 (en) * 1986-12-24 1988-12-01 Monsanto Co RESIN SUPPORT FOR THE SYNTHESIS OF PEPTIDES IN SOLID PHASE.
US4868256A (en) * 1988-08-02 1989-09-19 Hoechst Celanese Process for the production of 3-mono or 3,5-disubstituted-4-acetoxystyrene its polymerization, and hydrolysis
EP0554407A1 (en) * 1990-10-26 1993-08-11 Genta Incorporated Non-aromatic organic polymeric reagents for solid phase synthesis of oligomers
US5198531A (en) * 1991-06-14 1993-03-30 Research Diagnostic Antibodies Polymeric resin for peptide synthesis
EP0765477A4 (en) * 1994-06-14 2004-11-17 Smithkline Beecham Corp Resins for solid state synthesis
USH1729H (en) * 1996-05-09 1998-05-05 Bristol-Myers Squibb Company Method for preparing compounds employing solid phase synthesis and novel linker-resin

Also Published As

Publication number Publication date
WO2000026262A3 (en) 2000-07-27
WO2000026262A2 (en) 2000-05-11

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