WO2000024887A3 - Procede de production biotechnologique de fragments de liaisons aux ligands, en particulier extracellulaires, des sous-unites de recepteurs, en particulier de neurorecepteurs et de recepteurs hormonaux, sous forme isolee, native - Google Patents

Procede de production biotechnologique de fragments de liaisons aux ligands, en particulier extracellulaires, des sous-unites de recepteurs, en particulier de neurorecepteurs et de recepteurs hormonaux, sous forme isolee, native Download PDF

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Publication number
WO2000024887A3
WO2000024887A3 PCT/EP1999/007625 EP9907625W WO0024887A3 WO 2000024887 A3 WO2000024887 A3 WO 2000024887A3 EP 9907625 W EP9907625 W EP 9907625W WO 0024887 A3 WO0024887 A3 WO 0024887A3
Authority
WO
WIPO (PCT)
Prior art keywords
fragments
neuroreceptors
ligand binding
hormone receptors
biotechnological production
Prior art date
Application number
PCT/EP1999/007625
Other languages
German (de)
English (en)
Other versions
WO2000024887A2 (fr
Inventor
Alfred Maelicke
Andre Schrattenholz
Sascha Pfeiffer
Original Assignee
Alfred Maelicke
Andre Schrattenholz
Sascha Pfeiffer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfred Maelicke, Andre Schrattenholz, Sascha Pfeiffer filed Critical Alfred Maelicke
Priority to AU64702/99A priority Critical patent/AU6470299A/en
Publication of WO2000024887A2 publication Critical patent/WO2000024887A2/fr
Publication of WO2000024887A3 publication Critical patent/WO2000024887A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne entre autres un procédé de production biotechnologique de fragments de liaisons aux ligands des sous-unités de neurorécepteurs et de récepteurs hormonaux, sous forme isolée, native. Ledit procédé comporte les étapes suivantes: expression des fragments; solubilisation des fragments, en particulier de ceux contenus dans des corps d'inclusion; élimination des agents dénaturants nécessaires pour la solubilisation; renaturation des fragments; et élimination des agents nécessaires pour la renaturation. Les neurorécepteurs proviennent de la famille de supergènes des canaux ioniques pentamères régulés par ligands.
PCT/EP1999/007625 1998-10-27 1999-10-12 Procede de production biotechnologique de fragments de liaisons aux ligands, en particulier extracellulaires, des sous-unites de recepteurs, en particulier de neurorecepteurs et de recepteurs hormonaux, sous forme isolee, native WO2000024887A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU64702/99A AU6470299A (en) 1998-10-27 1999-10-12 Method for biotechnological production of ligand binding, especially extracellular, fragments of receptor subunits, especially neuroreceptors and hormone receptors in isolated native form

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1998150429 DE19850429A1 (de) 1998-10-27 1998-10-27 Fragmente
DE19850429.2 1998-10-27

Publications (2)

Publication Number Publication Date
WO2000024887A2 WO2000024887A2 (fr) 2000-05-04
WO2000024887A3 true WO2000024887A3 (fr) 2000-06-22

Family

ID=7886398

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/007625 WO2000024887A2 (fr) 1998-10-27 1999-10-12 Procede de production biotechnologique de fragments de liaisons aux ligands, en particulier extracellulaires, des sous-unites de recepteurs, en particulier de neurorecepteurs et de recepteurs hormonaux, sous forme isolee, native

Country Status (3)

Country Link
AU (1) AU6470299A (fr)
DE (1) DE19850429A1 (fr)
WO (1) WO2000024887A2 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0079466A2 (fr) * 1981-11-12 1983-05-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Substances biologiquement actives immobilisées et leur application
WO1991015602A1 (fr) * 1990-04-03 1991-10-17 The Salk Institute Biotechnology/Industrial Associates, Inc. Compositions receptrices de l'acetylcholine nicotinique neuronale humaine et techniques d'utilisation de ces compositions
WO1994008007A1 (fr) * 1992-09-29 1994-04-14 President And Fellows Of Harvard College Facteur trophique possedant une activite provoquant un canal d'ions dans des cellules neuronales
WO1996001842A1 (fr) * 1994-07-08 1996-01-25 La Jolla Cancer Research Foundation Procedes de purification de decorine humaine recombinee et de detection d'ions guanidinium
WO1996003504A1 (fr) * 1994-07-21 1996-02-08 The Salk Institute For Biological Studies Clonage et expression d'une sous-unite de recepteurs formant un canal ionique declenche par l'acetylcholine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3537708A1 (de) * 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0079466A2 (fr) * 1981-11-12 1983-05-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Substances biologiquement actives immobilisées et leur application
WO1991015602A1 (fr) * 1990-04-03 1991-10-17 The Salk Institute Biotechnology/Industrial Associates, Inc. Compositions receptrices de l'acetylcholine nicotinique neuronale humaine et techniques d'utilisation de ces compositions
WO1994008007A1 (fr) * 1992-09-29 1994-04-14 President And Fellows Of Harvard College Facteur trophique possedant une activite provoquant un canal d'ions dans des cellules neuronales
WO1996001842A1 (fr) * 1994-07-08 1996-01-25 La Jolla Cancer Research Foundation Procedes de purification de decorine humaine recombinee et de detection d'ions guanidinium
WO1996003504A1 (fr) * 1994-07-21 1996-02-08 The Salk Institute For Biological Studies Clonage et expression d'une sous-unite de recepteurs formant un canal ionique declenche par l'acetylcholine

Also Published As

Publication number Publication date
WO2000024887A2 (fr) 2000-05-04
AU6470299A (en) 2000-05-15
DE19850429A1 (de) 2000-05-04

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