WO2000023615A3 - Procede ameliore destine a une extraction quantitative d'information se rapportant a une influence sur une reponse cellulaire - Google Patents

Procede ameliore destine a une extraction quantitative d'information se rapportant a une influence sur une reponse cellulaire Download PDF

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Publication number
WO2000023615A3
WO2000023615A3 PCT/DK1999/000562 DK9900562W WO0023615A3 WO 2000023615 A3 WO2000023615 A3 WO 2000023615A3 DK 9900562 W DK9900562 W DK 9900562W WO 0023615 A3 WO0023615 A3 WO 0023615A3
Authority
WO
WIPO (PCT)
Prior art keywords
influence
cellular response
information relating
quantitative information
extracting quantitative
Prior art date
Application number
PCT/DK1999/000562
Other languages
English (en)
Other versions
WO2000023615A2 (fr
Inventor
Per O G Arkhammar
Bernard Robert Terry
Kurt Marshall Scudder
Sara Petersen Bjoern
Ole Thastrup
Grith Hagel
Original Assignee
Bioimage As
Per O G Arkhammar
Bernard Robert Terry
Kurt Marshall Scudder
Sara Petersen Bjoern
Ole Thastrup
Grith Hagel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioimage As, Per O G Arkhammar, Bernard Robert Terry, Kurt Marshall Scudder, Sara Petersen Bjoern, Ole Thastrup, Grith Hagel filed Critical Bioimage As
Priority to AU61895/99A priority Critical patent/AU6189599A/en
Priority to JP2000577322A priority patent/JP2002527761A/ja
Priority to EP99948731A priority patent/EP1121593A2/fr
Publication of WO2000023615A2 publication Critical patent/WO2000023615A2/fr
Publication of WO2000023615A3 publication Critical patent/WO2000023615A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5035—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on sub-cellular localization
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43595—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Abstract

La présente invention concerne un procédé amélioré et des outils de quantification de l'effet d'une influence sur une réponse cellulaire, et en particulier un procédé amélioré destiné à détecter une translocation ou une redistribution intercellulaire de polypeptides biologiquement actifs. L'invention concerne aussi plusieurs manières de mettre en contact les cellules avec une substance qui influence une réponse cellulaire et d'extraire une information quantitative se rapportant à la réponse, d'une façon hautement parallèle. Le procédé peut être utilisé en tant que procédure très efficace de test ou de découverte de l'influence d'une substance sur un processus physiologique à l'aide de techniques de tests parallèles à grands volumes commercialement disponibles, par exemple en relation avec le criblage de nouveaux médicaments, avec des tests de toxicité de substances, et avec l'identification de cibles de médicament pour des médicaments connus ou nouveaux.
PCT/DK1999/000562 1998-10-15 1999-10-15 Procede ameliore destine a une extraction quantitative d'information se rapportant a une influence sur une reponse cellulaire WO2000023615A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU61895/99A AU6189599A (en) 1998-10-15 1999-10-15 An improved method for extracting quantitative information relating to an influence on a cellular response
JP2000577322A JP2002527761A (ja) 1998-10-15 1999-10-15 細胞応答への影響に関する量的情報を入手するための改良方法
EP99948731A EP1121593A2 (fr) 1998-10-15 1999-10-15 Procede ameliore destine a une extraction quantitative d'information se rapportant a une influence sur une reponse cellulaire

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199801320 1998-10-15
DKPA199801320 1998-10-15

Publications (2)

Publication Number Publication Date
WO2000023615A2 WO2000023615A2 (fr) 2000-04-27
WO2000023615A3 true WO2000023615A3 (fr) 2001-03-29

Family

ID=8103540

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1999/000562 WO2000023615A2 (fr) 1998-10-15 1999-10-15 Procede ameliore destine a une extraction quantitative d'information se rapportant a une influence sur une reponse cellulaire

Country Status (4)

Country Link
EP (1) EP1121593A2 (fr)
JP (1) JP2002527761A (fr)
AU (1) AU6189599A (fr)
WO (1) WO2000023615A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7236888B2 (en) 1998-03-06 2007-06-26 The Regents Of The University Of California Method to measure the activation state of signaling pathways in cells
US7282347B2 (en) 2000-07-04 2007-10-16 Fisher Bioimage Aps Method for extracting quantitative information relating to interactions between cellular components
EP1333099B1 (fr) * 2000-11-06 2008-10-29 Ajinomoto Co., Inc. Procede de recherche d'une proteine de transport dans le noyau codant pour un gene
WO2002042732A2 (fr) * 2000-11-22 2002-05-30 The Regents Of The University Of California Procede de mesure de l'etat d'activation des voies de signalisation dans des cellules
US7033790B2 (en) 2001-04-03 2006-04-25 Curagen Corporation Proteins and nucleic acids encoding same
US20030039383A1 (en) * 2001-06-26 2003-02-27 Bio-Rad Laboratories, Inc. Flat field correction of two-dimensional biochemical assay images
WO2003012068A2 (fr) 2001-08-01 2003-02-13 Cellomics, Inc. Nouvelles proteines de fusion et analyses de detection de liaisons moleculaires
GB0203924D0 (en) * 2002-02-19 2002-04-03 Univ Bristol Screening method
FR3010521B1 (fr) * 2013-09-12 2015-10-09 Luxor Procede fluorimetrique simplifie pour evaluer l'influence d'une condition sur un echantillon biologique et ses applications
JP2015075477A (ja) * 2013-10-11 2015-04-20 独立行政法人産業技術総合研究所 応力発光評価装置並びに応力発光評価方法
CN105551009B (zh) * 2015-12-17 2018-03-16 哈尔滨工业大学 一种基于连续太赫兹共焦扫描偏振成像的图像融合方法
CN106770102A (zh) * 2016-12-05 2017-05-31 百奥森（江苏）食品安全科技有限公司 一种链霉素检测方法
CN113740531B (zh) * 2021-09-01 2023-02-03 陕西脉元生物科技有限公司 一类降低荧光非特异性显色的细胞及基于其的检测产品和检测自身抗体的应用

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WO1994023039A1 (fr) * 1993-04-07 1994-10-13 The Institute Of Cancer Research: Royal Cancer Hospital Procedes de criblage de substances a activite therapeutique et levure utilisee a cet effet
WO1995007463A1 (fr) * 1993-09-10 1995-03-16 The Trustees Of Columbia University In The City Of New York Methodes d'utilisation de proteines fluorescentes vertes
WO1996003649A1 (fr) * 1994-07-22 1996-02-08 The University Of North Carolina At Chapel Hill PEPTIDES SE FIXANT AUX SH3 DE Src ET LEURS METHODES D'ISOLEMENT ET D'UTILISATION
WO1996023898A1 (fr) * 1995-01-31 1996-08-08 Novo Nordisk A/S Procede de detection de substances biologiquement actives
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WO1991001305A1 (fr) * 1989-07-22 1991-02-07 University Of Wales College Of Medicine Proteines bioluminescentes modifiees et leur utilisation
WO1994023039A1 (fr) * 1993-04-07 1994-10-13 The Institute Of Cancer Research: Royal Cancer Hospital Procedes de criblage de substances a activite therapeutique et levure utilisee a cet effet
WO1995007463A1 (fr) * 1993-09-10 1995-03-16 The Trustees Of Columbia University In The City Of New York Methodes d'utilisation de proteines fluorescentes vertes
WO1996003649A1 (fr) * 1994-07-22 1996-02-08 The University Of North Carolina At Chapel Hill PEPTIDES SE FIXANT AUX SH3 DE Src ET LEURS METHODES D'ISOLEMENT ET D'UTILISATION
WO1996023898A1 (fr) * 1995-01-31 1996-08-08 Novo Nordisk A/S Procede de detection de substances biologiquement actives
WO1997011094A1 (fr) * 1995-09-22 1997-03-27 Novo Nordisk A/S Nouveaux variants de la proteine verte fluorescente (gfp)
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WO1998030715A1 (fr) * 1997-01-07 1998-07-16 California Institute Of Technology Detecteur optique de signalisation cellulaire
WO1998045704A2 (fr) * 1997-04-07 1998-10-15 Bioimage A/S Procede permettant d'extraire des informations quantitatives ayant trait a une influence exercee sur une reponse cellulaire

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Also Published As

Publication number Publication date
AU6189599A (en) 2000-05-08
EP1121593A2 (fr) 2001-08-08
JP2002527761A (ja) 2002-08-27
WO2000023615A2 (fr) 2000-04-27

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