WO2000018440A8 - Somatostatin receptor radioligand with increased uptake - Google Patents

Somatostatin receptor radioligand with increased uptake

Info

Publication number
WO2000018440A8
WO2000018440A8 PCT/US1999/022337 US9922337W WO0018440A8 WO 2000018440 A8 WO2000018440 A8 WO 2000018440A8 US 9922337 W US9922337 W US 9922337W WO 0018440 A8 WO0018440 A8 WO 0018440A8
Authority
WO
WIPO (PCT)
Prior art keywords
somatostatin receptor
increased uptake
radioligand
receptor radioligand
chelating agent
Prior art date
Application number
PCT/US1999/022337
Other languages
French (fr)
Other versions
WO2000018440A1 (en
WO2000018440A9 (en
Inventor
Jong Marion De
Wout A Breeman
Theofilus Johannes Visser
Eric Paul Krenning
Ananthachari Srinivasan
Original Assignee
Mallinckrodt Inc
Jong Marion De
Wout A Breeman
Theofilus Johannes Visser
Eric Paul Krenning
Ananthachari Srinivasan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc, Jong Marion De, Wout A Breeman, Theofilus Johannes Visser, Eric Paul Krenning, Ananthachari Srinivasan filed Critical Mallinckrodt Inc
Priority to JP2000571957A priority Critical patent/JP2002525341A/en
Priority to EP99954662A priority patent/EP1115429A1/en
Priority to AU10960/00A priority patent/AU1096000A/en
Priority to CA002341489A priority patent/CA2341489A1/en
Publication of WO2000018440A1 publication Critical patent/WO2000018440A1/en
Publication of WO2000018440A8 publication Critical patent/WO2000018440A8/en
Publication of WO2000018440A9 publication Critical patent/WO2000018440A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

A radioligand comprising a peptide capable of binding to a receptor wherein the peptide is coupled to at least one chelating agent, which chelating agent is not coordinated to a metal ion under physiological conditions and a composition comprising said radioligand as a diagnostic or pharmaceutical and a kit for the detection of receptors.
PCT/US1999/022337 1998-09-25 1999-09-24 Somatostatin receptor radioligand with increased uptake WO2000018440A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000571957A JP2002525341A (en) 1998-09-25 1999-09-24 Somatostatin receptor radioligand with enhanced uptake
EP99954662A EP1115429A1 (en) 1998-09-25 1999-09-24 Somatostatin receptor radioligand with increased uptake
AU10960/00A AU1096000A (en) 1998-09-25 1999-09-24 Somatostatin receptor radioligand with increased uptake
CA002341489A CA2341489A1 (en) 1998-09-25 1999-09-24 Somatostatin receptor radioligand with increased uptake

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP98203235 1998-09-25
EP98203235.1 1998-09-28
EP98203244.3 1998-09-28
EP98203244 1998-09-28

Publications (3)

Publication Number Publication Date
WO2000018440A1 WO2000018440A1 (en) 2000-04-06
WO2000018440A8 true WO2000018440A8 (en) 2000-08-24
WO2000018440A9 WO2000018440A9 (en) 2000-10-12

Family

ID=26150726

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/022337 WO2000018440A1 (en) 1998-09-25 1999-09-24 Somatostatin receptor radioligand with increased uptake

Country Status (5)

Country Link
EP (1) EP1115429A1 (en)
JP (1) JP2002525341A (en)
AU (1) AU1096000A (en)
CA (1) CA2341489A1 (en)
WO (1) WO2000018440A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108503695B (en) * 2018-03-09 2021-06-08 南方医科大学南方医院 Tracer based on GnRH polypeptide derivative and preparation method and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2113995C (en) * 1991-08-29 2003-04-22 Edward A. Deutsch Use of gentisic acid or gentisyl alcohol for stabilising radiolabeled peptides and proteins
AU3967593A (en) * 1992-03-25 1993-10-21 Mallinckrodt Medical, Inc. Method of intraoperatively detecting and locating tumoral tissues

Also Published As

Publication number Publication date
CA2341489A1 (en) 2000-04-06
EP1115429A1 (en) 2001-07-18
WO2000018440A1 (en) 2000-04-06
JP2002525341A (en) 2002-08-13
WO2000018440A9 (en) 2000-10-12
AU1096000A (en) 2000-04-17

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