WO2000014263A8 - Recombinant hepatitis a virus (hav), hav variants, hav-based vaccines and methods of producing them - Google Patents

Recombinant hepatitis a virus (hav), hav variants, hav-based vaccines and methods of producing them

Info

Publication number
WO2000014263A8
WO2000014263A8 PCT/US1999/020375 US9920375W WO0014263A8 WO 2000014263 A8 WO2000014263 A8 WO 2000014263A8 US 9920375 W US9920375 W US 9920375W WO 0014263 A8 WO0014263 A8 WO 0014263A8
Authority
WO
WIPO (PCT)
Prior art keywords
hav
variants
virus
methods
recombinant hepatitis
Prior art date
Application number
PCT/US1999/020375
Other languages
French (fr)
Other versions
WO2000014263A9 (en
WO2000014263A3 (en
WO2000014263A2 (en
Inventor
Stanley M Lemon
Michael R Beard
Original Assignee
Univ Texas
Stanley M Lemon
Michael R Beard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Stanley M Lemon, Michael R Beard filed Critical Univ Texas
Publication of WO2000014263A2 publication Critical patent/WO2000014263A2/en
Publication of WO2000014263A3 publication Critical patent/WO2000014263A3/en
Publication of WO2000014263A8 publication Critical patent/WO2000014263A8/en
Publication of WO2000014263A9 publication Critical patent/WO2000014263A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
    • C12N2770/32422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention described herein is directed to methods and compositions involving recombinant hepatitis A virus (HAV) expressing heterologous nucleic acid sequences and a forced selection method to identify viral variants, including HAV variants, that may contain characteristics beneficial for a vaccine. Accordingly, the invention includes HAV-based vaccine virus seed and other viral vaccine seed, including methods of making them. The viruses of the present invention also generally have diagnostic uses as well as therapeutic uses for gene therapy, especially with respect to liver-specific diseases and conditions.
PCT/US1999/020375 1998-09-03 1999-09-03 Recombinant hepatitis a virus (hav), hav variants, hav-based vaccines and methods of producing them WO2000014263A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9894598P 1998-09-03 1998-09-03
US60/098,945 1998-09-03

Publications (4)

Publication Number Publication Date
WO2000014263A2 WO2000014263A2 (en) 2000-03-16
WO2000014263A3 WO2000014263A3 (en) 2000-08-17
WO2000014263A8 true WO2000014263A8 (en) 2001-03-15
WO2000014263A9 WO2000014263A9 (en) 2001-11-22

Family

ID=22271678

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/020375 WO2000014263A2 (en) 1998-09-03 1999-09-03 Recombinant hepatitis a virus (hav), hav variants, hav-based vaccines and methods of producing them

Country Status (1)

Country Link
WO (1) WO2000014263A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6921634B2 (en) 1999-12-23 2005-07-26 Board Of Regents, The University Of Texas System Replication competent hepatitus C virus and methods of use
DK1694694T3 (en) 2003-12-01 2013-05-06 Univ Texas Replication competent hepatitis C virus as well as methods of use
GEP20156313B (en) 2010-09-22 2015-07-10 Alios Biopharma Inc Substituted nucleotide analogs
EP2794630A4 (en) 2011-12-22 2015-04-01 Alios Biopharma Inc Substituted phosphorothioate nucleotide analogs
CN104321333A (en) 2012-03-21 2015-01-28 沃泰克斯药物股份有限公司 Solid forms of a thiophosphoramidate nucleotide prodrug
WO2013142157A1 (en) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
CN104862287A (en) * 2015-05-21 2015-08-26 中国医学科学院医学生物学研究所 Preparation method of genetic engineering recombinant combined vaccine against hepatitis A and hepatitis E

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478746A (en) * 1982-04-07 1995-12-26 The United States Of America As Represented By The Department Of Health And Human Services cDNA encoding attenuated cell culture adapted hepatitis A virus genome
FR2619012B1 (en) * 1987-08-07 1989-12-22 Pasteur Institut VACCINES IN WHICH THE CHARACTERISTIC EPITOPE IS INCORPORATED IN A PROTEIN OF PICORNAVIRUS, ESPECIALLY POLIOVIRUS
EP0702724A1 (en) * 1993-06-03 1996-03-27 Institut Pasteur Mengovirus as a vector for expression of foreign polypeptides
WO1997040166A2 (en) * 1996-04-19 1997-10-30 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Simian-human hav having a chimeric 2c protein

Also Published As

Publication number Publication date
WO2000014263A9 (en) 2001-11-22
WO2000014263A3 (en) 2000-08-17
WO2000014263A2 (en) 2000-03-16

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