WO2000013592A1 - Device for receiving and actuating a biopsy needle - Google Patents

Device for receiving and actuating a biopsy needle Download PDF

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Publication number
WO2000013592A1
WO2000013592A1 PCT/DE1999/002841 DE9902841W WO0013592A1 WO 2000013592 A1 WO2000013592 A1 WO 2000013592A1 DE 9902841 W DE9902841 W DE 9902841W WO 0013592 A1 WO0013592 A1 WO 0013592A1
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WO
WIPO (PCT)
Prior art keywords
ƒ
da
receiving
biopsy needle
provided
Prior art date
Application number
PCT/DE1999/002841
Other languages
German (de)
French (fr)
Inventor
Jürgen Heinrich
Original Assignee
Gip Medizintechnik Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE1998140978 priority Critical patent/DE19840978A1/en
Priority to DE19840978.8 priority
Application filed by Gip Medizintechnik Gmbh filed Critical Gip Medizintechnik Gmbh
Publication of WO2000013592A1 publication Critical patent/WO2000013592A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/0233Pointed or sharp biopsy instruments
    • A61B10/0266Pointed or sharp biopsy instruments means for severing sample
    • A61B10/0275Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/04Endoscopic instruments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B2010/0208Biopsy devices with actuators, e.g. with triggered spring mechanisms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/04Endoscopic instruments
    • A61B2010/045Needles

Abstract

A handpiece (10) receiving a biopsy needle, whereby said handpiece can be applied to an endoscope and includes receiving devices (12, 13) for accommodating a hollow needle associated with said biopsy needle and a cutting device that is introduced into the hollow needle. The receiving devices can be tightened by means of a spring/locking arrangement (18, 19, 32, 21, 33, 34), whereby the hollow needle and the cutting device are drawn into the handpiece (10). With respect to said receiving devices (12, 13), the device (13) receiving the cutting device is released first. The device (12) receiving the hollow needle is released afterwards.

Description

Device for receiving and operating a biopsy needle

The invention relates to a device for receiving and operating a biopsy needle which is einfuhrbar m an endoscope.

A device of the type described above is already known (see for example US-A-4,249,541). In the previously known device, however, the biopsy needle is only manually betatig- bar, which sometimes is not sufficient to penetrate m-resistant patient tissue.

The invention is therefore based on the object to indicate a way in which a device of the type mentioned above is achieved in a secure manner that can also be m resistant fabric penetrated with the biopsy needle.

the above object is achieved erfmdungsgemaß at a forward direction of the aforementioned type characterized in that an attachable to the endoscope hand piece is provided, which receive a belonging to the biopsy needle cannula and a m of the respective hollow needle guided cutting means to the proximal ends m receiving devices allowed, which are by spring force in such a tensioned, that in the tensioned state, the hollow needle and the cutting device a piece of m, the hand stucco are fed, and that of the stretched receiving means processing the time allotted for receiving the cutting device Aufnahmeemrich- before provided for receiving the hollow needle up nahmeeinnchtung auslosbar is. The invention has the advantage that is able to penetrate solid tissue m within a very short time in a relatively simple manner, the biopsy needle, m which can not or only with difficulty penetrated by manually operating the biopsy needle.

Preferably, the spring force of two separate springs is provided which are individually associated with the two reception centers. This has the advantage of a particularly simple design with it.

It is advantageous furthermore, if the hollow needle and the cutting device are each connected to a separate holding part, which is accommodated in a separate receptacle. By this measure, a very simple view of the biopsy needle forming elements m of the device according to the invention becomes possible.

The above mentioned holding members are preferably each formed by a long symmetrical shaped body which has m its longitudinal direction extending, end provided strong Auswolbungen and an intermediate middle Auswolbung light, which is opposite to the end provided Auswolbungen reset; the transition be- see the Auswolbungen proceeds while on the respective

Side of the shaped body and sliding the receiving devices are each shaped to receive the shaped body in question formschlussig. This measure has the advantage that the occurring during use of the device according to the invention due to the action of the spring force

M forces the receiving devices can be very well received, so that no local Uber stresses may arise.

Expediently, the recording devices are associated with stop buffer, the nahmeemπchtungen together with the respective upward while maintaining their mutual waste prior m the axial direction of the biopsy needle can be adjusted. Thereby, a low impact effect to let m advantageous manner to the hand stucco and thus achieve the associated endoscope. The stop buffers are expediently formed from a resilient material, msbeson- particular plastic.

Expediently, a pointer part is connected with one of the stop buffer or with a bearing supporting this part, the pointer tip ends next to a particular provided on the hand piece of setting scale. Thus, the Ausfahrlange the biopsy needle can be precisely adjusted advantageously.

For the tensioning of the receiving devices m the hand piece of a Spannemrichtung is expediently provided, which is held by spring force of its rest position. This results in a relatively simple design with the tightening of the reception centers.

The question is Spannemrichtung m advantageously actuatable by a cable arrangement. This has the advantage of a particularly simple Spannemrichtung with it.

Preferably, the receiving means maintain the overall stressed condition with latches to hold parts tightly, one of which can be brought with the latch of the receptacle for the cutter system holding part is designed as a shutter release button m the hand piece, and the locking part of the serving for receiving the hollow needle receiving means is so noted that there will only be drawn emπchtung by the former recording, when the latter is nearing or at their bumpers. This results in the advantage of a relatively low design effort for the mentioned snap-in connections.

At the distal end of the hand stucco a tube assembly for receiving the biopsy needle is preferably provided, and the hand piece is with the respective pipe assembly to the endo-microscope attachable. This has the advantage of a particularly simple and easy connection of the hand Stuckes with the endoscope.

The pipe arrangement consists expediently of an outer tube and an inner tube through which the biopsy needle is durchfuhrbar, and between these two tubes, a retractable intermediate pipe is provided, the biopsy needle is durchfuhrbar through its distal end. By this measure, the handheld stucco with the respective Ronranordnung can be brought m advantageous manner to a respective desired length when attached to the endoscope.

The cutter of the biopsy needle is preferably designed as a stylet, which brings with it the advantage that can be particularly effective cut with the biopsy needle.

Expediently, the hollow needle of the biopsy needle is formed by a very thin-walled fabric tube made of plastic, and expediently a biopsy needle surrounding protective hose is formed by a braided hose of plastic.

It has proved particularly advantageous if the fabric tube is formed in such a way in each case that its surfaces are tissue-like structure. Thereby, a relatively low frictional resistance between the individual parts is let reach the biopsy needle, so that it can be easily used even at a considerable length in the range of about. 1

The invention is described hereinafter for example, the near reference to drawings.

Fig. 1 shows a sectional view of a tube assembly useful in the apparatus according to the invention

Figure imgf000006_0001
Fig. 2 shows a schematic m-sectional view of the basic construction of hand Stuckes of the device according to the invention in the relaxed state.

Fig. 3 shows the Figure is a schematic sectional view. Handpiece 2 shown in the tensioned state.

Fig. 4 shows a biopsy needle with holding parts that are receivable to the hand piece.

Fig. 5 shows an enlarged view m, the distal end of the biopsy needle. Fig. 6 shows a front view of a practically usable Halteteiles-

Fig. 7 shows a sectional view of the rare m Fig. Retaining member shown. 6

Fig. 8 shows the Fig. 6 and Fig. 7 shown holding part m of a top view together with a recording device.

In Fig. 1, a tube assembly 1 is shown which is usable in the device according to the invention m conjunction with the yet to be explained hand piece. The tube assembly 1 consists of an outer tube 2 and an inner tube 3 having a passage opening for a biopsy needle. Both tubes are designed as metal pipes, is used for the preferably aluminum and reciprocated by a biopsy needle is durchfuhrbar. The inner tube 3 is embedded at its right end with a plate-shaped part 5 in the end part 6 of the outer tube 2, which likewise has a passage opening for said biopsy needle. The inner tube 3 carries at its distal front end grooves absorbed m O-Rmge, is guided by a still provided between the outer tube 2 and the inner tube 3 intermediate tube 7 on this inner tube. 3 The intermediate pipe 7 is guided with a piston portion 8 in the outer tube 2; it has at its distal end to a fastening part 9, which likewise has a passage opening for said biopsy needle and to which the tube arrangement 1 can be attached to an endoscope. As is apparent from Fig. 1, the intermediate tube 7 can be led out of the tube assembly 1 with its exact leadership is always ensured. For a hmdurchgefuhrte through the tubing string biopsy needle is also always led well and safely, even when the intermediate tube 7 is pulled out of the tube assembly. 1

Fig. 2, the hand stucco already mentioned shows 10 m a schematic sectional view. Tube 1 arrangement illustrated at the left hand end face 11 of the Stuckes 10 m Fig. Attachable, which is indicated by the Stπchpunktlmie between FIG. 1 and FIG. 2. This hand stucco serves a belonging to a biopsy needle and a hollow needle m of the respective hollow needle guided cutting device, as is clear from Fig. 4 and 5 will be explained, at the proximal

receive ends m receiving devices 12 and 13. FIG. It should be noted that the explained in reference to FIG. 1 and the hand Pohranordnung stucco are interconnected so that the power consumed by the hand stucco needle biopsies and the aforementioned its passage aligned.

The receiving devices 12 and 13 sit m certain distance from each other on an adjusting rod 14 which carries a Gewmdeteil 15 at its right end, which is deoffnung of a Gewm- added Handpiece 10 16th By means of a Emstellrades 17, the adjusting rod 14 in question to rotate.

In the aforementioned adjustment rod 14, two compression springs 18 and 19 are provided which emπchtungen the pick-mentioned 12 or 13 of FIG. 2 are individually associated and which 12 and 13 print this receiving means respectively to the left against the stop buffers 20 and 21 , These buffers 20, 21, which consist of an elastic material, especially of plastic are, m their relative position fixed to each other. They can only together with the adjusting rod 14 and thus with the Aufnahmee obligations RICH be displaced 12 and 13 when the adjusting rod 14 is rotated by the dial 17th

With the stop buffers 20 in the present case a newspaper is gerteil 22 is connected which terminates with its pointer tip in the range of a setting scale 23 which is provided in particular on the handle 10 itself stucco. The pointer part 22 protrudes to the hand by a m Stuck 10 provided slot 24 therethrough.

still belongs to the hand piece of FIG. 2 is a Spannemrichtung 25 which can abut with detents 26 and 27 on abutment 28 and 29, respectively, which are connected to the receiving means 12 and 13 respectively. A tension spring 30 pulls the direction Spannem- 25 m to the left its rest position. By means of a cable assembly 31 is the Spannemrichtung concerned as shown in FIG. 2 to the right and pulled allowing thus the recording emrichtungen 12 to bring their tensioned state 13 m, as is illustrated FIG. 3.

FIG. 3 is a connected to the receiving device 12 latching pawl 32 on the stop buffer 21 for the upward nahmeemπchtung to 13, and means connected to the receiving device 13 latch 33 abuts a here likewise designed as a latching pawl support part 34, which by means of an actuating button 35, which is printed their upper position by a spring 36 m, can be locked. The above-mentioned compression springs 18 and 19 are thus considerably printed together, which means that the hand stucco or instructions precisely says its receiving devices 12 are tensioned. 13 If the operating button down printed 35, so first the latching connection between the latching parts 33, drawn 34 and the receiving device 13 is moved by the spring force of the spring 19 quickly to the left. Shortly before its stop buffer 21 or buffer against this stop the recording means 13 drawn from the latch 32, so that then the up nahmeemπchtung 12 is moved by the spring force of the spring 18 quickly to the left. As mentioned above, these Kraftige and rapid movement is needed for a biopsy needle to be inserted m solid tissue.

Fig. 4 shows such a biopsy needle 37. The biopsy needle 37 in question em has as Schneidemrichtung on executed inner part 38 which is accommodated at its proximal end by a holding device and a separate holding part 39 or vehicle by the receiving means 13 of the hand stucco 10 receivable. to the biopsy needle 37 further includes a hollow needle 40, which is received by a separate holding part 41st This holding member 41 is of the up nahmeemπchtung 12 of the hand 10 stucco receivable. In addition, 4 nor em protection tube or protective tube 42 is m Fig. Surrounding the biopsy needle.

F g. 5 shows an enlarged partial view of m, the distal end of the biopsy needle 37. The Schneidemrichtung 38 is designed as a stylet, behind which a spot of reduced material thickness is provided. The stylet and the cutting is emrichtung the hollow needle surrounded by a thin wall 40 forming fabric tube made of plastic, which in turn is surrounded by the protective tube 42 forming fabric tube. The fabric hoses are preferably made of a nylon material (protected brand name) formed with a distinct tissue structure. Through this fabric texture-like

Embodiment of the tissue hoses the friction of the individual elements of the biopsy needle is so small that it can be used over a length of about 1 m easily. It should be noted that the concerned shall biopsy needle can be used not only m connection with the previously described hand piece, but is generally used.

In FIG. 6, 7 and 8 e is practically realized holding part 50 is shown, which as a retaining part 39 and 41 of FIG. 4 can be used. Based on the Fig. 4 illustrated an enlarged scale conditions is selected m FIG. 6 to 8. Fig. 6 shows the aforementioned holding part 50 m of a front view, FIG. 7 shows an associated rare-sectional view, and FIG. 8, the holding member shows 50 m of a top view together with a holding device 54. The holding part 50 in question has, according to Fig. 6 and 7 passage opening 51 for receiving the Schneidemrichtung 38 and the hollow needle 40 of the biopsy needle shown in FIG. 4 and 5.

As is apparent from FIGS. 6 to 8 is the holding part

50 is formed by a long symmetrical shaped body which m its longitudinal direction extending, end provided strong Auswolbungen 52 and intermediate medium light Auswolbungen 53 which are set back from the end 52 superiors provided Auswolbungen. The transition between the Auswolbungen 52 and 53 on the respective side of the molded article 50 proceeds slidably. The Auswolbungen 52, 53 preferably each correspond to a circular cross-section whose center is located outside the longitudinal center of the associated Formkor- pers. The diameter of the respective central Auswolbung 53 about 2/3 of the diameter of each of the end provided Auswolbungen 52 may be.

From Fig. 8 is moreover clear that the holding part 50 with his Auswolbungen 52 is accommodated formschlussig 53 from a receiving device 54; this receiving device 54 corresponds to each of the receiving devices 12, 13 according to Fig. 2 and 3.

The shaped body has in the rest of its front and rear end faces recessed gripping sides, as shown in FIG. 7 clearly let. In this case, this handle rare at the bottom parts of the body are in the area provided with dreieckformigem cross section, which m conjunction with the above-mentioned Auswol- environments 52, 53 leads to a very good distribution of force when using the thus-formed holding parts and the correspondingly complementarily shaped to receiving devices.

Claims

Patentanspr├╝che
1. A device for receiving and Bet├ñtigung a biopsy needle, the endoscope is einfuhrbar m em, characterized in being provided to the endoscope da├ƒ e attachable Handpiece (10) comprising a to the biopsy needle (37) geh├╢rende hollow needle (40) and a m of the respective hollow needle (40) gef├╝hrte Schneidem- direction (38) allows to take on the proximal ends m receiving means (12,13) ​​which are so tensioned by spring force in the tensioned state da├ƒ the hollow needle (40) and the Schneidemrichtung (38) em m Stuck Stuck the hand (10) are fed, and of the tensioned da├ƒ receiving means (12,13) ​​the f├╝r receiving the Schneidemrichtung (38) provided upward nahmeemrichtung (13) provided in front of the f├╝r receiving the hollow needle (40) receiving means (12) is auslosbar.
2. Device according to claim 1, dadurchgeken nz eichnet that the spring force of two separate springs (18, 19) is provided to the two recording emπchtungen (12, 13) are individually zugehörig.
3. Device according to claim 1 or 2, dadurchg ek ennzeichnet that the hollow needle (40) and the Schneidemrichtung (38) are each connected to a separate holding member (41,39) having its own m Aufnah- eemrichtung (12, 13) is added.
4. Apparatus according to claim 3, dadurchgeken nz eichnet that the holding parts (41, 39) in each case by a long symmetrical moldings (50) are formed, which in L├ñngsrichtung extending, end provided strong Auswolbungen (52) and an intermediate middle slight having Auswolbung (53) which is zur├╝ckgesetzt gegen├╝ber the end provided Auswolbungen (52) ├ £ da├ƒ transition between the Auswolbungen (52, 53) on the respective side of the shaped body (50) slidably proceeds and da├ƒ the receiving devices (12, 13; 54) are each shaped so as they da├ƒ the respective shaped body (50) take form- conclusively.
5. Device according to one of Anspr├╝che 1 to 4, ch dadur geken nz eichnet, da├ƒ the receiving means (12,13) ​​stop buffers (20,21) are zugeh├╢rig, which (together with the respective receiving devices 12 , 13) are adjustable while retaining their mutual distance m the axial direction of the biopsy needle (37).
6. Apparatus according to claim 5, characterized dadurchgeken n-, daß with one of the stop buffers (20,21) or with a bearing supporting this part (14) em pointer part (22) is connected, the pointer tip next to a particular (on the hand Stuck 10) provided for setting scale (23) ends.
7. Device according to one of Anspr├╝che 1 to 6 characterized in, da├ƒ f├╝r the tensioning of the receiving means (12,13) ​​m said hand Stuck (10) has a Spannemrichtung (25) is provided, which by spring force m its rest position is maintained.
8. Apparatus according to claim 7, dadurchgeken nz eichnet that Spannemrichtung (25) daß by a cable assembly (31) is actuatable.
9. Device according to one of Anspr├╝che 1 to 8 characterized in that up da├ƒ nahmeem╧Çchtungen (12,13) ​​in the tensioned state with Rastklmken (32,33) on holding members (21,34) to hold, of which with the Rastklmke (33) of the receiving device
(13) für the Schneidemrichtung (38) can be brought m Plant holding part (34) as a shutter release button (35) is formed m the hand stucco (10), and daß the latching part (32) for receiving the hollow needle (40) serving receptacle (12) is held, it daß only through the first-mentioned receiving means (13) is triggered, if this is located just prior to or at its stop buffer (21).
10. The device according to one of Ansprüche 1 to 9, characterized in daß at the distal end of the hand Stuckes (10) a tube assembly (1) für receiving the biopsy needle (37) is provided, and daß the hand pieces (10) with the respective tube arrangement (1) to the endoscope can be attached.
11. The device according to claim 10, characterized in that the tube arrangement (1) from a daß Außen- röhr (2) and an inner tube (3), through which the biopsy needle (37) is durchfuhrbar, and since ß between these two pipes (2,3) em extensible intermediate tube (7) is provided, the biopsy needle (37) is durchfuhrbar through its distal end.
12. The device according to one of Ansprüche 1 to 11, characterized in that the Schneidemrichtung (38) daß the biopsy needle (37) is designed as a stylet.
13. The device according to one of Ansprüche 1 to 12, characterized in that the hollow needle (40) of the biopsy needle daß (37) by a very dünnwandigen fabric tube is formed of plastic.
14. The apparatus of claim 13, dadurchgeken nz eichnet, e daß the biopsy needle (37) surrounding protective hose (42) is formed by a braided hose of plastic.
15. The apparatus of claim 13 or 14, characterized in that the tissue daß hose (40, 42) is adapted in each case, its Oberflächen daß fabric texture like are.
PCT/DE1999/002841 1998-09-08 1999-09-08 Device for receiving and actuating a biopsy needle WO2000013592A1 (en)

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DE1998140978 DE19840978A1 (en) 1998-09-08 1998-09-08 Device for receiving and operating a biopsy needle
DE19840978.8 1998-09-08

Applications Claiming Priority (3)

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JP2000568403A JP2002524127A (en) 1998-09-08 1999-09-08 Apparatus for receive and manipulate the biopsy needle
EP19990955675 EP1112027A1 (en) 1998-09-08 1999-09-08 Device for receiving and actuating a biopsy needle
CA 2340376 CA2340376A1 (en) 1998-09-08 1999-09-08 Device for receiving and actuating a biopsy needle

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WO2000013592A1 true WO2000013592A1 (en) 2000-03-16

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JP (1) JP2002524127A (en)
CA (1) CA2340376A1 (en)
DE (1) DE19840978A1 (en)
WO (1) WO2000013592A1 (en)

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US7670282B2 (en) 2004-06-14 2010-03-02 Pneumrx, Inc. Lung access device
US7766938B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Pleural effusion treatment device, method and material
US7766891B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Lung device with sealing features
US8157837B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Minimally invasive lung volume reduction device and method
US8888800B2 (en) 2006-03-13 2014-11-18 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US9125639B2 (en) 2004-11-23 2015-09-08 Pneumrx, Inc. Steerable device for accessing a target site and methods
US9173669B2 (en) 2008-09-12 2015-11-03 Pneumrx, Inc. Enhanced efficacy lung volume reduction devices, methods, and systems
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US9474533B2 (en) 2006-03-13 2016-10-25 Pneumrx, Inc. Cross-sectional modification during deployment of an elongate lung volume reduction device

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US8192353B2 (en) * 2007-10-05 2012-06-05 Tyco Healthcare Group Lp Visual obturator

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US7775968B2 (en) 2004-06-14 2010-08-17 Pneumrx, Inc. Guided access to lung tissues
US7670282B2 (en) 2004-06-14 2010-03-02 Pneumrx, Inc. Lung access device
US7766938B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Pleural effusion treatment device, method and material
US7766891B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Lung device with sealing features
US9125639B2 (en) 2004-11-23 2015-09-08 Pneumrx, Inc. Steerable device for accessing a target site and methods
US10034999B2 (en) 2004-11-23 2018-07-31 Pneumrx, Inc. Steerable device for accessing a target site and methods
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US8932310B2 (en) 2006-03-13 2015-01-13 Pneumrx, Inc. Minimally invasive lung volume reduction devices, methods, and systems
US10226257B2 (en) 2006-03-13 2019-03-12 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US10188397B2 (en) 2006-03-13 2019-01-29 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US8888800B2 (en) 2006-03-13 2014-11-18 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US9402632B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US9402971B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Minimally invasive lung volume reduction devices, methods, and systems
US9474533B2 (en) 2006-03-13 2016-10-25 Pneumrx, Inc. Cross-sectional modification during deployment of an elongate lung volume reduction device
US9782558B2 (en) 2006-03-13 2017-10-10 Pneumrx, Inc. Minimally invasive lung volume reduction devices, methods, and systems
US8157837B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Minimally invasive lung volume reduction device and method
US10058331B2 (en) 2008-09-12 2018-08-28 Pneumrx, Inc. Enhanced efficacy lung volume reduction devices, methods, and systems
US9192403B2 (en) 2008-09-12 2015-11-24 Pneumrx, Inc. Elongated lung volume reduction devices, methods, and systems
US9173669B2 (en) 2008-09-12 2015-11-03 Pneumrx, Inc. Enhanced efficacy lung volume reduction devices, methods, and systems
US10285707B2 (en) 2008-09-12 2019-05-14 Pneumrx, Inc. Enhanced efficacy lung volume reduction devices, methods, and systems

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CA2340376A1 (en) 2000-03-16
EP1112027A1 (en) 2001-07-04
DE19840978A1 (en) 2000-03-09

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