WO2000011137A8 - Acid labile cationic amphiphiles - Google Patents

Acid labile cationic amphiphiles

Info

Publication number
WO2000011137A8
WO2000011137A8 PCT/US1999/019356 US9919356W WO0011137A8 WO 2000011137 A8 WO2000011137 A8 WO 2000011137A8 US 9919356 W US9919356 W US 9919356W WO 0011137 A8 WO0011137 A8 WO 0011137A8
Authority
WO
WIPO (PCT)
Prior art keywords
cationic amphiphiles
acid labile
amphiphiles
methods
compositions
Prior art date
Application number
PCT/US1999/019356
Other languages
French (fr)
Other versions
WO2000011137A1 (en
Inventor
Sean M Sullivan
Original Assignee
Valentis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valentis Inc filed Critical Valentis Inc
Priority to AU55843/99A priority Critical patent/AU5584399A/en
Publication of WO2000011137A1 publication Critical patent/WO2000011137A1/en
Publication of WO2000011137A8 publication Critical patent/WO2000011137A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups

Abstract

The invention relates to cationic amphiphiles, methods for their synthesis, methods for preparing compositions comprising such amphiphiles and polyanions, methods for delivering polyanions to cells by administering these compositions and treatment or prevention of diseases and disorders using these cationic amphiphiles and compositions.
PCT/US1999/019356 1998-08-24 1999-08-24 Acid labile cationic amphiphiles WO2000011137A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU55843/99A AU5584399A (en) 1998-08-24 1999-08-24 Acid labile cationic amphiphiles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9775998P 1998-08-24 1998-08-24
US60/097,759 1998-08-24

Publications (2)

Publication Number Publication Date
WO2000011137A1 WO2000011137A1 (en) 2000-03-02
WO2000011137A8 true WO2000011137A8 (en) 2001-07-05

Family

ID=22264985

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/019356 WO2000011137A1 (en) 1998-08-24 1999-08-24 Acid labile cationic amphiphiles

Country Status (2)

Country Link
AU (1) AU5584399A (en)
WO (1) WO2000011137A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2881392B1 (en) 2010-11-16 2018-06-06 Texas Heart Institute Agonists that enhance binding of integrin-expressing cells to integrin receptors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747471A (en) * 1994-12-09 1998-05-05 Genzyme Corporation Cationic amphiphiles containing steroid lipophilic groups for intracellular delivery of therapeutic molecules
US5650096A (en) * 1994-12-09 1997-07-22 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules

Also Published As

Publication number Publication date
WO2000011137A1 (en) 2000-03-02
AU5584399A (en) 2000-03-14

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