WO2000011032A3 - Method for producing biostatin (tt-232 triacetate) and analogs thereof - Google Patents

Method for producing biostatin (tt-232 triacetate) and analogs thereof Download PDF

Info

Publication number
WO2000011032A3
WO2000011032A3 PCT/EP1999/006131 EP9906131W WO0011032A3 WO 2000011032 A3 WO2000011032 A3 WO 2000011032A3 EP 9906131 W EP9906131 W EP 9906131W WO 0011032 A3 WO0011032 A3 WO 0011032A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
biostatin
solid phase
triacetate
analogs
Prior art date
Application number
PCT/EP1999/006131
Other languages
German (de)
French (fr)
Other versions
WO2000011032A2 (en
WO2000011032A9 (en
Inventor
Guenther Braum
Axel Lifferth
Christian Birr
Original Assignee
Orpegen Pharma Ges Fuer Biotec
Guenther Braum
Axel Lifferth
Christian Birr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orpegen Pharma Ges Fuer Biotec, Guenther Braum, Axel Lifferth, Christian Birr filed Critical Orpegen Pharma Ges Fuer Biotec
Priority to AU56234/99A priority Critical patent/AU5623499A/en
Priority to HU0103196A priority patent/HUP0103196A3/en
Priority to JP2000566304A priority patent/JP2002523425A/en
Priority to DE59913712T priority patent/DE59913712D1/en
Priority to EP99942897A priority patent/EP1104439B1/en
Publication of WO2000011032A2 publication Critical patent/WO2000011032A2/en
Publication of WO2000011032A3 publication Critical patent/WO2000011032A3/en
Publication of WO2000011032A9 publication Critical patent/WO2000011032A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to a method for synthesising biostatin (TT 232) by means of solid phase synthesis on a polymer support, by gradually building up the peptide using amino acids derivatized with protective groups. According to said method, the protective groups are split off and the peptide is detached from the solid phase. The disulphide bond is closed through the oxidation of the completely or partially built up peptide in the presence of a suitable solvent for as long as the peptide remains bound to the solid phase. The invention also relates to a method for synthesising biostatin (TT232) by means of peptide synthesis in solution.
PCT/EP1999/006131 1998-08-20 1999-08-20 Method for producing biostatin (tt-232 triacetate) and analogs thereof WO2000011032A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU56234/99A AU5623499A (en) 1998-08-20 1999-08-20 Method for producing biostatin (tt-232 triacetate) and analogs thereof
HU0103196A HUP0103196A3 (en) 1998-08-20 1999-08-20 Method for producing biostatin (tt-232 triacetate) and analogs thereof
JP2000566304A JP2002523425A (en) 1998-08-20 1999-08-20 Process for producing biostatin (TT-232 triacetate) and its analogs
DE59913712T DE59913712D1 (en) 1998-08-20 1999-08-20 PROCESS FOR PREPARING BIOSTATIN (TT-232 TRIACETATE) AND ITS ANALOGUE
EP99942897A EP1104439B1 (en) 1998-08-20 1999-08-20 Method for producing biostatin (tt-232 triacetate) and analogs thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP1998/005306 WO2000011031A1 (en) 1998-08-20 1998-08-20 Method for producing biostatin (tt-232 triacetate) and the analogs thereof
EPPCT/EP98/05306 1998-08-20

Publications (3)

Publication Number Publication Date
WO2000011032A2 WO2000011032A2 (en) 2000-03-02
WO2000011032A3 true WO2000011032A3 (en) 2000-09-14
WO2000011032A9 WO2000011032A9 (en) 2000-10-26

Family

ID=8167037

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP1998/005306 WO2000011031A1 (en) 1998-08-20 1998-08-20 Method for producing biostatin (tt-232 triacetate) and the analogs thereof
PCT/EP1999/006131 WO2000011032A2 (en) 1998-08-20 1999-08-20 Method for producing biostatin (tt-232 triacetate) and analogs thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/005306 WO2000011031A1 (en) 1998-08-20 1998-08-20 Method for producing biostatin (tt-232 triacetate) and the analogs thereof

Country Status (5)

Country Link
JP (1) JP2002523425A (en)
AU (2) AU9436298A (en)
DE (1) DE59913712D1 (en)
HU (1) HUP0103196A3 (en)
WO (2) WO2000011031A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017536A2 (en) * 1979-03-23 1980-10-15 Sanofi S.A. Process for the preparation of somatostatine
EP0505680A1 (en) * 1991-01-25 1992-09-30 BIOSIGNAL Kutato-Fejleszto Kft. Octapeptide or heptapeptide derivatives, a process for preparing them as well as medicaments containing these compounds and the use of them
JPH1067796A (en) * 1996-08-27 1998-03-10 Sumitomo Pharmaceut Co Ltd Synthesis of cyclic peptide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017536A2 (en) * 1979-03-23 1980-10-15 Sanofi S.A. Process for the preparation of somatostatine
EP0505680A1 (en) * 1991-01-25 1992-09-30 BIOSIGNAL Kutato-Fejleszto Kft. Octapeptide or heptapeptide derivatives, a process for preparing them as well as medicaments containing these compounds and the use of them
JPH1067796A (en) * 1996-08-27 1998-03-10 Sumitomo Pharmaceut Co Ltd Synthesis of cyclic peptide

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
C GARCIA-ECHEVERRIA ET AL.: "Convenient synthesis of a cyclic peptide disulfide: a type II beta-turn structural model", TETRAHEDRON LETTERS., vol. 30, no. 18, 1989, OXFORD GB, pages 2441 - 2444, XP002103314 *
CHEMICAL ABSTRACTS, vol. 128, no. 19, 11 May 1998, Columbus, Ohio, US; abstract no. 230702, H UNO & S KANAOKA: "preparation of cyclic peptides" XP002103315 *
M KAKIUCHI ET AL.: "Amino acids and peptides. XXVII. Solid phase synthesis of fibrinogen-related peptides with disulfide bond formed on solid support", CHEMICAL AND PHARMACEUTICAL BULLETIN., vol. 44, no. 5, May 1996 (1996-05-01), TOKYO JP, pages 1107 - 1110, XP002103313 *

Also Published As

Publication number Publication date
WO2000011031A1 (en) 2000-03-02
AU5623499A (en) 2000-03-14
WO2000011032A2 (en) 2000-03-02
HUP0103196A3 (en) 2002-05-28
WO2000011032A9 (en) 2000-10-26
JP2002523425A (en) 2002-07-30
HUP0103196A2 (en) 2002-02-28
AU9436298A (en) 2000-03-14
DE59913712D1 (en) 2006-09-07

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