WO2000009676A3 - Methods of forming neurons - Google Patents

Methods of forming neurons Download PDF

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Publication number
WO2000009676A3
WO2000009676A3 PCT/US1999/018525 US9918525W WO0009676A3 WO 2000009676 A3 WO2000009676 A3 WO 2000009676A3 US 9918525 W US9918525 W US 9918525W WO 0009676 A3 WO0009676 A3 WO 0009676A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
neurons
forming neurons
forming
neuronal
Prior art date
Application number
PCT/US1999/018525
Other languages
French (fr)
Other versions
WO2000009676A2 (en
Inventor
David J Anderson
Li-Ching Lo
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Priority to EP99942193A priority Critical patent/EP1105461A2/en
Priority to CA002339303A priority patent/CA2339303A1/en
Publication of WO2000009676A2 publication Critical patent/WO2000009676A2/en
Publication of WO2000009676A3 publication Critical patent/WO2000009676A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to novel methods of inducing non-neuronal cells to differentiate into neurons and to methods of inducing non-neuronal cells to express a neuronal subtype-specific marker.
PCT/US1999/018525 1998-08-14 1999-08-13 Methods of forming neurons WO2000009676A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99942193A EP1105461A2 (en) 1998-08-14 1999-08-13 Methods of forming neurons
CA002339303A CA2339303A1 (en) 1998-08-14 1999-08-13 Methods of forming neurons

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9663098P 1998-08-14 1998-08-14
US60/096,630 1998-08-14

Publications (2)

Publication Number Publication Date
WO2000009676A2 WO2000009676A2 (en) 2000-02-24
WO2000009676A3 true WO2000009676A3 (en) 2000-06-08

Family

ID=22258302

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/018525 WO2000009676A2 (en) 1998-08-14 1999-08-13 Methods of forming neurons

Country Status (3)

Country Link
EP (1) EP1105461A2 (en)
CA (1) CA2339303A1 (en)
WO (1) WO2000009676A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6967019B2 (en) 1999-04-06 2005-11-22 The Regents Of The University Of California Production of pancreatic islet cells and delivery of insulin
US6703220B1 (en) 1999-04-06 2004-03-09 The Regents Of The University Of California Human neurogenin 3-encoding nucleotide sequences
US8193330B2 (en) 1999-04-06 2012-06-05 The Regents Of The University Of California Polynucleotides comprising Neurogenin3 promoter and bHLH encoding domains
WO2001032712A2 (en) 1999-11-03 2001-05-10 Maxygen, Inc. Antibody diversity generation
US7312081B2 (en) 2000-05-11 2007-12-25 The Trustees Of Columbia University In The City Of New York Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation
US7393686B1 (en) 2000-05-11 2008-07-01 Trustees Of Columbia University In The City Of New York Genetic demonstration of requirement for NKX6.1 and NKX2.2 in ventral neuron generation
WO2002018545A1 (en) * 2000-09-01 2002-03-07 The Trustees Of Columbia University In The City Of New York Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation
US6955802B1 (en) 2000-05-11 2005-10-18 The Trustees Of Columbia University In The City Of New York Homeodomain protein code specifying progenitor cell identify and neuronal fate in the ventral neural tube
EP1318822A4 (en) * 2000-07-27 2006-01-18 Mclean Hospital Corp Cell implantation therapy for neurological diseases or disorders
CA2443123A1 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
AU2003218601A1 (en) * 2002-04-08 2003-10-27 The University Of Hong Kong Phox2b polymorphisms as hirschsprung's disease diagnostic markers and methods based thereon
EP1572099A4 (en) * 2002-10-04 2007-01-03 Univ California Screening and therapeutic methods relating to neurogenesis
US20040185429A1 (en) * 2002-12-09 2004-09-23 Judith Kelleher-Andersson Method for discovering neurogenic agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998013491A2 (en) * 1996-09-27 1998-04-02 California Institute Of Technology Neurogenin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998013491A2 (en) * 1996-09-27 1998-04-02 California Institute Of Technology Neurogenin

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 20 September 1993 (1993-09-20), HINXTON, GB, XP002130311 *
LO L ET AL.,: "MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity", DEVELOPMENT, vol. 125, 22 January 1998 (1998-01-22), pages 609 - 620, XP002130309 *
MA Q ET AL: "IDENTIFICATION OF NEUROGENIN, A VERTEBRAE NEURONAL DETERMINATION GENE", CELL,US,CELL PRESS, CAMBRIDGE, NA, vol. 87, no. 1, 4 October 1996 (1996-10-04), pages 43-52, XP002071056, ISSN: 0092-8674 *
MCCORMICK M B ET AL: "NEUROD2 AND NEUROD3: DISTINCT EXPRESSION PATTERNS AND TRANSCRIPTIONAL ACTIVATION POTENTIALS WITHIN THE NEUROD GENE FAMILY", MOLECULAR AND CELLULAR BIOLOGY,US,WASHINGTON, DC, vol. 16, no. 10, October 1996 (1996-10-01), pages 5792-5800, XP002071058, ISSN: 0270-7306 *
PATTYN A ET AL.,: "Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis", DEVELOPMENT, vol. 124, 1997, pages 4065 - 4075, XP002130312 *
PATTYN A ET AL.: "The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives", NATURE, vol. 399 (6734), 27 May 1999 (1999-05-27), pages 366-370, XP000876704 *
PEREZ SE ET AL.,: "Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo", DEVELOPMENT, vol. 126, no. 8, 17 March 1999 (1999-03-17), pages 1715 - 1728, XP000879058 *
SHIMIZU C ET AL: "MATH-2, A MAMMALIAN HELIX-LOOP-HELIX FACTOR STRUCTURALLY RELATED TO THE PRODUCT OF DROSOPHILA PRONEURAL GENE ATONAL, IS SPECIFICALLY EXPRESSED IN THE NERVOUS SYSTEM", EUROPEAN JOURNAL OF BIOCHEMISTRY,DE,BERLIN, vol. 229, no. 1, 1 April 1995 (1995-04-01), pages 239-248, XP002039567, ISSN: 0014-2956 *
SOMMER L ET AL: "NEUROGENINS, A NOVEL FAMILY OF ATONAL-RELATED BHLH TRANSCRIPTION FACTORS, ARE PUTATIVE MAMMALIAN NEURONAL DETERMINATION GENES THAT REVEAL PROGENITOR CELL HETEROGENEITY IN THE DEVELOPING CNS AND PNS", MOLECULAR AND CELLULAR NEUROSCIENCES,US,SAN DIEGO, vol. 8, no. 4, 1996, pages 221-241, XP002072615, ISSN: 1044-7431 *
SOMMER L ET AL: "THE CELLULAR FUNCTION OF MASH1 IN AUTONOMIC NEUROGENESIS", NEURON,US,CAMBRIDGE, MA, vol. 15, no. 6, December 1995 (1995-12-01), pages 1245-1258, XP002071060 *
TURNER D L ET AL: "EXPRESSION OF ACHAETE-SCUTE HOMOLOG 3 IN XENOPUS EMBRYOS CONVERTS ECTODERMAL CELLS TO A NEURAL FATE", GENES AND DEVELOPMENT,US,COLD SPRING HARBOR, NY, vol. 8, pages 1434-1447, XP002071061, ISSN: 0890-9369 *
VALARCHE I ET AL.,: "The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype", DEVELOPMENT, vol. 119, 1993, pages 881 - 896, XP002130310 *

Also Published As

Publication number Publication date
CA2339303A1 (en) 2000-02-24
WO2000009676A2 (en) 2000-02-24
EP1105461A2 (en) 2001-06-13

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