WO2000008202A3 - Modulateurs 3-methylidenyl-2-indolinone de proteine kinase - Google Patents
Modulateurs 3-methylidenyl-2-indolinone de proteine kinase Download PDFInfo
- Publication number
- WO2000008202A3 WO2000008202A3 PCT/US1999/017845 US9917845W WO0008202A3 WO 2000008202 A3 WO2000008202 A3 WO 2000008202A3 US 9917845 W US9917845 W US 9917845W WO 0008202 A3 WO0008202 A3 WO 0008202A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methylidenyl
- protein kinase
- indolinone
- modulators
- prodrugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002383623A CA2383623A1 (fr) | 1998-08-04 | 1999-08-04 | Modulateurs 3-methylidenyl-2-indolinone de proteine kinase |
US09/762,198 US6531502B1 (en) | 1998-01-21 | 1999-08-04 | 3-Methylidenyl-2-indolinone modulators of protein kinase |
JP2000563824A JP2002522452A (ja) | 1998-08-04 | 1999-08-04 | 蛋白質キナーゼの調節剤3−メチリデニル−2−インドリノン |
AU54684/99A AU5468499A (en) | 1998-08-04 | 1999-08-04 | 3-methylidenyl-2-indolinone modulators of protein kinase |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12925698A | 1998-08-04 | 1998-08-04 | |
US09/129,256 | 1998-08-04 | ||
US9547098P | 1998-08-05 | 1998-08-05 | |
US60/095,470 | 1998-08-05 | ||
US10217898P | 1998-09-28 | 1998-09-28 | |
US60/102,178 | 1998-09-28 | ||
US11610799P | 1999-01-15 | 1999-01-15 | |
US60/116,107 | 1999-01-15 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09762198 A-371-Of-International | 1999-08-04 | ||
US09/762,198 A-371-Of-International US6531502B1 (en) | 1998-01-21 | 1999-08-04 | 3-Methylidenyl-2-indolinone modulators of protein kinase |
US10/383,690 Division US6855730B2 (en) | 1998-08-05 | 2003-03-10 | 3-methylidenyl-2-indolinone modulators of protein kinase |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2000008202A2 WO2000008202A2 (fr) | 2000-02-17 |
WO2000008202A3 true WO2000008202A3 (fr) | 2000-05-18 |
WO2000008202A9 WO2000008202A9 (fr) | 2000-07-27 |
Family
ID=27492796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/017845 WO2000008202A2 (fr) | 1998-01-21 | 1999-08-04 | Modulateurs 3-methylidenyl-2-indolinone de proteine kinase |
Country Status (4)
Country | Link |
---|---|
JP (1) | JP2002522452A (fr) |
AU (1) | AU5468499A (fr) |
CA (1) | CA2383623A1 (fr) |
WO (1) | WO2000008202A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6777417B2 (en) | 2001-09-10 | 2004-08-17 | Sugen, Inc. | 3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene-2-indolinone derivatives as kinase inhibitors |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
KR20010101266A (ko) | 1998-12-17 | 2001-11-14 | 프리돌린 클라우스너, 롤란드 비. 보레르 | Jnk 단백질 키나제의 억제제로서의 4-아릴옥신돌 |
US6153634A (en) | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
CN1158283C (zh) | 1998-12-17 | 2004-07-21 | 霍夫曼-拉罗奇有限公司 | 作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚 |
TR200101860T2 (tr) * | 1998-12-17 | 2001-12-21 | F.Hoffmann-La Roche Ag | Sikline bağlı kinaz inhibitörleri olarak 4-alkenil (ve alkinil) oksidoller |
US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
JP5336686B2 (ja) * | 1999-11-24 | 2013-11-06 | スージェン, インク. | 遊離酸または遊離塩基としてイオン化可能な医薬品のための処方 |
US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
CA2407799A1 (fr) | 2000-05-02 | 2001-11-08 | Sugen, Inc. | Derives d'acide acetique (2-oxindole-3-ylidenyl) et leur utilisation comme inhibiteurs de la proteine kinase |
MY128449A (en) * | 2000-05-24 | 2007-02-28 | Sugen Inc | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
WO2001094312A2 (fr) * | 2000-06-02 | 2001-12-13 | Sugen, Inc. | Derives d'indolinone comme inhibiteurs de phosphatase/proteine kinase |
EP1349852A2 (fr) * | 2000-12-20 | 2003-10-08 | Sugen, Inc. | Indolinones 4-aryl substituees |
US7186745B2 (en) | 2001-03-06 | 2007-03-06 | Astrazeneca Ab | Indolone derivatives having vascular damaging activity |
US7081454B2 (en) | 2001-03-28 | 2006-07-25 | Bristol-Myers Squibb Co. | Tyrosine kinase inhibitors |
WO2002081466A1 (fr) * | 2001-04-09 | 2002-10-17 | Sugen, Inc. | Promedicaments a base de derives 3-(pyrrol-2-ylmethylidene)-2-indolinone |
EP1396490A1 (fr) * | 2001-05-24 | 2004-03-10 | Yamanouchi Pharmaceutical Co. Ltd. | Derives de 3-quinoleine-2-(1h)-ylideneindoline-2-one |
PE20030062A1 (es) | 2001-05-30 | 2003-02-08 | Sugen Inc | Derivados aralquilsulfonil-3-(pirrol-2-ilmetiliden)-2-indolinona como inhibidores de quinasas |
WO2003027111A1 (fr) * | 2001-09-27 | 2003-04-03 | Smithkline Beecham Corporation | Composes chimiques |
AU2003284572A1 (en) * | 2002-11-22 | 2004-06-18 | Yamanouchi Pharmaceutical Co., Ltd. | 2-oxoindoline derivatives |
JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
US7517697B2 (en) * | 2003-02-05 | 2009-04-14 | Applied Biosystems, Llc | Compositions and methods for preserving RNA in biological samples |
US7312215B2 (en) | 2003-07-29 | 2007-12-25 | Bristol-Myers Squibb Company | Benzimidazole C-2 heterocycles as kinase inhibitors |
GT200500321A (es) * | 2004-11-09 | 2006-09-04 | Compuestos y composiciones como inhibidores de proteina kinase. | |
US7960548B2 (en) * | 2005-04-29 | 2011-06-14 | The Ohio State University Research Foundation | Keratinocyte growth factor receptor—tyrosine specific inhibitors for the prevention of cancer metastatis |
WO2009030270A1 (fr) * | 2007-09-03 | 2009-03-12 | Novartis Ag | Dérivés dhydroindoles utilisés pour traiter la maladie de parkinson |
US8765748B2 (en) | 2007-12-21 | 2014-07-01 | University Health Network | Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer |
CA2756568C (fr) | 2009-04-06 | 2018-02-13 | University Health Network | Inhibiteurs de kinases et procede de traitement du cancer avec ceux-ci |
FR2948940B1 (fr) * | 2009-08-04 | 2011-07-22 | Servier Lab | Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
MX2012011516A (es) | 2010-04-06 | 2013-03-08 | Univ Health Network | Inhibidores de cinasa, y metodo para tratar el cancer con los mismos. |
WO2012048411A1 (fr) * | 2010-10-13 | 2012-04-19 | University Health Network | Inhibiteurs de plk4 et méthode de traitement du cancer à l'aide de ceux-ci |
WO2012142029A2 (fr) * | 2011-04-10 | 2012-10-18 | Florida A&M University | Modulateurs sélectifs des récepteurs des œstrogènes pour traitement de troubles à médiation par les récepteurs des œstrogènes |
AU2013314417B2 (en) | 2012-09-13 | 2016-01-21 | F. Hoffmann-La Roche Ag | 2-oxo-2,3-dihydro-indoles for the treatment of CNS disorders |
WO2014066840A1 (fr) | 2012-10-26 | 2014-05-01 | Regents Of The University Of Minnesota | Inhibiteurs d'aurora kinase |
EP3057593B1 (fr) | 2013-10-18 | 2021-12-08 | University Health Network | Traitement du cancer du pancréas |
EP3363799A4 (fr) * | 2015-11-12 | 2018-12-05 | LG Chem, Ltd. | Composition pharmaceutique contenant, en tant que principe actif, un dérivé ou un sel pharmaceutiquement acceptable de 7-azaindolin-2-one |
US10487054B2 (en) | 2017-04-21 | 2019-11-26 | Regents Of The University Of Minnesota | Therapeutic compounds |
PE20211054A1 (es) * | 2018-10-05 | 2021-06-07 | Ichnos Sciences S A | Compuestos de indolinona para uso como inhibidores de map4k1 |
GR1010103B (el) * | 2020-07-02 | 2021-10-18 | Uni-Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Αβεε, | 3-ινδολ-2-υλομεθυλιδενο-ινδολιν-2-ονες με δραση αναστολης της αυτοταξινης |
WO2022006412A2 (fr) * | 2020-07-02 | 2022-01-06 | The Regents Of The University Of Colorado, A Body Corporate | Conjugués d'inhibiteurs d'ampk et d'agents de dégradation de protac et utilisations associées |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5339992A (en) * | 1991-07-10 | 1994-08-23 | Societe De Prospection Et D'inventions Techniques (S.P.I.T. | Tubular cartridge for storing and applying a non-solid product, and a drive and thrust assembly for the cartridge |
US5374652A (en) * | 1990-02-28 | 1994-12-20 | Farmitalia Carlo Erba S R L | 2-oxindole compounds which are useful as tyrosine kinase inhibitors |
US5382593A (en) * | 1992-07-21 | 1995-01-17 | Adir Et Compagnie | New 3-(hydroxybenzylidenyl)-indolin-2-ones |
US5409949A (en) * | 1991-07-12 | 1995-04-25 | Farmitalia Carlo Erba S.R.L. | Methylen-oxindole derivatives compositions and tyrosine kinase inhibition therewith |
US5650415A (en) * | 1995-06-07 | 1997-07-22 | Sugen, Inc. | Quinoline compounds |
-
1999
- 1999-08-04 CA CA002383623A patent/CA2383623A1/fr not_active Abandoned
- 1999-08-04 JP JP2000563824A patent/JP2002522452A/ja not_active Withdrawn
- 1999-08-04 AU AU54684/99A patent/AU5468499A/en not_active Abandoned
- 1999-08-04 WO PCT/US1999/017845 patent/WO2000008202A2/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5374652A (en) * | 1990-02-28 | 1994-12-20 | Farmitalia Carlo Erba S R L | 2-oxindole compounds which are useful as tyrosine kinase inhibitors |
US5339992A (en) * | 1991-07-10 | 1994-08-23 | Societe De Prospection Et D'inventions Techniques (S.P.I.T. | Tubular cartridge for storing and applying a non-solid product, and a drive and thrust assembly for the cartridge |
US5409949A (en) * | 1991-07-12 | 1995-04-25 | Farmitalia Carlo Erba S.R.L. | Methylen-oxindole derivatives compositions and tyrosine kinase inhibition therewith |
US5382593A (en) * | 1992-07-21 | 1995-01-17 | Adir Et Compagnie | New 3-(hydroxybenzylidenyl)-indolin-2-ones |
US5650415A (en) * | 1995-06-07 | 1997-07-22 | Sugen, Inc. | Quinoline compounds |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6777417B2 (en) | 2001-09-10 | 2004-08-17 | Sugen, Inc. | 3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene-2-indolinone derivatives as kinase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
WO2000008202A2 (fr) | 2000-02-17 |
WO2000008202A9 (fr) | 2000-07-27 |
JP2002522452A (ja) | 2002-07-23 |
CA2383623A1 (fr) | 2000-02-17 |
AU5468499A (en) | 2000-02-28 |
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