WO2000002660A1 - Flacon de reactif pour appareil de traitement automatique - Google Patents

Flacon de reactif pour appareil de traitement automatique Download PDF

Info

Publication number
WO2000002660A1
WO2000002660A1 PCT/US1999/011823 US9911823W WO0002660A1 WO 2000002660 A1 WO2000002660 A1 WO 2000002660A1 US 9911823 W US9911823 W US 9911823W WO 0002660 A1 WO0002660 A1 WO 0002660A1
Authority
WO
WIPO (PCT)
Prior art keywords
reagent
vial
reagent vial
container portion
adapter
Prior art date
Application number
PCT/US1999/011823
Other languages
English (en)
Inventor
James C. Smith
Original Assignee
Biogenex Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogenex Laboratories filed Critical Biogenex Laboratories
Priority to JP2000558913A priority Critical patent/JP2002520578A/ja
Priority to EP99925963A priority patent/EP1119413A1/fr
Priority to AU42145/99A priority patent/AU4214599A/en
Publication of WO2000002660A1 publication Critical patent/WO2000002660A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers

Definitions

  • the present invention relates to reagent containers and, more particularly, to reagent containers for use with automated processing devices such as immunostainers.
  • U.S. Patent No. 4,985,206 describes an apparatus and process for automating the application of staining reagents to a thin tissue section mounted on a microscope slide.
  • the apparatus and method use a channel -defining element that is assembled with the microscope slide to provide an enclosure of capillary dimensions into which liquids can be injected. Liquids are added sequentially to the capillary space, where the addition of a new liquid forces out the previous liquid.
  • a plurality of these assemblies of microscope slides and specialized covers can be placed in a rack on an apparatus for automated addition of liquids.
  • a further automated immunostaining apparatus known as the Ventana 320TM is produced by Ventana Medical Systems, Inc.
  • This apparatus applies a liquid known as Liquid CoverslipTM to each slide prior to reagent addition.
  • Liquid CoverslipTM is a non- aqueous material having a density less than that of water.
  • the reagent sinks to the bottom of the Liquid CoverslipTM layer, spreading across the surface of the slide. Slides are organized on a carousel which rotates beneath a dispensing head of the apparatus for application of reagents or wash fluids.
  • Yet another apparatus known as the Jung Histostainer IgTM Automated
  • Immunostainer is produced by Leica Instrument GmbH. This is also a carousel-type device, but reagents are applied by a spraying operation rather than by dropping liquid onto an organic film.
  • the apparatus contains a permanent reagent spraying head that can be moved along a single axis to provide spray coverage over a microscope slide located on the rotating tray when the slide is rotated into position underneath the head.
  • Excess reagent is removed by a permanent clearing nozzle which blows air in a pressure front across the slide, forcing excess liquid off at the completion of the reagent incubation step.
  • a further apparatus is the subject of U.S. Patent No. 5,439,649.
  • This device includes an arm moveable in three dimensions attached to a framework.
  • a hollow tip head is carried on the arm, and includes a wash/blow head for dispensing reagents and clearing the slides.
  • the reagent application tip can be attached to the hollow tip head or removed by a pre-selected movement of the arm.
  • a reagent container which is designed to be used in conjunction with an automated apparatus that can permit the device to reliably and accurately meter the reagent withdrawn from the container, while allowing the device to use virtually all of the residual reagent in the container.
  • the present invention provides a reagent vial designed for use with automated processing devices.
  • the present reagent vial comprises a container portion configured to contain a volume of liquid reagent, and having an upper end and a lower end.
  • the upper end of the container portion is configured to provide access to the contents of the container portion by a probe, typically of a type used by an automated processing apparatus to withdraw the liquid reagent therein contained.
  • the lower end of the container portion is configured to provide a chamber aligned with the probe access, and having a lesser cross sectional area than the main container portion.
  • the chamber is thus configured to contain a portion of the volume of liquid reagent of the container to provide a means for reducing the residual volume of reagent which can not be withdrawn from the vial by the probe.
  • the vial of the present invention will be used in conjunction with an adapter assembly which is configured to provide a receptacle for holding a reagent vial according to the invention, and further configured to fit into the available receptacle in an automated processing apparatus.
  • a still further aspect of the invention provides a system employing the reagent vial and the adapter assembly in a cooperative relationship.
  • Figure 1 depicts an embodiment of the reagent vial of the present invention, wherein Figure 1A is a side elevation thereof, Figure IB is an end view elevation thereof, Figure 1C is cross sectional side view thereof, Figure ID is an cross sectional end view thereof, Figure IE is a top plan view thereof, and Figure IF is a bottom plan view thereof;
  • Figure 2 depicts an alternative embodiment of the reagent vial of the present invention, wherein Figure 2A is a side elevation thereof, Figure 2B is an end view elevation thereof, Figure 2C is cross sectional side view thereof, Figure 2D is an cross sectional end view thereof, Figure 2E is a top plan view thereof, and Figure 2F is a bottom plan view thereof;
  • Figure 3 depicts an embodiment of an adapter assembly for the reagent vial of Figure 2 of the present invention, wherein Figure 3A is a side elevation thereof, Figure 3B is an end view elevation thereof, Figure 3C is cross sectional side view thereof, Figure 3D is an cross sectional end view thereof, Figure 3E is a top plan view thereof, and Figure 4F is a bottom plan view thereof; and
  • Figure 4 depicts the operation of a typical automated processing apparatus utilizing the reagent vial of the present invention.
  • the present invention provides a reagent vial primarily designed for use with automated processing apparatus.
  • the present reagent vial comprises a container portion configured to contain a volume of liquid reagent, and having an upper end and a lower end.
  • the upper end of the container portion is configured to provide access to the contents of the container portion by a probe, typically of a type used by an automated processing apparatus to withdraw the liquid reagent therein contained.
  • the lower end of the container portion is configured to provide a chamber aligned with the probe access, and having a lesser cross sectional area than the main container portion.
  • the chamber is thus configured to contain a portion of the volume of liquid reagent of the container to provide a means for reducing the residual volume of reagent which can not be withdrawn from the vial by the probe.
  • the reagent vial 10 may be constructed in accordance with known techniques, desirably blow molded or injection molded from a suitable plastic material.
  • the reagent vial could be formed of glass or other suitable material.
  • the reagent vial will be formed from glass for storing reagents which may be susceptible to the intrusion of moisture that conceivably could migrate through certain plastics.
  • the vial 10 comprises a container portion 12 which is intended to contain the major share of the reagent, typically the vial will be supplied in predetermined convenient volumes such as lOmL, 12mL, 20mL, and the like.
  • the present vial 10 is generally configured for placement and use in an appropriate automated processing apparatus for clinical testing or analysis, such as the OptiMax ® automated immunostainer apparatus (BioGenex Laboratories, San Ramon,
  • reagent vials are positioned in a reagent vial rack which is either affixed to the apparatus or removable from the apparatus for loading the reagent vials in a more convenient location.
  • the rack in this apparatus contains a number of separate receptacles of generally rectangular cross section, to facilitate the efficient storage of a plurality of vials.
  • vial 10 is depicted with container portion 12 having a complimentary rectangular horizontal cross section, the container having four substantially planar sidewalls, although numerous other shapes are possible to accommodate different racks, or other applications.
  • the container portion 12 will have an upper surface 13 which will approximate the cross sectional shape of the container portion, in this embodiment rectangular.
  • Upper surface 13 will include an opening 14 defining a neck extending upwardly from vial 10.
  • the opening neck 14 is generally characterized by an array of external threads 16 formed thereon.
  • the opening 14 permits the addition of an appropriate reagent or reagent diluent, such as water, sterile water, saline, phosphate buffered saline, TRIS or TWEEN ® buffers or the like, into the reagent container 12, as well as the withdrawal of desired amounts of the liquid reagent contained in the vial.
  • the opening neck 14 of the present reagent vial 10 will typically be located off- center in the upper surface 13 of the present vial 10, in order to provide a shoulder region which is available for labeling with relevant information regarding the contents of the vial and the like.
  • labeling will be accomplished either in human- readable printed form or by machine-readable bar-code, or both.
  • bar-code technology format typically three bar-codes are printed in close proximity to each other on the label.
  • the information content of the bar-code can include: 1) Name of the reagent solution; 2) Manufacture date; 3) Expiration date; 4) Serial number; 5) Reagent volume.
  • the height of the bar-code is generally approximately 0.25 inch, so that there will remain sufficient space for the user to write any other desired information.
  • the coding used in this application will desirably be codel28, as this code can provide advantageous information density.
  • a human-readable string is desirably also printed on the label and is shown on the side wall of the reagent vial.
  • OptiMax ® automated immunostainer there will usually be a pre-printed label applied to a region on the upper surface of the microscope slide.
  • This label is intended for the user to include certain information.
  • the content of this bar-code will include the name of the protocol to be used in processing the particular slide.
  • a human-readable string can also be printed immediately under this bar-code as well.
  • the availability of a bar code label will provide a machine readable function which can be integrated with the programmed instruction set of the automated processing apparatus and thereby provide a more efficient means of identifying and verifying the contents of the vial and its appropriate use in the pre-programmed instruction set sequence of the apparatus.
  • such assembly and labeling will be performed by the manufacturer of the reagent at the place of manufacture and subsequently shipped to the appropriate facility, such as a clinical chemical laboratory or reference laboratory and readied for use.
  • the manufacture of the reagent will also dispose an appropriate color code on the reagent vial to identify the particular reagent stored therein.
  • the same manufacturer of the reagent may also provide an appropriate adapter assembly to facilitate storage and use of the reagent vial.
  • Also desirable could be an optional removable seal over the opening neck of the reagent vial.
  • the reagent buffer or reagent can be placed in the reagent vial container by the appropriate personnel in the clinical chemical laboratory.
  • the apparatus moves a laser bar-code scanner around the bar-codes located both on the microscope slides and the reagent vials.
  • the digital computer will then recognize the reagents and the slides to be treated, and will calculate the required volumes of the reagents.
  • a reagent map can also be printed by the computer for user reference. If any deficiency occurs in the reagent supply, the computer will halt the processing and request additional reagent supplies.
  • the reagent vial 10 shown in Figure 1 further comprises a lower end 18 which can be formed as an integral part of the blow molded container portion. This lower end
  • the reagent vial 10 will have a region defining a reduced cross-sectional area compared to the container portion 12 of reagent vial 10.
  • This reduced cross sectional area will provide a well region 19 in the lower end of the vial 10, and depending from the container portion 12, into which liquid reagent will collect as the reagent supply in the container portion 12 becomes depleted.
  • the residual volume of the reagent will continue to concentrate into a smaller cross section, rendering the reagent more readily accessible to the means used to withdraw the reagent.
  • the actual configuration of the cross section of this well region 19 is not considered to be critical, rectangular or curvilinear shapes will each prove acceptable.
  • the lower-most floor portion of well region 19 be somewhat rounded, as depicted most clearly in Figures IC and 2C, so that the last remaining volume of the liquid reagent be most concentrated in the region surrounding the tip of the probe which is used to withdraw the reagent.
  • the OptiMax ® apparatus described previously utilizes a reagent pipette tip mounted on a mechanical reagent tip head to withdraw reagents from the storage vials.
  • the tip head is adapted to pick up disposable plastic pipette tips from the standard containers in which such tips are supplied (for example, Catalog No. 3510-R from E&K Scientific Products, Saratoga, CA). These disposable pipette tips are currently sold in a rack which presents the base of the tip for insertion of a hand-held pipette body into the hollow tip, the tips being arranged in an array so that all individual tips in the container are accessible to the user.
  • the attachment steps for attaching pipette tips to the tip head are generally carried out by a pre-selected movement of the arm of the apparatus, and the apparatus is programmed as appropriate for the individual slides being treated and reagent vials placed at their own predetermined locations.
  • the tip head on the movable arm then picks up a disposable pipette tip from the pipette tip rack, is repositioned over the opening neck 14 of the reagent vial 10, and activated to take up a reagent to be applied to a slide or group of slides from the reagent vial in the reagent container holder.
  • the plurality of reagent vials each share a set of relatively uniform dimensions, such as overall size, depth, and position of the opening neck 14 on the upper surface 13 of the vial 10.
  • the opening neck 14 of the container portion 12 will be generally aligned with the lower end 18 well configuration, so that a elongate probe such as the aforementioned pipette tip and tip head, or a manual pipette device, inserted through the opening neck 14 and through the container portion 12 will be capable of accessing the well chamber 19 to the bottom-most extent.
  • the well chamber 19 is depicted as having a substantially elongate configuration, complementary to the typical shape of the aforementioned disposable pipette tips, so as to enhance the reagent-concentrating effect of the vial 10 as the reagent supply nears exhaustion.
  • the present reagent vial 10 will typically include a suitably-configured stopper plug 20, which is typically of a configuration to engage with the array of external threads 16 formed on opening neck 14. Such a stopper plug will aid in the transportation of liquid reagents contained in vial 10, as well as any necessary mixing or dilution of reagents prior to their use.
  • the reagent vial of the present invention is depicted in an alternative embodiment includes a container portion 22 which is substantially smaller in total volume that the container portion 12 of the embodiment of Figure 1.
  • This embodiment is intended to contain substantially lower volumes of reagent, a feature deemed desirable for particularly costly reagents.
  • container portion 22 is similar to that portrayed in the embodiment of Figure 1, the lower end well region 24 configuration is shown to be substantially elongated, when compared to well region 19 as depicted in the embodiment of Figure 1. This is intended, in part, to maintain the depth parameter of the vial 10, as discussed previously. This feature will allow vials of substantially different volumes to be utilized in a single operation, for example to be positioned in the same reagent vial rack such as the aforementioned rack for the OptiMax ® automated immunostainer apparatus.
  • each of container portions 12 and 22 are adapted to be engaged with an adapter assembly 26 as depicted in Figure 3.
  • the adapter assembly 26 will typically also be constructed in accordance with known techniques, desirably blow molded or injection molded from a suitable plastic material, in a manner similar to the reagent vial 10.
  • the cross section of the adapter assembly will be complementary to the cross section of the reagent vial 10, or at least the container portion thereof, so as to provide a receptacle for releasably receiving the reagent vial and maintaining it in a substantially upright position. It may also be considered desirable to configure both the reagent vial 10 and the adapter assembly 26 to engage each other via a plurality of complementary configurations, or paired recesses and detents.
  • reagent vial 10 can be configured with a plurality of stepped shoulder regions
  • adapter assembly 26 can be configured with a plurality of complementary stepped shoulder regions, as depicted in Figure 3.
  • the engagement between the reagent vial 10 and the adapter assembly 26 will comprise the horizontal positioning provided by the complementary cross sectional configurations and the vertical positioning provided by the complementary shoulder configurations.
  • the adapter assembly 26 will be configured to occupy the available space in the rack or other receptacle of the selected automated processing apparatus, and to provide a more secure and precise placement of reagent vial 10.
  • the assembly 26 will also generally include a means for positively locating the well region of the vial, to provide reference orientation for the vial, and contribute to the stability of its positioning on the rack.
  • Figure 3 depicts adapter assembly 26 as including a orifice 28 which is selectively engageable with the well regions 14 and 24 of container portions 12 and 22.
  • the present invention further provides a reagent vial adapter for use with the present reagent vial in automated processing devices comprising a receptacle portion configured to releasably receive and maintain the reagent vial in a substantially upright position, and a positioning means for positively locating the chamber of the reagent vial, and thereby maintaining said reagent vial in the desired location within the adapter.
  • the present reagent vial 10 as depicted in Figures 1 and 2, with or without the adapter assembly 26 depicted in Figure 3, is employed initially as shown in Figure 4.
  • a reagent vial 10 having a reagent stored therein is utilized by a clinical laboratory where, shortly prior to conducting an appropriate test or staining procedure, a laboratory technician will match a reagent vial with a reagent storage location in the automated processing apparatus preparatory for use in the procedures determined by the operator.
  • the reagent vial may be color coded to insure a proper match for a particular operation of the automated processing apparatus.
  • the technician may add an appropriate reagent to an empty container and place the same into the appropriate location in the automated processing apparatus.
  • the probe of the apparatus Upon selection of the appropriate manipulation steps or instruction set preprogrammed into the automated processing apparatus, the probe of the apparatus will be programed to position itself above the opening neck of the present reagent vial and extend the probe into the reagent vial for access by the probe to the reagent contents therein. The iteration of this sequence of steps, the operation of the apparatus will allow successive aliquots of reagent to be withdrawn from the reagent vial until the supply is exhausted. By virtue of the utilization of the present reagent vial 10, the residual reagent in the vial which is inaccessible to the apparatus will be minimized.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

La présente invention concerne un flacon de réactif conçu pour être utilisé avec des dispositifs de traitement automatique. Dans un aspect, le flacon de la présente invention comprend une partie contenant (24) configurée pour contenir un volume de réactif liquide et présentant une extrémité supérieure ainsi qu'une extrémité inférieure. L'extrémité supérieure de la partie contenant est configurée pour permettre l'accès au contenu de la partie contenant par une sonde, typiquement d'un type utilisé par un appareil de traitement automatique afin d'extraire le réactif liquide contenu. L'extrémité inférieure de la partie contenant est configurée pour former une chambre alignée avec l'accès de la sonde, et ayant une superficie de section inférieure à celle de la partie contenant principale. La chambre est ainsi configurée pour contenir une partie du volume du réactif liquide du contenant afin de constituer un moyen de réduction du volume résiduel du réactif ne pouvant être extrait du flacon par la sonde. Un autre aspect de l'invention a trait à un adaptateur (26) permettant le positionnement du flacon de réactif, ainsi qu'un système utilisant le flacon de réactif et l'adaptateur conjointement.
PCT/US1999/011823 1998-07-13 1999-05-27 Flacon de reactif pour appareil de traitement automatique WO2000002660A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2000558913A JP2002520578A (ja) 1998-07-13 1999-05-27 自動化プロセス装置用試薬びん
EP99925963A EP1119413A1 (fr) 1998-07-13 1999-05-27 Flacon de reactif pour appareil de traitement automatique
AU42145/99A AU4214599A (en) 1998-07-13 1999-05-27 Reagent vial for automated processing apparatus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11455398A 1998-07-13 1998-07-13
US09/114,553 1998-07-13

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09744092 A-371-Of-International 2001-07-09
US10/659,767 Continuation US20040115099A1 (en) 2001-07-09 2003-09-09 Reagent vial for automated processing apparatus

Publications (1)

Publication Number Publication Date
WO2000002660A1 true WO2000002660A1 (fr) 2000-01-20

Family

ID=22355967

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/011823 WO2000002660A1 (fr) 1998-07-13 1999-05-27 Flacon de reactif pour appareil de traitement automatique

Country Status (4)

Country Link
EP (1) EP1119413A1 (fr)
JP (1) JP2002520578A (fr)
AU (1) AU4214599A (fr)
WO (1) WO2000002660A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1733240A2 (fr) * 2004-03-02 2006-12-20 Dako Denmark A/S Systeme de distribution de reactifs, dispositif de distribution et contenant pour un appareil de coloration biologique
US7584019B2 (en) 2003-12-15 2009-09-01 Dako Denmark A/S Systems and methods for the automated pre-treatment and processing of biological samples
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US7850912B2 (en) 2003-05-14 2010-12-14 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7867443B2 (en) 2004-07-23 2011-01-11 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7875245B2 (en) 2003-05-14 2011-01-25 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US9117024B2 (en) 2001-11-13 2015-08-25 Dako Denmark A/S System for tracking biological samples
US9767425B2 (en) 2008-02-29 2017-09-19 Dako Denmark A/S Systems and methods for tracking and providing workflow information

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104678120B (zh) * 2010-02-26 2016-07-06 希森美康株式会社 试剂容器

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075082A (en) * 1986-07-11 1991-12-24 Beckman Instruments, Inc. Reagent cartridge
US5424036A (en) * 1992-04-24 1995-06-13 Olympus Optical Co., Ltd. Automatic analyzer
US5536476A (en) * 1991-04-06 1996-07-16 Chromacol Limited Apparatus for use in analytical instruments

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075082A (en) * 1986-07-11 1991-12-24 Beckman Instruments, Inc. Reagent cartridge
US5536476A (en) * 1991-04-06 1996-07-16 Chromacol Limited Apparatus for use in analytical instruments
US5424036A (en) * 1992-04-24 1995-06-13 Olympus Optical Co., Ltd. Automatic analyzer

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9633176B2 (en) 2001-11-13 2017-04-25 Dako Denmark A/S Method for tracking and imaging biological samples
US9117024B2 (en) 2001-11-13 2015-08-25 Dako Denmark A/S System for tracking biological samples
US8216512B2 (en) 2002-12-20 2012-07-10 Dako Denmark A/S Apparatus for automated processing biological samples
US8663978B2 (en) 2002-12-20 2014-03-04 Dako Denmark A/S Method and apparatus for automatic staining of tissue samples
US9229016B2 (en) 2002-12-20 2016-01-05 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US7758809B2 (en) 2002-12-20 2010-07-20 Dako Cytomation Denmark A/S Method and system for pretreatment of tissue slides
US9599630B2 (en) 2002-12-20 2017-03-21 Dako Denmark A/S Method and apparatus for automatic staining of tissue samples
US8257968B2 (en) 2002-12-20 2012-09-04 Dako Denmark A/S Method and apparatus for automatic staining of tissue samples
US8969086B2 (en) 2002-12-20 2015-03-03 Dako Denmark A/S Enhanced scheduling sample processing system and methods of biological slide processing
US7937228B2 (en) 2002-12-20 2011-05-03 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US7960178B2 (en) 2002-12-20 2011-06-14 Dako Denmark A/S Enhanced scheduling sample processing system and methods of biological slide processing
US9182324B2 (en) 2002-12-20 2015-11-10 Dako Denmark A/S Systems and methods for the automated pre-treatment and processing of biological samples
US10156580B2 (en) 2002-12-20 2018-12-18 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US8394635B2 (en) 2002-12-20 2013-03-12 Dako Denmark A/S Enhanced scheduling sample processing system and methods of biological slide processing
US8386195B2 (en) 2002-12-20 2013-02-26 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US8298815B2 (en) 2002-12-20 2012-10-30 Dako Denmark A/S Systems and methods of sample processing and temperature control
US8529836B2 (en) 2002-12-20 2013-09-10 Dako Denmark A/S Apparatus for automated processing biological samples
US9778273B2 (en) 2002-12-20 2017-10-03 Dako Denmark A/S Isolated communication sample processing system and methods of biological slide processing
US8673642B2 (en) 2002-12-20 2014-03-18 Dako Denmark A/S Enhanced scheduling sample processing system and methods of biological slide processing
US8788217B2 (en) 2002-12-20 2014-07-22 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US8784735B2 (en) 2002-12-20 2014-07-22 Dako Denmark A/S Apparatus for automated processing biological samples
US7875245B2 (en) 2003-05-14 2011-01-25 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7850912B2 (en) 2003-05-14 2010-12-14 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7603201B2 (en) 2003-12-08 2009-10-13 Dako Denmark A/S Systems and methods for the automated pre-treatment and processing of biological samples
US7584019B2 (en) 2003-12-15 2009-09-01 Dako Denmark A/S Systems and methods for the automated pre-treatment and processing of biological samples
US9164013B2 (en) 2004-03-02 2015-10-20 Dako Denmark A/S Reagent delivery system, dispensing device and container for a biological staining apparatus
EP1733240A2 (fr) * 2004-03-02 2006-12-20 Dako Denmark A/S Systeme de distribution de reactifs, dispositif de distribution et contenant pour un appareil de coloration biologique
EP1733240A4 (fr) * 2004-03-02 2007-08-22 Dako Denmark As Systeme de distribution de reactifs, dispositif de distribution et contenant pour un appareil de coloration biologique
US7867443B2 (en) 2004-07-23 2011-01-11 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7593787B2 (en) 2005-07-07 2009-09-22 Dako Denmark A/S Systems and methods for the automated pre-treatment and processing of biological samples
US9767425B2 (en) 2008-02-29 2017-09-19 Dako Denmark A/S Systems and methods for tracking and providing workflow information
US10832199B2 (en) 2008-02-29 2020-11-10 Agilent Technologies, Inc. Systems and methods for tracking and providing workflow information

Also Published As

Publication number Publication date
JP2002520578A (ja) 2002-07-09
AU4214599A (en) 2000-02-01
EP1119413A1 (fr) 2001-08-01

Similar Documents

Publication Publication Date Title
US8486714B2 (en) Reagent delivery system, dispensing device and container for a biological staining apparatus
US8142719B2 (en) Analysis device
EP0722363B1 (fr) Procede et appareil automatiques de coloration des plaquettes de microscope
US7435383B2 (en) Automated tissue staining system and reagent container
KR102643765B1 (ko) 생물학적 표본의 자동 제조를 위한 시스템 및 방법
US8158059B2 (en) Integrated dissolution processing and sample transfer system
US9114392B2 (en) Apparatus and method for handling fluids for analysis
RU2556994C2 (ru) Автоматический способ и автомат для подготовки и анализа множества клеточных суспензий
US5098663A (en) Specimen rack for specimen containers
AU6941798A (en) Automated staining apparatus
US20040033163A1 (en) Automated tissue staining system and reagent container
EP1284823A1 (fr) Dispositif automatique de traitement de specimen presentant une caracteristique de detection de liquide
WO2000002660A1 (fr) Flacon de reactif pour appareil de traitement automatique
US20040115099A1 (en) Reagent vial for automated processing apparatus
US20190316993A1 (en) Disposable container for stains or reagents for staining machines of biological material and staining system comprising said container
US20210031181A1 (en) Cartridge and device for chemical or biological assays
US8870059B1 (en) Laboratory sampling machine and methods for maintaining chain of custody for samples
WO2022019740A1 (fr) Dispositif automatique de coloration de plusieurs échantillons histologiques
JPS61231460A (ja) 点着カツプ装填装置

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU CA JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 558913

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1999925963

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 09744092

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1999925963

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1999925963

Country of ref document: EP