WO2000002031A1 - Improved method for mixing and processing specimen samples - Google Patents

Improved method for mixing and processing specimen samples Download PDF

Info

Publication number
WO2000002031A1
WO2000002031A1 PCT/US1999/015281 US9915281W WO0002031A1 WO 2000002031 A1 WO2000002031 A1 WO 2000002031A1 US 9915281 W US9915281 W US 9915281W WO 0002031 A1 WO0002031 A1 WO 0002031A1
Authority
WO
WIPO (PCT)
Prior art keywords
cover
particulate matter
container
sample
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/015281
Other languages
English (en)
French (fr)
Other versions
WO2000002031A9 (en
Inventor
Marianna El-Amin
Raouf A. Guirguis
Nashed Samaan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lamina Inc
Original Assignee
Lamina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lamina Inc filed Critical Lamina Inc
Priority to JP2000558376A priority Critical patent/JP2002519692A/ja
Priority to MXPA01000222A priority patent/MXPA01000222A/es
Priority to CA002336093A priority patent/CA2336093C/en
Priority to AT99935428T priority patent/ATE228650T1/de
Priority to DE69904179T priority patent/DE69904179T2/de
Priority to EP99935428A priority patent/EP1093572B1/en
Priority to AU50909/99A priority patent/AU758047B2/en
Priority to US09/720,543 priority patent/US6830935B1/en
Publication of WO2000002031A1 publication Critical patent/WO2000002031A1/en
Publication of WO2000002031A9 publication Critical patent/WO2000002031A9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/60—Mixers with rotating receptacles rotating about a horizontal or inclined axis, e.g. drum mixers
    • B01F29/63—Mixers with rotating receptacles rotating about a horizontal or inclined axis, e.g. drum mixers with fixed bars, i.e. stationary, or fixed on the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F35/32—Driving arrangements
    • B01F35/32005—Type of drive
    • B01F35/3202—Hand driven
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/75465—Discharge mechanisms characterised by the means for discharging the components from the mixer using suction, vacuum, e.g. with a pipette
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on

Definitions

  • an exemplary device may include a cover within a cover, wherein the agitator is fixed to a stationary inner cover and the container and outer cover freely rotate. Such relative motion moves the agitator in relation to the sample, and disperses particulate matter in the fluid.
  • the present invention also includes preparing a fluid for microscopic examination by processing a fluid using a device according to the invention, and collecting particulate matter on a collection site in the device.
  • specimen container 10 includes a pump 40.
  • pump 40 is a syringe or the like for altering differential pressure within the apparatus so that fluid can move through the specimen container.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
PCT/US1999/015281 1998-07-07 1999-07-07 Improved method for mixing and processing specimen samples Ceased WO2000002031A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2000558376A JP2002519692A (ja) 1998-07-07 1999-07-07 試料サンプルを混合及び処理するための改善された方法
MXPA01000222A MXPA01000222A (es) 1998-07-07 1999-07-07 Metodo mejorado para mezclar y procesar muestras de especimen.
CA002336093A CA2336093C (en) 1998-07-07 1999-07-07 Improved method for mixing and processing specimen samples
AT99935428T ATE228650T1 (de) 1998-07-07 1999-07-07 Verbesserte methode zum mischen und aufbereiten von probenmaterial
DE69904179T DE69904179T2 (de) 1998-07-07 1999-07-07 Verbesserte methode zum mischen und aufbereiten von probenmaterial
EP99935428A EP1093572B1 (en) 1998-07-07 1999-07-07 Improved method for mixing and processing specimen samples
AU50909/99A AU758047B2 (en) 1998-07-07 1999-07-07 Improved method for mixing and processing specimen samples
US09/720,543 US6830935B1 (en) 1998-07-07 1999-07-07 Method for mixing and processing specimen samples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9202998P 1998-07-07 1998-07-07
US60/092,029 1998-07-07

Publications (2)

Publication Number Publication Date
WO2000002031A1 true WO2000002031A1 (en) 2000-01-13
WO2000002031A9 WO2000002031A9 (en) 2000-04-06

Family

ID=22230970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/015281 Ceased WO2000002031A1 (en) 1998-07-07 1999-07-07 Improved method for mixing and processing specimen samples

Country Status (10)

Country Link
EP (1) EP1093572B1 (enExample)
JP (1) JP2002519692A (enExample)
KR (1) KR100886264B1 (enExample)
CN (1) CN1136446C (enExample)
AT (1) ATE228650T1 (enExample)
AU (1) AU758047B2 (enExample)
CA (1) CA2336093C (enExample)
DE (1) DE69904179T2 (enExample)
MX (1) MXPA01000222A (enExample)
WO (1) WO2000002031A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2846548A1 (fr) 2002-11-04 2004-05-07 Sofradim Production Piece composite intermediaire pour faconnage de protheses de renfort
WO2005047866A1 (en) * 2003-11-14 2005-05-26 Enfer Technology Sample homogeniser
WO2005054824A1 (en) * 2003-12-08 2005-06-16 Blue I Water Technologies Ltd. A measuring cell
FR2955458A1 (fr) * 2010-01-27 2011-07-29 Novacyt Solution de fixation pour des cellules biologiques
US12221518B2 (en) 2019-02-18 2025-02-11 Toyobo Co., Ltd. Biaxially stretched polyamide film and laminate film

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0211963D0 (en) * 2002-05-24 2002-07-03 British American Tobacco Co An exposure device
US8216528B2 (en) * 2005-09-29 2012-07-10 Sysmex Corporation Sample preparation kit, sample preparation container, and sample processing device
KR101157027B1 (ko) 2011-01-05 2012-06-20 조윤희 배합기
GB2496597B (en) * 2011-11-14 2017-10-04 Bio-Check(Uk) Ltd Cartridge for containing a sample
CN104677674A (zh) * 2013-11-29 2015-06-03 武汉迪艾斯科技有限公司 可搅拌取样装置
WO2015119863A1 (en) * 2014-02-04 2015-08-13 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
CN104297033B (zh) * 2014-10-20 2017-03-29 浙江海洋学院 非水相液体土壤污染物浓度配制装置及方法
EP3600669A4 (en) * 2017-03-24 2020-12-23 Universal Biosensors, Pty. Ltd. DEVICES AND METHODS FOR PRE-TREATMENT OF SAMPLE
ES2902704T3 (es) * 2018-09-06 2022-03-29 Milestone Srl Sistema y método para llenar un recipiente cerrado con una solución fijadora
US20210220817A1 (en) * 2018-12-08 2021-07-22 Min Wei Apparatus For Manufacturing Cell Therapy Product
GB2592430B (en) 2020-02-28 2022-12-21 Agilent Technologies Inc Sample injector with sample fluid filtering

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845025A (en) * 1987-11-10 1989-07-04 Coulter Corporation Biological sample mixing apparatus and method
US5000922A (en) * 1986-02-19 1991-03-19 Jon Turpen Sample filtration, separation and dispensing device
EP0590504A1 (en) * 1992-09-29 1994-04-06 F. Hoffmann-La Roche Ag Device for disaggregating cytological specimens
WO1994020385A1 (en) * 1993-03-08 1994-09-15 Kvm Technologies, Inc. Fluid sample receptacle
US5471994A (en) * 1989-01-10 1995-12-05 Guirguis; Raouf A. Method and apparatus for obtaining a cytology monolayer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5000922A (en) * 1986-02-19 1991-03-19 Jon Turpen Sample filtration, separation and dispensing device
US4845025A (en) * 1987-11-10 1989-07-04 Coulter Corporation Biological sample mixing apparatus and method
US5471994A (en) * 1989-01-10 1995-12-05 Guirguis; Raouf A. Method and apparatus for obtaining a cytology monolayer
EP0590504A1 (en) * 1992-09-29 1994-04-06 F. Hoffmann-La Roche Ag Device for disaggregating cytological specimens
WO1994020385A1 (en) * 1993-03-08 1994-09-15 Kvm Technologies, Inc. Fluid sample receptacle

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2846548A1 (fr) 2002-11-04 2004-05-07 Sofradim Production Piece composite intermediaire pour faconnage de protheses de renfort
WO2004041123A1 (fr) 2002-11-04 2004-05-21 Sofradim Production Piece composite intermediaire pour faconnage de protheses de renfort
WO2005047866A1 (en) * 2003-11-14 2005-05-26 Enfer Technology Sample homogeniser
WO2005054824A1 (en) * 2003-12-08 2005-06-16 Blue I Water Technologies Ltd. A measuring cell
US7662342B2 (en) 2003-12-08 2010-02-16 Blue I Water Technologies Ltd. Measuring cell
FR2955458A1 (fr) * 2010-01-27 2011-07-29 Novacyt Solution de fixation pour des cellules biologiques
WO2011092414A1 (fr) * 2010-01-27 2011-08-04 Novacyt Solution de fixation pour des cellules biologiques
CN102791124A (zh) * 2010-01-27 2012-11-21 诺瓦赛特公司 用于生物细胞的固定溶液
CN102791124B (zh) * 2010-01-27 2014-12-03 诺瓦赛特公司 用于生物细胞的固定溶液
US12221518B2 (en) 2019-02-18 2025-02-11 Toyobo Co., Ltd. Biaxially stretched polyamide film and laminate film

Also Published As

Publication number Publication date
CN1316053A (zh) 2001-10-03
KR100886264B1 (ko) 2009-02-27
EP1093572B1 (en) 2002-11-27
ATE228650T1 (de) 2002-12-15
WO2000002031A9 (en) 2000-04-06
EP1093572A1 (en) 2001-04-25
AU758047B2 (en) 2003-03-13
CA2336093C (en) 2008-05-20
KR20010071768A (ko) 2001-07-31
CN1136446C (zh) 2004-01-28
DE69904179T2 (de) 2003-07-24
CA2336093A1 (en) 2000-01-13
JP2002519692A (ja) 2002-07-02
MXPA01000222A (es) 2003-09-10
DE69904179D1 (de) 2003-01-09
AU5090999A (en) 2000-01-24

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