WO2000000208A1 - Utilisation de solutions salines isoosmotiques, leur procede de preparation et medicaments cerumenolytiques a base de ces solutions - Google Patents

Utilisation de solutions salines isoosmotiques, leur procede de preparation et medicaments cerumenolytiques a base de ces solutions Download PDF

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Publication number
WO2000000208A1
WO2000000208A1 PCT/FR1999/001564 FR9901564W WO0000208A1 WO 2000000208 A1 WO2000000208 A1 WO 2000000208A1 FR 9901564 W FR9901564 W FR 9901564W WO 0000208 A1 WO0000208 A1 WO 0000208A1
Authority
WO
WIPO (PCT)
Prior art keywords
cerumenolytic
solutions
saline solution
isoosmotic
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR1999/001564
Other languages
English (en)
French (fr)
Inventor
Jean-Claude Yvin
Isabelle Cadudal
Olivier Tabary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Goemar SA
Original Assignee
Laboratoires Goemar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Goemar SA filed Critical Laboratoires Goemar SA
Priority to EP99926567A priority Critical patent/EP1091746B1/fr
Priority to US09/743,010 priority patent/US6709680B1/en
Priority to DE69900852T priority patent/DE69900852T2/de
Priority to AT99926567T priority patent/ATE212553T1/de
Priority to DK99926567T priority patent/DK1091746T3/da
Priority to AU43765/99A priority patent/AU4376599A/en
Priority to CA2335913A priority patent/CA2335913C/fr
Priority to JP2000556793A priority patent/JP2002519330A/ja
Publication of WO2000000208A1 publication Critical patent/WO2000000208A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/08—Mineral waters; Sea water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals

Definitions

  • the subject of the invention is a cerumenolytic medicament, that is to say a medicament suitable for dissolving earwax plugs.
  • earwax is a very oily yellow-brown substance which, when agglomerated, forms plugs and which is secreted by the sebaceous glands which cover the external auditory canal which connects the pavilion of the ear to the eardrum. Earwax plugs cause ringing in the ears and disturb hearing.
  • Cerumenolytic drugs and preparations are already known, that is to say products intended for dissolving existing earwax plugs and preventing the formation of new plugs.
  • cerumenolytic preparation based on purified and sterilized seawater of at least 36 g of salt per liter, marketed under the brand AUDISPRAY by the company DIEPHA.
  • AUDISPRAY a cerumenolytic preparation based on purified and sterilized seawater of at least 36 g of salt per liter
  • the medicament according to the invention is characterized in that it is based on an isoosmotic saline solution.
  • This isoosmotic saline solution is characterized: by a pH of 7.8 to 8.3 by a density of 1.008 and 1.01 by a dry matter content of 1 to 2% by weight and
  • the invention resides in the use of an isoosmotic saline solution, in particular obtained from sea water, for obtaining a medicament intended for a cerumenolytic treatment.
  • sea water is advantageously taken from a depth of 5 to 10 meters in an area with strong current movements, and characterized by a salt content greater than 32 g / l.
  • This water is analyzed, decanted and then quickly: deoded by the electrodialysis technique until the isotonicity is approximately 9 equivalent-grams of sodium chloride per liter, filtered and stored under sterile conditions in a steel tank stainless.
  • the cerumenolytic effect of the saline solution, isoosmotic used, in accordance with the invention and of the cerumenolytic products of the prior art identified above was also analyzed by densitometry (these are analyzes carried out using the BIORAD densitometer, digital images corresponding to the different solutions A to G and A 'to G', taken in photo), this to assess the effect of dissolution of earwax plugs by examining the disorder that appears in the tubes.
  • densitometry are analyzes carried out using the BIORAD densitometer, digital images corresponding to the different solutions A to G and A 'to G', taken in photo
  • Table B relates to the first series of tests. TABLE B
  • the new cerumenolytic drugs according to the invention can be applied by spraying or by instillation in the form of drops in the external auditory canal of the ear.
  • they can advantageously be applied at the rate of two sprays or instillations daily for a period of 3 to 4 days.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PCT/FR1999/001564 1998-06-29 1999-06-29 Utilisation de solutions salines isoosmotiques, leur procede de preparation et medicaments cerumenolytiques a base de ces solutions Ceased WO2000000208A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP99926567A EP1091746B1 (fr) 1998-06-29 1999-06-29 Utilisation de solutions salines isoosmotiques pour la preparation de medicaments cerumenolytiques
US09/743,010 US6709680B1 (en) 1998-06-29 1999-06-29 Use of iso-osmotic saline solutions, method for preparing same and cerumenolytic medicines based on said solutions
DE69900852T DE69900852T2 (de) 1998-06-29 1999-06-29 Verwendung von isoosmotische salzlösungen zur herstellung von cerumenolytischer pharmazeutischer präparate
AT99926567T ATE212553T1 (de) 1998-06-29 1999-06-29 Verwendung von isoosmotische salzlösungen zur herstellung von cerumenolytischer pharmazeutischer präparate
DK99926567T DK1091746T3 (da) 1998-06-29 1999-06-29 Anvendelse af isoosmotiske saltopløsninger til fremstilling af cerumenolytiske lægemidler
AU43765/99A AU4376599A (en) 1998-06-29 1999-06-29 Use of iso-osmotic saline solutions, method for preparing same and cerumenolyticmedicines based on said solutions
CA2335913A CA2335913C (fr) 1998-06-29 1999-06-29 Utilisation de solutions salines isoosmotiques, leur procede de preparation et medicaments cerumenolytiques a base de ces solutions
JP2000556793A JP2002519330A (ja) 1998-06-29 1999-06-29 等浸透性食塩水溶液、その製法及び当該溶液に基づく耳垢溶解剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR98/08249 1998-06-29
FR9808249A FR2780284B1 (fr) 1998-06-29 1998-06-29 Utilisation de solutions salines isoosmotiques, leur procede de preparation et medicaments cerumenolytiques a base de ces solutions

Publications (1)

Publication Number Publication Date
WO2000000208A1 true WO2000000208A1 (fr) 2000-01-06

Family

ID=9528002

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1999/001564 Ceased WO2000000208A1 (fr) 1998-06-29 1999-06-29 Utilisation de solutions salines isoosmotiques, leur procede de preparation et medicaments cerumenolytiques a base de ces solutions

Country Status (12)

Country Link
US (1) US6709680B1 (enExample)
EP (1) EP1091746B1 (enExample)
JP (1) JP2002519330A (enExample)
AT (1) ATE212553T1 (enExample)
AU (1) AU4376599A (enExample)
CA (1) CA2335913C (enExample)
DE (1) DE69900852T2 (enExample)
DK (1) DK1091746T3 (enExample)
ES (1) ES2172332T3 (enExample)
FR (1) FR2780284B1 (enExample)
PT (1) PT1091746E (enExample)
WO (1) WO2000000208A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100785441B1 (ko) 2006-07-13 2007-12-13 주식회사 워터비스 해양 심층수 미네랄을 함유하는 항균성 생리식염수
WO2009143624A1 (en) 2008-05-30 2009-12-03 The University Of British Columbia Methods of diagnosing rejection of a kidney allograft using genomic or proteomic expression profiling
WO2016178121A1 (en) 2015-05-01 2016-11-10 The University Of British Columbia Biomarkers for the detection of acute rejection in heart transplantation

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2803205B1 (fr) * 1999-12-31 2002-10-18 Goemar Lab Sa Solutions ioniques aqueuses et leurs utilisations notamment en ophtalmologie
FR2915389B1 (fr) * 2007-04-26 2012-12-21 De La Mer Laboratoire Utilisation de solutions ioniques isoosmotiques a base d'eau de mer pour la fabrication de dispositifs medicaux pour la prevention des complications du rhume courant
US20090258091A1 (en) * 2008-04-09 2009-10-15 Marine Bio Co., Ltd. Compositions and methods for treating neurodegenerative diseases
FR2971713B1 (fr) 2011-02-18 2019-03-29 Laboratoire De La Mer Solution ionique aqueuse contenant de l'eau de mer et au moins un compose originellement non miscible a l'eau de mer.
WO2015129800A1 (ja) * 2014-02-26 2015-09-03 セオリアファーマ株式会社 ジオクチルソジウムスルホサクシネート耳鼻科用液剤

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2688133A1 (fr) * 1992-03-06 1993-09-10 Plantes Tropicales Lab Composition d'hygiene a base d'eau de mer.
EP0747044A1 (fr) * 1995-06-08 1996-12-11 Renée-Jane Maugendre Procédé de préparation d'eau de mer pour la désagrégation du cérumen
FR2735980A1 (fr) * 1995-06-30 1997-01-03 Sun Trading Ltd Nouvelles preparations pour l'otologie et leur procede de preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581226A (en) * 1983-04-07 1986-04-08 Dillon Richard S Method of treating sensitive animal tissue with a specially processed seawater solution
JP2912421B2 (ja) * 1990-05-10 1999-06-28 千寿製薬株式会社 水性液剤
US5296472A (en) * 1991-12-05 1994-03-22 Vyrex Corporation Methods for delipidation of skin and cerumen removal

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2688133A1 (fr) * 1992-03-06 1993-09-10 Plantes Tropicales Lab Composition d'hygiene a base d'eau de mer.
EP0747044A1 (fr) * 1995-06-08 1996-12-11 Renée-Jane Maugendre Procédé de préparation d'eau de mer pour la désagrégation du cérumen
FR2735980A1 (fr) * 1995-06-30 1997-01-03 Sun Trading Ltd Nouvelles preparations pour l'otologie et leur procede de preparation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100785441B1 (ko) 2006-07-13 2007-12-13 주식회사 워터비스 해양 심층수 미네랄을 함유하는 항균성 생리식염수
WO2009143624A1 (en) 2008-05-30 2009-12-03 The University Of British Columbia Methods of diagnosing rejection of a kidney allograft using genomic or proteomic expression profiling
WO2016178121A1 (en) 2015-05-01 2016-11-10 The University Of British Columbia Biomarkers for the detection of acute rejection in heart transplantation

Also Published As

Publication number Publication date
DE69900852T2 (de) 2002-09-12
FR2780284B1 (fr) 2001-10-05
CA2335913C (fr) 2010-10-19
ES2172332T3 (es) 2002-09-16
DK1091746T3 (da) 2002-05-21
US6709680B1 (en) 2004-03-23
JP2002519330A (ja) 2002-07-02
EP1091746B1 (fr) 2002-01-30
AU4376599A (en) 2000-01-17
FR2780284A1 (fr) 1999-12-31
PT1091746E (pt) 2002-07-31
ATE212553T1 (de) 2002-02-15
CA2335913A1 (fr) 2000-01-06
EP1091746A1 (fr) 2001-04-18
DE69900852D1 (de) 2002-03-14

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