WO1999064439A3 - Methods for increasing cationic antimicrobial peptides - Google Patents

Methods for increasing cationic antimicrobial peptides Download PDF

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Publication number
WO1999064439A3
WO1999064439A3 PCT/US1999/013335 US9913335W WO9964439A3 WO 1999064439 A3 WO1999064439 A3 WO 1999064439A3 US 9913335 W US9913335 W US 9913335W WO 9964439 A3 WO9964439 A3 WO 9964439A3
Authority
WO
WIPO (PCT)
Prior art keywords
inducer
cap
stimulant
antimicrobial peptides
cationic antimicrobial
Prior art date
Application number
PCT/US1999/013335
Other languages
French (fr)
Other versions
WO1999064439A2 (en
Inventor
Aaron Weinberg
Beverly A Dale-Crunk
Suttichai Krisanaprakomkit
Original Assignee
Univ Case Western Reserve
Aaron Weinberg
Dale Crunk Beverly A
Suttichai Krisanaprakomkit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Case Western Reserve, Aaron Weinberg, Dale Crunk Beverly A, Suttichai Krisanaprakomkit filed Critical Univ Case Western Reserve
Priority to AU45645/99A priority Critical patent/AU4564599A/en
Publication of WO1999064439A2 publication Critical patent/WO1999064439A2/en
Publication of WO1999064439A3 publication Critical patent/WO1999064439A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4721—Cationic antimicrobial peptides, e.g. defensins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Novel methods for enhancing or inducing the endogenous production of cationic antimicrobial peptides (CAP), preferably defensins, in epithelial cells preferably is provided. The method involves administering to cells either in vitro or in vivo a CAP stimulant. The CAP stimulant comprises the inducer and optionally an aqueous carrier. The inducer is selected from the group consisting of: a bacterial cell wall extract, a purified inducer, a peptidoglycan inducer and mixtures thereof. The bacterial cell wall extract inducer is an extract of a commensal bacteria such as Fusobacterium nucleatum. The CAP stimulant when administered to cells enhances the production of CAPs, particularly defensins. Novel methods of CAP detection are also provided.
PCT/US1999/013335 1998-06-12 1999-06-11 Methods for increasing cationic antimicrobial peptides WO1999064439A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU45645/99A AU4564599A (en) 1998-06-12 1999-06-11 Methods for increasing cationic antimicrobial peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8902698P 1998-06-12 1998-06-12
US60/089,026 1998-06-12

Publications (2)

Publication Number Publication Date
WO1999064439A2 WO1999064439A2 (en) 1999-12-16
WO1999064439A3 true WO1999064439A3 (en) 2000-04-27

Family

ID=22215085

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/013335 WO1999064439A2 (en) 1998-06-12 1999-06-11 Methods for increasing cationic antimicrobial peptides

Country Status (2)

Country Link
AU (1) AU4564599A (en)
WO (1) WO1999064439A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8329865B2 (en) 2001-06-13 2012-12-11 Eberhard-Karls-Univresitaet Tuebingen Universitaetsklinikum Antimicrobially active peptides
DE10129983A1 (en) * 2001-06-13 2003-01-30 Univ Eberhard Karls Antimicrobial peptide
US7442375B2 (en) 2002-12-13 2008-10-28 Case Western Reserve University Compositions of beta-defensin inducing agents
US20040224883A1 (en) * 2002-12-13 2004-11-11 Case Western Reserve University Compositions and methods for treating HIV infections
WO2004055041A2 (en) * 2002-12-13 2004-07-01 Case Western Reserve University Defensin-inducing peptides from fusobacterium
ES2324192B1 (en) * 2008-01-30 2010-06-17 PUIG BEAUTY & FASHION GROUP, S.L. PEPTIDIC DERIVATIVES USEFUL IN THE TREATMENT, CARE OR CLEANING OF THE SKIN, MUCOSA, LEATHER HAIR OR NAILS.
GB2532488B (en) * 2014-11-21 2019-07-31 Univ Of The Western Cape Use of AMP1 or AMP8 to diagnose HIV infection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447914A (en) * 1990-06-21 1995-09-05 Emory University Antimicrobial peptides
US5550109A (en) * 1994-05-24 1996-08-27 Magainin Pharmaceuticals Inc. Inducible defensin peptide from mammalian epithelia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447914A (en) * 1990-06-21 1995-09-05 Emory University Antimicrobial peptides
US5550109A (en) * 1994-05-24 1996-08-27 Magainin Pharmaceuticals Inc. Inducible defensin peptide from mammalian epithelia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KRISANAPRAKORNKIT S.: "Expression of the Peptide Antibiotic Human B-Defensin 1 in Cultured Gingival Epithelial Cells and Gingival Tissue", INFECTION AND IMMUNITY, vol. 66, no. 9, September 1998 (1998-09-01), pages 4222 - 42228, XP002923990 *

Also Published As

Publication number Publication date
AU4564599A (en) 1999-12-30
WO1999064439A2 (en) 1999-12-16

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