SE9501472D0 - Truncated IGF-I - Google Patents

Truncated IGF-I

Info

Publication number
SE9501472D0
SE9501472D0 SE9501472A SE9501472A SE9501472D0 SE 9501472 D0 SE9501472 D0 SE 9501472D0 SE 9501472 A SE9501472 A SE 9501472A SE 9501472 A SE9501472 A SE 9501472A SE 9501472 D0 SE9501472 D0 SE 9501472D0
Authority
SE
Sweden
Prior art keywords
igf
truncated
truncated variant
expressing
variant
Prior art date
Application number
SE9501472A
Other languages
Swedish (sv)
Inventor
Rolf Eriksson
Stig Johansson
Harriet Roennholm
Anna Skottner
Karin Sonesson
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Priority to SE9501472A priority Critical patent/SE9501472D0/en
Publication of SE9501472D0 publication Critical patent/SE9501472D0/en
Priority to AU54129/96A priority patent/AU5412996A/en
Priority to PCT/SE1996/000520 priority patent/WO1996033216A1/en
Priority to IL11790796A priority patent/IL117907A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to a truncated variant of IGF-I having 1-69 of the amino acids of authentic IGF-I (IGF-I(1-69)) and a method of obtaining the truncated IGF-I either by expressing of IGF-I in yeast cells, enzymatic cleavage and thereafter isolating the truncated IGF-I from the medium or by introducing a plasmid encoding for the truncated variant of IGF-I and expressing the truncated variant of IGF-I. The invention also relates to a pharmaceutical composition containing this new truncated variant of IGF-I and to the use of IGF-I(1-69) for the preparation of a medicament.
SE9501472A 1995-04-21 1995-04-21 Truncated IGF-I SE9501472D0 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
SE9501472A SE9501472D0 (en) 1995-04-21 1995-04-21 Truncated IGF-I
AU54129/96A AU5412996A (en) 1995-04-21 1996-04-19 Truncated igf-i
PCT/SE1996/000520 WO1996033216A1 (en) 1995-04-21 1996-04-19 Truncated igf-i
IL11790796A IL117907A0 (en) 1995-04-21 1996-05-14 Truncated IGF-I

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9501472A SE9501472D0 (en) 1995-04-21 1995-04-21 Truncated IGF-I

Publications (1)

Publication Number Publication Date
SE9501472D0 true SE9501472D0 (en) 1995-04-21

Family

ID=20398031

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9501472A SE9501472D0 (en) 1995-04-21 1995-04-21 Truncated IGF-I

Country Status (4)

Country Link
AU (1) AU5412996A (en)
IL (1) IL117907A0 (en)
SE (1) SE9501472D0 (en)
WO (1) WO1996033216A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US6121416A (en) 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
US6420518B1 (en) 1997-04-04 2002-07-16 Genetech, Inc. Insulin-like growth factor agonist molecules
SE9802938D0 (en) 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions
DE60042550D1 (en) 1999-01-06 2009-08-27 Genentech Inc MUTED VARIANTS OF THE INSULIN-SIMILAR GROWTH FACTOR I (IGF-I)
AU762351B2 (en) 1999-01-06 2003-06-26 Genentech Inc. Insulin-like growth factor (IGF) I mutant variants
WO2000078341A1 (en) * 1999-06-21 2000-12-28 Murdoch Childrens Research Institute A method for the prophylaxis and/or treatment of medical disorders
ES2301547T3 (en) 2000-05-16 2008-07-01 Genentech, Inc. TREATMENT OF CARTILAGO DISORDERS.
EP1772464B1 (en) 2001-02-09 2009-08-12 Genentech, Inc. Methods of identifying indirect agonists of IGF-1
WO2002072780A2 (en) 2001-03-14 2002-09-19 Genentech, Inc. Igf antagonist peptides
EP1667521B1 (en) 2003-09-12 2011-12-07 Tercica, Inc. Methods for treatment of insulin-like growth factor-1 (igf-1) deficiency
WO2021005604A1 (en) 2019-07-11 2021-01-14 Opko Biologics Ltd. Long-acting igf-1 or igf-1 variants and methods of producing same
GB201913196D0 (en) 2019-09-12 2019-10-30 Univ Newcastle Culture method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5126324A (en) * 1990-06-07 1992-06-30 Genentech, Inc. Method of enhancing growth in patients using combination therapy
GB9217696D0 (en) * 1992-08-20 1992-09-30 Agricultural & Food Res Use of specific binding molecules
SE9402332D0 (en) * 1994-07-01 1994-07-01 Pharmacia Ab IGF-1

Also Published As

Publication number Publication date
WO1996033216A1 (en) 1996-10-24
IL117907A0 (en) 1996-08-04
AU5412996A (en) 1996-11-07

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