WO1999061610A3 - TUMORSUPPRESSORGENE DER p53-FAMILIE - Google Patents

TUMORSUPPRESSORGENE DER p53-FAMILIE Download PDF

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Publication number
WO1999061610A3
WO1999061610A3 PCT/DE1999/001557 DE9901557W WO9961610A3 WO 1999061610 A3 WO1999061610 A3 WO 1999061610A3 DE 9901557 W DE9901557 W DE 9901557W WO 9961610 A3 WO9961610 A3 WO 9961610A3
Authority
WO
WIPO (PCT)
Prior art keywords
family
suppressor genes
tumour suppressor
code
relates
Prior art date
Application number
PCT/DE1999/001557
Other languages
English (en)
French (fr)
Other versions
WO1999061610A2 (de
Inventor
Dieter Paul
Martin Augustin
Hartwig Schmale
Casimir Bamberger
Original Assignee
Fraunhofer Ges Forschung
Dieter Paul
Martin Augustin
Hartwig Schmale
Casimir Bamberger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Ges Forschung, Dieter Paul, Martin Augustin, Hartwig Schmale, Casimir Bamberger filed Critical Fraunhofer Ges Forschung
Priority to EP99936328A priority Critical patent/EP1082429A2/de
Publication of WO1999061610A2 publication Critical patent/WO1999061610A2/de
Publication of WO1999061610A3 publication Critical patent/WO1999061610A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Die Erfindung betrifft neue Tumorsuppressorgene der p53-Familie, Polypeptide die sie kodieren, sowie ihre Verwendung. Bevorzugt betrifft sie KET-kodierende Nukleinsäuren, insbesondere der Ratte, des Menschen und der Maus.
PCT/DE1999/001557 1998-05-25 1999-05-25 TUMORSUPPRESSORGENE DER p53-FAMILIE WO1999061610A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP99936328A EP1082429A2 (de) 1998-05-25 1999-05-25 TUMORSUPPRESSORGENE DER p53-FAMILIE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19822985A DE19822985C1 (de) 1998-05-25 1998-05-25 Tumorsuppressorgene der p53-Familie
DE19822985.2 1998-05-25

Publications (2)

Publication Number Publication Date
WO1999061610A2 WO1999061610A2 (de) 1999-12-02
WO1999061610A3 true WO1999061610A3 (de) 2000-04-06

Family

ID=7868643

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/001557 WO1999061610A2 (de) 1998-05-25 1999-05-25 TUMORSUPPRESSORGENE DER p53-FAMILIE

Country Status (3)

Country Link
EP (1) EP1082429A2 (de)
DE (1) DE19822985C1 (de)
WO (1) WO1999061610A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7030227B1 (en) 1997-10-15 2006-04-18 President & Fellows Of Harvard College Cell regulatory genes, encoded products, and uses related thereto
CN100340665C (zh) 1998-03-27 2007-10-03 大塚制药株式会社 人p51基因及其基因产物
WO2001000818A1 (fr) * 1999-06-29 2001-01-04 Nippon Kayaku Kabushiki Kaisha Gene codant le domaine promoteur du gene suppresseur de tumeur p51 et utilisation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0390323A2 (de) * 1989-03-29 1990-10-03 The Johns Hopkins University Nachweis des Ausfalls des Wildtyps des p53-Gens
WO1999019357A2 (en) * 1997-10-15 1999-04-22 President And Fellows Of Harvard College Cell regulatory genes, encoded products, and uses related thereto
WO1999047674A2 (en) * 1998-03-18 1999-09-23 Corixa Corporation Compounds and methods for therapy and diagnosis of lung cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0390323A2 (de) * 1989-03-29 1990-10-03 The Johns Hopkins University Nachweis des Ausfalls des Wildtyps des p53-Gens
WO1999019357A2 (en) * 1997-10-15 1999-04-22 President And Fellows Of Harvard College Cell regulatory genes, encoded products, and uses related thereto
WO1999047674A2 (en) * 1998-03-18 1999-09-23 Corixa Corporation Compounds and methods for therapy and diagnosis of lung cancer

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
AUGUSTIN,M. ET AL: "Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16", MAMMALIAN GENOME, vol. 9, no. 11, November 1998 (1998-11-01), pages 899 - 902, XP000866187 *
DATABASE GENEMBL 22 September 1997 (1997-09-22), SCHMALE H: "Rattus sp. mRNA for DNA binding protein KET", XP002128184 *
DATABASE GENEMBL 25 September 1998 (1998-09-25), LEE, L.A.: "Homo sapiens CUSP mRNA, complete cds", XP002127509 *
DATABASE GENEMBL 3 December 1998 (1998-12-03), SCHMALE,H.: "Homo sapiens mRNA for KET protein", XP002128185 *
DATABASE GENEMBL 3 September 1998 (1998-09-03), IKAWA, S. AND OSADA, M.: "Homo sapiens mRNA for p51B, complete cds.", XP002128187 *
DATABASE GENEMBL 30 July 1998 (1998-07-30), SENOO M ET AL: "Homo sapiens mRNA for p73H, complete cds.", XP002128186 *
LEE, LELA A. ET AL: "The KET protein, a novel keratinocyte protein with homology to the p53 tumor suppressor, is the target of autoantibodies in patients with a specific subset of chronic ulcerative stomatitis.", JOURNAL OF DERMATOLOGICAL SCIENCE. MEETING INFO.: THIRD JOINT MEETING OF THE EUROPEAN SOCIETY FOR DERMATOLOGICAL RESEARCH, JAPANESE SOCIETY FOR INVESTIGATIVE DERMATOLOGY, SOCIETY FOR INVESTIGATIVE DERMATOLOGY, COLOGNE, GERMANY, 7-10 MAY 1998, vol. 16, no. Suppl. 1, March 1998 (1998-03-01), pages S32, XP000866523 *
OSADA ET AL: "Cloning and functional analysis of human p51, which structurally and functonally resembles p53", NATURE MEDICINE, vol. 4, no. 7, July 1998 (1998-07-01), pages 839 - 843, XP002127507 *
SAUTER G ET AL: "Physical deletion of the p53 gene in bladder cancer. Detection by fluorescence in situ hybridization.", AMERICAN JOURNAL OF PATHOLOGY, vol. 144, no. 4, April 1994 (1994-04-01), pages 756 - 766, XP000866304 *
SCHMALE H AND BAMBERGER C: "A novel protein with strong homology to the tumor suppressor p53", ONCOGENE, vol. 15, no. 11, September 1997 (1997-09-01), pages 1363 - 1367, XP002101717 *
SENOO M ET AL: "A second p53-related protein, p73L, with high homology to p73", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 248, no. 3, 30 July 1998 (1998-07-30), pages 603 - 607, XP002127506 *

Also Published As

Publication number Publication date
DE19822985C1 (de) 2000-01-13
EP1082429A2 (de) 2001-03-14
WO1999061610A2 (de) 1999-12-02

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