WO1999058641A8 - Nt2lp, novel g-protein coupled receptors having homology to neurotensin-2 receptors - Google Patents

Nt2lp, novel g-protein coupled receptors having homology to neurotensin-2 receptors

Info

Publication number
WO1999058641A8
WO1999058641A8 PCT/US1999/010311 US9910311W WO9958641A8 WO 1999058641 A8 WO1999058641 A8 WO 1999058641A8 US 9910311 W US9910311 W US 9910311W WO 9958641 A8 WO9958641 A8 WO 9958641A8
Authority
WO
WIPO (PCT)
Prior art keywords
nt2lp
protein
methods
gene
receptors
Prior art date
Application number
PCT/US1999/010311
Other languages
French (fr)
Other versions
WO1999058641A2 (en
Inventor
Rory Curtis
Maria Alexandra Glucksmann
Original Assignee
Millennium Pharm Inc
Rory Curtis
Maria Alexandra Glucksmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Rory Curtis, Maria Alexandra Glucksmann filed Critical Millennium Pharm Inc
Priority to AU38976/99A priority Critical patent/AU3897699A/en
Priority to EP99921872A priority patent/EP1078040A4/en
Priority to JP2000548434A priority patent/JP2003525576A/en
Priority to CA002327548A priority patent/CA2327548A1/en
Publication of WO1999058641A2 publication Critical patent/WO1999058641A2/en
Publication of WO1999058641A8 publication Critical patent/WO1999058641A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention is based on the identification of a novel G-protein coupled receptor (GPCR) that is expressed predominantly in the brain and nucleic acid molecules that encoded the GPCR, referred to herein as the NT2LP protein and NT2LP gene respectively. The NT2LP protein has high sequence homology to the NT family of receptors, particularly members of the NT2 subfamily. Based on this identification, the present invention provides: 1) isolated NT2LP protein, 2) isolated nucleic acid molecules that encode a NT2LP protein, 3) antibodies that selectively bind to the NT2LP protein, 4) methods of isolating allelic variants of the NT2LP protein and gene, 5) methods of identifying cells and tissues that express the NT2LP protein/gene, 6) methods of identifying agents and cellular compounds that bind to the NT2LP protein, 7) methods of identifying agents that modulate the expression of the NT2LP gene, 8) methods of modulating the activity of the NT2LP protein in a cell or organism and 9) a method for treating diseases, pathologies, or biological processes, for example, pain, comprising administering an agent that binds to and/or modulates NT2LP proteins.
PCT/US1999/010311 1998-05-11 1999-05-11 Nt2lp, novel g-protein coupled receptors having homology to neurotensin-2 receptors WO1999058641A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU38976/99A AU3897699A (en) 1998-05-11 1999-05-11 Nt2lp, novel g-protein coupled receptors having homology to neurotensin-2 receptors
EP99921872A EP1078040A4 (en) 1998-05-11 1999-05-11 Nt2lp, novel g-protein coupled receptors having homology to neurotensin-2 receptors
JP2000548434A JP2003525576A (en) 1998-05-11 1999-05-11 NT2LP, a novel G protein-coupled receptor having homology to the neurotensin-2 receptor
CA002327548A CA2327548A1 (en) 1998-05-11 1999-05-11 Nt2lp, novel g-protein coupled receptors having homology to neurotensin-2 receptors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7631398A 1998-05-11 1998-05-11
US09/076,313 1998-05-11
US22349298A 1998-12-30 1998-12-30
US09/223,492 1998-12-30

Publications (2)

Publication Number Publication Date
WO1999058641A2 WO1999058641A2 (en) 1999-11-18
WO1999058641A8 true WO1999058641A8 (en) 2000-01-20

Family

ID=26757952

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/010311 WO1999058641A2 (en) 1998-05-11 1999-05-11 Nt2lp, novel g-protein coupled receptors having homology to neurotensin-2 receptors

Country Status (5)

Country Link
EP (1) EP1078040A4 (en)
JP (1) JP2003525576A (en)
AU (1) AU3897699A (en)
CA (1) CA2327548A1 (en)
WO (1) WO1999058641A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4551401A (en) * 2000-03-08 2001-09-17 Upjohn Co Novel g protein-coupled receptors
WO2001090149A2 (en) * 2000-05-22 2001-11-29 Pharmacia & Upjohn Company G protein-coupled receptors

Also Published As

Publication number Publication date
AU3897699A (en) 1999-11-29
WO1999058641A2 (en) 1999-11-18
JP2003525576A (en) 2003-09-02
EP1078040A4 (en) 2003-01-02
EP1078040A1 (en) 2001-02-28
CA2327548A1 (en) 1999-11-18

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