WO1999058477A3 - Derives de n-[3-[2-[(2,3-dihydro-1h-inden-2-yl)alkylamino]-ethyl]phenyl]carboxamide, leur preparation et leur application en therapeutique - Google Patents

Derives de n-[3-[2-[(2,3-dihydro-1h-inden-2-yl)alkylamino]-ethyl]phenyl]carboxamide, leur preparation et leur application en therapeutique Download PDF

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Publication number
WO1999058477A3
WO1999058477A3 PCT/FR1999/001049 FR9901049W WO9958477A3 WO 1999058477 A3 WO1999058477 A3 WO 1999058477A3 FR 9901049 W FR9901049 W FR 9901049W WO 9958477 A3 WO9958477 A3 WO 9958477A3
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WO
WIPO (PCT)
Prior art keywords
group
inden
dihydro
alkylamino
ethyl
Prior art date
Application number
PCT/FR1999/001049
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English (en)
Other versions
WO1999058477A2 (fr
Inventor
Yannick Evanno
Benoit Marabout
Mireille Sevrin
Genevieve Estenne-Bouhtou
Emmanuelle Dachary
Corinne Veronique
Original Assignee
Sanofi Synthelabo
Yannick Evanno
Benoit Marabout
Mireille Sevrin
Estenne Bouhtou Genevieve
Emmanuelle Dachary
Corinne Veronique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo, Yannick Evanno, Benoit Marabout, Mireille Sevrin, Estenne Bouhtou Genevieve, Emmanuelle Dachary, Corinne Veronique filed Critical Sanofi Synthelabo
Priority to AU35271/99A priority Critical patent/AU3527199A/en
Publication of WO1999058477A2 publication Critical patent/WO1999058477A2/fr
Publication of WO1999058477A3 publication Critical patent/WO1999058477A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Composé répondant à la formule générale (I) dans laquelle R1 représente un groupe 2,3-dihydro-1H-indén-2-yle éventuellement substitué par un ou deux groupes méthoxy, R2 représente un groupe alkyle, et R3 représente soit un groupe alkyle, soit un groupe phényle éventuellement substitué par un ou plusieurs atomes de fluor ou par un ou plusieurs groupes alkyles, méthoxy, méthoxyméthyle, cyano, carbamoyle, phényle, oxazolyle, imidazolyle, cycloalkyle, pyrimidinyle ou furanyle, soit un groupe cyclohexyle soit un groupe naphtyle, soit un groupe furanyle ou benzofuranyle, soit un groupe pyridinyle. Application en thérapeutique.
PCT/FR1999/001049 1998-05-12 1999-05-04 Derives de n-[3-[2-[(2,3-dihydro-1h-inden-2-yl)alkylamino]-ethyl]phenyl]carboxamide, leur preparation et leur application en therapeutique WO1999058477A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU35271/99A AU3527199A (en) 1998-05-12 1999-05-04 (n)-{3-{2-{(2,3-dihydro-1(h)-inden-2-yl)alkylamino}-ethyl}ph enyl carboxamide derivatives, preparation and therapeutic applications

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR98/05935 1998-05-12
FR9805935A FR2778658B1 (fr) 1998-05-12 1998-05-12 Derives de n-[3-[2-[(2,3-dihydro-1h-inden-2-yl)alkylamino]- ethyl] phenyl] carboxamide, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
WO1999058477A2 WO1999058477A2 (fr) 1999-11-18
WO1999058477A3 true WO1999058477A3 (fr) 2000-01-27

Family

ID=9526237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1999/001049 WO1999058477A2 (fr) 1998-05-12 1999-05-04 Derives de n-[3-[2-[(2,3-dihydro-1h-inden-2-yl)alkylamino]-ethyl]phenyl]carboxamide, leur preparation et leur application en therapeutique

Country Status (5)

Country Link
AR (1) AR019841A1 (fr)
AU (1) AU3527199A (fr)
CO (1) CO4810303A1 (fr)
FR (1) FR2778658B1 (fr)
WO (1) WO1999058477A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0532398A1 (fr) * 1991-09-12 1993-03-17 Synthelabo Dérivés de N-(4,7-diméthoxyindan-2-yl)-1-(phénylcarbonyl)-N-propyl-pipéridine-4-méthanamine, leur préparation et leur application en thérapeutique
US5272157A (en) * 1990-03-07 1993-12-21 Synthelabo Derivatives of 4-(aminomethyl) piperidine, their preparation and their therapeutic application

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272157A (en) * 1990-03-07 1993-12-21 Synthelabo Derivatives of 4-(aminomethyl) piperidine, their preparation and their therapeutic application
EP0532398A1 (fr) * 1991-09-12 1993-03-17 Synthelabo Dérivés de N-(4,7-diméthoxyindan-2-yl)-1-(phénylcarbonyl)-N-propyl-pipéridine-4-méthanamine, leur préparation et leur application en thérapeutique

Also Published As

Publication number Publication date
AU3527199A (en) 1999-11-29
AR019841A1 (es) 2002-03-20
CO4810303A1 (es) 1999-06-30
WO1999058477A2 (fr) 1999-11-18
FR2778658A1 (fr) 1999-11-19
FR2778658B1 (fr) 2000-06-30

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